Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL01759:Hrob'

278855

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Hrob

Ensembl Gene

ENSMUSG00000034773

Gene Name

homologous recombination factor with OB-fold

Synonyms

BC030867

Accession Numbers

Essential gene?

Possibly non essential (E-score: 0.481) question?

Stock #

IGL01759

Quality Score

Status

Chromosome

Chromosomal Location

102139708-102156013 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 102146422 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Cysteine to Arginine at position 233 (C233R)

Ref Sequence

ENSEMBL: ENSMUSP00000137686 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000100392] [ENSMUST00000133930]

AlphaFold

Q32P12

Predicted Effect

probably benign
Transcript: ENSMUST00000100392
AA Change: C233R

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)

SMART Domains

Protein: ENSMUSP00000097961
Gene: ENSMUSG00000034773
AA Change: C233R

Domain	Start	End	E-Value	Type
low complexity region	8	25	N/A	INTRINSIC
low complexity region	100	108	N/A	INTRINSIC
low complexity region	302	317	N/A	INTRINSIC
Pfam:DUF4539	458	541	4.4e-33	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000133930
AA Change: C233R

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)

SMART Domains

Protein: ENSMUSP00000137686
Gene: ENSMUSG00000034773
AA Change: C233R

Domain	Start	End	E-Value	Type
low complexity region	8	25	N/A	INTRINSIC
low complexity region	100	108	N/A	INTRINSIC
low complexity region	302	317	N/A	INTRINSIC
Pfam:DUF4539	457	542	3.2e-34	PFAM

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000148867

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000152897

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 62 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Abi3	A	T	11: 95,726,625 (GRCm39)	D150E	probably damaging	Het
Akr1c14	T	A	13: 4,131,139 (GRCm39)	I277N	probably damaging	Het
Ap1b1	C	T	11: 4,969,433 (GRCm39)	T263I	probably damaging	Het
Atp6v0d2	C	A	4: 19,878,335 (GRCm39)	V313L	probably damaging	Het
Car2	G	A	3: 14,960,688 (GRCm39)		probably null	Het
Cdh17	T	A	4: 11,771,262 (GRCm39)		probably benign	Het
Cep295	A	G	9: 15,234,855 (GRCm39)		probably null	Het
Cep97	T	C	16: 55,750,936 (GRCm39)	K27E	probably damaging	Het
Cops5	A	T	1: 10,097,474 (GRCm39)	N258K	probably damaging	Het
Dchs1	T	A	7: 105,404,509 (GRCm39)	T2678S	probably benign	Het
Dnah10	T	A	5: 124,832,850 (GRCm39)	F861Y	probably benign	Het
Dock10	T	C	1: 80,503,990 (GRCm39)	E1777G	probably damaging	Het
Dock5	G	A	14: 68,118,708 (GRCm39)	Q23*	probably null	Het
Ermp1	T	C	19: 29,593,236 (GRCm39)	K752R	probably benign	Het
Fhip1a	A	C	3: 85,595,754 (GRCm39)	I377S	probably damaging	Het
Gjd2	T	A	2: 113,841,587 (GRCm39)	I297L	probably benign	Het
Gm1123	T	C	9: 98,905,307 (GRCm39)	M68V	probably benign	Het
Gm28372	C	T	2: 130,248,818 (GRCm39)	R59W	probably damaging	Het
Gm9912	A	C	3: 148,891,074 (GRCm39)	F20V	unknown	Het
Gpat2	T	C	2: 127,272,816 (GRCm39)	F176S	possibly damaging	Het
Gpr150	T	C	13: 76,203,784 (GRCm39)	H387R	possibly damaging	Het
Gpr20	T	A	15: 73,568,269 (GRCm39)	D40V	probably damaging	Het
Jakmip3	A	T	7: 138,622,633 (GRCm39)	Q331L	probably damaging	Het
Kif5b	A	G	18: 6,225,647 (GRCm39)	V179A	probably damaging	Het
Kif5b	A	T	18: 6,211,019 (GRCm39)		probably benign	Het
Krt14	A	T	11: 100,095,242 (GRCm39)		probably benign	Het
L3mbtl3	A	G	10: 26,207,798 (GRCm39)	F307S	unknown	Het
Laptm4a	T	C	12: 8,984,687 (GRCm39)		probably benign	Het
Marveld3	T	C	8: 110,674,719 (GRCm39)	S366G	possibly damaging	Het
Mga	C	A	2: 119,781,676 (GRCm39)	T2234K	possibly damaging	Het
Mkrn2os	T	C	6: 115,569,292 (GRCm39)	N54S	probably benign	Het
Mras	T	C	9: 99,293,548 (GRCm39)	I31V	probably damaging	Het
Myh1	A	G	11: 67,110,732 (GRCm39)	D1518G	probably damaging	Het
Myoz2	A	T	3: 122,807,430 (GRCm39)	Y127N	possibly damaging	Het
Nhlrc1	C	A	13: 47,167,438 (GRCm39)	W273L	probably benign	Het
Nol9	C	T	4: 152,130,500 (GRCm39)		probably benign	Het
Nrxn2	T	C	19: 6,559,959 (GRCm39)	V1206A	probably damaging	Het
Or2ag1b	T	C	7: 106,288,540 (GRCm39)	T133A	probably benign	Het
Or5k16	A	T	16: 58,736,291 (GRCm39)	F238I	probably damaging	Het
Or6c5	T	A	10: 129,074,941 (GRCm39)	F308I	probably benign	Het
Or6f2	T	C	7: 139,756,447 (GRCm39)	I138T	probably benign	Het
Or8g2b	T	A	9: 39,750,907 (GRCm39)	M59K	probably damaging	Het
Pappa	T	C	4: 65,123,395 (GRCm39)		probably null	Het
Pfkl	A	G	10: 77,836,565 (GRCm39)	S151P	probably damaging	Het
Pgbd5	C	T	8: 125,111,118 (GRCm39)	G191D	probably damaging	Het
Pikfyve	T	C	1: 65,292,512 (GRCm39)	V1276A	probably benign	Het
Pla2g4c	T	A	7: 13,082,241 (GRCm39)	Y486N	probably damaging	Het
Rasal2	C	A	1: 157,003,502 (GRCm39)	V386L	probably benign	Het
S1pr3	G	A	13: 51,573,548 (GRCm39)	R243Q	probably damaging	Het
Slc44a4	A	G	17: 35,140,219 (GRCm39)	D208G	probably benign	Het
Slc6a4	T	C	11: 76,904,114 (GRCm39)	S190P	probably damaging	Het
Snapc5	A	T	9: 64,087,779 (GRCm39)		probably null	Het
Tbc1d14	C	A	5: 36,728,913 (GRCm39)	R151L	probably damaging	Het
Tecpr2	T	A	12: 110,897,826 (GRCm39)		probably benign	Het
Tmem219	G	A	7: 126,496,310 (GRCm39)	P44L	probably damaging	Het
Ube2e1	T	C	14: 18,330,951 (GRCm38)	R51G	probably null	Het
Ugp2	T	C	11: 21,303,447 (GRCm39)	K53E	probably benign	Het
Vmn1r214	T	C	13: 23,218,662 (GRCm39)	I52T	probably benign	Het
Vmn2r124	C	T	17: 18,284,330 (GRCm39)	T457I	probably benign	Het
Vps13b	A	G	15: 35,878,935 (GRCm39)	E2978G	probably damaging	Het
Zfr	A	G	15: 12,159,741 (GRCm39)	D679G	probably damaging	Het
Zhx3	T	C	2: 160,622,634 (GRCm39)	N511S	probably damaging	Het

Other mutations in Hrob

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00485:Hrob	APN	11	102,146,783 (GRCm39)	missense	possibly damaging	0.95
IGL01645:Hrob	APN	11	102,146,012 (GRCm39)	missense	probably damaging	1.00
IGL01750:Hrob	APN	11	102,145,777 (GRCm39)	splice site	probably benign
IGL01760:Hrob	APN	11	102,146,422 (GRCm39)	missense	probably benign
IGL01761:Hrob	APN	11	102,146,422 (GRCm39)	missense	probably benign
IGL01762:Hrob	APN	11	102,146,422 (GRCm39)	missense	probably benign
IGL01764:Hrob	APN	11	102,146,422 (GRCm39)	missense	probably benign
IGL01769:Hrob	APN	11	102,146,422 (GRCm39)	missense	probably benign
IGL01778:Hrob	APN	11	102,146,422 (GRCm39)	missense	probably benign
IGL02156:Hrob	APN	11	102,145,865 (GRCm39)	missense	probably damaging	1.00
IGL02159:Hrob	APN	11	102,150,991 (GRCm39)	critical splice donor site	probably null
IGL02284:Hrob	APN	11	102,146,422 (GRCm39)	missense	probably benign
IGL02522:Hrob	APN	11	102,148,746 (GRCm39)	missense	possibly damaging	0.94
IGL02989:Hrob	APN	11	102,146,125 (GRCm39)	missense	probably benign	0.00
R2376:Hrob	UTSW	11	102,141,542 (GRCm39)	missense	probably benign	0.05
R2504:Hrob	UTSW	11	102,146,122 (GRCm39)	missense	possibly damaging	0.48
R3731:Hrob	UTSW	11	102,148,732 (GRCm39)	missense	possibly damaging	0.95
R5566:Hrob	UTSW	11	102,146,659 (GRCm39)	missense	probably damaging	0.99
R5774:Hrob	UTSW	11	102,146,495 (GRCm39)	missense	possibly damaging	0.82
R5864:Hrob	UTSW	11	102,145,972 (GRCm39)	missense	probably benign	0.00
R6013:Hrob	UTSW	11	102,145,859 (GRCm39)	missense	probably benign	0.00
R6250:Hrob	UTSW	11	102,145,888 (GRCm39)	missense	probably benign
R7264:Hrob	UTSW	11	102,146,422 (GRCm39)	missense	probably benign	0.00
R8013:Hrob	UTSW	11	102,148,725 (GRCm39)	missense	probably benign	0.02
R8014:Hrob	UTSW	11	102,148,725 (GRCm39)	missense	probably benign	0.02
R8266:Hrob	UTSW	11	102,153,046 (GRCm39)	missense	possibly damaging	0.94
R8770:Hrob	UTSW	11	102,145,976 (GRCm39)	missense	probably benign	0.00
R8982:Hrob	UTSW	11	102,146,110 (GRCm39)	missense	probably benign	0.22
R9058:Hrob	UTSW	11	102,146,386 (GRCm39)	missense	probably benign	0.03
R9498:Hrob	UTSW	11	102,150,167 (GRCm39)	missense	probably benign	0.03
R9646:Hrob	UTSW	11	102,146,586 (GRCm39)	missense	possibly damaging	0.84
R9647:Hrob	UTSW	11	102,146,586 (GRCm39)	missense	possibly damaging	0.84
R9766:Hrob	UTSW	11	102,146,586 (GRCm39)	missense	possibly damaging	0.84
X0062:Hrob	UTSW	11	102,146,581 (GRCm39)	missense	possibly damaging	0.89
X0065:Hrob	UTSW	11	102,141,553 (GRCm39)	missense	probably damaging	1.00

Posted On

2015-04-16