Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL01915:Gm21738'

279100

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Gm21738

Ensembl Gene

ENSMUSG00000095280

Gene Name

predicted gene, 21738

Synonyms

Accession Numbers

Essential gene?

Probably essential (E-score: 0.883) question?

Stock #

IGL01915

Quality Score

Status

Chromosome

Chromosomal Location

(GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

G to A at 19416979 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Serine to Leucine at position 144 (S144L)

Ref Sequence

ENSEMBL: ENSMUSP00000137127 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000177817]

AlphaFold

no structure available at present

Predicted Effect

probably benign
Transcript: ENSMUST00000177817
AA Change: S144L

PolyPhen 2 Score 0.011 (Sensitivity: 0.96; Specificity: 0.78)

SMART Domains

Protein: ENSMUSP00000137127
Gene: ENSMUSG00000095280
AA Change: S144L

Domain	Start	End	E-Value	Type
internal_repeat_1	1	19	1.11e-9	PROSPERO
transmembrane domain	20	42	N/A	INTRINSIC
transmembrane domain	77	99	N/A	INTRINSIC
internal_repeat_1	117	135	1.11e-9	PROSPERO
transmembrane domain	152	174	N/A	INTRINSIC
low complexity region	179	195	N/A	INTRINSIC
transmembrane domain	198	220	N/A	INTRINSIC

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 32 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Abt1	T	C	13: 23,607,938 (GRCm39)	E22G	unknown	Het
Aoc1l2	T	A	6: 48,908,582 (GRCm39)	D527E	probably damaging	Het
Atp11b	T	G	3: 35,885,612 (GRCm39)	H668Q	probably damaging	Het
Birc6	T	A	17: 74,938,715 (GRCm39)	V2687D	probably benign	Het
Cadm3	T	C	1: 173,168,675 (GRCm39)	T298A	possibly damaging	Het
Car12	G	A	9: 66,670,552 (GRCm39)	A174T	possibly damaging	Het
Ccdc180	T	C	4: 45,904,544 (GRCm39)	L380P	probably damaging	Het
Col7a1	A	T	9: 108,784,813 (GRCm39)	R214W	unknown	Het
Cyp2d26	T	G	15: 82,674,450 (GRCm39)	R477S	probably benign	Het
Dgkd	T	C	1: 87,853,780 (GRCm39)	V541A	possibly damaging	Het
Dip2b	T	A	15: 100,076,392 (GRCm39)	F797I	probably damaging	Het
Dot1l	A	T	10: 80,616,728 (GRCm39)	N63I	probably damaging	Het
Ints5	T	C	19: 8,874,357 (GRCm39)	I772T	probably benign	Het
Nosip	T	A	7: 44,726,283 (GRCm39)	I230N	probably damaging	Het
Or2r3	A	T	6: 42,448,223 (GRCm39)	D296E	probably benign	Het
Or4d11	A	T	19: 12,013,461 (GRCm39)	L215Q	probably damaging	Het
Or5ac22	T	A	16: 59,135,473 (GRCm39)	Q99L	probably damaging	Het
Or6c210	G	A	10: 129,496,519 (GRCm39)	M281I	probably benign	Het
Orc5	A	T	5: 22,727,381 (GRCm39)		probably benign	Het
Parp1	A	G	1: 180,425,907 (GRCm39)	I879M	probably damaging	Het
Pcdh18	A	G	3: 49,699,370 (GRCm39)	S1031P	probably benign	Het
Pdzd2	A	G	15: 12,371,725 (GRCm39)	S2557P	probably damaging	Het
Rccd1	T	C	7: 79,969,966 (GRCm39)		probably benign	Het
Rsad1	A	G	11: 94,439,803 (GRCm39)		probably null	Het
Samd9l	A	T	6: 3,373,864 (GRCm39)	C1132*	probably null	Het
Sema6d	A	G	2: 124,500,491 (GRCm39)		probably benign	Het
Slc10a5	T	C	3: 10,400,580 (GRCm39)	N27D	probably damaging	Het
Slco1a5	C	T	6: 142,189,599 (GRCm39)	M462I	probably benign	Het
Tyw5	T	C	1: 57,440,628 (GRCm39)	T45A	probably damaging	Het
Usp21	T	A	1: 171,110,307 (GRCm39)	Q489L	possibly damaging	Het
Vmn2r129	C	T	4: 156,690,549 (GRCm39)		noncoding transcript	Het
Vmn2r20	A	G	6: 123,370,924 (GRCm39)	S519P	possibly damaging	Het

Other mutations in Gm21738

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00990:Gm21738	APN	14	19,418,885 (GRCm38)	missense	probably benign
IGL01010:Gm21738	APN	14	19,417,361 (GRCm38)	missense	probably benign	0.03
IGL01018:Gm21738	APN	14	19,418,856 (GRCm38)	missense	probably benign	0.39
IGL01865:Gm21738	APN	14	19,416,979 (GRCm38)	missense	probably benign	0.01
IGL01869:Gm21738	APN	14	19,416,979 (GRCm38)	missense	probably benign	0.01
IGL01873:Gm21738	APN	14	19,416,979 (GRCm38)	missense	probably benign	0.01
IGL01877:Gm21738	APN	14	19,416,979 (GRCm38)	missense	probably benign	0.01
IGL01878:Gm21738	APN	14	19,416,979 (GRCm38)	missense	probably benign	0.01
IGL01879:Gm21738	APN	14	19,416,979 (GRCm38)	missense	probably benign	0.01
IGL01880:Gm21738	APN	14	19,416,979 (GRCm38)	missense	probably benign	0.01
IGL01882:Gm21738	APN	14	19,416,979 (GRCm38)	missense	probably benign	0.01
IGL01883:Gm21738	APN	14	19,416,979 (GRCm38)	missense	probably benign	0.01
IGL01884:Gm21738	APN	14	19,416,979 (GRCm38)	missense	probably benign	0.01
IGL01885:Gm21738	APN	14	19,416,979 (GRCm38)	missense	probably benign	0.01
IGL01886:Gm21738	APN	14	19,416,979 (GRCm38)	missense	probably benign	0.01
IGL01888:Gm21738	APN	14	19,416,979 (GRCm38)	missense	probably benign	0.01
IGL01891:Gm21738	APN	14	19,416,979 (GRCm38)	missense	probably benign	0.01
IGL01892:Gm21738	APN	14	19,416,979 (GRCm38)	missense	probably benign	0.01
IGL01893:Gm21738	APN	14	19,416,979 (GRCm38)	missense	probably benign	0.01
IGL01894:Gm21738	APN	14	19,416,979 (GRCm38)	missense	probably benign	0.01
IGL01895:Gm21738	APN	14	19,416,979 (GRCm38)	missense	probably benign	0.01
IGL01896:Gm21738	APN	14	19,416,979 (GRCm38)	missense	probably benign	0.01
IGL01898:Gm21738	APN	14	19,416,979 (GRCm38)	missense	probably benign	0.01
IGL01899:Gm21738	APN	14	19,416,979 (GRCm38)	missense	probably benign	0.01
IGL01900:Gm21738	APN	14	19,416,979 (GRCm38)	missense	probably benign	0.01
IGL01901:Gm21738	APN	14	19,416,979 (GRCm38)	missense	probably benign	0.01
IGL01902:Gm21738	APN	14	19,416,979 (GRCm38)	missense	probably benign	0.01
IGL01903:Gm21738	APN	14	19,416,979 (GRCm38)	missense	probably benign	0.01
IGL01904:Gm21738	APN	14	19,416,979 (GRCm38)	missense	probably benign	0.01
IGL01905:Gm21738	APN	14	19,416,979 (GRCm38)	missense	probably benign	0.01
IGL01906:Gm21738	APN	14	19,416,979 (GRCm38)	missense	probably benign	0.01
IGL01908:Gm21738	APN	14	19,416,979 (GRCm38)	missense	probably benign	0.01
IGL01909:Gm21738	APN	14	19,416,979 (GRCm38)	missense	probably benign	0.01
IGL01910:Gm21738	APN	14	19,416,979 (GRCm38)	missense	probably benign	0.01
IGL01911:Gm21738	APN	14	19,416,979 (GRCm38)	missense	probably benign	0.01
IGL01912:Gm21738	APN	14	19,416,979 (GRCm38)	missense	probably benign	0.01
IGL01913:Gm21738	APN	14	19,416,979 (GRCm38)	missense	probably benign	0.01
IGL01914:Gm21738	APN	14	19,416,979 (GRCm38)	missense	probably benign	0.01
IGL01916:Gm21738	APN	14	19,416,979 (GRCm38)	missense	probably benign	0.01
IGL01917:Gm21738	APN	14	19,416,979 (GRCm38)	missense	probably benign	0.01
IGL01918:Gm21738	APN	14	19,416,979 (GRCm38)	missense	probably benign	0.01
IGL01919:Gm21738	APN	14	19,416,979 (GRCm38)	missense	probably benign	0.01
IGL01922:Gm21738	APN	14	19,416,979 (GRCm38)	missense	probably benign	0.01
IGL01923:Gm21738	APN	14	19,416,979 (GRCm38)	missense	probably benign	0.01
IGL01924:Gm21738	APN	14	19,416,979 (GRCm38)	missense	probably benign	0.01
IGL01925:Gm21738	APN	14	19,416,979 (GRCm38)	missense	probably benign	0.01
IGL01926:Gm21738	APN	14	19,416,979 (GRCm38)	missense	probably benign	0.01
IGL01932:Gm21738	APN	14	19,416,979 (GRCm38)	missense	probably benign	0.01
IGL01940:Gm21738	APN	14	19,416,979 (GRCm38)	missense	probably benign	0.01
IGL01949:Gm21738	APN	14	19,416,979 (GRCm38)	missense	probably benign	0.01
PIT4131001:Gm21738	UTSW	14	19,417,330 (GRCm38)	missense	probably benign	0.00
PIT4142001:Gm21738	UTSW	14	19,417,330 (GRCm38)	missense	probably benign	0.00
R0831:Gm21738	UTSW	14	19,415,963 (GRCm38)	missense	probably benign
R0831:Gm21738	UTSW	14	19,415,957 (GRCm38)	missense	probably benign	0.01
R0976:Gm21738	UTSW	14	19,415,963 (GRCm38)	missense	probably benign
R1029:Gm21738	UTSW	14	19,415,957 (GRCm38)	missense	probably benign	0.01
R1146:Gm21738	UTSW	14	19,415,963 (GRCm38)	missense	probably benign
R1231:Gm21738	UTSW	14	19,415,963 (GRCm38)	missense	probably benign
R1231:Gm21738	UTSW	14	19,415,957 (GRCm38)	missense	probably benign	0.01
R1402:Gm21738	UTSW	14	19,415,963 (GRCm38)	missense	probably benign
R1402:Gm21738	UTSW	14	19,415,957 (GRCm38)	missense	probably benign	0.01
R1638:Gm21738	UTSW	14	19,418,908 (GRCm38)	missense	probably benign
R1874:Gm21738	UTSW	14	19,418,824 (GRCm38)	missense	possibly damaging	0.64
R4392:Gm21738	UTSW	14	19,417,178 (GRCm38)	missense	probably benign
R4393:Gm21738	UTSW	14	19,417,178 (GRCm38)	missense	probably benign
R5049:Gm21738	UTSW	14	19,415,957 (GRCm38)	missense	probably benign	0.01
R5257:Gm21738	UTSW	14	19,415,942 (GRCm38)	missense	probably benign
R6756:Gm21738	UTSW	14	19,418,824 (GRCm38)	missense	possibly damaging	0.64
R6915:Gm21738	UTSW	14	19,415,933 (GRCm38)	missense	probably benign
V5622:Gm21738	UTSW	14	19,417,180 (GRCm38)	missense	probably damaging	1.00

Posted On

2015-04-16