Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL01893:Gm21738'

279023

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Gm21738

Ensembl Gene

ENSMUSG00000095280

Gene Name

predicted gene, 21738

Synonyms

Accession Numbers

Essential gene?

Probably essential (E-score: 0.874) question?

Stock #

IGL01893

Quality Score

Status

Chromosome

Chromosomal Location

19415857-19418930 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

G to A at 19416979 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Serine to Leucine at position 144 (S144L)

Ref Sequence

ENSEMBL: ENSMUSP00000137127 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000177817]

AlphaFold

no structure available at present

Predicted Effect

probably benign
Transcript: ENSMUST00000177817
AA Change: S144L

PolyPhen 2 Score 0.011 (Sensitivity: 0.96; Specificity: 0.78)

SMART Domains

Protein: ENSMUSP00000137127
Gene: ENSMUSG00000095280
AA Change: S144L

Domain	Start	End	E-Value	Type
internal_repeat_1	1	19	1.11e-9	PROSPERO
transmembrane domain	20	42	N/A	INTRINSIC
transmembrane domain	77	99	N/A	INTRINSIC
internal_repeat_1	117	135	1.11e-9	PROSPERO
transmembrane domain	152	174	N/A	INTRINSIC
low complexity region	179	195	N/A	INTRINSIC
transmembrane domain	198	220	N/A	INTRINSIC

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 47 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Agl	T	A	3: 116,788,549	I275F	probably damaging	Het
Avil	G	A	10: 127,020,546	E815K	possibly damaging	Het
C130026I21Rik	A	G	1: 85,254,186		probably benign	Het
Car9	T	A	4: 43,510,252	I278N	probably damaging	Het
Cast	T	A	13: 74,727,289	K480*	probably null	Het
Cenpj	A	G	14: 56,553,474	F373L	probably damaging	Het
Cspp1	T	C	1: 10,134,141		probably null	Het
Diaph3	G	A	14: 86,918,852	T675I	possibly damaging	Het
Dip2b	A	T	15: 100,171,220		probably benign	Het
Dnah1	T	C	14: 31,266,470	D3425G	probably damaging	Het
Dolk	A	G	2: 30,285,914	Y40H	probably benign	Het
Drosha	T	C	15: 12,866,650		probably benign	Het
Dusp15	A	G	2: 152,949,036		probably null	Het
Edrf1	T	C	7: 133,657,102	F770L	probably benign	Het
Gabra1	T	C	11: 42,133,759	K363R	possibly damaging	Het
Glipr1l1	A	C	10: 112,076,169	T203P	probably benign	Het
Gm10717	C	T	9: 3,025,616	S67L	probably benign	Het
H2-Q10	T	C	17: 35,473,271	S270P	probably damaging	Het
Hipk2	A	T	6: 38,818,395	M313K	probably benign	Het
Htt	T	A	5: 34,876,830	I1920N	probably damaging	Het
Lsr	A	T	7: 30,962,232	V210E	possibly damaging	Het
Mbtd1	A	T	11: 93,921,412	I181L	probably null	Het
Mettl16	A	T	11: 74,805,271	T273S	possibly damaging	Het
Mlst8	T	C	17: 24,477,987	N74D	probably benign	Het
Nek9	A	G	12: 85,336,400	I102T	probably damaging	Het
Nme7	C	T	1: 164,345,281	A187V	probably damaging	Het
Nphp1	A	T	2: 127,769,644	W261R	probably damaging	Het
Olfr1148	G	T	2: 87,833,863	G275*	probably null	Het
Olfr1306	A	T	2: 111,912,244	S229T	possibly damaging	Het
Olfr90	A	G	17: 37,085,868	L99P	probably damaging	Het
Orc6	A	G	8: 85,307,643	D165G	probably damaging	Het
Ovca2	A	G	11: 75,178,307	S89P	probably benign	Het
Pcdhb12	T	G	18: 37,437,210	S470A	probably benign	Het
Phactr2	T	C	10: 13,247,188	T397A	probably benign	Het
Pms2	T	C	5: 143,923,519	L50P	probably damaging	Het
Prr36	G	A	8: 4,215,243	P169L	probably damaging	Het
Serpinb11	C	A	1: 107,377,657	S254R	probably benign	Het
Serpinb11	C	A	1: 107,377,658	Q255K	probably benign	Het
Skap2	T	C	6: 51,874,576	T79A	probably damaging	Het
Tbx19	A	T	1: 165,140,198	S327T	possibly damaging	Het
Themis3	A	G	17: 66,559,627	L206P	possibly damaging	Het
Tmem132c	T	A	5: 127,463,029	L373Q	possibly damaging	Het
Unc13c	G	T	9: 73,693,366	N1365K	probably benign	Het
Vmn2r106	A	T	17: 20,277,468	M503K	probably benign	Het
Vmn2r33	A	G	7: 7,563,777	I112T	probably benign	Het
Vmn2r-ps159	C	T	4: 156,338,254		noncoding transcript	Het
Vps13a	A	C	19: 16,663,775	W2328G	probably damaging	Het

Other mutations in Gm21738

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00990:Gm21738	APN	14	19418885	missense	probably benign
IGL01010:Gm21738	APN	14	19417361	missense	probably benign	0.03
IGL01018:Gm21738	APN	14	19418856	missense	probably benign	0.39
IGL01865:Gm21738	APN	14	19416979	missense	probably benign	0.01
IGL01869:Gm21738	APN	14	19416979	missense	probably benign	0.01
IGL01873:Gm21738	APN	14	19416979	missense	probably benign	0.01
IGL01877:Gm21738	APN	14	19416979	missense	probably benign	0.01
IGL01878:Gm21738	APN	14	19416979	missense	probably benign	0.01
IGL01879:Gm21738	APN	14	19416979	missense	probably benign	0.01
IGL01880:Gm21738	APN	14	19416979	missense	probably benign	0.01
IGL01882:Gm21738	APN	14	19416979	missense	probably benign	0.01
IGL01883:Gm21738	APN	14	19416979	missense	probably benign	0.01
IGL01884:Gm21738	APN	14	19416979	missense	probably benign	0.01
IGL01885:Gm21738	APN	14	19416979	missense	probably benign	0.01
IGL01886:Gm21738	APN	14	19416979	missense	probably benign	0.01
IGL01888:Gm21738	APN	14	19416979	missense	probably benign	0.01
IGL01891:Gm21738	APN	14	19416979	missense	probably benign	0.01
IGL01892:Gm21738	APN	14	19416979	missense	probably benign	0.01
IGL01894:Gm21738	APN	14	19416979	missense	probably benign	0.01
IGL01895:Gm21738	APN	14	19416979	missense	probably benign	0.01
IGL01896:Gm21738	APN	14	19416979	missense	probably benign	0.01
IGL01898:Gm21738	APN	14	19416979	missense	probably benign	0.01
IGL01899:Gm21738	APN	14	19416979	missense	probably benign	0.01
IGL01900:Gm21738	APN	14	19416979	missense	probably benign	0.01
IGL01901:Gm21738	APN	14	19416979	missense	probably benign	0.01
IGL01902:Gm21738	APN	14	19416979	missense	probably benign	0.01
IGL01903:Gm21738	APN	14	19416979	missense	probably benign	0.01
IGL01904:Gm21738	APN	14	19416979	missense	probably benign	0.01
IGL01905:Gm21738	APN	14	19416979	missense	probably benign	0.01
IGL01906:Gm21738	APN	14	19416979	missense	probably benign	0.01
IGL01908:Gm21738	APN	14	19416979	missense	probably benign	0.01
IGL01909:Gm21738	APN	14	19416979	missense	probably benign	0.01
IGL01910:Gm21738	APN	14	19416979	missense	probably benign	0.01
IGL01911:Gm21738	APN	14	19416979	missense	probably benign	0.01
IGL01912:Gm21738	APN	14	19416979	missense	probably benign	0.01
IGL01913:Gm21738	APN	14	19416979	missense	probably benign	0.01
IGL01914:Gm21738	APN	14	19416979	missense	probably benign	0.01
IGL01915:Gm21738	APN	14	19416979	missense	probably benign	0.01
IGL01916:Gm21738	APN	14	19416979	missense	probably benign	0.01
IGL01917:Gm21738	APN	14	19416979	missense	probably benign	0.01
IGL01918:Gm21738	APN	14	19416979	missense	probably benign	0.01
IGL01919:Gm21738	APN	14	19416979	missense	probably benign	0.01
IGL01922:Gm21738	APN	14	19416979	missense	probably benign	0.01
IGL01923:Gm21738	APN	14	19416979	missense	probably benign	0.01
IGL01924:Gm21738	APN	14	19416979	missense	probably benign	0.01
IGL01925:Gm21738	APN	14	19416979	missense	probably benign	0.01
IGL01926:Gm21738	APN	14	19416979	missense	probably benign	0.01
IGL01932:Gm21738	APN	14	19416979	missense	probably benign	0.01
IGL01940:Gm21738	APN	14	19416979	missense	probably benign	0.01
IGL01949:Gm21738	APN	14	19416979	missense	probably benign	0.01
PIT4131001:Gm21738	UTSW	14	19417330	missense	probably benign	0.00
PIT4142001:Gm21738	UTSW	14	19417330	missense	probably benign	0.00
R0831:Gm21738	UTSW	14	19415957	missense	probably benign	0.01
R0831:Gm21738	UTSW	14	19415963	missense	probably benign
R0976:Gm21738	UTSW	14	19415963	missense	probably benign
R1029:Gm21738	UTSW	14	19415957	missense	probably benign	0.01
R1146:Gm21738	UTSW	14	19415963	missense	probably benign
R1231:Gm21738	UTSW	14	19415957	missense	probably benign	0.01
R1231:Gm21738	UTSW	14	19415963	missense	probably benign
R1402:Gm21738	UTSW	14	19415957	missense	probably benign	0.01
R1402:Gm21738	UTSW	14	19415963	missense	probably benign
R1638:Gm21738	UTSW	14	19418908	missense	probably benign
R1874:Gm21738	UTSW	14	19418824	missense	possibly damaging	0.64
R4392:Gm21738	UTSW	14	19417178	missense	probably benign
R4393:Gm21738	UTSW	14	19417178	missense	probably benign
R5049:Gm21738	UTSW	14	19415957	missense	probably benign	0.01
R5257:Gm21738	UTSW	14	19415942	missense	probably benign
R6756:Gm21738	UTSW	14	19418824	missense	possibly damaging	0.64
R6915:Gm21738	UTSW	14	19415933	missense	probably benign
V5622:Gm21738	UTSW	14	19417180	missense	probably damaging	1.00

Posted On

2015-04-16