Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL01865:Gm21738'

278941

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Gm21738

Ensembl Gene

ENSMUSG00000095280

Gene Name

predicted gene, 21738

Synonyms

Accession Numbers

Essential gene?

Probably essential (E-score: 0.874) question?

Stock #

IGL01865

Quality Score

Status

Chromosome

Chromosomal Location

19415857-19418930 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

G to A at 19416979 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Serine to Leucine at position 144 (S144L)

Ref Sequence

ENSEMBL: ENSMUSP00000137127 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000177817]

AlphaFold

no structure available at present

Predicted Effect

probably benign
Transcript: ENSMUST00000177817
AA Change: S144L

PolyPhen 2 Score 0.011 (Sensitivity: 0.96; Specificity: 0.78)

SMART Domains

Protein: ENSMUSP00000137127
Gene: ENSMUSG00000095280
AA Change: S144L

Domain	Start	End	E-Value	Type
internal_repeat_1	1	19	1.11e-9	PROSPERO
transmembrane domain	20	42	N/A	INTRINSIC
transmembrane domain	77	99	N/A	INTRINSIC
internal_repeat_1	117	135	1.11e-9	PROSPERO
transmembrane domain	152	174	N/A	INTRINSIC
low complexity region	179	195	N/A	INTRINSIC
transmembrane domain	198	220	N/A	INTRINSIC

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 45 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
9130023H24Rik	T	C	7: 128,236,935	H162R	probably damaging	Het
Adamts10	T	A	17: 33,553,166	M1096K	probably damaging	Het
Asap3	G	T	4: 136,236,404	C325F	probably damaging	Het
Atm	T	C	9: 53,461,002	E2160G	probably damaging	Het
Col4a1	G	A	8: 11,201,790		probably benign	Het
Ctdp1	C	T	18: 80,455,984	G248S	probably damaging	Het
Dcaf5	A	T	12: 80,339,314	D679E	probably benign	Het
Efcab2	C	A	1: 178,475,688	Y91*	probably null	Het
Eif3d	G	T	15: 77,967,346	T88K	probably benign	Het
Gapvd1	G	A	2: 34,695,503	A1049V	probably null	Het
Gm10717	C	T	9: 3,025,616	S67L	probably benign	Het
Gm10717	A	T	9: 3,026,287	Y195F	probably damaging	Het
Gm10718	A	T	9: 3,025,118	Y194F	probably benign	Het
Gm18856	T	A	13: 13,964,923		probably benign	Het
Gm9991	A	G	1: 90,678,913		noncoding transcript	Het
Hapln1	T	C	13: 89,601,665	Y110H	probably damaging	Het
Htr1f	A	G	16: 64,925,919	Y337H	probably damaging	Het
Kirrel	T	A	3: 87,086,424	S509C	probably damaging	Het
Limch1	A	T	5: 66,974,580	R138*	probably null	Het
Lypla1	A	C	1: 4,837,036	I108L	probably damaging	Het
Mc3r	A	G	2: 172,249,055	N66D	probably damaging	Het
Melk	T	A	4: 44,344,988	C373S	probably benign	Het
Myocd	C	A	11: 65,200,897	S73I	probably benign	Het
Nell2	A	G	15: 95,385,081	V360A	possibly damaging	Het
Npas4	G	A	19: 4,985,791	Q782*	probably null	Het
Olfr1352	A	T	10: 78,984,678	D296V	possibly damaging	Het
Pdzd8	T	C	19: 59,299,645	K1108E	possibly damaging	Het
Per2	A	G	1: 91,421,517	I1044T	probably benign	Het
Pgm3	A	G	9: 86,555,318	F501S	possibly damaging	Het
Ppp1r3c	A	G	19: 36,734,178	V64A	probably benign	Het
Ptpn6	A	T	6: 124,732,465	I15N	probably damaging	Het
Pxk	T	C	14: 8,136,923	V148A	possibly damaging	Het
Rngtt	T	A	4: 33,325,157		probably benign	Het
Rtkn2	T	G	10: 68,035,875	S364R	probably benign	Het
Rtn1	A	C	12: 72,219,300	L167R	probably damaging	Het
Sp2	G	A	11: 96,961,042	T352I	probably damaging	Het
Tbc1d17	A	G	7: 44,842,689	M459T	possibly damaging	Het
Tbcd	T	A	11: 121,590,380	M694K	possibly damaging	Het
Tln2	G	A	9: 67,250,614	R1148*	probably null	Het
Trim27	T	C	13: 21,192,492	V294A	probably damaging	Het
Tspyl5	G	T	15: 33,687,712	A29E	unknown	Het
Vmn2r-ps159	C	T	4: 156,338,254		noncoding transcript	Het
Vrk2	C	T	11: 26,535,560	V143I	possibly damaging	Het
Zfp952	G	A	17: 33,002,817	R52Q	probably benign	Het
Zfp979	A	T	4: 147,615,317	D55E	probably benign	Het

Other mutations in Gm21738

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00990:Gm21738	APN	14	19418885	missense	probably benign
IGL01010:Gm21738	APN	14	19417361	missense	probably benign	0.03
IGL01018:Gm21738	APN	14	19418856	missense	probably benign	0.39
IGL01869:Gm21738	APN	14	19416979	missense	probably benign	0.01
IGL01873:Gm21738	APN	14	19416979	missense	probably benign	0.01
IGL01877:Gm21738	APN	14	19416979	missense	probably benign	0.01
IGL01878:Gm21738	APN	14	19416979	missense	probably benign	0.01
IGL01879:Gm21738	APN	14	19416979	missense	probably benign	0.01
IGL01880:Gm21738	APN	14	19416979	missense	probably benign	0.01
IGL01882:Gm21738	APN	14	19416979	missense	probably benign	0.01
IGL01883:Gm21738	APN	14	19416979	missense	probably benign	0.01
IGL01884:Gm21738	APN	14	19416979	missense	probably benign	0.01
IGL01885:Gm21738	APN	14	19416979	missense	probably benign	0.01
IGL01886:Gm21738	APN	14	19416979	missense	probably benign	0.01
IGL01888:Gm21738	APN	14	19416979	missense	probably benign	0.01
IGL01891:Gm21738	APN	14	19416979	missense	probably benign	0.01
IGL01892:Gm21738	APN	14	19416979	missense	probably benign	0.01
IGL01893:Gm21738	APN	14	19416979	missense	probably benign	0.01
IGL01894:Gm21738	APN	14	19416979	missense	probably benign	0.01
IGL01895:Gm21738	APN	14	19416979	missense	probably benign	0.01
IGL01896:Gm21738	APN	14	19416979	missense	probably benign	0.01
IGL01898:Gm21738	APN	14	19416979	missense	probably benign	0.01
IGL01899:Gm21738	APN	14	19416979	missense	probably benign	0.01
IGL01900:Gm21738	APN	14	19416979	missense	probably benign	0.01
IGL01901:Gm21738	APN	14	19416979	missense	probably benign	0.01
IGL01902:Gm21738	APN	14	19416979	missense	probably benign	0.01
IGL01903:Gm21738	APN	14	19416979	missense	probably benign	0.01
IGL01904:Gm21738	APN	14	19416979	missense	probably benign	0.01
IGL01905:Gm21738	APN	14	19416979	missense	probably benign	0.01
IGL01906:Gm21738	APN	14	19416979	missense	probably benign	0.01
IGL01908:Gm21738	APN	14	19416979	missense	probably benign	0.01
IGL01909:Gm21738	APN	14	19416979	missense	probably benign	0.01
IGL01910:Gm21738	APN	14	19416979	missense	probably benign	0.01
IGL01911:Gm21738	APN	14	19416979	missense	probably benign	0.01
IGL01912:Gm21738	APN	14	19416979	missense	probably benign	0.01
IGL01913:Gm21738	APN	14	19416979	missense	probably benign	0.01
IGL01914:Gm21738	APN	14	19416979	missense	probably benign	0.01
IGL01915:Gm21738	APN	14	19416979	missense	probably benign	0.01
IGL01916:Gm21738	APN	14	19416979	missense	probably benign	0.01
IGL01917:Gm21738	APN	14	19416979	missense	probably benign	0.01
IGL01918:Gm21738	APN	14	19416979	missense	probably benign	0.01
IGL01919:Gm21738	APN	14	19416979	missense	probably benign	0.01
IGL01922:Gm21738	APN	14	19416979	missense	probably benign	0.01
IGL01923:Gm21738	APN	14	19416979	missense	probably benign	0.01
IGL01924:Gm21738	APN	14	19416979	missense	probably benign	0.01
IGL01925:Gm21738	APN	14	19416979	missense	probably benign	0.01
IGL01926:Gm21738	APN	14	19416979	missense	probably benign	0.01
IGL01932:Gm21738	APN	14	19416979	missense	probably benign	0.01
IGL01940:Gm21738	APN	14	19416979	missense	probably benign	0.01
IGL01949:Gm21738	APN	14	19416979	missense	probably benign	0.01
PIT4131001:Gm21738	UTSW	14	19417330	missense	probably benign	0.00
PIT4142001:Gm21738	UTSW	14	19417330	missense	probably benign	0.00
R0831:Gm21738	UTSW	14	19415957	missense	probably benign	0.01
R0831:Gm21738	UTSW	14	19415963	missense	probably benign
R0976:Gm21738	UTSW	14	19415963	missense	probably benign
R1029:Gm21738	UTSW	14	19415957	missense	probably benign	0.01
R1146:Gm21738	UTSW	14	19415963	missense	probably benign
R1231:Gm21738	UTSW	14	19415957	missense	probably benign	0.01
R1231:Gm21738	UTSW	14	19415963	missense	probably benign
R1402:Gm21738	UTSW	14	19415957	missense	probably benign	0.01
R1402:Gm21738	UTSW	14	19415963	missense	probably benign
R1638:Gm21738	UTSW	14	19418908	missense	probably benign
R1874:Gm21738	UTSW	14	19418824	missense	possibly damaging	0.64
R4392:Gm21738	UTSW	14	19417178	missense	probably benign
R4393:Gm21738	UTSW	14	19417178	missense	probably benign
R5049:Gm21738	UTSW	14	19415957	missense	probably benign	0.01
R5257:Gm21738	UTSW	14	19415942	missense	probably benign
R6756:Gm21738	UTSW	14	19418824	missense	possibly damaging	0.64
R6915:Gm21738	UTSW	14	19415933	missense	probably benign
V5622:Gm21738	UTSW	14	19417180	missense	probably damaging	1.00

Posted On

2015-04-16