Incidental Mutation 'IGL01521:Gpr22'
ID278570
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Gpr22
Ensembl Gene ENSMUSG00000044067
Gene NameG protein-coupled receptor 22
Synonyms
Accession Numbers
Is this an essential gene? Non essential (E-score: 0.000) question?
Stock #IGL01521
Quality Score
Status
Chromosome12
Chromosomal Location31706867-31713947 bp(-) (GRCm38)
Type of Mutationunclassified
DNA Base Change (assembly) C to T at 31708710 bp
ZygosityHeterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000134839 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000036862] [ENSMUST00000057783] [ENSMUST00000174480] [ENSMUST00000176710]
Predicted Effect probably benign
Transcript: ENSMUST00000036862
SMART Domains Protein: ENSMUSP00000044797
Gene: ENSMUSG00000035933

DomainStartEndE-ValueType
low complexity region 9 23 N/A INTRINSIC
Pfam:COG5 35 158 3.8e-37 PFAM
Pfam:Vps51 37 120 1.8e-12 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000057783
SMART Domains Protein: ENSMUSP00000056125
Gene: ENSMUSG00000044067

DomainStartEndE-ValueType
low complexity region 58 64 N/A INTRINSIC
Pfam:7tm_1 95 403 2.3e-23 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000174480
SMART Domains Protein: ENSMUSP00000134674
Gene: ENSMUSG00000044067

DomainStartEndE-ValueType
low complexity region 21 27 N/A INTRINSIC
Pfam:7tm_1 58 186 3.3e-11 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000176710
SMART Domains Protein: ENSMUSP00000134839
Gene: ENSMUSG00000044067

DomainStartEndE-ValueType
low complexity region 21 27 N/A INTRINSIC
Pfam:7tm_1 58 366 1.4e-26 PFAM
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene is a member of the G-protein coupled receptor 1 family and encodes a multi-pass membrane protein. [provided by RefSeq, Jul 2008]
PHENOTYPE: Mice homozygous for a null allele exhibit increased response to aortic banding including decreased fractional shortening and decompensated heart failure. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 35 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Aars A T 8: 111,043,787 I406F possibly damaging Het
Adgrb2 A G 4: 129,992,292 E75G probably damaging Het
Als2cr12 T G 1: 58,670,394 K201Q probably damaging Het
Angptl2 T C 2: 33,246,203 Y467H probably damaging Het
Arap1 G T 7: 101,400,605 probably null Het
Arfgap1 G A 2: 180,971,578 C22Y probably damaging Het
Artn G A 4: 117,927,287 P25S probably damaging Het
Bicra G T 7: 15,989,188 Q135K probably benign Het
Clpx T C 9: 65,318,744 V367A probably damaging Het
Clstn3 C T 6: 124,458,031 W308* probably null Het
Cpb2 T A 14: 75,257,631 V67D probably damaging Het
Cyp2c38 A G 19: 39,460,670 Y80H probably damaging Het
Dbt A G 3: 116,533,383 D127G probably benign Het
Fhod1 G A 8: 105,330,423 A973V probably benign Het
Focad A T 4: 88,410,690 *1713C probably null Het
Gemin5 A T 11: 58,134,918 probably benign Het
Ikbkap T A 4: 56,771,059 E961D probably benign Het
Kif23 T A 9: 61,919,900 T890S probably damaging Het
Kmt5b T A 19: 3,786,618 S52T possibly damaging Het
Lipo1 A T 19: 33,785,683 D53E probably damaging Het
Lrrc14b G A 13: 74,363,572 R130C probably damaging Het
Myt1 T A 2: 181,825,911 I1046K probably damaging Het
Napsa A T 7: 44,586,637 I367F probably damaging Het
Olfr1107 C T 2: 87,071,733 V134I probably benign Het
Olfr923 A T 9: 38,827,889 Y66F probably damaging Het
Rgcc T G 14: 79,300,745 S69R probably damaging Het
Rin3 T A 12: 102,369,048 I326N probably benign Het
Sipa1 C A 19: 5,660,978 M1I probably null Het
Sirpb1a T A 3: 15,410,501 M325L probably benign Het
Sult1a1 C A 7: 126,675,279 V71F possibly damaging Het
Tgds G T 14: 118,113,094 P349Q probably damaging Het
Tmem63c T A 12: 87,069,144 H186Q probably damaging Het
Trappc9 A G 15: 73,052,167 L242S probably damaging Het
Trip12 T A 1: 84,766,198 probably benign Het
Zfp451 T C 1: 33,777,331 probably null Het
Other mutations in Gpr22
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01517:Gpr22 APN 12 31708710 unclassified probably benign
IGL01533:Gpr22 APN 12 31708710 unclassified probably benign
IGL01585:Gpr22 APN 12 31709337 missense probably benign 0.23
IGL01601:Gpr22 APN 12 31710045 splice site probably benign
IGL01608:Gpr22 APN 12 31708780 nonsense probably null
IGL02307:Gpr22 APN 12 31708740 missense possibly damaging 0.95
IGL02440:Gpr22 APN 12 31709140 missense probably damaging 0.99
IGL02863:Gpr22 APN 12 31710007 missense probably benign 0.36
IGL03163:Gpr22 APN 12 31709172 missense possibly damaging 0.68
R0078:Gpr22 UTSW 12 31711641 missense probably benign
R0358:Gpr22 UTSW 12 31709982 missense probably benign 0.03
R0395:Gpr22 UTSW 12 31709462 missense possibly damaging 0.48
R0452:Gpr22 UTSW 12 31708794 missense possibly damaging 0.69
R0729:Gpr22 UTSW 12 31709313 missense probably damaging 1.00
R1295:Gpr22 UTSW 12 31709514 missense probably benign 0.01
R1991:Gpr22 UTSW 12 31709203 missense probably benign
R4201:Gpr22 UTSW 12 31708913 nonsense probably null
R5203:Gpr22 UTSW 12 31709788 missense probably damaging 1.00
R5505:Gpr22 UTSW 12 31709725 missense probably damaging 1.00
R5541:Gpr22 UTSW 12 31709349 missense probably damaging 0.97
R6218:Gpr22 UTSW 12 31711617 nonsense probably null
R6844:Gpr22 UTSW 12 31709952 missense probably benign
R7448:Gpr22 UTSW 12 31709515 missense probably benign 0.06
R7956:Gpr22 UTSW 12 31709220 missense possibly damaging 0.75
Posted On2015-04-16