Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL01608:Adh4'

278592

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Adh4

Ensembl Gene

ENSMUSG00000037797

Gene Name

alcohol dehydrogenase 4 (class II), pi polypeptide

Synonyms

Adh2, mouse class II type ADH

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.120) question?

Stock #

IGL01608

Quality Score

Status

Chromosome

Chromosomal Location

138121227-138136653 bp(+) (GRCm39)

Type of Mutation

unclassified

DNA Base Change (assembly)

C to T at 138134788 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Ref Sequence

ENSEMBL: ENSMUSP00000124163 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000013458] [ENSMUST00000161312]

AlphaFold

Q9QYY9

Predicted Effect

probably benign
Transcript: ENSMUST00000013458

SMART Domains

Protein: ENSMUSP00000013458
Gene: ENSMUSG00000037797

Domain	Start	End	E-Value	Type
Pfam:ADH_N	34	165	3.1e-23	PFAM
Pfam:ADH_zinc_N	207	337	8.2e-24	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000161312

SMART Domains

Protein: ENSMUSP00000124163
Gene: ENSMUSG00000037797

Domain	Start	End	E-Value	Type
Pfam:ADH_N	46	177	2.8e-25	PFAM

Coding Region Coverage

Validation Efficiency

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes class II alcohol dehydrogenase 4 pi subunit, which is a member of the alcohol dehydrogenase family. Members of this enzyme family metabolize a wide variety of substrates, including ethanol, retinol, other aliphatic alcohols, hydroxysteroids, and lipid peroxidation products. Class II alcohol dehydrogenase is a homodimer composed of 2 pi subunits. It exhibits a high activity for oxidation of long-chain aliphatic alcohols and aromatic alcohols and is less sensitive to pyrazole. This gene is localized to chromosome 4 in the cluster of alcohol dehydrogenase genes. [provided by RefSeq, Jul 2008]

Allele List at MGI

Other mutations in this stock

Total: 60 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Abca1	A	T	4: 53,038,158 (GRCm39)	L2068Q	probably damaging	Het
Abca12	G	T	1: 71,298,601 (GRCm39)	D2340E	probably damaging	Het
Adcy5	A	G	16: 35,092,535 (GRCm39)	Y632C	probably damaging	Het
Adgrb3	A	G	1: 25,592,855 (GRCm39)	S311P	probably damaging	Het
Atf2	G	T	2: 73,649,422 (GRCm39)	H396Q	probably damaging	Het
Atp8a1	G	A	5: 67,970,479 (GRCm39)	R74*	probably null	Het
Brpf3	T	C	17: 29,040,491 (GRCm39)	S971P	probably benign	Het
Btn1a1	T	C	13: 23,645,778 (GRCm39)	E197G	probably benign	Het
Ccdc136	C	T	6: 29,406,113 (GRCm39)	A87V	possibly damaging	Het
Celf4	A	G	18: 25,630,560 (GRCm39)	L376P	probably damaging	Het
Chrm3	G	A	13: 9,928,634 (GRCm39)	A134V	possibly damaging	Het
Col19a1	G	A	1: 24,321,626 (GRCm39)	R961C	probably damaging	Het
Cr2	A	G	1: 194,837,528 (GRCm39)	V1190A	possibly damaging	Het
Dop1a	T	A	9: 86,389,614 (GRCm39)	S515T	probably benign	Het
Eprs1	T	A	1: 185,117,311 (GRCm39)		probably benign	Het
Fbn2	G	T	18: 58,186,776 (GRCm39)	Y1708*	probably null	Het
Glt1d1	A	G	5: 127,741,746 (GRCm39)	N148S	possibly damaging	Het
Gm20425	T	A	9: 103,068,293 (GRCm39)	I44F	probably damaging	Het
Gpr22	T	A	12: 31,758,779 (GRCm39)	K411*	probably null	Het
Ipo11	A	G	13: 106,971,002 (GRCm39)		probably benign	Het
Klri1	T	A	6: 129,675,130 (GRCm39)	N210I	possibly damaging	Het
Kmt2c	C	T	5: 25,559,809 (GRCm39)	V950M	probably damaging	Het
Knop1	T	C	7: 118,445,019 (GRCm39)	K315R	probably benign	Het
Krt90	A	G	15: 101,471,064 (GRCm39)	I66T	probably benign	Het
Lrrc32	T	A	7: 98,148,564 (GRCm39)	V448D	probably benign	Het
Met	T	C	6: 17,558,729 (GRCm39)	V1119A	probably damaging	Het
Minar1	T	C	9: 89,478,551 (GRCm39)	T832A	probably benign	Het
Mipep	T	A	14: 61,039,679 (GRCm39)	I236N	possibly damaging	Het
Mrpl45	A	G	11: 97,207,747 (GRCm39)	T81A	probably benign	Het
Mtbp	G	T	15: 55,421,085 (GRCm39)	E24*	probably null	Het
Muc5b	C	T	7: 141,400,174 (GRCm39)	T476I	unknown	Het
Mup6	C	T	4: 60,006,021 (GRCm39)	T163I	probably benign	Het
Myo1g	T	A	11: 6,466,780 (GRCm39)	I278F	possibly damaging	Het
Myo9a	A	T	9: 59,778,119 (GRCm39)	K1292*	probably null	Het
Nbeal1	T	A	1: 60,281,694 (GRCm39)		probably benign	Het
Nck1	C	A	9: 100,379,440 (GRCm39)	R270S	probably benign	Het
Neb	T	C	2: 52,060,548 (GRCm39)	E6035G	probably damaging	Het
Nlrp4f	A	C	13: 65,343,357 (GRCm39)	L96*	probably null	Het
Or11g1	A	T	14: 50,651,910 (GRCm39)	H303L	probably benign	Het
Or4a77	A	T	2: 89,486,835 (GRCm39)		probably benign	Het
Or51l14	A	T	7: 103,101,011 (GRCm39)	I156F	probably benign	Het
Or5t18	A	C	2: 86,636,769 (GRCm39)	Y191*	probably null	Het
Padi2	A	G	4: 140,659,541 (GRCm39)	E282G	probably damaging	Het
Pcdhb4	A	G	18: 37,441,803 (GRCm39)	D371G	probably damaging	Het
Pcdhb8	A	G	18: 37,489,978 (GRCm39)	D552G	probably damaging	Het
Peli3	A	G	19: 4,982,855 (GRCm39)	I270T	probably damaging	Het
Phf20	A	G	2: 156,118,516 (GRCm39)	M407V	probably benign	Het
Ppm1h	C	T	10: 122,777,185 (GRCm39)	R103*	probably null	Het
Rangap1	C	T	15: 81,593,705 (GRCm39)	V457M	probably benign	Het
Scube2	A	G	7: 109,442,461 (GRCm39)	V257A	probably benign	Het
Shc1	C	A	3: 89,332,156 (GRCm39)	Q204K	probably damaging	Het
Slc6a4	T	A	11: 76,917,961 (GRCm39)	Y568N	probably damaging	Het
Srgap3	A	G	6: 112,923,439 (GRCm39)	F7L	probably benign	Het
St6galnac4	T	A	2: 32,484,098 (GRCm39)	C99S	probably damaging	Het
Strc	T	C	2: 121,206,075 (GRCm39)	D779G	probably benign	Het
Supt6	A	T	11: 78,116,309 (GRCm39)	Y685N	probably damaging	Het
Traf3ip3	T	C	1: 192,869,418 (GRCm39)	T256A	probably benign	Het
Vmn1r74	A	T	7: 11,581,560 (GRCm39)	I287F	probably damaging	Het
Zmym2	C	A	14: 57,185,472 (GRCm39)	Q1035K	possibly damaging	Het
Zswim3	G	A	2: 164,663,440 (GRCm39)	R640H	probably damaging	Het

Other mutations in Adh4

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00592:Adh4	APN	3	138,126,397 (GRCm39)	missense	probably damaging	0.99
IGL01450:Adh4	APN	3	138,129,794 (GRCm39)	missense	probably benign	0.05
IGL01618:Adh4	APN	3	138,134,788 (GRCm39)	unclassified	probably benign
IGL01621:Adh4	APN	3	138,134,788 (GRCm39)	unclassified	probably benign
IGL01640:Adh4	APN	3	138,134,788 (GRCm39)	unclassified	probably benign
IGL01979:Adh4	APN	3	138,134,788 (GRCm39)	unclassified	probably benign
IGL01982:Adh4	APN	3	138,134,788 (GRCm39)	unclassified	probably benign
IGL01993:Adh4	APN	3	138,134,788 (GRCm39)	unclassified	probably benign
IGL02720:Adh4	APN	3	138,124,981 (GRCm39)	missense	possibly damaging	0.87
IGL03030:Adh4	APN	3	138,134,906 (GRCm39)	missense	probably benign	0.13
PIT4403001:Adh4	UTSW	3	138,129,939 (GRCm39)	missense	probably damaging	0.97
R0295:Adh4	UTSW	3	138,134,837 (GRCm39)	missense	probably damaging	1.00
R0308:Adh4	UTSW	3	138,129,863 (GRCm39)	missense	probably damaging	1.00
R0636:Adh4	UTSW	3	138,133,835 (GRCm39)	missense	probably damaging	1.00
R1450:Adh4	UTSW	3	138,129,935 (GRCm39)	missense	probably damaging	1.00
R4824:Adh4	UTSW	3	138,134,807 (GRCm39)	missense	possibly damaging	0.81
R5137:Adh4	UTSW	3	138,127,996 (GRCm39)	missense	probably benign	0.00
R5263:Adh4	UTSW	3	138,133,816 (GRCm39)	missense	probably benign	0.00
R5566:Adh4	UTSW	3	138,129,950 (GRCm39)	missense	probably damaging	1.00
R6162:Adh4	UTSW	3	138,121,250 (GRCm39)	splice site	probably null
R7297:Adh4	UTSW	3	138,134,901 (GRCm39)	missense	possibly damaging	0.88
R8430:Adh4	UTSW	3	138,128,145 (GRCm39)	missense	probably damaging	1.00
R9053:Adh4	UTSW	3	138,128,045 (GRCm39)	missense	probably damaging	0.99
R9253:Adh4	UTSW	3	138,129,860 (GRCm39)	missense	probably damaging	1.00
Z1187:Adh4	UTSW	3	138,125,091 (GRCm39)	critical splice donor site	probably null

Posted On

2015-04-16