Incidental Mutation 'IGL01622:Tst'
ID278639
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Tst
Ensembl Gene ENSMUSG00000044986
Gene Namethiosulfate sulfurtransferase, mitochondrial
SynonymsRhodanese
Accession Numbers
Is this an essential gene? Non essential (E-score: 0.000) question?
Stock #IGL01622
Quality Score
Status
Chromosome15
Chromosomal Location78399556-78405907 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) G to T at 78399764 bp
ZygosityHeterozygous
Amino Acid Change Arginine to Serine at position 288 (R288S)
Ref Sequence ENSEMBL: ENSMUSP00000055743 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000058659] [ENSMUST00000074380] [ENSMUST00000165170] [ENSMUST00000229878]
Predicted Effect probably benign
Transcript: ENSMUST00000058659
AA Change: R288S

PolyPhen 2 Score 0.064 (Sensitivity: 0.94; Specificity: 0.84)
SMART Domains Protein: ENSMUSP00000055743
Gene: ENSMUSG00000044986
AA Change: R288S

DomainStartEndE-ValueType
RHOD 11 140 2.88e-18 SMART
RHOD 163 285 1.48e-20 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000074380
SMART Domains Protein: ENSMUSP00000073984
Gene: ENSMUSG00000062154

DomainStartEndE-ValueType
low complexity region 47 61 N/A INTRINSIC
low complexity region 63 71 N/A INTRINSIC
Pfam:TEX33 128 266 4.2e-73 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000165170
SMART Domains Protein: ENSMUSP00000133264
Gene: ENSMUSG00000062154

DomainStartEndE-ValueType
low complexity region 47 61 N/A INTRINSIC
low complexity region 63 71 N/A INTRINSIC
Pfam:TEX33 128 265 1.7e-73 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000229479
Predicted Effect probably benign
Transcript: ENSMUST00000229878
Predicted Effect noncoding transcript
Transcript: ENSMUST00000231525
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This is one of two neighboring genes encoding similar proteins that each contain two rhodanese domains. The encoded protein is localized to the mitochondria and catalyzes the conversion of thiosulfate and cyanide to thiocyanate and sulfite. In addition, the protein interacts with 5S ribosomal RNA and facilitates its import into the mitochondria. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2012]
Allele List at MGI
Other mutations in this stock
Total: 54 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4930596D02Rik G A 14: 35,810,067 Q184* probably null Het
A1bg A C 15: 60,917,893 I502S possibly damaging Het
Actl11 T C 9: 107,928,576 S33P probably benign Het
Aftph G T 11: 20,709,632 D730E probably damaging Het
Arhgap29 A G 3: 121,974,124 probably benign Het
Brf1 T G 12: 112,961,175 E643A probably benign Het
Caskin1 G T 17: 24,503,940 probably null Het
Ccnjl T C 11: 43,585,327 V259A probably benign Het
Ccser2 G T 14: 36,940,963 T88K probably benign Het
Cdk17 T C 10: 93,238,962 probably benign Het
Clec16a G A 16: 10,577,910 S309N possibly damaging Het
Cpxm1 C A 2: 130,391,271 A633S probably benign Het
Ctnnbl1 A T 2: 157,819,548 N326I probably damaging Het
Cyp46a1 T C 12: 108,351,975 V215A possibly damaging Het
Daxx A G 17: 33,913,480 D528G probably benign Het
Dnah6 T C 6: 73,144,718 Y1427C probably damaging Het
Dpy19l3 G A 7: 35,722,744 T228I probably damaging Het
Fam131c C T 4: 141,382,450 A131V possibly damaging Het
Fam71e2 A G 7: 4,758,723 V330A probably benign Het
Fat1 A G 8: 45,029,555 T3061A possibly damaging Het
Fgl2 T A 5: 21,373,177 L154H possibly damaging Het
Fhod3 T A 18: 25,022,867 I514K probably benign Het
Ficd G A 5: 113,738,561 G266S probably damaging Het
Frem3 A G 8: 80,613,915 T946A probably benign Het
Gan T A 8: 117,187,178 V105D probably damaging Het
Gramd1c A G 16: 43,990,698 V221A probably damaging Het
Hacd1 A G 2: 14,035,856 V196A probably benign Het
Kcna6 C A 6: 126,738,613 V438L probably damaging Het
Kif14 T C 1: 136,497,356 probably benign Het
Klhl41 T C 2: 69,678,238 V512A probably benign Het
Lrfn1 A G 7: 28,466,686 T502A probably damaging Het
Notch3 A T 17: 32,158,870 F105I possibly damaging Het
Olfr1023 A T 2: 85,886,962 H54L probably benign Het
Olfr142 T G 2: 90,252,609 K126N probably damaging Het
P3h1 C T 4: 119,235,283 T171I probably damaging Het
Pcdhb1 A G 18: 37,266,313 E439G possibly damaging Het
Pik3c3 A G 18: 30,293,049 probably benign Het
Pik3c3 A T 18: 30,290,525 K225* probably null Het
Pik3r5 T A 11: 68,486,626 probably null Het
Pnpt1 A C 11: 29,148,272 probably benign Het
Ppp2r1b T A 9: 50,878,122 V495D probably damaging Het
Rbfox3 C A 11: 118,505,614 probably benign Het
Sec14l2 G A 11: 4,103,966 P234S possibly damaging Het
Sec16a A C 2: 26,438,903 D1033E probably benign Het
Sept14 A G 5: 129,685,955 V357A probably damaging Het
Sf3a3 C T 4: 124,718,343 T131I possibly damaging Het
Snrpa A T 7: 27,192,970 M55K probably benign Het
Swt1 G T 1: 151,411,009 T244N probably benign Het
Tbl1xr1 A G 3: 22,192,074 T253A probably benign Het
Vmn2r60 A G 7: 42,136,486 I238V probably benign Het
Zbtb14 A G 17: 69,388,189 K294R probably benign Het
Zfp710 T A 7: 80,081,123 V16E probably damaging Het
Zfpm2 A G 15: 41,101,924 T602A probably benign Het
Zfr2 G A 10: 81,251,359 M850I probably benign Het
Other mutations in Tst
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00435:Tst APN 15 78405461 missense probably damaging 1.00
IGL01457:Tst APN 15 78399767 missense probably benign 0.01
IGL01623:Tst APN 15 78399764 missense probably benign 0.06
IGL03277:Tst APN 15 78405321 missense probably damaging 1.00
R0456:Tst UTSW 15 78405580 missense probably damaging 1.00
R1522:Tst UTSW 15 78399943 missense possibly damaging 0.67
R2518:Tst UTSW 15 78405833 start codon destroyed probably null 0.98
R5456:Tst UTSW 15 78399958 missense probably damaging 1.00
R7623:Tst UTSW 15 78405703 missense probably damaging 1.00
R7765:Tst UTSW 15 78405616 missense possibly damaging 0.61
R8296:Tst UTSW 15 78399820 missense probably damaging 1.00
Posted On2015-04-16