Incidental Mutation 'IGL01602:Taar5'
| ID |
278760 |
| Institutional Source |
Australian Phenomics Network
(link to record)
|
| Gene Symbol |
Taar5
|
| Ensembl Gene |
ENSMUSG00000069706 |
| Gene Name |
trace amine-associated receptor 5 |
| Synonyms |
LOC215854 |
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.077)
|
| Stock # |
IGL01602
|
| Quality Score |
|
|
Status
|
|
| Chromosome |
10 |
| Chromosomal Location |
23846604-23847617 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
C to T
at 23846962 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Threonine to Isoleucine
at position 120
(T120I)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000090329
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000092659]
|
| AlphaFold |
Q5QD14 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000092659
AA Change: T120I
PolyPhen 2
Score 0.065 (Sensitivity: 0.94; Specificity: 0.84)
|
| SMART Domains |
Protein: ENSMUSP00000090329
Gene: ENSMUSG00000069706
AA Change: T120I
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:7TM_GPCR_Srsx
|
45 |
320 |
8.3e-9 |
PFAM |
|
Pfam:7tm_1
|
51 |
305 |
1.3e-54 |
PFAM |
|
| Coding Region Coverage |
|
| Validation Efficiency |
|
| MGI Phenotype |
PHENOTYPE: Mice homozygous for a knock-out allele exhibit abnormal olfactory system physiology. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 29 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Adamts17 |
A |
T |
7: 66,538,159 (GRCm39) |
M242L |
probably benign |
Het |
| Brip1 |
T |
A |
11: 85,952,830 (GRCm39) |
T984S |
possibly damaging |
Het |
| Cdh17 |
T |
C |
4: 11,795,670 (GRCm39) |
Y417H |
probably damaging |
Het |
| Chd7 |
T |
A |
4: 8,833,834 (GRCm39) |
I1196N |
probably damaging |
Het |
| Cyp3a57 |
T |
C |
5: 145,323,854 (GRCm39) |
F447S |
probably damaging |
Het |
| Dnah12 |
C |
T |
14: 26,431,430 (GRCm39) |
|
probably benign |
Het |
| Dock8 |
C |
T |
19: 25,067,252 (GRCm39) |
|
probably benign |
Het |
| Eif1ad5 |
A |
T |
12: 87,940,530 (GRCm39) |
|
noncoding transcript |
Het |
| Fam163b |
A |
G |
2: 27,002,688 (GRCm39) |
F103S |
probably damaging |
Het |
| G0s2 |
A |
G |
1: 192,954,964 (GRCm39) |
L40P |
probably damaging |
Het |
| Gucy1b1 |
C |
T |
3: 81,942,660 (GRCm39) |
R494Q |
probably benign |
Het |
| Hsd17b1 |
T |
C |
11: 100,969,755 (GRCm39) |
V89A |
probably damaging |
Het |
| Iqcg |
T |
C |
16: 32,837,348 (GRCm39) |
|
probably benign |
Het |
| Lmo7 |
T |
C |
14: 102,148,192 (GRCm39) |
|
probably benign |
Het |
| Mmp17 |
A |
G |
5: 129,679,008 (GRCm39) |
D331G |
probably benign |
Het |
| Mnx1 |
T |
C |
5: 29,682,591 (GRCm39) |
D228G |
unknown |
Het |
| Msantd2 |
A |
G |
9: 37,428,736 (GRCm39) |
E101G |
probably benign |
Het |
| Msh2 |
T |
C |
17: 88,003,917 (GRCm39) |
|
probably benign |
Het |
| Pabpc1 |
A |
G |
15: 36,599,550 (GRCm39) |
Y382H |
probably benign |
Het |
| Prl7b1 |
A |
G |
13: 27,786,027 (GRCm39) |
S214P |
possibly damaging |
Het |
| Rbpj-ps3 |
T |
C |
6: 46,507,025 (GRCm39) |
|
probably benign |
Het |
| Sgsm1 |
A |
T |
5: 113,433,531 (GRCm39) |
M162K |
possibly damaging |
Het |
| Skint2 |
A |
G |
4: 112,483,191 (GRCm39) |
T199A |
probably benign |
Het |
| Slc24a1 |
T |
A |
9: 64,833,463 (GRCm39) |
D1044V |
probably damaging |
Het |
| Stim1 |
A |
G |
7: 102,035,322 (GRCm39) |
D100G |
possibly damaging |
Het |
| Trhde |
A |
G |
10: 114,623,848 (GRCm39) |
V352A |
probably benign |
Het |
| Ubap2 |
T |
A |
4: 41,227,237 (GRCm39) |
D160V |
probably damaging |
Het |
| Vmn2r18 |
A |
G |
5: 151,510,106 (GRCm39) |
V89A |
possibly damaging |
Het |
| Wbp1l |
A |
G |
19: 46,642,839 (GRCm39) |
D264G |
possibly damaging |
Het |
|
| Other mutations in Taar5 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01605:Taar5
|
APN |
10 |
23,846,962 (GRCm39) |
missense |
probably benign |
0.06 |
|
IGL02935:Taar5
|
APN |
10 |
23,847,415 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02962:Taar5
|
APN |
10 |
23,846,883 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
R0136:Taar5
|
UTSW |
10 |
23,847,607 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1216:Taar5
|
UTSW |
10 |
23,847,605 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1537:Taar5
|
UTSW |
10 |
23,846,620 (GRCm39) |
missense |
probably benign |
0.25 |
|
R2033:Taar5
|
UTSW |
10 |
23,846,992 (GRCm39) |
missense |
possibly damaging |
0.84 |
|
R2158:Taar5
|
UTSW |
10 |
23,846,986 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4914:Taar5
|
UTSW |
10 |
23,847,468 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R4999:Taar5
|
UTSW |
10 |
23,847,445 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
R5084:Taar5
|
UTSW |
10 |
23,846,836 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6277:Taar5
|
UTSW |
10 |
23,847,169 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6516:Taar5
|
UTSW |
10 |
23,847,564 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
R7974:Taar5
|
UTSW |
10 |
23,847,120 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R8147:Taar5
|
UTSW |
10 |
23,846,749 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8156:Taar5
|
UTSW |
10 |
23,847,393 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9306:Taar5
|
UTSW |
10 |
23,846,781 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
Z1177:Taar5
|
UTSW |
10 |
23,847,339 (GRCm39) |
missense |
probably benign |
0.00 |
|
| Posted On |
2015-04-16 |
Incidental Mutation