Incidental Mutation 'IGL01622:Fgl2'
ID 278632
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Fgl2
Ensembl Gene ENSMUSG00000039899
Gene Name fibrinogen-like protein 2
Synonyms
Accession Numbers
Essential gene? Possibly non essential (E-score: 0.295) question?
Stock # IGL01622
Quality Score
Status
Chromosome 5
Chromosomal Location 21577671-21583384 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 21578175 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Leucine to Histidine at position 154 (L154H)
Ref Sequence ENSEMBL: ENSMUSP00000046131 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000030552] [ENSMUST00000035799] [ENSMUST00000115245]
AlphaFold P12804
Predicted Effect probably benign
Transcript: ENSMUST00000030552
SMART Domains Protein: ENSMUSP00000030552
Gene: ENSMUSG00000064280

DomainStartEndE-ValueType
coiled coil region 1 33 N/A INTRINSIC
low complexity region 120 130 N/A INTRINSIC
coiled coil region 194 320 N/A INTRINSIC
low complexity region 333 342 N/A INTRINSIC
Predicted Effect possibly damaging
Transcript: ENSMUST00000035799
AA Change: L154H

PolyPhen 2 Score 0.574 (Sensitivity: 0.88; Specificity: 0.91)
SMART Domains Protein: ENSMUSP00000046131
Gene: ENSMUSG00000039899
AA Change: L154H

DomainStartEndE-ValueType
signal peptide 1 19 N/A INTRINSIC
low complexity region 54 70 N/A INTRINSIC
coiled coil region 71 158 N/A INTRINSIC
FBG 201 428 1.6e-131 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000115245
SMART Domains Protein: ENSMUSP00000110900
Gene: ENSMUSG00000064280

DomainStartEndE-ValueType
coiled coil region 1 33 N/A INTRINSIC
low complexity region 120 130 N/A INTRINSIC
coiled coil region 194 320 N/A INTRINSIC
low complexity region 333 342 N/A INTRINSIC
coiled coil region 438 477 N/A INTRINSIC
coiled coil region 549 595 N/A INTRINSIC
coiled coil region 617 663 N/A INTRINSIC
coiled coil region 690 720 N/A INTRINSIC
coiled coil region 770 793 N/A INTRINSIC
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a secreted protein that is similar to the beta- and gamma-chains of fibrinogen. The carboxyl-terminus of the encoded protein consists of the fibrinogen-related domains (FRED). The encoded protein forms a tetrameric complex which is stabilized by interchain disulfide bonds. This protein may play a role in physiologic functions at mucosal sites. [provided by RefSeq, Jul 2008]
PHENOTYPE: Homozygous null mice for one allele have unaltered type 1 immunity responses. Homozygous null mice for another allele show partial embryonic lethality, hemorrhage at implantation sites, decreased susceptibility to hepatitis virus infection and prolongedsurvival of heart grafts. [provided by MGI curators]
Allele List at MGI

All alleles(2) : Targeted, knock-out(1) Targeted, other(1)

Other mutations in this stock
Total: 54 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4930596D02Rik G A 14: 35,532,024 (GRCm39) Q184* probably null Het
A1bg A C 15: 60,789,742 (GRCm39) I502S possibly damaging Het
Actl11 T C 9: 107,805,775 (GRCm39) S33P probably benign Het
Aftph G T 11: 20,659,632 (GRCm39) D730E probably damaging Het
Arhgap29 A G 3: 121,767,773 (GRCm39) probably benign Het
Brf1 T G 12: 112,924,795 (GRCm39) E643A probably benign Het
Caskin1 G T 17: 24,722,914 (GRCm39) probably null Het
Ccnjl T C 11: 43,476,154 (GRCm39) V259A probably benign Het
Ccser2 G T 14: 36,662,920 (GRCm39) T88K probably benign Het
Cdk17 T C 10: 93,074,824 (GRCm39) probably benign Het
Clec16a G A 16: 10,395,774 (GRCm39) S309N possibly damaging Het
Cpxm1 C A 2: 130,233,191 (GRCm39) A633S probably benign Het
Ctnnbl1 A T 2: 157,661,468 (GRCm39) N326I probably damaging Het
Cyp46a1 T C 12: 108,318,234 (GRCm39) V215A possibly damaging Het
Daxx A G 17: 34,132,454 (GRCm39) D528G probably benign Het
Dnah6 T C 6: 73,121,701 (GRCm39) Y1427C probably damaging Het
Dpy19l3 G A 7: 35,422,169 (GRCm39) T228I probably damaging Het
Fam131c C T 4: 141,109,761 (GRCm39) A131V possibly damaging Het
Fat1 A G 8: 45,482,592 (GRCm39) T3061A possibly damaging Het
Fhod3 T A 18: 25,155,924 (GRCm39) I514K probably benign Het
Ficd G A 5: 113,876,622 (GRCm39) G266S probably damaging Het
Frem3 A G 8: 81,340,544 (GRCm39) T946A probably benign Het
Gan T A 8: 117,913,917 (GRCm39) V105D probably damaging Het
Garin5b A G 7: 4,761,722 (GRCm39) V330A probably benign Het
Gramd1c A G 16: 43,811,061 (GRCm39) V221A probably damaging Het
Hacd1 A G 2: 14,040,667 (GRCm39) V196A probably benign Het
Kcna6 C A 6: 126,715,576 (GRCm39) V438L probably damaging Het
Kif14 T C 1: 136,425,094 (GRCm39) probably benign Het
Klhl41 T C 2: 69,508,582 (GRCm39) V512A probably benign Het
Lrfn1 A G 7: 28,166,111 (GRCm39) T502A probably damaging Het
Notch3 A T 17: 32,377,844 (GRCm39) F105I possibly damaging Het
Or4b13 T G 2: 90,082,953 (GRCm39) K126N probably damaging Het
Or5m10 A T 2: 85,717,306 (GRCm39) H54L probably benign Het
P3h1 C T 4: 119,092,480 (GRCm39) T171I probably damaging Het
Pcdhb1 A G 18: 37,399,366 (GRCm39) E439G possibly damaging Het
Pik3c3 A T 18: 30,423,578 (GRCm39) K225* probably null Het
Pik3c3 A G 18: 30,426,102 (GRCm39) probably benign Het
Pik3r5 T A 11: 68,377,452 (GRCm39) probably null Het
Pnpt1 A C 11: 29,098,272 (GRCm39) probably benign Het
Ppp2r1b T A 9: 50,789,422 (GRCm39) V495D probably damaging Het
Rbfox3 C A 11: 118,396,440 (GRCm39) probably benign Het
Sec14l2 G A 11: 4,053,966 (GRCm39) P234S possibly damaging Het
Sec16a A C 2: 26,328,915 (GRCm39) D1033E probably benign Het
Septin14 A G 5: 129,763,019 (GRCm39) V357A probably damaging Het
Sf3a3 C T 4: 124,612,136 (GRCm39) T131I possibly damaging Het
Snrpa A T 7: 26,892,395 (GRCm39) M55K probably benign Het
Swt1 G T 1: 151,286,760 (GRCm39) T244N probably benign Het
Tbl1xr1 A G 3: 22,246,238 (GRCm39) T253A probably benign Het
Tst G T 15: 78,283,964 (GRCm39) R288S probably benign Het
Vmn2r60 A G 7: 41,785,910 (GRCm39) I238V probably benign Het
Zbtb14 A G 17: 69,695,184 (GRCm39) K294R probably benign Het
Zfp710 T A 7: 79,730,871 (GRCm39) V16E probably damaging Het
Zfpm2 A G 15: 40,965,320 (GRCm39) T602A probably benign Het
Zfr2 G A 10: 81,087,193 (GRCm39) M850I probably benign Het
Other mutations in Fgl2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01623:Fgl2 APN 5 21,578,175 (GRCm39) missense possibly damaging 0.57
IGL02056:Fgl2 APN 5 21,580,543 (GRCm39) missense probably damaging 0.99
IGL03128:Fgl2 APN 5 21,578,291 (GRCm39) missense probably benign
A4554:Fgl2 UTSW 5 21,577,776 (GRCm39) missense probably benign 0.01
R0049:Fgl2 UTSW 5 21,580,661 (GRCm39) missense possibly damaging 0.95
R0049:Fgl2 UTSW 5 21,580,661 (GRCm39) missense possibly damaging 0.95
R0052:Fgl2 UTSW 5 21,580,347 (GRCm39) missense probably damaging 1.00
R0052:Fgl2 UTSW 5 21,580,347 (GRCm39) missense probably damaging 1.00
R0149:Fgl2 UTSW 5 21,580,783 (GRCm39) missense probably damaging 1.00
R0316:Fgl2 UTSW 5 21,580,521 (GRCm39) missense possibly damaging 0.82
R1336:Fgl2 UTSW 5 21,578,181 (GRCm39) missense possibly damaging 0.52
R1703:Fgl2 UTSW 5 21,577,730 (GRCm39) missense possibly damaging 0.89
R1893:Fgl2 UTSW 5 21,580,669 (GRCm39) missense probably benign 0.01
R2371:Fgl2 UTSW 5 21,580,816 (GRCm39) missense probably damaging 1.00
R4803:Fgl2 UTSW 5 21,580,918 (GRCm39) missense probably benign 0.00
R5250:Fgl2 UTSW 5 21,580,521 (GRCm39) missense possibly damaging 0.82
R5422:Fgl2 UTSW 5 21,580,808 (GRCm39) missense probably damaging 1.00
R6759:Fgl2 UTSW 5 21,578,256 (GRCm39) missense probably benign 0.00
R7808:Fgl2 UTSW 5 21,578,229 (GRCm39) missense possibly damaging 0.53
R7812:Fgl2 UTSW 5 21,577,896 (GRCm39) missense probably benign 0.01
R7838:Fgl2 UTSW 5 21,577,752 (GRCm39) missense probably benign 0.01
R8177:Fgl2 UTSW 5 21,578,307 (GRCm39) critical splice donor site probably null
R8725:Fgl2 UTSW 5 21,580,677 (GRCm39) nonsense probably null
R8727:Fgl2 UTSW 5 21,580,677 (GRCm39) nonsense probably null
R9114:Fgl2 UTSW 5 21,580,363 (GRCm39) missense probably damaging 1.00
R9198:Fgl2 UTSW 5 21,577,920 (GRCm39) missense probably damaging 0.96
R9513:Fgl2 UTSW 5 21,580,790 (GRCm39) nonsense probably null
R9606:Fgl2 UTSW 5 21,577,991 (GRCm39) missense possibly damaging 0.87
X0017:Fgl2 UTSW 5 21,580,650 (GRCm39) missense probably damaging 0.98
X0026:Fgl2 UTSW 5 21,580,711 (GRCm39) missense probably damaging 1.00
Posted On 2015-04-16