Incidental Mutation 'IGL01886:Gm21738'
ID 279003
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Gm21738
Ensembl Gene ENSMUSG00000095280
Gene Name predicted gene, 21738
Synonyms
Accession Numbers
Essential gene? Probably essential (E-score: 0.905) question?
Stock # IGL01886
Quality Score
Status
Chromosome 14
Chromosomal Location (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) G to A at 19416979 bp (GRCm38)
Zygosity Heterozygous
Amino Acid Change Serine to Leucine at position 144 (S144L)
Ref Sequence ENSEMBL: ENSMUSP00000137127 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000177817]
AlphaFold no structure available at present
Predicted Effect probably benign
Transcript: ENSMUST00000177817
AA Change: S144L

PolyPhen 2 Score 0.011 (Sensitivity: 0.96; Specificity: 0.78)
SMART Domains Protein: ENSMUSP00000137127
Gene: ENSMUSG00000095280
AA Change: S144L

DomainStartEndE-ValueType
internal_repeat_1 1 19 1.11e-9 PROSPERO
transmembrane domain 20 42 N/A INTRINSIC
transmembrane domain 77 99 N/A INTRINSIC
internal_repeat_1 117 135 1.11e-9 PROSPERO
transmembrane domain 152 174 N/A INTRINSIC
low complexity region 179 195 N/A INTRINSIC
transmembrane domain 198 220 N/A INTRINSIC
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 43 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Akt1 C T 12: 112,625,592 (GRCm39) V136M probably benign Het
Ankrd34c A T 9: 89,612,318 (GRCm39) L8M possibly damaging Het
Anks6 C A 4: 47,044,850 (GRCm39) W352L probably damaging Het
Arhgap12 A T 18: 6,027,613 (GRCm39) N768K probably damaging Het
Clec7a A T 6: 129,440,140 (GRCm39) probably benign Het
Cyp3a13 G A 5: 137,897,082 (GRCm39) P411S probably damaging Het
Elavl2 A G 4: 91,152,330 (GRCm39) V129A probably damaging Het
Ercc6 T A 14: 32,291,537 (GRCm39) S994T possibly damaging Het
Esco1 T A 18: 10,595,262 (GRCm39) K8I probably damaging Het
Esr1 T A 10: 4,806,861 (GRCm39) I259K probably damaging Het
Filip1l A G 16: 57,391,613 (GRCm39) I734V possibly damaging Het
Gm10717 C T 9: 3,025,616 (GRCm39) S67L probably benign Het
Gm10718 A T 9: 3,025,118 (GRCm39) Y194F probably benign Het
Grin3a T A 4: 49,702,814 (GRCm39) I891F probably damaging Het
Kat7 T C 11: 95,196,959 (GRCm39) T27A probably benign Het
Kdm1a A G 4: 136,288,327 (GRCm39) probably null Het
Kifc5b T C 17: 27,151,091 (GRCm39) V663A probably damaging Het
Lama1 T G 17: 68,114,792 (GRCm39) S2314A probably benign Het
Lrrc69 C T 4: 14,703,984 (GRCm39) V279I probably benign Het
Mast3 A T 8: 71,234,783 (GRCm39) L774Q possibly damaging Het
Med27 C A 2: 29,303,494 (GRCm39) P9Q probably damaging Het
Myo5a C A 9: 75,076,372 (GRCm39) probably benign Het
Myoz1 T C 14: 20,705,377 (GRCm39) K14E probably damaging Het
Neb T C 2: 52,073,857 (GRCm39) probably benign Het
Nlrp1a T C 11: 71,014,327 (GRCm39) T308A probably benign Het
Or1l4b A G 2: 37,036,521 (GRCm39) Y99C probably damaging Het
Or8d2b G T 9: 38,788,844 (GRCm39) C124F probably damaging Het
Orc1 T A 4: 108,461,154 (GRCm39) probably null Het
Pnkp G A 7: 44,511,631 (GRCm39) A76T probably damaging Het
Polr3h T C 15: 81,801,591 (GRCm39) E95G probably damaging Het
Prpf40b T A 15: 99,202,328 (GRCm39) M62K unknown Het
Prpf8 C A 11: 75,386,570 (GRCm39) Q1075K probably benign Het
Ptprg A G 14: 12,179,280 (GRCm38) K766E probably benign Het
Rabgap1l A T 1: 160,169,612 (GRCm39) N778K probably damaging Het
Riok3 T A 18: 12,272,442 (GRCm39) N204K probably damaging Het
Shank3 A G 15: 89,415,866 (GRCm39) K650E probably damaging Het
Sim1 T A 10: 50,860,411 (GRCm39) S758T probably damaging Het
Slu7 T G 11: 43,330,087 (GRCm39) N171K probably damaging Het
Sp140l2 A G 1: 85,231,907 (GRCm39) probably benign Het
Sult6b2 A G 6: 142,735,852 (GRCm39) probably null Het
Taf6l C T 19: 8,755,450 (GRCm39) probably null Het
Ubtfl1 G A 9: 18,321,017 (GRCm39) V182M possibly damaging Het
Vmn2r129 C T 4: 156,690,549 (GRCm39) noncoding transcript Het
Other mutations in Gm21738
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00990:Gm21738 APN 14 19,418,885 (GRCm38) missense probably benign
IGL01010:Gm21738 APN 14 19,417,361 (GRCm38) missense probably benign 0.03
IGL01018:Gm21738 APN 14 19,418,856 (GRCm38) missense probably benign 0.39
IGL01865:Gm21738 APN 14 19,416,979 (GRCm38) missense probably benign 0.01
IGL01869:Gm21738 APN 14 19,416,979 (GRCm38) missense probably benign 0.01
IGL01873:Gm21738 APN 14 19,416,979 (GRCm38) missense probably benign 0.01
IGL01877:Gm21738 APN 14 19,416,979 (GRCm38) missense probably benign 0.01
IGL01878:Gm21738 APN 14 19,416,979 (GRCm38) missense probably benign 0.01
IGL01879:Gm21738 APN 14 19,416,979 (GRCm38) missense probably benign 0.01
IGL01880:Gm21738 APN 14 19,416,979 (GRCm38) missense probably benign 0.01
IGL01882:Gm21738 APN 14 19,416,979 (GRCm38) missense probably benign 0.01
IGL01883:Gm21738 APN 14 19,416,979 (GRCm38) missense probably benign 0.01
IGL01884:Gm21738 APN 14 19,416,979 (GRCm38) missense probably benign 0.01
IGL01885:Gm21738 APN 14 19,416,979 (GRCm38) missense probably benign 0.01
IGL01888:Gm21738 APN 14 19,416,979 (GRCm38) missense probably benign 0.01
IGL01891:Gm21738 APN 14 19,416,979 (GRCm38) missense probably benign 0.01
IGL01892:Gm21738 APN 14 19,416,979 (GRCm38) missense probably benign 0.01
IGL01893:Gm21738 APN 14 19,416,979 (GRCm38) missense probably benign 0.01
IGL01894:Gm21738 APN 14 19,416,979 (GRCm38) missense probably benign 0.01
IGL01895:Gm21738 APN 14 19,416,979 (GRCm38) missense probably benign 0.01
IGL01896:Gm21738 APN 14 19,416,979 (GRCm38) missense probably benign 0.01
IGL01898:Gm21738 APN 14 19,416,979 (GRCm38) missense probably benign 0.01
IGL01899:Gm21738 APN 14 19,416,979 (GRCm38) missense probably benign 0.01
IGL01900:Gm21738 APN 14 19,416,979 (GRCm38) missense probably benign 0.01
IGL01901:Gm21738 APN 14 19,416,979 (GRCm38) missense probably benign 0.01
IGL01902:Gm21738 APN 14 19,416,979 (GRCm38) missense probably benign 0.01
IGL01903:Gm21738 APN 14 19,416,979 (GRCm38) missense probably benign 0.01
IGL01904:Gm21738 APN 14 19,416,979 (GRCm38) missense probably benign 0.01
IGL01905:Gm21738 APN 14 19,416,979 (GRCm38) missense probably benign 0.01
IGL01906:Gm21738 APN 14 19,416,979 (GRCm38) missense probably benign 0.01
IGL01908:Gm21738 APN 14 19,416,979 (GRCm38) missense probably benign 0.01
IGL01909:Gm21738 APN 14 19,416,979 (GRCm38) missense probably benign 0.01
IGL01910:Gm21738 APN 14 19,416,979 (GRCm38) missense probably benign 0.01
IGL01911:Gm21738 APN 14 19,416,979 (GRCm38) missense probably benign 0.01
IGL01912:Gm21738 APN 14 19,416,979 (GRCm38) missense probably benign 0.01
IGL01913:Gm21738 APN 14 19,416,979 (GRCm38) missense probably benign 0.01
IGL01914:Gm21738 APN 14 19,416,979 (GRCm38) missense probably benign 0.01
IGL01915:Gm21738 APN 14 19,416,979 (GRCm38) missense probably benign 0.01
IGL01916:Gm21738 APN 14 19,416,979 (GRCm38) missense probably benign 0.01
IGL01917:Gm21738 APN 14 19,416,979 (GRCm38) missense probably benign 0.01
IGL01918:Gm21738 APN 14 19,416,979 (GRCm38) missense probably benign 0.01
IGL01919:Gm21738 APN 14 19,416,979 (GRCm38) missense probably benign 0.01
IGL01922:Gm21738 APN 14 19,416,979 (GRCm38) missense probably benign 0.01
IGL01923:Gm21738 APN 14 19,416,979 (GRCm38) missense probably benign 0.01
IGL01924:Gm21738 APN 14 19,416,979 (GRCm38) missense probably benign 0.01
IGL01925:Gm21738 APN 14 19,416,979 (GRCm38) missense probably benign 0.01
IGL01926:Gm21738 APN 14 19,416,979 (GRCm38) missense probably benign 0.01
IGL01932:Gm21738 APN 14 19,416,979 (GRCm38) missense probably benign 0.01
IGL01940:Gm21738 APN 14 19,416,979 (GRCm38) missense probably benign 0.01
IGL01949:Gm21738 APN 14 19,416,979 (GRCm38) missense probably benign 0.01
PIT4131001:Gm21738 UTSW 14 19,417,330 (GRCm38) missense probably benign 0.00
PIT4142001:Gm21738 UTSW 14 19,417,330 (GRCm38) missense probably benign 0.00
R0831:Gm21738 UTSW 14 19,415,963 (GRCm38) missense probably benign
R0831:Gm21738 UTSW 14 19,415,957 (GRCm38) missense probably benign 0.01
R0976:Gm21738 UTSW 14 19,415,963 (GRCm38) missense probably benign
R1029:Gm21738 UTSW 14 19,415,957 (GRCm38) missense probably benign 0.01
R1146:Gm21738 UTSW 14 19,415,963 (GRCm38) missense probably benign
R1231:Gm21738 UTSW 14 19,415,963 (GRCm38) missense probably benign
R1231:Gm21738 UTSW 14 19,415,957 (GRCm38) missense probably benign 0.01
R1402:Gm21738 UTSW 14 19,415,963 (GRCm38) missense probably benign
R1402:Gm21738 UTSW 14 19,415,957 (GRCm38) missense probably benign 0.01
R1638:Gm21738 UTSW 14 19,418,908 (GRCm38) missense probably benign
R1874:Gm21738 UTSW 14 19,418,824 (GRCm38) missense possibly damaging 0.64
R4392:Gm21738 UTSW 14 19,417,178 (GRCm38) missense probably benign
R4393:Gm21738 UTSW 14 19,417,178 (GRCm38) missense probably benign
R5049:Gm21738 UTSW 14 19,415,957 (GRCm38) missense probably benign 0.01
R5257:Gm21738 UTSW 14 19,415,942 (GRCm38) missense probably benign
R6756:Gm21738 UTSW 14 19,418,824 (GRCm38) missense possibly damaging 0.64
R6915:Gm21738 UTSW 14 19,415,933 (GRCm38) missense probably benign
V5622:Gm21738 UTSW 14 19,417,180 (GRCm38) missense probably damaging 1.00
Posted On 2015-04-16