Incidental Mutation 'IGL01622:Pik3r5'
ID 278654
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Pik3r5
Ensembl Gene ENSMUSG00000020901
Gene Name phosphoinositide-3-kinase regulatory subunit 5
Synonyms p101, Foap2
Accession Numbers
Essential gene? Probably non essential (E-score: 0.121) question?
Stock # IGL01622
Quality Score
Status
Chromosome 11
Chromosomal Location 68322951-68388675 bp(+) (GRCm39)
Type of Mutation splice site (6 bp from exon)
DNA Base Change (assembly) T to A at 68377452 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000021283 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000021283]
AlphaFold Q5SW28
Predicted Effect probably null
Transcript: ENSMUST00000021283
SMART Domains Protein: ENSMUSP00000021283
Gene: ENSMUSG00000020901

DomainStartEndE-ValueType
Pfam:PI3K_1B_p101 6 871 N/A PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000126876
Predicted Effect noncoding transcript
Transcript: ENSMUST00000155887
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] Phosphatidylinositol 3-kinases (PI3Ks) phosphorylate the inositol ring of phosphatidylinositol at the 3-prime position, and play important roles in cell growth, proliferation, differentiation, motility, survival and intracellular trafficking. The PI3Ks are divided into three classes: I, II and III, and only the class I PI3Ks are involved in oncogenesis. This gene encodes the 101 kD regulatory subunit of the class I PI3K gamma complex, which is a dimeric enzyme, consisting of a 110 kD catalytic subunit gamma and a regulatory subunit of either 55, 87 or 101 kD. This protein recruits the catalytic subunit from the cytosol to the plasma membrane through high-affinity interaction with G-beta-gamma proteins. Multiple alternatively spliced transcript variants encoding two distinct isoforms have been found. [provided by RefSeq, Oct 2011]
PHENOTYPE: Mice homozygous for a knock-out allele exhibit significantly reduced neutrophil chemotaxis and chemokinesis in vitro and impaired neutrophil recruitment into the peritoneum in a model of thioglycollate-induced aseptic peritonitis. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 54 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4930596D02Rik G A 14: 35,532,024 (GRCm39) Q184* probably null Het
A1bg A C 15: 60,789,742 (GRCm39) I502S possibly damaging Het
Actl11 T C 9: 107,805,775 (GRCm39) S33P probably benign Het
Aftph G T 11: 20,659,632 (GRCm39) D730E probably damaging Het
Arhgap29 A G 3: 121,767,773 (GRCm39) probably benign Het
Brf1 T G 12: 112,924,795 (GRCm39) E643A probably benign Het
Caskin1 G T 17: 24,722,914 (GRCm39) probably null Het
Ccnjl T C 11: 43,476,154 (GRCm39) V259A probably benign Het
Ccser2 G T 14: 36,662,920 (GRCm39) T88K probably benign Het
Cdk17 T C 10: 93,074,824 (GRCm39) probably benign Het
Clec16a G A 16: 10,395,774 (GRCm39) S309N possibly damaging Het
Cpxm1 C A 2: 130,233,191 (GRCm39) A633S probably benign Het
Ctnnbl1 A T 2: 157,661,468 (GRCm39) N326I probably damaging Het
Cyp46a1 T C 12: 108,318,234 (GRCm39) V215A possibly damaging Het
Daxx A G 17: 34,132,454 (GRCm39) D528G probably benign Het
Dnah6 T C 6: 73,121,701 (GRCm39) Y1427C probably damaging Het
Dpy19l3 G A 7: 35,422,169 (GRCm39) T228I probably damaging Het
Fam131c C T 4: 141,109,761 (GRCm39) A131V possibly damaging Het
Fat1 A G 8: 45,482,592 (GRCm39) T3061A possibly damaging Het
Fgl2 T A 5: 21,578,175 (GRCm39) L154H possibly damaging Het
Fhod3 T A 18: 25,155,924 (GRCm39) I514K probably benign Het
Ficd G A 5: 113,876,622 (GRCm39) G266S probably damaging Het
Frem3 A G 8: 81,340,544 (GRCm39) T946A probably benign Het
Gan T A 8: 117,913,917 (GRCm39) V105D probably damaging Het
Garin5b A G 7: 4,761,722 (GRCm39) V330A probably benign Het
Gramd1c A G 16: 43,811,061 (GRCm39) V221A probably damaging Het
Hacd1 A G 2: 14,040,667 (GRCm39) V196A probably benign Het
Kcna6 C A 6: 126,715,576 (GRCm39) V438L probably damaging Het
Kif14 T C 1: 136,425,094 (GRCm39) probably benign Het
Klhl41 T C 2: 69,508,582 (GRCm39) V512A probably benign Het
Lrfn1 A G 7: 28,166,111 (GRCm39) T502A probably damaging Het
Notch3 A T 17: 32,377,844 (GRCm39) F105I possibly damaging Het
Or4b13 T G 2: 90,082,953 (GRCm39) K126N probably damaging Het
Or5m10 A T 2: 85,717,306 (GRCm39) H54L probably benign Het
P3h1 C T 4: 119,092,480 (GRCm39) T171I probably damaging Het
Pcdhb1 A G 18: 37,399,366 (GRCm39) E439G possibly damaging Het
Pik3c3 A T 18: 30,423,578 (GRCm39) K225* probably null Het
Pik3c3 A G 18: 30,426,102 (GRCm39) probably benign Het
Pnpt1 A C 11: 29,098,272 (GRCm39) probably benign Het
Ppp2r1b T A 9: 50,789,422 (GRCm39) V495D probably damaging Het
Rbfox3 C A 11: 118,396,440 (GRCm39) probably benign Het
Sec14l2 G A 11: 4,053,966 (GRCm39) P234S possibly damaging Het
Sec16a A C 2: 26,328,915 (GRCm39) D1033E probably benign Het
Septin14 A G 5: 129,763,019 (GRCm39) V357A probably damaging Het
Sf3a3 C T 4: 124,612,136 (GRCm39) T131I possibly damaging Het
Snrpa A T 7: 26,892,395 (GRCm39) M55K probably benign Het
Swt1 G T 1: 151,286,760 (GRCm39) T244N probably benign Het
Tbl1xr1 A G 3: 22,246,238 (GRCm39) T253A probably benign Het
Tst G T 15: 78,283,964 (GRCm39) R288S probably benign Het
Vmn2r60 A G 7: 41,785,910 (GRCm39) I238V probably benign Het
Zbtb14 A G 17: 69,695,184 (GRCm39) K294R probably benign Het
Zfp710 T A 7: 79,730,871 (GRCm39) V16E probably damaging Het
Zfpm2 A G 15: 40,965,320 (GRCm39) T602A probably benign Het
Zfr2 G A 10: 81,087,193 (GRCm39) M850I probably benign Het
Other mutations in Pik3r5
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01345:Pik3r5 APN 11 68,387,020 (GRCm39) missense possibly damaging 0.68
IGL01400:Pik3r5 APN 11 68,385,373 (GRCm39) missense probably benign 0.01
IGL01597:Pik3r5 APN 11 68,386,827 (GRCm39) missense probably damaging 1.00
IGL01623:Pik3r5 APN 11 68,377,452 (GRCm39) splice site probably null
IGL01878:Pik3r5 APN 11 68,383,356 (GRCm39) missense probably benign 0.00
IGL01953:Pik3r5 APN 11 68,384,997 (GRCm39) missense probably benign 0.00
IGL02056:Pik3r5 APN 11 68,381,681 (GRCm39) missense possibly damaging 0.86
IGL02345:Pik3r5 APN 11 68,383,552 (GRCm39) missense probably benign 0.03
palmetto UTSW 11 68,385,059 (GRCm39) missense probably damaging 1.00
Palmito UTSW 11 68,382,826 (GRCm39) missense probably damaging 1.00
palms UTSW 11 68,377,448 (GRCm39) critical splice donor site probably null
piranha UTSW 11 68,377,407 (GRCm39) missense probably damaging 1.00
Serenoa_repens UTSW 11 68,366,250 (GRCm39) nonsense probably null
IGL02799:Pik3r5 UTSW 11 68,386,773 (GRCm39) missense probably damaging 0.98
R0077:Pik3r5 UTSW 11 68,377,448 (GRCm39) critical splice donor site probably null
R0092:Pik3r5 UTSW 11 68,383,629 (GRCm39) missense probably benign
R0105:Pik3r5 UTSW 11 68,381,337 (GRCm39) missense probably damaging 0.99
R0118:Pik3r5 UTSW 11 68,381,306 (GRCm39) missense probably damaging 1.00
R1204:Pik3r5 UTSW 11 68,385,050 (GRCm39) missense probably benign 0.03
R1447:Pik3r5 UTSW 11 68,385,003 (GRCm39) missense probably benign 0.18
R1865:Pik3r5 UTSW 11 68,383,318 (GRCm39) missense probably damaging 1.00
R2034:Pik3r5 UTSW 11 68,384,403 (GRCm39) missense probably damaging 0.99
R2356:Pik3r5 UTSW 11 68,383,743 (GRCm39) missense probably damaging 1.00
R4588:Pik3r5 UTSW 11 68,384,087 (GRCm39) intron probably benign
R4716:Pik3r5 UTSW 11 68,386,030 (GRCm39) missense possibly damaging 0.48
R4960:Pik3r5 UTSW 11 68,384,464 (GRCm39) missense probably benign 0.19
R5217:Pik3r5 UTSW 11 68,382,790 (GRCm39) missense possibly damaging 0.67
R5518:Pik3r5 UTSW 11 68,368,294 (GRCm39) missense possibly damaging 0.86
R5528:Pik3r5 UTSW 11 68,386,803 (GRCm39) missense probably damaging 1.00
R5554:Pik3r5 UTSW 11 68,385,059 (GRCm39) missense probably damaging 1.00
R5693:Pik3r5 UTSW 11 68,385,077 (GRCm39) missense probably damaging 1.00
R5841:Pik3r5 UTSW 11 68,383,096 (GRCm39) missense probably damaging 1.00
R6025:Pik3r5 UTSW 11 68,383,144 (GRCm39) missense probably damaging 0.97
R6168:Pik3r5 UTSW 11 68,383,501 (GRCm39) missense probably benign
R6243:Pik3r5 UTSW 11 68,382,826 (GRCm39) missense probably damaging 1.00
R6322:Pik3r5 UTSW 11 68,383,567 (GRCm39) missense probably benign
R6420:Pik3r5 UTSW 11 68,366,250 (GRCm39) nonsense probably null
R6505:Pik3r5 UTSW 11 68,383,615 (GRCm39) missense probably benign 0.16
R6534:Pik3r5 UTSW 11 68,381,443 (GRCm39) missense possibly damaging 0.59
R6817:Pik3r5 UTSW 11 68,377,407 (GRCm39) missense probably damaging 1.00
R7246:Pik3r5 UTSW 11 68,383,769 (GRCm39) missense probably benign 0.01
R7459:Pik3r5 UTSW 11 68,383,416 (GRCm39) missense probably benign 0.03
R7527:Pik3r5 UTSW 11 68,367,177 (GRCm39) missense probably damaging 1.00
R7739:Pik3r5 UTSW 11 68,381,324 (GRCm39) missense probably damaging 1.00
R7817:Pik3r5 UTSW 11 68,384,483 (GRCm39) missense probably damaging 0.99
R7877:Pik3r5 UTSW 11 68,381,431 (GRCm39) missense probably damaging 1.00
R7885:Pik3r5 UTSW 11 68,383,528 (GRCm39) missense possibly damaging 0.57
R7960:Pik3r5 UTSW 11 68,386,796 (GRCm39) missense probably benign 0.22
R8816:Pik3r5 UTSW 11 68,385,060 (GRCm39) missense probably damaging 1.00
R8836:Pik3r5 UTSW 11 68,385,104 (GRCm39) missense probably benign 0.06
R9131:Pik3r5 UTSW 11 68,383,099 (GRCm39) missense possibly damaging 0.64
R9649:Pik3r5 UTSW 11 68,381,720 (GRCm39) missense probably benign 0.00
R9706:Pik3r5 UTSW 11 68,381,426 (GRCm39) missense probably benign 0.00
Z1177:Pik3r5 UTSW 11 68,383,722 (GRCm39) missense possibly damaging 0.67
Posted On 2015-04-16