Incidental Mutation 'IGL01895:Gm10718'
ID 279032
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Gm10718
Ensembl Gene ENSMUSG00000095186
Gene Name predicted gene 10718
Synonyms
Accession Numbers
Essential gene? Possibly essential (E-score: 0.537) question?
Stock # IGL01895
Quality Score
Status
Chromosome 9
Chromosomal Location 3023547-3025218 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 3025118 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Tyrosine to Phenylalanine at position 194 (Y194F)
Ref Sequence ENSEMBL: ENSMUSP00000096645 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000075573] [ENSMUST00000099046] [ENSMUST00000099047] [ENSMUST00000099051] [ENSMUST00000177601] [ENSMUST00000177875] [ENSMUST00000179272] [ENSMUST00000179982]
AlphaFold D3Z1I7
Predicted Effect probably benign
Transcript: ENSMUST00000075573
SMART Domains Protein: ENSMUSP00000096644
Gene: ENSMUSG00000095891

DomainStartEndE-ValueType
internal_repeat_1 1 41 1.06e-10 PROSPERO
transmembrane domain 68 90 N/A INTRINSIC
internal_repeat_1 118 177 1.06e-10 PROSPERO
transmembrane domain 200 222 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000099046
AA Change: Y194F

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
SMART Domains Protein: ENSMUSP00000096645
Gene: ENSMUSG00000095186
AA Change: Y194F

DomainStartEndE-ValueType
internal_repeat_1 1 41 4.44e-7 PROSPERO
transmembrane domain 67 89 N/A INTRINSIC
internal_repeat_1 117 177 4.44e-7 PROSPERO
transmembrane domain 197 219 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000099047
SMART Domains Protein: ENSMUSP00000096646
Gene: ENSMUSG00000095547

DomainStartEndE-ValueType
internal_repeat_1 1 40 1.58e-10 PROSPERO
transmembrane domain 53 72 N/A INTRINSIC
transmembrane domain 77 99 N/A INTRINSIC
internal_repeat_1 117 176 1.58e-10 PROSPERO
transmembrane domain 199 221 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000099051
SMART Domains Protein: ENSMUSP00000096650
Gene: ENSMUSG00000095891

DomainStartEndE-ValueType
internal_repeat_1 2 38 6.22e-5 PROSPERO
transmembrane domain 58 80 N/A INTRINSIC
transmembrane domain 90 109 N/A INTRINSIC
internal_repeat_1 118 174 6.22e-5 PROSPERO
transmembrane domain 185 207 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000177601
SMART Domains Protein: ENSMUSP00000136755
Gene: ENSMUSG00000095891

DomainStartEndE-ValueType
internal_repeat_2 1 24 2.26e-6 PROSPERO
internal_repeat_1 2 37 2.26e-6 PROSPERO
internal_repeat_1 40 95 2.26e-6 PROSPERO
internal_repeat_2 118 142 2.26e-6 PROSPERO
low complexity region 147 159 N/A INTRINSIC
low complexity region 169 183 N/A INTRINSIC
transmembrane domain 186 208 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000177875
SMART Domains Protein: ENSMUSP00000137419
Gene: ENSMUSG00000095891

DomainStartEndE-ValueType
internal_repeat_1 1 49 1.49e-11 PROSPERO
transmembrane domain 68 90 N/A INTRINSIC
internal_repeat_1 118 186 1.49e-11 PROSPERO
transmembrane domain 197 219 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000179272
SMART Domains Protein: ENSMUSP00000136170
Gene: ENSMUSG00000095547

DomainStartEndE-ValueType
internal_repeat_1 1 49 2.1e-10 PROSPERO
transmembrane domain 74 96 N/A INTRINSIC
internal_repeat_1 118 186 2.1e-10 PROSPERO
transmembrane domain 198 217 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000179982
SMART Domains Protein: ENSMUSP00000136365
Gene: ENSMUSG00000095891

DomainStartEndE-ValueType
internal_repeat_1 1 35 7.76e-13 PROSPERO
transmembrane domain 67 89 N/A INTRINSIC
internal_repeat_1 117 152 7.76e-13 PROSPERO
low complexity region 157 169 N/A INTRINSIC
transmembrane domain 198 220 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000181572
Predicted Effect noncoding transcript
Transcript: ENSMUST00000181957
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 38 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abcc6 A T 7: 45,678,482 (GRCm39) I56N possibly damaging Het
Akr1c13 A T 13: 4,255,372 (GRCm39) E321V possibly damaging Het
Atp8b3 A T 10: 80,357,662 (GRCm39) V1119D possibly damaging Het
Cacna1e G T 1: 154,319,646 (GRCm39) F1351L probably damaging Het
Cadps2 A G 6: 23,427,274 (GRCm39) W585R probably damaging Het
Ccdc113 C T 8: 96,263,086 (GRCm39) probably benign Het
Ccer1 A T 10: 97,529,912 (GRCm39) I192F unknown Het
Chd8 T C 14: 52,436,551 (GRCm39) N90S probably benign Het
Clca3a1 A T 3: 144,453,333 (GRCm39) C463* probably null Het
Cplane1 T A 15: 8,258,591 (GRCm39) V2279E possibly damaging Het
Cyp2c65 T A 19: 39,060,676 (GRCm39) C179S possibly damaging Het
Dennd4b A G 3: 90,182,874 (GRCm39) Q35R probably benign Het
Enpep T C 3: 129,063,983 (GRCm39) E928G possibly damaging Het
Fem1c T C 18: 46,638,629 (GRCm39) T458A probably benign Het
Fezf2 A T 14: 12,342,498 (GRCm38) *456R probably null Het
Gm21738 G A 14: 19,416,979 (GRCm38) S144L probably benign Het
Iqcm T G 8: 76,615,188 (GRCm39) L423R probably damaging Het
Kcnc4 C A 3: 107,355,534 (GRCm39) V305L probably benign Het
Kif1a G A 1: 92,953,455 (GRCm39) T1337I possibly damaging Het
Lpxn A G 19: 12,810,450 (GRCm39) D298G probably damaging Het
Lypd8 A G 11: 58,281,046 (GRCm39) T203A possibly damaging Het
Mrps28 C T 3: 8,965,119 (GRCm39) V107M probably damaging Het
Myo15b A G 11: 115,774,324 (GRCm39) E586G possibly damaging Het
Pdzk1 C T 3: 96,776,417 (GRCm39) A459V possibly damaging Het
Rbpj A G 5: 53,808,728 (GRCm39) D285G probably damaging Het
Rimbp3 T C 16: 17,029,300 (GRCm39) L908P probably damaging Het
Samd4b T C 7: 28,101,334 (GRCm39) probably null Het
Slc28a2b A C 2: 122,355,572 (GRCm39) Y588S possibly damaging Het
Stau2 C T 1: 16,416,161 (GRCm39) G401S probably damaging Het
Trpa1 A T 1: 14,957,867 (GRCm39) I697K possibly damaging Het
Ttc17 A C 2: 94,205,491 (GRCm39) V285G possibly damaging Het
Unc5b A G 10: 60,602,864 (GRCm39) F845S probably damaging Het
Vmn1r19 A T 6: 57,382,245 (GRCm39) Q266L probably benign Het
Vmn2r106 T C 17: 20,499,227 (GRCm39) N228S probably benign Het
Vps13d A G 4: 144,882,836 (GRCm39) F919S possibly damaging Het
Zbtb38 C T 9: 96,570,461 (GRCm39) V208I probably benign Het
Zfp990 A T 4: 145,263,427 (GRCm39) T142S probably damaging Het
Zfp990 C A 4: 145,263,428 (GRCm39) T142N probably damaging Het
Other mutations in Gm10718
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01863:Gm10718 APN 9 3,025,118 (GRCm39) missense probably benign 0.00
IGL01865:Gm10718 APN 9 3,025,118 (GRCm39) missense probably benign 0.00
IGL01867:Gm10718 APN 9 3,025,118 (GRCm39) missense probably benign 0.00
IGL01868:Gm10718 APN 9 3,025,118 (GRCm39) missense probably benign 0.00
IGL01869:Gm10718 APN 9 3,025,118 (GRCm39) missense probably benign 0.00
IGL01870:Gm10718 APN 9 3,025,118 (GRCm39) missense probably benign 0.00
IGL01871:Gm10718 APN 9 3,025,118 (GRCm39) missense probably benign 0.00
IGL01874:Gm10718 APN 9 3,025,118 (GRCm39) missense probably benign 0.00
IGL01877:Gm10718 APN 9 3,025,118 (GRCm39) missense probably benign 0.00
IGL01878:Gm10718 APN 9 3,025,118 (GRCm39) missense probably benign 0.00
IGL01879:Gm10718 APN 9 3,025,118 (GRCm39) missense probably benign 0.00
IGL01880:Gm10718 APN 9 3,025,118 (GRCm39) missense probably benign 0.00
IGL01881:Gm10718 APN 9 3,025,118 (GRCm39) missense probably benign 0.00
IGL01883:Gm10718 APN 9 3,025,118 (GRCm39) missense probably benign 0.00
IGL01884:Gm10718 APN 9 3,025,118 (GRCm39) missense probably benign 0.00
IGL01885:Gm10718 APN 9 3,025,118 (GRCm39) missense probably benign 0.00
IGL01886:Gm10718 APN 9 3,025,118 (GRCm39) missense probably benign 0.00
IGL01887:Gm10718 APN 9 3,025,118 (GRCm39) missense probably benign 0.00
IGL01888:Gm10718 APN 9 3,025,118 (GRCm39) missense probably benign 0.00
IGL01890:Gm10718 APN 9 3,025,118 (GRCm39) missense probably benign 0.00
IGL01891:Gm10718 APN 9 3,025,118 (GRCm39) missense probably benign 0.00
IGL01894:Gm10718 APN 9 3,025,118 (GRCm39) missense probably benign 0.00
IGL01896:Gm10718 APN 9 3,025,118 (GRCm39) missense probably benign 0.00
IGL01897:Gm10718 APN 9 3,025,118 (GRCm39) missense probably benign 0.00
IGL01898:Gm10718 APN 9 3,025,118 (GRCm39) missense probably benign 0.00
IGL01901:Gm10718 APN 9 3,025,118 (GRCm39) missense probably benign 0.00
IGL01903:Gm10718 APN 9 3,025,118 (GRCm39) missense probably benign 0.00
IGL01904:Gm10718 APN 9 3,025,118 (GRCm39) missense probably benign 0.00
IGL01905:Gm10718 APN 9 3,025,118 (GRCm39) missense probably benign 0.00
IGL01908:Gm10718 APN 9 3,025,118 (GRCm39) missense probably benign 0.00
IGL01909:Gm10718 APN 9 3,025,118 (GRCm39) missense probably benign 0.00
IGL01910:Gm10718 APN 9 3,025,118 (GRCm39) missense probably benign 0.00
IGL01912:Gm10718 APN 9 3,025,118 (GRCm39) missense probably benign 0.00
IGL01917:Gm10718 APN 9 3,025,118 (GRCm39) missense probably benign 0.00
IGL01918:Gm10718 APN 9 3,025,118 (GRCm39) missense probably benign 0.00
IGL01919:Gm10718 APN 9 3,025,118 (GRCm39) missense probably benign 0.00
IGL01920:Gm10718 APN 9 3,025,118 (GRCm39) missense probably benign 0.00
IGL01924:Gm10718 APN 9 3,025,118 (GRCm39) missense probably benign 0.00
IGL01925:Gm10718 APN 9 3,025,118 (GRCm39) missense probably benign 0.00
IGL01926:Gm10718 APN 9 3,025,118 (GRCm39) missense probably benign 0.00
IGL01928:Gm10718 APN 9 3,025,118 (GRCm39) missense probably benign 0.00
IGL01929:Gm10718 APN 9 3,025,118 (GRCm39) missense probably benign 0.00
IGL01932:Gm10718 APN 9 3,025,118 (GRCm39) missense probably benign 0.00
IGL01933:Gm10718 APN 9 3,025,118 (GRCm39) missense probably benign 0.00
IGL01934:Gm10718 APN 9 3,025,118 (GRCm39) missense probably benign 0.00
IGL01937:Gm10718 APN 9 3,025,118 (GRCm39) missense probably benign 0.00
IGL01938:Gm10718 APN 9 3,025,118 (GRCm39) missense probably benign 0.00
IGL01941:Gm10718 APN 9 3,025,118 (GRCm39) missense probably benign 0.00
IGL01944:Gm10718 APN 9 3,025,118 (GRCm39) missense probably benign 0.00
IGL01945:Gm10718 APN 9 3,025,118 (GRCm39) missense probably benign 0.00
IGL01946:Gm10718 APN 9 3,025,118 (GRCm39) missense probably benign 0.00
IGL01947:Gm10718 APN 9 3,025,118 (GRCm39) missense probably benign 0.00
IGL01949:Gm10718 APN 9 3,025,118 (GRCm39) missense probably benign 0.00
IGL01950:Gm10718 APN 9 3,025,118 (GRCm39) missense probably benign 0.00
IGL01951:Gm10718 APN 9 3,025,118 (GRCm39) missense probably benign 0.00
IGL01952:Gm10718 APN 9 3,025,118 (GRCm39) missense probably benign 0.00
IGL01953:Gm10718 APN 9 3,025,118 (GRCm39) missense probably benign 0.00
IGL01958:Gm10718 APN 9 3,025,118 (GRCm39) missense probably benign 0.00
PIT4131001:Gm10718 UTSW 9 3,024,417 (GRCm39) missense probably benign 0.01
PIT4142001:Gm10718 UTSW 9 3,024,417 (GRCm39) missense probably benign 0.01
R4567:Gm10718 UTSW 9 3,023,716 (GRCm39) missense probably benign 0.01
R4850:Gm10718 UTSW 9 3,023,716 (GRCm39) missense probably benign 0.01
RF039:Gm10718 UTSW 9 3,024,385 (GRCm39) frame shift probably null
Posted On 2015-04-16