Incidental Mutation 'IGL00959:Slc28a1'
ID27885
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Slc28a1
Ensembl Gene ENSMUSG00000025726
Gene Namesolute carrier family 28 (sodium-coupled nucleoside transporter), member 1
SynonymsCnt1
Accession Numbers

Genbank: NM_001004184; MGI: 3605073

Is this an essential gene? Probably non essential (E-score: 0.094) question?
Stock #IGL00959
Quality Score
Status
Chromosome7
Chromosomal Location81114799-81170416 bp(+) (GRCm38)
Type of Mutationsplice site
DNA Base Change (assembly) T to C at 81169068 bp
ZygosityHeterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000112421 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000026820] [ENSMUST00000119083]
Predicted Effect probably benign
Transcript: ENSMUST00000026820
SMART Domains Protein: ENSMUSP00000026820
Gene: ENSMUSG00000025726

DomainStartEndE-ValueType
transmembrane domain 82 104 N/A INTRINSIC
transmembrane domain 109 128 N/A INTRINSIC
transmembrane domain 149 168 N/A INTRINSIC
Pfam:Nucleos_tra2_N 183 257 1e-24 PFAM
Pfam:Gate 263 392 5.5e-10 PFAM
Pfam:Nucleos_tra2_C 366 591 4e-74 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000119083
SMART Domains Protein: ENSMUSP00000112421
Gene: ENSMUSG00000025726

DomainStartEndE-ValueType
transmembrane domain 82 104 N/A INTRINSIC
transmembrane domain 109 128 N/A INTRINSIC
transmembrane domain 149 168 N/A INTRINSIC
Pfam:Nucleos_tra2_N 183 256 4.8e-27 PFAM
Pfam:Gate 263 364 1.1e-9 PFAM
Pfam:Nucleos_tra2_C 366 590 9.2e-76 PFAM
Coding Region Coverage
Validation Efficiency
Allele List at MGI

All alleles(30) : Gene trapped(30)

Other mutations in this stock
Total: 37 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Alox12b A T 11: 69,166,243 H430L probably damaging Het
Aox4 G T 1: 58,239,174 V443F probably damaging Het
Bmpr2 A T 1: 59,815,315 I108F possibly damaging Het
Cflar G A 1: 58,729,162 probably null Het
Chchd3 A G 6: 32,968,253 V106A probably benign Het
Chl1 G T 6: 103,709,250 probably null Het
Clvs2 C T 10: 33,528,463 M252I probably benign Het
Cntnap5a T A 1: 116,184,327 L449Q probably benign Het
Col6a2 T A 10: 76,614,534 I188F probably damaging Het
Cyp2c55 A G 19: 39,038,143 D398G probably benign Het
Dennd1b T C 1: 139,143,888 probably benign Het
Dopey1 T A 9: 86,487,431 Y106N probably damaging Het
Dpy19l1 A T 9: 24,423,197 probably null Het
Extl3 C T 14: 65,076,912 V274I probably benign Het
Fras1 G A 5: 96,781,281 R3848H probably damaging Het
Gm11437 A C 11: 84,148,622 probably benign Het
Gss T A 2: 155,581,951 D2V probably damaging Het
Hnrnpm C A 17: 33,649,902 R517L probably damaging Het
Ilvbl G A 10: 78,583,905 D548N probably damaging Het
Jmjd6 A T 11: 116,842,376 D115E possibly damaging Het
Kidins220 T A 12: 25,051,133 S1110R possibly damaging Het
Kmt2c T A 5: 25,276,229 I4784F probably damaging Het
Mrpl52 T C 14: 54,427,037 V11A possibly damaging Het
Myo3b A G 2: 70,314,292 Y1036C probably damaging Het
Olfr769 T A 10: 129,112,024 M134L probably benign Het
Omp T C 7: 98,145,150 D90G probably damaging Het
Osmr T C 15: 6,824,605 I541V probably benign Het
Ppp1r32 A T 19: 10,477,523 probably null Het
Ppp2r1a A T 17: 20,961,578 probably benign Het
Ptpn13 T A 5: 103,517,571 probably null Het
Rock2 C A 12: 16,978,055 N1429K probably benign Het
Slc25a20 T G 9: 108,681,999 M188R possibly damaging Het
Sult2a6 T C 7: 14,254,709 Y42C probably damaging Het
Tgfb2 A G 1: 186,704,587 V63A probably benign Het
Ugt2b38 A T 5: 87,411,823 N403K probably damaging Het
Vmn2r29 A G 7: 7,241,856 W340R probably benign Het
Wnt5a C T 14: 28,522,909 T351M probably damaging Het
Other mutations in Slc28a1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01386:Slc28a1 APN 7 81164679 missense probably benign 0.01
IGL02586:Slc28a1 APN 7 81164419 missense probably benign 0.04
IGL02695:Slc28a1 APN 7 81167991 missense probably benign 0.00
IGL02836:Slc28a1 APN 7 81126161 missense probably damaging 1.00
7510:Slc28a1 UTSW 7 81169269 missense probably benign
R0206:Slc28a1 UTSW 7 81117706 splice site probably benign
R0208:Slc28a1 UTSW 7 81117706 splice site probably benign
R0379:Slc28a1 UTSW 7 81138177 missense probably benign
R0733:Slc28a1 UTSW 7 81124900 missense probably benign 0.37
R1435:Slc28a1 UTSW 7 81153517 missense probably damaging 1.00
R1827:Slc28a1 UTSW 7 81138202 missense possibly damaging 0.85
R1909:Slc28a1 UTSW 7 81142035 missense probably damaging 1.00
R1917:Slc28a1 UTSW 7 81169586 missense probably benign 0.00
R2147:Slc28a1 UTSW 7 81126267 missense possibly damaging 0.94
R3804:Slc28a1 UTSW 7 81126221 missense probably damaging 1.00
R4004:Slc28a1 UTSW 7 81169038 missense probably damaging 1.00
R4967:Slc28a1 UTSW 7 81142009 missense possibly damaging 0.91
R5055:Slc28a1 UTSW 7 81169048 missense possibly damaging 0.77
R5256:Slc28a1 UTSW 7 81122121 missense probably damaging 0.98
R5494:Slc28a1 UTSW 7 81168039 missense probably damaging 1.00
R5924:Slc28a1 UTSW 7 81115612 missense probably benign 0.26
R6062:Slc28a1 UTSW 7 81115563 nonsense probably null
R6229:Slc28a1 UTSW 7 81125005 missense probably benign 0.00
R6737:Slc28a1 UTSW 7 81169248 missense probably benign 0.21
RF018:Slc28a1 UTSW 7 81169284 splice site probably null
X0020:Slc28a1 UTSW 7 81124963 missense possibly damaging 0.85
Z1088:Slc28a1 UTSW 7 81138168 missense probably damaging 1.00
Posted On2013-04-17