Incidental Mutation 'IGL00959:Omp'
ID 27884
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Omp
Ensembl Gene ENSMUSG00000074006
Gene Name olfactory marker protein
Synonyms
Accession Numbers
Essential gene? Probably non essential (E-score: 0.106) question?
Stock # IGL00959
Quality Score
Status
Chromosome 7
Chromosomal Location 97792566-97794654 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 97794357 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Aspartic acid to Glycine at position 90 (D90G)
Ref Sequence ENSEMBL: ENSMUSP00000095882 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000040971] [ENSMUST00000098281] [ENSMUST00000107112]
AlphaFold Q64288
PDB Structure CRYSTAL STRUCTURE OF MURINE OLFACTORY MARKER PROTEIN [X-RAY DIFFRACTION]
Crystal Structure of Murine Olfactory Marker Protein in Spacegroup P3121 [X-RAY DIFFRACTION]
Crystal Structure of Murine Olfactory Marker Protein in Spacegroup P43212 [X-RAY DIFFRACTION]
Predicted Effect probably benign
Transcript: ENSMUST00000040971
SMART Domains Protein: ENSMUSP00000048183
Gene: ENSMUSG00000035547

DomainStartEndE-ValueType
CysPc 8 351 4.18e-212 SMART
calpain_III 353 496 1.21e-66 SMART
C2 518 619 1.29e-9 SMART
Predicted Effect probably damaging
Transcript: ENSMUST00000098281
AA Change: D90G

PolyPhen 2 Score 0.998 (Sensitivity: 0.27; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000095882
Gene: ENSMUSG00000074006
AA Change: D90G

DomainStartEndE-ValueType
Pfam:Olfactory_mark 11 161 7.6e-82 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000107112
SMART Domains Protein: ENSMUSP00000102729
Gene: ENSMUSG00000035547

DomainStartEndE-ValueType
CysPc 8 351 4.18e-212 SMART
calpain_III 353 496 1.21e-66 SMART
C2 518 619 1.29e-9 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000134638
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] Olfactory marker protein is uniquely associated with the mature olfactory receptor neurons in many vertebrate species from fish to man. The OMP gene structure and protein sequence are highly conserved between mouse, rat and human. Results of the mouse knockout studies show that OMP-null mice are compromised in their ability to respond to odor stimuli, and that OMP represents a novel modulatory component of the odor detection/signal transduction cascade. [provided by RefSeq, Jul 2008]
PHENOTYPE: Mice lacking both copies of the coding sequence for this gene exhibit no overt phenotype. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 37 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Alox12b A T 11: 69,057,069 (GRCm39) H430L probably damaging Het
Aox4 G T 1: 58,278,333 (GRCm39) V443F probably damaging Het
Bmpr2 A T 1: 59,854,474 (GRCm39) I108F possibly damaging Het
Cflar G A 1: 58,768,321 (GRCm39) probably null Het
Chchd3 A G 6: 32,945,188 (GRCm39) V106A probably benign Het
Chl1 G T 6: 103,686,211 (GRCm39) probably null Het
Clvs2 C T 10: 33,404,459 (GRCm39) M252I probably benign Het
Cntnap5a T A 1: 116,112,057 (GRCm39) L449Q probably benign Het
Col6a2 T A 10: 76,450,368 (GRCm39) I188F probably damaging Het
Cyp2c55 A G 19: 39,026,587 (GRCm39) D398G probably benign Het
Dennd1b T C 1: 139,071,626 (GRCm39) probably benign Het
Dop1a T A 9: 86,369,484 (GRCm39) Y106N probably damaging Het
Dpy19l1 A T 9: 24,334,493 (GRCm39) probably null Het
Extl3 C T 14: 65,314,361 (GRCm39) V274I probably benign Het
Fras1 G A 5: 96,929,140 (GRCm39) R3848H probably damaging Het
Gm11437 A C 11: 84,039,448 (GRCm39) probably benign Het
Gss T A 2: 155,423,871 (GRCm39) D2V probably damaging Het
Hnrnpm C A 17: 33,868,876 (GRCm39) R517L probably damaging Het
Ilvbl G A 10: 78,419,739 (GRCm39) D548N probably damaging Het
Jmjd6 A T 11: 116,733,202 (GRCm39) D115E possibly damaging Het
Kidins220 T A 12: 25,101,132 (GRCm39) S1110R possibly damaging Het
Kmt2c T A 5: 25,481,227 (GRCm39) I4784F probably damaging Het
Mrpl52 T C 14: 54,664,494 (GRCm39) V11A possibly damaging Het
Myo3b A G 2: 70,144,636 (GRCm39) Y1036C probably damaging Het
Or6c2b T A 10: 128,947,893 (GRCm39) M134L probably benign Het
Osmr T C 15: 6,854,086 (GRCm39) I541V probably benign Het
Ppp2r1a A T 17: 21,181,840 (GRCm39) probably benign Het
Ptpn13 T A 5: 103,665,437 (GRCm39) probably null Het
Rock2 C A 12: 17,028,056 (GRCm39) N1429K probably benign Het
Saxo4 A T 19: 10,454,887 (GRCm39) probably null Het
Slc25a20 T G 9: 108,559,198 (GRCm39) M188R possibly damaging Het
Slc28a1 T C 7: 80,818,816 (GRCm39) probably benign Het
Sult2a6 T C 7: 13,988,634 (GRCm39) Y42C probably damaging Het
Tgfb2 A G 1: 186,436,784 (GRCm39) V63A probably benign Het
Ugt2b38 A T 5: 87,559,682 (GRCm39) N403K probably damaging Het
Vmn2r29 A G 7: 7,244,855 (GRCm39) W340R probably benign Het
Wnt5a C T 14: 28,244,866 (GRCm39) T351M probably damaging Het
Other mutations in Omp
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01361:Omp APN 7 97,794,489 (GRCm39) missense probably benign 0.04
R1589:Omp UTSW 7 97,794,566 (GRCm39) missense probably benign 0.00
R2510:Omp UTSW 7 97,794,552 (GRCm39) missense possibly damaging 0.64
R3722:Omp UTSW 7 97,794,420 (GRCm39) missense probably benign 0.01
R4612:Omp UTSW 7 97,794,348 (GRCm39) missense probably damaging 0.99
R4876:Omp UTSW 7 97,794,233 (GRCm39) missense probably benign
R6662:Omp UTSW 7 97,794,546 (GRCm39) missense probably damaging 0.99
R6844:Omp UTSW 7 97,794,283 (GRCm39) missense probably benign 0.00
R8440:Omp UTSW 7 97,794,253 (GRCm39) missense probably damaging 1.00
R9013:Omp UTSW 7 97,794,552 (GRCm39) missense probably benign 0.00
Posted On 2013-04-17