Incidental Mutation 'IGL01602:G0s2'
ID 278771
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol G0s2
Ensembl Gene ENSMUSG00000009633
Gene Name G0/G1 switch gene 2
Synonyms
Accession Numbers
Essential gene? Probably non essential (E-score: 0.124) question?
Stock # IGL01602
Quality Score
Status
Chromosome 1
Chromosomal Location 192954468-192955496 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 192954964 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Leucine to Proline at position 40 (L40P)
Ref Sequence ENSEMBL: ENSMUSP00000009777 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000009777] [ENSMUST00000192322] [ENSMUST00000194677]
AlphaFold Q61585
Predicted Effect probably damaging
Transcript: ENSMUST00000009777
AA Change: L40P

PolyPhen 2 Score 0.998 (Sensitivity: 0.27; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000009777
Gene: ENSMUSG00000009633
AA Change: L40P

DomainStartEndE-ValueType
Pfam:G0-G1_switch_2 1 103 1.8e-46 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000192322
SMART Domains Protein: ENSMUSP00000141302
Gene: ENSMUSG00000026639

DomainStartEndE-ValueType
signal peptide 1 17 N/A INTRINSIC
LamNT 20 244 2.9e-80 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000193128
Predicted Effect probably benign
Transcript: ENSMUST00000194677
SMART Domains Protein: ENSMUSP00000142053
Gene: ENSMUSG00000026639

DomainStartEndE-ValueType
signal peptide 1 17 N/A INTRINSIC
LamNT 20 248 7.63e-84 SMART
EGF_Lam 250 310 1.67e-7 SMART
EGF_Lam 313 373 1.14e-9 SMART
EGF_Lam 376 425 5.56e-13 SMART
EGF_Lam 428 475 6.05e-14 SMART
EGF_Lam 478 528 5e-6 SMART
EGF_Lam 531 575 3.01e-9 SMART
low complexity region 662 673 N/A INTRINSIC
low complexity region 727 763 N/A INTRINSIC
coiled coil region 830 879 N/A INTRINSIC
coiled coil region 949 979 N/A INTRINSIC
coiled coil region 1037 1090 N/A INTRINSIC
low complexity region 1116 1126 N/A INTRINSIC
Coding Region Coverage
Validation Efficiency
MGI Phenotype PHENOTYPE: Homozygous null mice are lean, glucose tolerant and insulin sensitive, and show reduced liver triglyceride levels, enhanced lipolysis, reduced white fat cell size, resistance to diet-induced obesity and liver steatosis, increased oxygen consumption and thermogenesis, and enhanced cold tolerance. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 29 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adamts17 A T 7: 66,538,159 (GRCm39) M242L probably benign Het
Brip1 T A 11: 85,952,830 (GRCm39) T984S possibly damaging Het
Cdh17 T C 4: 11,795,670 (GRCm39) Y417H probably damaging Het
Chd7 T A 4: 8,833,834 (GRCm39) I1196N probably damaging Het
Cyp3a57 T C 5: 145,323,854 (GRCm39) F447S probably damaging Het
Dnah12 C T 14: 26,431,430 (GRCm39) probably benign Het
Dock8 C T 19: 25,067,252 (GRCm39) probably benign Het
Eif1ad5 A T 12: 87,940,530 (GRCm39) noncoding transcript Het
Fam163b A G 2: 27,002,688 (GRCm39) F103S probably damaging Het
Gucy1b1 C T 3: 81,942,660 (GRCm39) R494Q probably benign Het
Hsd17b1 T C 11: 100,969,755 (GRCm39) V89A probably damaging Het
Iqcg T C 16: 32,837,348 (GRCm39) probably benign Het
Lmo7 T C 14: 102,148,192 (GRCm39) probably benign Het
Mmp17 A G 5: 129,679,008 (GRCm39) D331G probably benign Het
Mnx1 T C 5: 29,682,591 (GRCm39) D228G unknown Het
Msantd2 A G 9: 37,428,736 (GRCm39) E101G probably benign Het
Msh2 T C 17: 88,003,917 (GRCm39) probably benign Het
Pabpc1 A G 15: 36,599,550 (GRCm39) Y382H probably benign Het
Prl7b1 A G 13: 27,786,027 (GRCm39) S214P possibly damaging Het
Rbpj-ps3 T C 6: 46,507,025 (GRCm39) probably benign Het
Sgsm1 A T 5: 113,433,531 (GRCm39) M162K possibly damaging Het
Skint2 A G 4: 112,483,191 (GRCm39) T199A probably benign Het
Slc24a1 T A 9: 64,833,463 (GRCm39) D1044V probably damaging Het
Stim1 A G 7: 102,035,322 (GRCm39) D100G possibly damaging Het
Taar5 C T 10: 23,846,962 (GRCm39) T120I probably benign Het
Trhde A G 10: 114,623,848 (GRCm39) V352A probably benign Het
Ubap2 T A 4: 41,227,237 (GRCm39) D160V probably damaging Het
Vmn2r18 A G 5: 151,510,106 (GRCm39) V89A possibly damaging Het
Wbp1l A G 19: 46,642,839 (GRCm39) D264G possibly damaging Het
Other mutations in G0s2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01558:G0s2 APN 1 192,955,003 (GRCm39) missense probably damaging 1.00
IGL01605:G0s2 APN 1 192,954,964 (GRCm39) missense probably damaging 1.00
R5070:G0s2 UTSW 1 192,954,870 (GRCm39) missense probably damaging 0.96
R5638:G0s2 UTSW 1 192,954,859 (GRCm39) missense probably damaging 0.98
R7566:G0s2 UTSW 1 192,955,076 (GRCm39) missense probably benign 0.16
R7838:G0s2 UTSW 1 192,955,081 (GRCm39) start codon destroyed probably null 1.00
Posted On 2015-04-16