Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL01878:Gm21738'

278976

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Gm21738

Ensembl Gene

ENSMUSG00000095280

Gene Name

predicted gene, 21738

Synonyms

Accession Numbers

Essential gene?

Probably essential (E-score: 0.874) question?

Stock #

IGL01878

Quality Score

Status

Chromosome

Chromosomal Location

19415857-19418930 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

G to A at 19416979 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Serine to Leucine at position 144 (S144L)

Ref Sequence

ENSEMBL: ENSMUSP00000137127 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000177817]

AlphaFold

no structure available at present

Predicted Effect

probably benign
Transcript: ENSMUST00000177817
AA Change: S144L

PolyPhen 2 Score 0.011 (Sensitivity: 0.96; Specificity: 0.78)

SMART Domains

Protein: ENSMUSP00000137127
Gene: ENSMUSG00000095280
AA Change: S144L

Domain	Start	End	E-Value	Type
internal_repeat_1	1	19	1.11e-9	PROSPERO
transmembrane domain	20	42	N/A	INTRINSIC
transmembrane domain	77	99	N/A	INTRINSIC
internal_repeat_1	117	135	1.11e-9	PROSPERO
transmembrane domain	152	174	N/A	INTRINSIC
low complexity region	179	195	N/A	INTRINSIC
transmembrane domain	198	220	N/A	INTRINSIC

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 48 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Alox8	G	T	11: 69,197,038	Q147K	probably benign	Het
Ankib1	T	A	5: 3,734,152	M275L	possibly damaging	Het
Asb2	G	A	12: 103,321,663	P546S	possibly damaging	Het
B9d1	T	C	11: 61,507,623		probably benign	Het
Col12a1	T	C	9: 79,649,975	D1957G	possibly damaging	Het
Cryzl2	T	C	1: 157,472,400	V44A	possibly damaging	Het
Fbxw19	A	C	9: 109,483,279		probably benign	Het
Gabrb3	T	C	7: 57,816,415	F326L	probably damaging	Het
Gm10717	C	T	9: 3,025,616	S67L	probably benign	Het
Gm10718	A	T	9: 3,025,118	Y194F	probably benign	Het
Gm11168	T	C	9: 3,005,204	C16R	probably benign	Het
Gm7808	T	A	9: 19,928,246		probably benign	Het
Gpam	T	C	19: 55,083,374	I312V	probably benign	Het
H2-M10.5	A	G	17: 36,773,816	Y144C	probably damaging	Het
Hivep3	T	C	4: 120,095,227	S247P	possibly damaging	Het
Hs3st4	T	G	7: 124,397,313	C401G	probably damaging	Het
Klhl2	A	G	8: 64,759,824	V227A	probably damaging	Het
Lct	T	C	1: 128,294,266	N1512S	probably damaging	Het
Lipm	T	A	19: 34,116,511	L276Q	possibly damaging	Het
Lmf2	T	A	15: 89,352,418	H515L	probably damaging	Het
Mccc1	G	A	3: 35,975,892	S423L	probably damaging	Het
Mettl21e	G	A	1: 44,211,033	S71L	probably null	Het
Muc16	T	A	9: 18,495,543	H251L	possibly damaging	Het
Neb	T	C	2: 52,169,840		probably benign	Het
Ntf5	T	C	7: 45,416,026	I194T	probably damaging	Het
Olfr1124	T	C	2: 87,434,970	I161T	possibly damaging	Het
Olfr1154	A	T	2: 87,903,331	L115*	probably null	Het
Olfr1265	T	C	2: 90,037,134	S72P	probably damaging	Het
Olfr1361	T	C	13: 21,658,783	D180G	possibly damaging	Het
Olfr99	A	G	17: 37,280,000	V140A	possibly damaging	Het
Pigv	T	C	4: 133,665,117	I247M	probably benign	Het
Pik3r5	A	G	11: 68,492,530	N392D	probably benign	Het
Postn	A	G	3: 54,383,480		probably null	Het
Prl2c5	G	A	13: 13,185,817	S23N	probably benign	Het
Prpf40b	T	C	15: 99,306,532	C220R	possibly damaging	Het
Pzp	A	G	6: 128,495,298	S843P	probably damaging	Het
Rpl23	C	A	11: 97,778,351	R85L	probably benign	Het
Shcbp1	A	G	8: 4,749,721	S252P	probably damaging	Het
Slc26a7	C	T	4: 14,519,388		probably null	Het
Sptbn4	T	C	7: 27,364,146	E2285G	probably damaging	Het
Telo2	G	T	17: 25,101,358	T784K	probably benign	Het
Tnfrsf19	C	T	14: 60,996,644	V136M	probably damaging	Het
Trpm5	T	A	7: 143,074,497	I22F	probably damaging	Het
Trpv6	G	T	6: 41,626,867		probably benign	Het
Vmn1r173	T	G	7: 23,702,452	H37Q	probably damaging	Het
Vmn2r-ps159	C	T	4: 156,338,254		noncoding transcript	Het
Xpo6	T	A	7: 126,174,193	H20L	probably benign	Het
Zfp462	T	C	4: 55,010,613	Y860H	probably damaging	Het

Other mutations in Gm21738

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00990:Gm21738	APN	14	19418885	missense	probably benign
IGL01010:Gm21738	APN	14	19417361	missense	probably benign	0.03
IGL01018:Gm21738	APN	14	19418856	missense	probably benign	0.39
IGL01865:Gm21738	APN	14	19416979	missense	probably benign	0.01
IGL01869:Gm21738	APN	14	19416979	missense	probably benign	0.01
IGL01873:Gm21738	APN	14	19416979	missense	probably benign	0.01
IGL01877:Gm21738	APN	14	19416979	missense	probably benign	0.01
IGL01879:Gm21738	APN	14	19416979	missense	probably benign	0.01
IGL01880:Gm21738	APN	14	19416979	missense	probably benign	0.01
IGL01882:Gm21738	APN	14	19416979	missense	probably benign	0.01
IGL01883:Gm21738	APN	14	19416979	missense	probably benign	0.01
IGL01884:Gm21738	APN	14	19416979	missense	probably benign	0.01
IGL01885:Gm21738	APN	14	19416979	missense	probably benign	0.01
IGL01886:Gm21738	APN	14	19416979	missense	probably benign	0.01
IGL01888:Gm21738	APN	14	19416979	missense	probably benign	0.01
IGL01891:Gm21738	APN	14	19416979	missense	probably benign	0.01
IGL01892:Gm21738	APN	14	19416979	missense	probably benign	0.01
IGL01893:Gm21738	APN	14	19416979	missense	probably benign	0.01
IGL01894:Gm21738	APN	14	19416979	missense	probably benign	0.01
IGL01895:Gm21738	APN	14	19416979	missense	probably benign	0.01
IGL01896:Gm21738	APN	14	19416979	missense	probably benign	0.01
IGL01898:Gm21738	APN	14	19416979	missense	probably benign	0.01
IGL01899:Gm21738	APN	14	19416979	missense	probably benign	0.01
IGL01900:Gm21738	APN	14	19416979	missense	probably benign	0.01
IGL01901:Gm21738	APN	14	19416979	missense	probably benign	0.01
IGL01902:Gm21738	APN	14	19416979	missense	probably benign	0.01
IGL01903:Gm21738	APN	14	19416979	missense	probably benign	0.01
IGL01904:Gm21738	APN	14	19416979	missense	probably benign	0.01
IGL01905:Gm21738	APN	14	19416979	missense	probably benign	0.01
IGL01906:Gm21738	APN	14	19416979	missense	probably benign	0.01
IGL01908:Gm21738	APN	14	19416979	missense	probably benign	0.01
IGL01909:Gm21738	APN	14	19416979	missense	probably benign	0.01
IGL01910:Gm21738	APN	14	19416979	missense	probably benign	0.01
IGL01911:Gm21738	APN	14	19416979	missense	probably benign	0.01
IGL01912:Gm21738	APN	14	19416979	missense	probably benign	0.01
IGL01913:Gm21738	APN	14	19416979	missense	probably benign	0.01
IGL01914:Gm21738	APN	14	19416979	missense	probably benign	0.01
IGL01915:Gm21738	APN	14	19416979	missense	probably benign	0.01
IGL01916:Gm21738	APN	14	19416979	missense	probably benign	0.01
IGL01917:Gm21738	APN	14	19416979	missense	probably benign	0.01
IGL01918:Gm21738	APN	14	19416979	missense	probably benign	0.01
IGL01919:Gm21738	APN	14	19416979	missense	probably benign	0.01
IGL01922:Gm21738	APN	14	19416979	missense	probably benign	0.01
IGL01923:Gm21738	APN	14	19416979	missense	probably benign	0.01
IGL01924:Gm21738	APN	14	19416979	missense	probably benign	0.01
IGL01925:Gm21738	APN	14	19416979	missense	probably benign	0.01
IGL01926:Gm21738	APN	14	19416979	missense	probably benign	0.01
IGL01932:Gm21738	APN	14	19416979	missense	probably benign	0.01
IGL01940:Gm21738	APN	14	19416979	missense	probably benign	0.01
IGL01949:Gm21738	APN	14	19416979	missense	probably benign	0.01
PIT4131001:Gm21738	UTSW	14	19417330	missense	probably benign	0.00
PIT4142001:Gm21738	UTSW	14	19417330	missense	probably benign	0.00
R0831:Gm21738	UTSW	14	19415957	missense	probably benign	0.01
R0831:Gm21738	UTSW	14	19415963	missense	probably benign
R0976:Gm21738	UTSW	14	19415963	missense	probably benign
R1029:Gm21738	UTSW	14	19415957	missense	probably benign	0.01
R1146:Gm21738	UTSW	14	19415963	missense	probably benign
R1231:Gm21738	UTSW	14	19415957	missense	probably benign	0.01
R1231:Gm21738	UTSW	14	19415963	missense	probably benign
R1402:Gm21738	UTSW	14	19415957	missense	probably benign	0.01
R1402:Gm21738	UTSW	14	19415963	missense	probably benign
R1638:Gm21738	UTSW	14	19418908	missense	probably benign
R1874:Gm21738	UTSW	14	19418824	missense	possibly damaging	0.64
R4392:Gm21738	UTSW	14	19417178	missense	probably benign
R4393:Gm21738	UTSW	14	19417178	missense	probably benign
R5049:Gm21738	UTSW	14	19415957	missense	probably benign	0.01
R5257:Gm21738	UTSW	14	19415942	missense	probably benign
R6756:Gm21738	UTSW	14	19418824	missense	possibly damaging	0.64
R6915:Gm21738	UTSW	14	19415933	missense	probably benign
V5622:Gm21738	UTSW	14	19417180	missense	probably damaging	1.00

Posted On

2015-04-16