Incidental Mutation 'IGL01752:Vmn1r195'
ID278849
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Vmn1r195
Ensembl Gene ENSMUSG00000069296
Gene Namevomeronasal 1 receptor 195
SynonymsV1ri6
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.058) question?
Stock #IGL01752
Quality Score
Status
Chromosome13
Chromosomal Location22270522-22281230 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) G to T at 22279251 bp
ZygosityHeterozygous
Amino Acid Change Cysteine to Phenylalanine at position 297 (C297F)
Ref Sequence ENSEMBL: ENSMUSP00000154274 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000091736] [ENSMUST00000228711]
Predicted Effect probably benign
Transcript: ENSMUST00000091736
AA Change: C297F

PolyPhen 2 Score 0.451 (Sensitivity: 0.89; Specificity: 0.90)
SMART Domains Protein: ENSMUSP00000089330
Gene: ENSMUSG00000069296
AA Change: C297F

DomainStartEndE-ValueType
transmembrane domain 10 32 N/A INTRINSIC
Pfam:V1R 34 300 5.6e-41 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000121379
Predicted Effect probably benign
Transcript: ENSMUST00000228711
AA Change: C297F

PolyPhen 2 Score 0.451 (Sensitivity: 0.89; Specificity: 0.90)
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 31 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Akap11 A T 14: 78,509,878 probably null Het
Btbd11 C A 10: 85,654,502 Q1011K probably damaging Het
Cdh4 A T 2: 179,890,884 N713I probably damaging Het
Cdkl4 T A 17: 80,543,614 probably benign Het
Ddx21 A G 10: 62,587,507 S639P probably damaging Het
Dock3 T C 9: 107,025,313 probably benign Het
Fan1 G A 7: 64,372,794 T237M probably benign Het
Fbn2 T A 18: 58,075,977 probably null Het
Fhad1 T C 4: 141,972,899 K347E possibly damaging Het
Gucy2c C A 6: 136,770,108 A118S probably benign Het
Itgb4 G A 11: 115,988,926 V635I probably damaging Het
Lox A G 18: 52,520,854 V390A possibly damaging Het
Lyn A T 4: 3,743,286 M69L probably benign Het
Mrgprb5 A G 7: 48,168,667 F107L probably benign Het
Neurod2 T C 11: 98,327,375 E321G possibly damaging Het
Olfr912 C T 9: 38,581,513 P79S probably damaging Het
Pcnx3 T A 19: 5,665,337 K1962* probably null Het
Pde3a T C 6: 141,487,613 probably benign Het
Phf10 A G 17: 14,954,950 probably benign Het
Prune2 A G 19: 17,123,903 E2257G possibly damaging Het
Rock1 A G 18: 10,079,113 probably null Het
Slc4a11 T G 2: 130,688,145 T238P probably damaging Het
Ssu2 T A 6: 112,375,592 K279N probably damaging Het
Tead3 A T 17: 28,333,594 I275N probably damaging Het
Ttn T C 2: 76,744,793 E25252G probably damaging Het
Twsg1 T C 17: 65,929,784 T84A probably benign Het
Ugt3a1 A T 15: 9,306,146 K127M probably damaging Het
Unc13c A T 9: 73,931,811 M586K probably benign Het
Vps13c T A 9: 67,948,228 I2525N probably damaging Het
Zdhhc2 G A 8: 40,473,001 A346T probably benign Het
Zfp52 T G 17: 21,560,150 C87G probably benign Het
Other mutations in Vmn1r195
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01751:Vmn1r195 APN 13 22279251 missense probably benign 0.45
IGL01780:Vmn1r195 APN 13 22279085 missense probably benign 0.34
PIT4812001:Vmn1r195 UTSW 13 22278863 missense probably benign 0.22
R0066:Vmn1r195 UTSW 13 22279239 missense possibly damaging 0.94
R0066:Vmn1r195 UTSW 13 22279239 missense possibly damaging 0.94
R0350:Vmn1r195 UTSW 13 22279233 missense probably damaging 0.99
R0639:Vmn1r195 UTSW 13 22278941 missense probably damaging 1.00
R0751:Vmn1r195 UTSW 13 22279011 missense probably damaging 1.00
R1184:Vmn1r195 UTSW 13 22279011 missense probably damaging 1.00
R1464:Vmn1r195 UTSW 13 22279178 missense probably benign 0.01
R1464:Vmn1r195 UTSW 13 22279178 missense probably benign 0.01
R1999:Vmn1r195 UTSW 13 22278764 missense possibly damaging 0.83
R2150:Vmn1r195 UTSW 13 22278764 missense possibly damaging 0.83
R4924:Vmn1r195 UTSW 13 22279019 missense probably benign 0.03
R5190:Vmn1r195 UTSW 13 22278386 nonsense probably null
R5522:Vmn1r195 UTSW 13 22278950 missense probably damaging 1.00
R5621:Vmn1r195 UTSW 13 22278389 missense probably benign 0.01
R6509:Vmn1r195 UTSW 13 22279109 missense probably benign 0.45
R7288:Vmn1r195 UTSW 13 22279004 missense probably damaging 1.00
R7291:Vmn1r195 UTSW 13 22278749 missense probably damaging 1.00
R7428:Vmn1r195 UTSW 13 22278852 missense probably benign 0.01
R7810:Vmn1r195 UTSW 13 22279074 missense probably damaging 1.00
Posted On2015-04-16