Incidental Mutation 'IGL01622:Or5m10'
ID 278607
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Or5m10
Ensembl Gene ENSMUSG00000050128
Gene Name olfactory receptor family 5 subfamily M member 10
Synonyms GA_x6K02T2Q125-47363965-47364900, MOR196-3, Olfr1023
Accession Numbers
Essential gene? Probably non essential (E-score: 0.066) question?
Stock # IGL01622
Quality Score
Status
Chromosome 2
Chromosomal Location 85717146-85718081 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 85717306 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Histidine to Leucine at position 54 (H54L)
Ref Sequence ENSEMBL: ENSMUSP00000149138 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000056408] [ENSMUST00000213441]
AlphaFold A2ASU6
Predicted Effect probably benign
Transcript: ENSMUST00000056408
AA Change: H54L

PolyPhen 2 Score 0.014 (Sensitivity: 0.96; Specificity: 0.79)
SMART Domains Protein: ENSMUSP00000059849
Gene: ENSMUSG00000050128
AA Change: H54L

DomainStartEndE-ValueType
Pfam:7tm_4 31 308 2.6e-52 PFAM
Pfam:7TM_GPCR_Srsx 35 304 2.6e-7 PFAM
Pfam:7tm_1 41 290 2.4e-25 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000082871
Predicted Effect probably benign
Transcript: ENSMUST00000213441
AA Change: H54L

PolyPhen 2 Score 0.014 (Sensitivity: 0.96; Specificity: 0.79)
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 54 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4930596D02Rik G A 14: 35,532,024 (GRCm39) Q184* probably null Het
A1bg A C 15: 60,789,742 (GRCm39) I502S possibly damaging Het
Actl11 T C 9: 107,805,775 (GRCm39) S33P probably benign Het
Aftph G T 11: 20,659,632 (GRCm39) D730E probably damaging Het
Arhgap29 A G 3: 121,767,773 (GRCm39) probably benign Het
Brf1 T G 12: 112,924,795 (GRCm39) E643A probably benign Het
Caskin1 G T 17: 24,722,914 (GRCm39) probably null Het
Ccnjl T C 11: 43,476,154 (GRCm39) V259A probably benign Het
Ccser2 G T 14: 36,662,920 (GRCm39) T88K probably benign Het
Cdk17 T C 10: 93,074,824 (GRCm39) probably benign Het
Clec16a G A 16: 10,395,774 (GRCm39) S309N possibly damaging Het
Cpxm1 C A 2: 130,233,191 (GRCm39) A633S probably benign Het
Ctnnbl1 A T 2: 157,661,468 (GRCm39) N326I probably damaging Het
Cyp46a1 T C 12: 108,318,234 (GRCm39) V215A possibly damaging Het
Daxx A G 17: 34,132,454 (GRCm39) D528G probably benign Het
Dnah6 T C 6: 73,121,701 (GRCm39) Y1427C probably damaging Het
Dpy19l3 G A 7: 35,422,169 (GRCm39) T228I probably damaging Het
Fam131c C T 4: 141,109,761 (GRCm39) A131V possibly damaging Het
Fat1 A G 8: 45,482,592 (GRCm39) T3061A possibly damaging Het
Fgl2 T A 5: 21,578,175 (GRCm39) L154H possibly damaging Het
Fhod3 T A 18: 25,155,924 (GRCm39) I514K probably benign Het
Ficd G A 5: 113,876,622 (GRCm39) G266S probably damaging Het
Frem3 A G 8: 81,340,544 (GRCm39) T946A probably benign Het
Gan T A 8: 117,913,917 (GRCm39) V105D probably damaging Het
Garin5b A G 7: 4,761,722 (GRCm39) V330A probably benign Het
Gramd1c A G 16: 43,811,061 (GRCm39) V221A probably damaging Het
Hacd1 A G 2: 14,040,667 (GRCm39) V196A probably benign Het
Kcna6 C A 6: 126,715,576 (GRCm39) V438L probably damaging Het
Kif14 T C 1: 136,425,094 (GRCm39) probably benign Het
Klhl41 T C 2: 69,508,582 (GRCm39) V512A probably benign Het
Lrfn1 A G 7: 28,166,111 (GRCm39) T502A probably damaging Het
Notch3 A T 17: 32,377,844 (GRCm39) F105I possibly damaging Het
Or4b13 T G 2: 90,082,953 (GRCm39) K126N probably damaging Het
P3h1 C T 4: 119,092,480 (GRCm39) T171I probably damaging Het
Pcdhb1 A G 18: 37,399,366 (GRCm39) E439G possibly damaging Het
Pik3c3 A T 18: 30,423,578 (GRCm39) K225* probably null Het
Pik3c3 A G 18: 30,426,102 (GRCm39) probably benign Het
Pik3r5 T A 11: 68,377,452 (GRCm39) probably null Het
Pnpt1 A C 11: 29,098,272 (GRCm39) probably benign Het
Ppp2r1b T A 9: 50,789,422 (GRCm39) V495D probably damaging Het
Rbfox3 C A 11: 118,396,440 (GRCm39) probably benign Het
Sec14l2 G A 11: 4,053,966 (GRCm39) P234S possibly damaging Het
Sec16a A C 2: 26,328,915 (GRCm39) D1033E probably benign Het
Septin14 A G 5: 129,763,019 (GRCm39) V357A probably damaging Het
Sf3a3 C T 4: 124,612,136 (GRCm39) T131I possibly damaging Het
Snrpa A T 7: 26,892,395 (GRCm39) M55K probably benign Het
Swt1 G T 1: 151,286,760 (GRCm39) T244N probably benign Het
Tbl1xr1 A G 3: 22,246,238 (GRCm39) T253A probably benign Het
Tst G T 15: 78,283,964 (GRCm39) R288S probably benign Het
Vmn2r60 A G 7: 41,785,910 (GRCm39) I238V probably benign Het
Zbtb14 A G 17: 69,695,184 (GRCm39) K294R probably benign Het
Zfp710 T A 7: 79,730,871 (GRCm39) V16E probably damaging Het
Zfpm2 A G 15: 40,965,320 (GRCm39) T602A probably benign Het
Zfr2 G A 10: 81,087,193 (GRCm39) M850I probably benign Het
Other mutations in Or5m10
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01536:Or5m10 APN 2 85,717,944 (GRCm39) missense probably damaging 1.00
IGL01623:Or5m10 APN 2 85,717,306 (GRCm39) missense probably benign 0.01
IGL01977:Or5m10 APN 2 85,717,711 (GRCm39) missense probably damaging 1.00
IGL02057:Or5m10 APN 2 85,717,275 (GRCm39) missense probably benign 0.00
IGL02555:Or5m10 APN 2 85,717,742 (GRCm39) missense probably benign 0.34
IGL03133:Or5m10 APN 2 85,717,478 (GRCm39) missense probably damaging 1.00
IGL03180:Or5m10 APN 2 85,717,740 (GRCm39) missense probably benign 0.00
R0415:Or5m10 UTSW 2 85,717,782 (GRCm39) missense possibly damaging 0.94
R1476:Or5m10 UTSW 2 85,717,592 (GRCm39) nonsense probably null
R1544:Or5m10 UTSW 2 85,717,615 (GRCm39) missense probably damaging 1.00
R2058:Or5m10 UTSW 2 85,717,296 (GRCm39) missense possibly damaging 0.48
R4096:Or5m10 UTSW 2 85,717,767 (GRCm39) missense probably damaging 0.98
R5055:Or5m10 UTSW 2 85,717,585 (GRCm39) missense probably benign 0.12
R5703:Or5m10 UTSW 2 85,717,783 (GRCm39) missense probably benign 0.06
R6297:Or5m10 UTSW 2 85,717,159 (GRCm39) missense probably benign 0.35
R7041:Or5m10 UTSW 2 85,717,965 (GRCm39) missense probably benign 0.01
R7070:Or5m10 UTSW 2 85,718,034 (GRCm39) missense probably benign 0.13
R7563:Or5m10 UTSW 2 85,717,482 (GRCm39) missense probably damaging 0.98
R7777:Or5m10 UTSW 2 85,717,951 (GRCm39) missense possibly damaging 0.83
R7913:Or5m10 UTSW 2 85,718,074 (GRCm39) missense probably damaging 0.96
R9060:Or5m10 UTSW 2 85,717,920 (GRCm39) missense probably benign 0.06
R9789:Or5m10 UTSW 2 85,717,338 (GRCm39) missense probably damaging 1.00
S24628:Or5m10 UTSW 2 85,717,782 (GRCm39) missense possibly damaging 0.94
Posted On 2015-04-16