Incidental Mutation 'IGL00963:Or52z13'
ID 27888
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Or52z13
Ensembl Gene ENSMUSG00000073945
Gene Name olfactory receptor family 52 subfamily Z member 13
Synonyms MOR31-9, GA_x6K02T2PBJ9-6320148-6321104, Olfr618
Accession Numbers
Essential gene? Probably non essential (E-score: 0.054) question?
Stock # IGL00963
Quality Score
Status
Chromosome 7
Chromosomal Location 103246525-103247481 bp(+) (GRCm39)
Type of Mutation splice site
DNA Base Change (assembly) T to A at 103246844 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000150630 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000098197] [ENSMUST00000214883] [ENSMUST00000215732]
AlphaFold K7N6B3
Predicted Effect probably damaging
Transcript: ENSMUST00000098197
AA Change: L107Q

PolyPhen 2 Score 0.990 (Sensitivity: 0.72; Specificity: 0.97)
SMART Domains Protein: ENSMUSP00000095799
Gene: ENSMUSG00000073945
AA Change: L107Q

DomainStartEndE-ValueType
Pfam:7tm_4 34 314 3.1e-109 PFAM
Pfam:7TM_GPCR_Srsx 38 311 6.3e-12 PFAM
Pfam:7tm_1 44 296 8.2e-21 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000214883
AA Change: L107Q

PolyPhen 2 Score 0.990 (Sensitivity: 0.72; Specificity: 0.97)
Predicted Effect probably null
Transcript: ENSMUST00000215732
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 42 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
AI606181 A C 19: 41,582,228 (GRCm39) probably benign Het
Alyref2 C T 1: 171,331,816 (GRCm39) Q198* probably null Het
Ankrd13a T C 5: 114,939,863 (GRCm39) S497P probably damaging Het
Chd5 C A 4: 152,467,395 (GRCm39) N1644K probably damaging Het
Col13a1 T C 10: 61,674,476 (GRCm39) probably benign Het
Ctnna3 T A 10: 64,781,728 (GRCm39) D730E probably damaging Het
Dock11 A G X: 35,296,035 (GRCm39) Q1197R possibly damaging Het
Drosha T A 15: 12,926,083 (GRCm39) I1224N probably damaging Het
Dsc1 T C 18: 20,245,043 (GRCm39) K42R probably null Het
Engase A G 11: 118,373,824 (GRCm39) D322G probably damaging Het
Ephb2 T C 4: 136,386,262 (GRCm39) D829G probably benign Het
Fgfr2 C T 7: 129,830,491 (GRCm39) M47I probably damaging Het
Gad1-ps G T 10: 99,281,310 (GRCm39) noncoding transcript Het
Gatb A G 3: 85,526,255 (GRCm39) S378G probably benign Het
Hivep2 G A 10: 14,005,091 (GRCm39) S563N probably damaging Het
Irs2 G A 8: 11,055,867 (GRCm39) A855V probably benign Het
Jagn1 T C 6: 113,424,436 (GRCm39) S103P probably damaging Het
Kdm6a T A X: 18,112,665 (GRCm39) probably benign Het
Lmcd1 T C 6: 112,306,895 (GRCm39) C356R probably damaging Het
Mefv T A 16: 3,533,584 (GRCm39) Y229F possibly damaging Het
Myef2 T C 2: 124,957,395 (GRCm39) Y120C probably damaging Het
Myo9a T G 9: 59,807,655 (GRCm39) I2074S probably damaging Het
Nhs A G X: 160,630,045 (GRCm39) S337P probably damaging Het
Nphp4 T G 4: 152,622,318 (GRCm39) H566Q probably benign Het
Or2d2 A T 7: 106,728,272 (GRCm39) C109* probably null Het
Pabpc2 C A 18: 39,908,390 (GRCm39) Q552K possibly damaging Het
Podn T A 4: 107,879,371 (GRCm39) N104I probably damaging Het
Rit1 T C 3: 88,633,738 (GRCm39) V94A probably damaging Het
Scn7a A T 2: 66,534,289 (GRCm39) probably benign Het
Septin4 A T 11: 87,474,199 (GRCm39) K29M possibly damaging Het
Sowahb T C 5: 93,191,870 (GRCm39) Y283C probably damaging Het
Srbd1 A T 17: 86,422,637 (GRCm39) W460R probably damaging Het
Svep1 T A 4: 58,072,791 (GRCm39) K2173* probably null Het
Tlr6 T C 5: 65,112,019 (GRCm39) N296S possibly damaging Het
Trpm8 A G 1: 88,307,549 (GRCm39) D1073G possibly damaging Het
Ttc28 A T 5: 111,434,255 (GRCm39) K2399* probably null Het
Ttn A G 2: 76,717,627 (GRCm39) probably benign Het
Uroc1 C T 6: 90,315,810 (GRCm39) T189I probably benign Het
Usp18 C T 6: 121,232,341 (GRCm39) Q122* probably null Het
Zfp420 T C 7: 29,574,518 (GRCm39) I246T probably damaging Het
Zfp644 T C 5: 106,786,503 (GRCm39) probably null Het
Zfp871 A T 17: 32,993,726 (GRCm39) V483E probably benign Het
Other mutations in Or52z13
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00926:Or52z13 APN 7 103,247,369 (GRCm39) missense possibly damaging 0.65
IGL01772:Or52z13 APN 7 103,247,120 (GRCm39) missense probably benign 0.12
IGL02014:Or52z13 APN 7 103,246,937 (GRCm39) missense probably damaging 1.00
IGL03409:Or52z13 APN 7 103,246,574 (GRCm39) missense possibly damaging 0.51
R0087:Or52z13 UTSW 7 103,246,928 (GRCm39) missense probably benign 0.44
R0831:Or52z13 UTSW 7 103,247,338 (GRCm39) missense probably benign 0.02
R1779:Or52z13 UTSW 7 103,247,107 (GRCm39) missense probably damaging 1.00
R1909:Or52z13 UTSW 7 103,246,550 (GRCm39) missense probably benign 0.01
R5903:Or52z13 UTSW 7 103,247,128 (GRCm39) nonsense probably null
R5952:Or52z13 UTSW 7 103,247,174 (GRCm39) missense probably damaging 1.00
R6328:Or52z13 UTSW 7 103,247,073 (GRCm39) missense probably damaging 1.00
R7264:Or52z13 UTSW 7 103,246,955 (GRCm39) missense probably damaging 0.97
R7573:Or52z13 UTSW 7 103,246,735 (GRCm39) missense probably benign 0.08
R7870:Or52z13 UTSW 7 103,247,473 (GRCm39) missense probably damaging 1.00
R8394:Or52z13 UTSW 7 103,247,404 (GRCm39) missense probably damaging 1.00
R8833:Or52z13 UTSW 7 103,247,444 (GRCm39) missense possibly damaging 0.75
R9563:Or52z13 UTSW 7 103,247,225 (GRCm39) missense probably benign
R9601:Or52z13 UTSW 7 103,246,598 (GRCm39) missense probably benign 0.20
Posted On 2013-04-17