Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL01767:Olfr134'

278841

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Olfr134

Ensembl Gene

ENSMUSG00000096009

Gene Name

olfactory receptor 134

Synonyms

MOR256-5, GA_x6K02T2PSCP-2623613-2624551

Accession Numbers

Is this an essential gene?

Probably non essential (E-score: 0.134) question?

Stock #

IGL01767

Quality Score

Status

Chromosome

Chromosomal Location

38171388-38176578 bp(+) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

G to T at 38175686 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Valine to Leucine at position 201 (V201L)

Ref Sequence

ENSEMBL: ENSMUSP00000151069 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000074883] [ENSMUST00000215900]

AlphaFold

Q8VG95

Predicted Effect

probably benign
Transcript: ENSMUST00000074883
AA Change: V201L

PolyPhen 2 Score 0.040 (Sensitivity: 0.94; Specificity: 0.83)

SMART Domains

Protein: ENSMUSP00000074423
Gene: ENSMUSG00000096009
AA Change: V201L

Domain	Start	End	E-Value	Type
Pfam:7tm_4	31	308	3.4e-50	PFAM
Pfam:7tm_1	41	290	2e-25	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000215900
AA Change: V201L

PolyPhen 2 Score 0.040 (Sensitivity: 0.94; Specificity: 0.83)

Coding Region Coverage

Validation Efficiency

MGI Phenotype

FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

Allele List at MGI

Other mutations in this stock

Total: 67 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
4932438A13Rik	T	C	3: 37,041,363	V4505A	probably benign	Het
Aadat	A	T	8: 60,507,092	D31V	probably damaging	Het
Acaca	A	T	11: 84,320,542	Y1560F	probably benign	Het
Actl7a	A	G	4: 56,743,980	E169G	probably damaging	Het
Adgrb3	A	G	1: 25,559,814	V270A	probably benign	Het
Adgre4	G	A	17: 55,797,740	V269I	probably benign	Het
Ankhd1	A	G	18: 36,648,374	T2160A	probably damaging	Het
Bnip2	T	A	9: 70,002,116		probably benign	Het
Casp16-ps	A	G	17: 23,552,053	V126A	probably damaging	Het
Ccser1	C	A	6: 61,718,152	T157K	probably benign	Het
Cdh23	A	G	10: 60,315,724	S2459P	probably damaging	Het
Cdk5rap3	A	T	11: 96,913,465	C21S	probably damaging	Het
Chmp6	G	A	11: 119,916,986	E72K	probably benign	Het
Cldn23	T	C	8: 35,825,662	Y224C	probably damaging	Het
Cry1	C	T	10: 85,146,474	G336D	probably damaging	Het
Cyp4f17	T	A	17: 32,506,982	F30I	probably benign	Het
Dgcr8	T	A	16: 18,278,336	D496V	probably damaging	Het
Dhx9	A	G	1: 153,468,868		probably benign	Het
Dnah10	C	T	5: 124,743,737		probably benign	Het
Dock9	T	C	14: 121,622,870	E880G	possibly damaging	Het
Dscam	A	G	16: 96,654,936	V1264A	probably damaging	Het
Eno1	T	C	4: 150,246,710	Y270H	probably benign	Het
Eprs	A	G	1: 185,384,915	D385G	probably damaging	Het
Ercc2	A	G	7: 19,390,421	Y215C	probably damaging	Het
Fam208b	G	A	13: 3,576,633	P1106S	probably benign	Het
Fscn2	A	G	11: 120,367,750	N400S	possibly damaging	Het
Fuca1	C	T	4: 135,939,201	T449I	probably benign	Het
Gm43638	T	C	5: 87,465,431	K492E	probably damaging	Het
Gm4778	T	A	3: 94,266,484	D262E	probably benign	Het
Gm5263	T	G	1: 146,420,564		noncoding transcript	Het
Gm8122	T	C	14: 43,232,701	T111A	unknown	Het
Gtf3c2	T	A	5: 31,157,635	N923Y	probably benign	Het
Il17a	T	A	1: 20,733,640	D86E	probably benign	Het
Itgb2l	G	T	16: 96,430,575	N330K	probably benign	Het
Kcnj11	T	C	7: 46,099,065	H278R	probably benign	Het
Khdrbs2	T	A	1: 32,619,176	Y272*	probably null	Het
Kndc1	A	T	7: 139,930,046	Q1267L	probably damaging	Het
Loxhd1	T	A	18: 77,286,424	F64I	possibly damaging	Het
Lrig2	T	A	3: 104,491,545	K222N	probably benign	Het
Lrrcc1	T	A	3: 14,547,272	Y378N	probably damaging	Het
Mblac2	T	C	13: 81,750,315	L270P	probably damaging	Het
Med13	A	T	11: 86,319,783	I511N	probably benign	Het
Myo3a	A	T	2: 22,423,222	E763D	probably damaging	Het
Olfr1240	C	T	2: 89,439,800	V160I	probably benign	Het
Olfr1447	T	A	19: 12,901,748	T11S	probably benign	Het
Olfr384	T	A	11: 73,603,032	F151I	probably benign	Het
Olfr845	G	A	9: 19,339,302	V281I	possibly damaging	Het
Plxna4	T	A	6: 32,237,678	I623F	possibly damaging	Het
Ppp2ca	T	A	11: 52,118,055	Y127*	probably null	Het
Psg18	A	G	7: 18,353,397	V112A	possibly damaging	Het
Ptprj	A	T	2: 90,469,574	N108K	probably benign	Het
Rictor	A	G	15: 6,777,384	Y707C	probably damaging	Het
Rptn	T	C	3: 93,395,639	F93S	probably benign	Het
Rxrg	T	A	1: 167,627,315	C156S	probably damaging	Het
Slc24a4	T	C	12: 102,223,687		probably benign	Het
Slc25a27	C	T	17: 43,664,073		probably null	Het
Slx4	T	C	16: 3,990,248	K481E	probably benign	Het
Snx19	T	C	9: 30,463,264	W940R	possibly damaging	Het
Tcf20	G	A	15: 82,856,008	P414L	probably damaging	Het
Treml2	T	C	17: 48,302,810	V90A	probably benign	Het
Uckl1	C	T	2: 181,569,534	V501M	probably damaging	Het
Unc79	C	T	12: 103,141,997	T1937I	probably damaging	Het
Vmn2r17	A	T	5: 109,420,037	I9F	probably benign	Het
Vmn2r44	T	C	7: 8,380,238	H119R	probably benign	Het
Vmn2r78	A	G	7: 86,954,435	D607G	probably benign	Het
Vps13a	C	T	19: 16,663,894	G2288D	probably damaging	Het
Znfx1	G	T	2: 167,055,723	T427N	probably damaging	Het

Other mutations in Olfr134

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01677:Olfr134	APN	17	38175875	missense	probably damaging	1.00
IGL01749:Olfr134	APN	17	38175686	missense	probably benign	0.04
IGL01750:Olfr134	APN	17	38175686	missense	probably benign	0.04
IGL01751:Olfr134	APN	17	38175686	missense	probably benign	0.04
IGL01753:Olfr134	APN	17	38175686	missense	probably benign	0.04
IGL01757:Olfr134	APN	17	38175686	missense	probably benign	0.04
IGL01765:Olfr134	APN	17	38175686	missense	probably benign	0.04
IGL01766:Olfr134	APN	17	38175686	missense	probably benign	0.04
IGL01822:Olfr134	APN	17	38175448	missense	probably damaging	1.00
IGL02256:Olfr134	APN	17	38175686	missense	probably benign	0.04
IGL02257:Olfr134	APN	17	38175686	missense	probably benign	0.04
IGL02258:Olfr134	APN	17	38175686	missense	probably benign	0.04
IGL02259:Olfr134	APN	17	38175686	missense	probably benign	0.04
IGL02275:Olfr134	APN	17	38175686	missense	probably benign	0.04
IGL02293:Olfr134	APN	17	38175686	missense	probably benign	0.04
IGL02295:Olfr134	APN	17	38175686	missense	probably benign	0.04
IGL02317:Olfr134	APN	17	38175686	missense	probably benign	0.04
IGL02318:Olfr134	APN	17	38175686	missense	probably benign	0.04
R0230:Olfr134	UTSW	17	38175950	missense	probably damaging	1.00
R0363:Olfr134	UTSW	17	38175447	missense	probably damaging	1.00
R1074:Olfr134	UTSW	17	38175440	missense	probably damaging	1.00
R1506:Olfr134	UTSW	17	38175200	missense	probably benign
R2300:Olfr134	UTSW	17	38175550	nonsense	probably null
R3743:Olfr134	UTSW	17	38175902	missense	probably damaging	1.00
R3975:Olfr134	UTSW	17	38175495	missense	probably benign	0.03
R4230:Olfr134	UTSW	17	38175881	missense	possibly damaging	0.67
R5158:Olfr134	UTSW	17	38175454	nonsense	probably null
R5439:Olfr134	UTSW	17	38176026	splice site	probably null
R6144:Olfr134	UTSW	17	38175225	missense	probably damaging	1.00
R6309:Olfr134	UTSW	17	38175519	missense	probably benign	0.00
R6675:Olfr134	UTSW	17	38176014	missense	probably benign
R6800:Olfr134	UTSW	17	38175122	missense	probably benign	0.01
R6873:Olfr134	UTSW	17	38175368	missense	probably benign
R7193:Olfr134	UTSW	17	38175096	missense	probably benign	0.44
R7534:Olfr134	UTSW	17	38175297	missense	probably benign	0.22
R7869:Olfr134	UTSW	17	38175939	missense	possibly damaging	0.94
R7912:Olfr134	UTSW	17	38175267	missense	probably damaging	0.99
R8048:Olfr134	UTSW	17	38175528	missense	probably benign	0.11
R8305:Olfr134	UTSW	17	38175573	missense	probably damaging	1.00
R9396:Olfr134	UTSW	17	38175530	missense	probably damaging	1.00
R9445:Olfr134	UTSW	17	38175803	missense	probably damaging	1.00
X0011:Olfr134	UTSW	17	38175851	missense	probably damaging	1.00

Posted On

2015-04-16