Incidental Mutation 'IGL01909:Gm21738'
ID279079
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Gm21738
Ensembl Gene ENSMUSG00000095280
Gene Namepredicted gene, 21738
Synonyms
Accession Numbers
Is this an essential gene? Probably essential (E-score: 0.822) question?
Stock #IGL01909
Quality Score
Status
Chromosome14
Chromosomal Location19415857-19418930 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) G to A at 19416979 bp
ZygosityHeterozygous
Amino Acid Change Serine to Leucine at position 144 (S144L)
Ref Sequence ENSEMBL: ENSMUSP00000137127 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000177817]
Predicted Effect probably benign
Transcript: ENSMUST00000177817
AA Change: S144L

PolyPhen 2 Score 0.011 (Sensitivity: 0.96; Specificity: 0.78)
SMART Domains Protein: ENSMUSP00000137127
Gene: ENSMUSG00000095280
AA Change: S144L

DomainStartEndE-ValueType
internal_repeat_1 1 19 1.11e-9 PROSPERO
transmembrane domain 20 42 N/A INTRINSIC
transmembrane domain 77 99 N/A INTRINSIC
internal_repeat_1 117 135 1.11e-9 PROSPERO
transmembrane domain 152 174 N/A INTRINSIC
low complexity region 179 195 N/A INTRINSIC
transmembrane domain 198 220 N/A INTRINSIC
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 35 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1700111E14Rik A T 6: 36,937,217 probably benign Het
Actn2 A T 13: 12,309,593 probably null Het
Apom C T 17: 35,131,232 A78T probably benign Het
Bambi A G 18: 3,508,229 Y7C possibly damaging Het
C130026I21Rik A G 1: 85,254,186 probably benign Het
Cdc42bpb T C 12: 111,323,142 M418V probably benign Het
Clptm1 T C 7: 19,655,776 N43D probably benign Het
Cspp1 T C 1: 10,066,661 V241A probably benign Het
Ctnna3 T A 10: 63,504,131 I32N probably benign Het
Elp2 A G 18: 24,619,519 probably benign Het
Frmd4a A G 2: 4,604,033 D893G probably benign Het
Gm10718 A T 9: 3,025,118 Y194F probably benign Het
Gm5862 A C 5: 26,022,771 W41G probably benign Het
H2-M10.1 C A 17: 36,325,079 G154* probably null Het
Igdcc3 C T 9: 65,144,537 R141W probably damaging Het
Igkv14-130 A G 6: 67,791,339 K60E possibly damaging Het
Kcnmb2 A G 3: 32,198,363 probably benign Het
Lrp4 T C 2: 91,494,184 L1288P possibly damaging Het
Mavs T A 2: 131,245,521 M313K probably benign Het
Mia2 A G 12: 59,107,945 E148G possibly damaging Het
Olfr26 T A 9: 38,855,717 Y218* probably null Het
Olfr813 A T 10: 129,857,081 T188S probably damaging Het
Olfr875 T A 9: 37,772,863 I68K possibly damaging Het
Plekha3 C T 2: 76,686,703 T133M probably damaging Het
Plxna1 A T 6: 89,332,084 probably null Het
Sept2 A G 1: 93,499,101 N144S probably damaging Het
Slc9a4 T C 1: 40,612,291 probably benign Het
Slco1b2 T A 6: 141,648,586 I59K probably damaging Het
Tnrc6b A G 15: 80,901,983 S1243G possibly damaging Het
Unc13a T A 8: 71,639,210 probably benign Het
Vmn2r105 T C 17: 20,224,656 R525G probably damaging Het
Vmn2r37 T A 7: 9,216,033 K451* probably null Het
Vmn2r71 C T 7: 85,620,793 T504I probably benign Het
Vmn2r-ps159 C T 4: 156,338,254 noncoding transcript Het
Zfp668 A T 7: 127,866,822 C397S probably damaging Het
Other mutations in Gm21738
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00990:Gm21738 APN 14 19418885 missense probably benign
IGL01010:Gm21738 APN 14 19417361 missense probably benign 0.03
IGL01018:Gm21738 APN 14 19418856 missense probably benign 0.39
IGL01865:Gm21738 APN 14 19416979 missense probably benign 0.01
IGL01869:Gm21738 APN 14 19416979 missense probably benign 0.01
IGL01873:Gm21738 APN 14 19416979 missense probably benign 0.01
IGL01877:Gm21738 APN 14 19416979 missense probably benign 0.01
IGL01878:Gm21738 APN 14 19416979 missense probably benign 0.01
IGL01879:Gm21738 APN 14 19416979 missense probably benign 0.01
IGL01880:Gm21738 APN 14 19416979 missense probably benign 0.01
IGL01882:Gm21738 APN 14 19416979 missense probably benign 0.01
IGL01883:Gm21738 APN 14 19416979 missense probably benign 0.01
IGL01884:Gm21738 APN 14 19416979 missense probably benign 0.01
IGL01885:Gm21738 APN 14 19416979 missense probably benign 0.01
IGL01886:Gm21738 APN 14 19416979 missense probably benign 0.01
IGL01888:Gm21738 APN 14 19416979 missense probably benign 0.01
IGL01891:Gm21738 APN 14 19416979 missense probably benign 0.01
IGL01892:Gm21738 APN 14 19416979 missense probably benign 0.01
IGL01893:Gm21738 APN 14 19416979 missense probably benign 0.01
IGL01894:Gm21738 APN 14 19416979 missense probably benign 0.01
IGL01895:Gm21738 APN 14 19416979 missense probably benign 0.01
IGL01896:Gm21738 APN 14 19416979 missense probably benign 0.01
IGL01898:Gm21738 APN 14 19416979 missense probably benign 0.01
IGL01899:Gm21738 APN 14 19416979 missense probably benign 0.01
IGL01900:Gm21738 APN 14 19416979 missense probably benign 0.01
IGL01901:Gm21738 APN 14 19416979 missense probably benign 0.01
IGL01902:Gm21738 APN 14 19416979 missense probably benign 0.01
IGL01903:Gm21738 APN 14 19416979 missense probably benign 0.01
IGL01904:Gm21738 APN 14 19416979 missense probably benign 0.01
IGL01905:Gm21738 APN 14 19416979 missense probably benign 0.01
IGL01906:Gm21738 APN 14 19416979 missense probably benign 0.01
IGL01908:Gm21738 APN 14 19416979 missense probably benign 0.01
IGL01910:Gm21738 APN 14 19416979 missense probably benign 0.01
IGL01911:Gm21738 APN 14 19416979 missense probably benign 0.01
IGL01912:Gm21738 APN 14 19416979 missense probably benign 0.01
IGL01913:Gm21738 APN 14 19416979 missense probably benign 0.01
IGL01914:Gm21738 APN 14 19416979 missense probably benign 0.01
IGL01915:Gm21738 APN 14 19416979 missense probably benign 0.01
IGL01916:Gm21738 APN 14 19416979 missense probably benign 0.01
IGL01917:Gm21738 APN 14 19416979 missense probably benign 0.01
IGL01918:Gm21738 APN 14 19416979 missense probably benign 0.01
IGL01919:Gm21738 APN 14 19416979 missense probably benign 0.01
IGL01922:Gm21738 APN 14 19416979 missense probably benign 0.01
IGL01923:Gm21738 APN 14 19416979 missense probably benign 0.01
IGL01924:Gm21738 APN 14 19416979 missense probably benign 0.01
IGL01925:Gm21738 APN 14 19416979 missense probably benign 0.01
IGL01926:Gm21738 APN 14 19416979 missense probably benign 0.01
IGL01932:Gm21738 APN 14 19416979 missense probably benign 0.01
IGL01940:Gm21738 APN 14 19416979 missense probably benign 0.01
IGL01949:Gm21738 APN 14 19416979 missense probably benign 0.01
PIT4131001:Gm21738 UTSW 14 19417330 missense probably benign 0.00
PIT4142001:Gm21738 UTSW 14 19417330 missense probably benign 0.00
R0831:Gm21738 UTSW 14 19415957 missense probably benign 0.01
R0831:Gm21738 UTSW 14 19415963 missense probably benign
R0976:Gm21738 UTSW 14 19415963 missense probably benign
R1029:Gm21738 UTSW 14 19415957 missense probably benign 0.01
R1146:Gm21738 UTSW 14 19415963 missense probably benign
R1231:Gm21738 UTSW 14 19415957 missense probably benign 0.01
R1231:Gm21738 UTSW 14 19415963 missense probably benign
R1402:Gm21738 UTSW 14 19415957 missense probably benign 0.01
R1402:Gm21738 UTSW 14 19415963 missense probably benign
R1638:Gm21738 UTSW 14 19418908 missense probably benign
R1874:Gm21738 UTSW 14 19418824 missense possibly damaging 0.64
R4392:Gm21738 UTSW 14 19417178 missense probably benign
R4393:Gm21738 UTSW 14 19417178 missense probably benign
R5049:Gm21738 UTSW 14 19415957 missense probably benign 0.01
R5257:Gm21738 UTSW 14 19415942 missense probably benign
R6756:Gm21738 UTSW 14 19418824 missense possibly damaging 0.64
R6915:Gm21738 UTSW 14 19415933 missense probably benign
V5622:Gm21738 UTSW 14 19417180 missense probably damaging 1.00
Posted On2015-04-16