Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL00948:Zfp764'

27853

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Zfp764

Ensembl Gene

ENSMUSG00000045757

Gene Name

zinc finger protein 764

Synonyms

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.052) question?

Stock #

IGL00948

Quality Score

Status

Chromosome

Chromosomal Location

127403668-127406822 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 127405204 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Serine to Glycine at position 252 (S252G)

Ref Sequence

ENSEMBL: ENSMUSP00000052944 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000059199]

AlphaFold

E9QAP1

Predicted Effect

possibly damaging
Transcript: ENSMUST00000059199
AA Change: S252G

PolyPhen 2 Score 0.927 (Sensitivity: 0.81; Specificity: 0.94)

SMART Domains

Protein: ENSMUSP00000052944
Gene: ENSMUSG00000045757
AA Change: S252G

Domain	Start	End	E-Value	Type
KRAB	22	82	7.33e-31	SMART
low complexity region	102	115	N/A	INTRINSIC
ZnF_C2H2	152	174	4.47e-3	SMART
ZnF_C2H2	180	202	1.47e-3	SMART
ZnF_C2H2	208	230	4.3e-5	SMART
ZnF_C2H2	236	258	6.78e-3	SMART
ZnF_C2H2	264	286	1.47e-3	SMART
ZnF_C2H2	292	315	1.45e-2	SMART
ZnF_C2H2	321	343	6.52e-5	SMART
ZnF_C2H2	349	371	6.67e-2	SMART
ZnF_C2H2	377	399	1.67e-2	SMART

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000139118

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 25 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Ccl2	A	T	11: 82,035,732	Q24L	possibly damaging	Het
Cd33	G	A	7: 43,529,558		probably benign	Het
Cmya5	T	C	13: 93,091,036	I2515V	probably benign	Het
Cntnap5b	A	G	1: 100,141,357	T101A	probably benign	Het
Cyp4a12a	T	A	4: 115,301,962	M143K	probably damaging	Het
Ephb4	C	A	5: 137,366,659	S663R	probably damaging	Het
Gm4847	T	C	1: 166,630,338	D482G	probably benign	Het
Gskip	C	A	12: 105,698,844	N47K	probably damaging	Het
Kmt2c	T	C	5: 25,377,161	Y473C	probably benign	Het
Lrrc7	T	A	3: 158,161,557	N849I	probably damaging	Het
Magel2	T	A	7: 62,379,322	V658E	unknown	Het
Nmral1	C	T	16: 4,716,406	G57E	probably damaging	Het
Olfr801	A	T	10: 129,669,887	L211I	probably damaging	Het
Olfr921	C	T	9: 38,775,812	Q186*	probably null	Het
Padi3	C	A	4: 140,788,943	R542L	possibly damaging	Het
Plrg1	T	C	3: 83,068,119	V260A	probably damaging	Het
Prex2	A	G	1: 11,170,614	H982R	probably damaging	Het
Rbm26	T	A	14: 105,150,343	T448S	probably damaging	Het
Ryr1	C	T	7: 29,020,195	M4262I	possibly damaging	Het
Slc41a3	A	T	6: 90,645,714	D441V	probably damaging	Het
Slc7a2	A	G	8: 40,912,524	E448G	probably benign	Het
Smtnl2	C	A	11: 72,411,241		probably null	Het
Tox3	G	A	8: 90,270,434	P66L	probably damaging	Het
Vmn1r19	T	C	6: 57,405,262	F267L	probably benign	Het
Vmn2r12	A	G	5: 109,097,675	S64P	possibly damaging	Het

Other mutations in Zfp764

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
PIT4514001:Zfp764	UTSW	7	127404741	missense	probably benign	0.26
R0528:Zfp764	UTSW	7	127404879	missense	possibly damaging	0.92
R0619:Zfp764	UTSW	7	127406541	missense	probably benign	0.08
R1183:Zfp764	UTSW	7	127406247	missense	probably damaging	1.00
R1770:Zfp764	UTSW	7	127405567	nonsense	probably null
R1878:Zfp764	UTSW	7	127405042	missense	probably benign	0.04
R1885:Zfp764	UTSW	7	127405039	missense	probably benign
R2181:Zfp764	UTSW	7	127406499	missense	probably damaging	1.00
R4780:Zfp764	UTSW	7	127404771	missense	probably benign	0.13
R5242:Zfp764	UTSW	7	127405369	missense	probably benign
R5493:Zfp764	UTSW	7	127404933	missense	probably benign	0.00
R7109:Zfp764	UTSW	7	127404715	missense	possibly damaging	0.92
R7214:Zfp764	UTSW	7	127405278	missense	probably benign	0.05
R8047:Zfp764	UTSW	7	127406240	missense	probably damaging	1.00
R8748:Zfp764	UTSW	7	127404690	missense	possibly damaging	0.92
R9131:Zfp764	UTSW	7	127406547	nonsense	probably null
R9187:Zfp764	UTSW	7	127405436	missense	probably damaging	1.00

Posted On

2013-04-17