Incidental Mutation 'IGL01895:Gm21738'
ID279031
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Gm21738
Ensembl Gene ENSMUSG00000095280
Gene Namepredicted gene, 21738
Synonyms
Accession Numbers
Is this an essential gene? Probably essential (E-score: 0.887) question?
Stock #IGL01895
Quality Score
Status
Chromosome14
Chromosomal Location19415857-19418930 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) G to A at 19416979 bp
ZygosityHeterozygous
Amino Acid Change Serine to Leucine at position 144 (S144L)
Ref Sequence ENSEMBL: ENSMUSP00000137127 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000177817]
Predicted Effect probably benign
Transcript: ENSMUST00000177817
AA Change: S144L

PolyPhen 2 Score 0.011 (Sensitivity: 0.96; Specificity: 0.78)
SMART Domains Protein: ENSMUSP00000137127
Gene: ENSMUSG00000095280
AA Change: S144L

DomainStartEndE-ValueType
internal_repeat_1 1 19 1.11e-9 PROSPERO
transmembrane domain 20 42 N/A INTRINSIC
transmembrane domain 77 99 N/A INTRINSIC
internal_repeat_1 117 135 1.11e-9 PROSPERO
transmembrane domain 152 174 N/A INTRINSIC
low complexity region 179 195 N/A INTRINSIC
transmembrane domain 198 220 N/A INTRINSIC
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 38 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
2410089E03Rik T A 15: 8,229,107 V2279E possibly damaging Het
Abcc6 A T 7: 46,029,058 I56N possibly damaging Het
Akr1c13 A T 13: 4,205,373 E321V possibly damaging Het
Atp8b3 A T 10: 80,521,828 V1119D possibly damaging Het
Cacna1e G T 1: 154,443,900 F1351L probably damaging Het
Cadps2 A G 6: 23,427,275 W585R probably damaging Het
Ccdc113 C T 8: 95,536,458 probably benign Het
Ccer1 A T 10: 97,694,050 I192F unknown Het
Chd8 T C 14: 52,199,094 N90S probably benign Het
Clca3a1 A T 3: 144,747,572 C463* probably null Het
Cyp2c65 T A 19: 39,072,232 C179S possibly damaging Het
Dennd4b A G 3: 90,275,567 Q35R probably benign Het
Enpep T C 3: 129,270,334 E928G possibly damaging Het
Fem1c T C 18: 46,505,562 T458A probably benign Het
Fezf2 A T 14: 12,342,498 *456R probably null Het
Gm10718 A T 9: 3,025,118 Y194F probably benign Het
Gm14085 A C 2: 122,525,091 Y588S possibly damaging Het
Iqcm T G 8: 75,888,560 L423R probably damaging Het
Kcnc4 C A 3: 107,448,218 V305L probably benign Het
Kif1a G A 1: 93,025,733 T1337I possibly damaging Het
Lpxn A G 19: 12,833,086 D298G probably damaging Het
Lypd8 A G 11: 58,390,220 T203A possibly damaging Het
Mrps28 C T 3: 8,900,059 V107M probably damaging Het
Myo15b A G 11: 115,883,498 E586G possibly damaging Het
Pdzk1 C T 3: 96,869,101 A459V possibly damaging Het
Rbpj A G 5: 53,651,386 D285G probably damaging Het
Rimbp3 T C 16: 17,211,436 L908P probably damaging Het
Samd4b T C 7: 28,401,909 probably null Het
Stau2 C T 1: 16,345,937 G401S probably damaging Het
Trpa1 A T 1: 14,887,643 I697K possibly damaging Het
Ttc17 A C 2: 94,375,146 V285G possibly damaging Het
Unc5b A G 10: 60,767,085 F845S probably damaging Het
Vmn1r19 A T 6: 57,405,260 Q266L probably benign Het
Vmn2r106 T C 17: 20,278,965 N228S probably benign Het
Vps13d A G 4: 145,156,266 F919S possibly damaging Het
Zbtb38 C T 9: 96,688,408 V208I probably benign Het
Zfp990 A T 4: 145,536,857 T142S probably damaging Het
Zfp990 C A 4: 145,536,858 T142N probably damaging Het
Other mutations in Gm21738
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00990:Gm21738 APN 14 19418885 missense probably benign
IGL01010:Gm21738 APN 14 19417361 missense probably benign 0.03
IGL01018:Gm21738 APN 14 19418856 missense probably benign 0.39
IGL01865:Gm21738 APN 14 19416979 missense probably benign 0.01
IGL01869:Gm21738 APN 14 19416979 missense probably benign 0.01
IGL01873:Gm21738 APN 14 19416979 missense probably benign 0.01
IGL01877:Gm21738 APN 14 19416979 missense probably benign 0.01
IGL01878:Gm21738 APN 14 19416979 missense probably benign 0.01
IGL01879:Gm21738 APN 14 19416979 missense probably benign 0.01
IGL01880:Gm21738 APN 14 19416979 missense probably benign 0.01
IGL01882:Gm21738 APN 14 19416979 missense probably benign 0.01
IGL01883:Gm21738 APN 14 19416979 missense probably benign 0.01
IGL01884:Gm21738 APN 14 19416979 missense probably benign 0.01
IGL01885:Gm21738 APN 14 19416979 missense probably benign 0.01
IGL01886:Gm21738 APN 14 19416979 missense probably benign 0.01
IGL01888:Gm21738 APN 14 19416979 missense probably benign 0.01
IGL01891:Gm21738 APN 14 19416979 missense probably benign 0.01
IGL01892:Gm21738 APN 14 19416979 missense probably benign 0.01
IGL01893:Gm21738 APN 14 19416979 missense probably benign 0.01
IGL01894:Gm21738 APN 14 19416979 missense probably benign 0.01
IGL01896:Gm21738 APN 14 19416979 missense probably benign 0.01
IGL01898:Gm21738 APN 14 19416979 missense probably benign 0.01
IGL01899:Gm21738 APN 14 19416979 missense probably benign 0.01
IGL01900:Gm21738 APN 14 19416979 missense probably benign 0.01
IGL01901:Gm21738 APN 14 19416979 missense probably benign 0.01
IGL01902:Gm21738 APN 14 19416979 missense probably benign 0.01
IGL01903:Gm21738 APN 14 19416979 missense probably benign 0.01
IGL01904:Gm21738 APN 14 19416979 missense probably benign 0.01
IGL01905:Gm21738 APN 14 19416979 missense probably benign 0.01
IGL01906:Gm21738 APN 14 19416979 missense probably benign 0.01
IGL01908:Gm21738 APN 14 19416979 missense probably benign 0.01
IGL01909:Gm21738 APN 14 19416979 missense probably benign 0.01
IGL01910:Gm21738 APN 14 19416979 missense probably benign 0.01
IGL01911:Gm21738 APN 14 19416979 missense probably benign 0.01
IGL01912:Gm21738 APN 14 19416979 missense probably benign 0.01
IGL01913:Gm21738 APN 14 19416979 missense probably benign 0.01
IGL01914:Gm21738 APN 14 19416979 missense probably benign 0.01
IGL01915:Gm21738 APN 14 19416979 missense probably benign 0.01
IGL01916:Gm21738 APN 14 19416979 missense probably benign 0.01
IGL01917:Gm21738 APN 14 19416979 missense probably benign 0.01
IGL01918:Gm21738 APN 14 19416979 missense probably benign 0.01
IGL01919:Gm21738 APN 14 19416979 missense probably benign 0.01
IGL01922:Gm21738 APN 14 19416979 missense probably benign 0.01
IGL01923:Gm21738 APN 14 19416979 missense probably benign 0.01
IGL01924:Gm21738 APN 14 19416979 missense probably benign 0.01
IGL01925:Gm21738 APN 14 19416979 missense probably benign 0.01
IGL01926:Gm21738 APN 14 19416979 missense probably benign 0.01
IGL01932:Gm21738 APN 14 19416979 missense probably benign 0.01
IGL01940:Gm21738 APN 14 19416979 missense probably benign 0.01
IGL01949:Gm21738 APN 14 19416979 missense probably benign 0.01
PIT4131001:Gm21738 UTSW 14 19417330 missense probably benign 0.00
PIT4142001:Gm21738 UTSW 14 19417330 missense probably benign 0.00
R0831:Gm21738 UTSW 14 19415957 missense probably benign 0.01
R0831:Gm21738 UTSW 14 19415963 missense probably benign
R0976:Gm21738 UTSW 14 19415963 missense probably benign
R1029:Gm21738 UTSW 14 19415957 missense probably benign 0.01
R1146:Gm21738 UTSW 14 19415963 missense probably benign
R1231:Gm21738 UTSW 14 19415957 missense probably benign 0.01
R1231:Gm21738 UTSW 14 19415963 missense probably benign
R1402:Gm21738 UTSW 14 19415957 missense probably benign 0.01
R1402:Gm21738 UTSW 14 19415963 missense probably benign
R1638:Gm21738 UTSW 14 19418908 missense probably benign
R1874:Gm21738 UTSW 14 19418824 missense possibly damaging 0.64
R4392:Gm21738 UTSW 14 19417178 missense probably benign
R4393:Gm21738 UTSW 14 19417178 missense probably benign
R5049:Gm21738 UTSW 14 19415957 missense probably benign 0.01
R5257:Gm21738 UTSW 14 19415942 missense probably benign
R6756:Gm21738 UTSW 14 19418824 missense possibly damaging 0.64
R6915:Gm21738 UTSW 14 19415933 missense probably benign
V5622:Gm21738 UTSW 14 19417180 missense probably damaging 1.00
Posted On2015-04-16