Incidental Mutation 'IGL01933:Gm10718'
ID 279154
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Gm10718
Ensembl Gene ENSMUSG00000095186
Gene Name predicted gene 10718
Synonyms
Accession Numbers
Essential gene? Possibly essential (E-score: 0.509) question?
Stock # IGL01933
Quality Score
Status
Chromosome 9
Chromosomal Location 3023547-3025218 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 3025118 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Tyrosine to Phenylalanine at position 194 (Y194F)
Ref Sequence ENSEMBL: ENSMUSP00000096645 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000075573] [ENSMUST00000099046] [ENSMUST00000099047] [ENSMUST00000099051] [ENSMUST00000177601] [ENSMUST00000177875] [ENSMUST00000179272] [ENSMUST00000179982]
AlphaFold D3Z1I7
Predicted Effect probably benign
Transcript: ENSMUST00000075573
SMART Domains Protein: ENSMUSP00000096644
Gene: ENSMUSG00000095891

DomainStartEndE-ValueType
internal_repeat_1 1 41 1.06e-10 PROSPERO
transmembrane domain 68 90 N/A INTRINSIC
internal_repeat_1 118 177 1.06e-10 PROSPERO
transmembrane domain 200 222 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000099046
AA Change: Y194F

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
SMART Domains Protein: ENSMUSP00000096645
Gene: ENSMUSG00000095186
AA Change: Y194F

DomainStartEndE-ValueType
internal_repeat_1 1 41 4.44e-7 PROSPERO
transmembrane domain 67 89 N/A INTRINSIC
internal_repeat_1 117 177 4.44e-7 PROSPERO
transmembrane domain 197 219 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000099047
SMART Domains Protein: ENSMUSP00000096646
Gene: ENSMUSG00000095547

DomainStartEndE-ValueType
internal_repeat_1 1 40 1.58e-10 PROSPERO
transmembrane domain 53 72 N/A INTRINSIC
transmembrane domain 77 99 N/A INTRINSIC
internal_repeat_1 117 176 1.58e-10 PROSPERO
transmembrane domain 199 221 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000099051
SMART Domains Protein: ENSMUSP00000096650
Gene: ENSMUSG00000095891

DomainStartEndE-ValueType
internal_repeat_1 2 38 6.22e-5 PROSPERO
transmembrane domain 58 80 N/A INTRINSIC
transmembrane domain 90 109 N/A INTRINSIC
internal_repeat_1 118 174 6.22e-5 PROSPERO
transmembrane domain 185 207 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000177601
SMART Domains Protein: ENSMUSP00000136755
Gene: ENSMUSG00000095891

DomainStartEndE-ValueType
internal_repeat_2 1 24 2.26e-6 PROSPERO
internal_repeat_1 2 37 2.26e-6 PROSPERO
internal_repeat_1 40 95 2.26e-6 PROSPERO
internal_repeat_2 118 142 2.26e-6 PROSPERO
low complexity region 147 159 N/A INTRINSIC
low complexity region 169 183 N/A INTRINSIC
transmembrane domain 186 208 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000177875
SMART Domains Protein: ENSMUSP00000137419
Gene: ENSMUSG00000095891

DomainStartEndE-ValueType
internal_repeat_1 1 49 1.49e-11 PROSPERO
transmembrane domain 68 90 N/A INTRINSIC
internal_repeat_1 118 186 1.49e-11 PROSPERO
transmembrane domain 197 219 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000181957
Predicted Effect noncoding transcript
Transcript: ENSMUST00000181572
Predicted Effect probably benign
Transcript: ENSMUST00000179272
SMART Domains Protein: ENSMUSP00000136170
Gene: ENSMUSG00000095547

DomainStartEndE-ValueType
internal_repeat_1 1 49 2.1e-10 PROSPERO
transmembrane domain 74 96 N/A INTRINSIC
internal_repeat_1 118 186 2.1e-10 PROSPERO
transmembrane domain 198 217 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000179982
SMART Domains Protein: ENSMUSP00000136365
Gene: ENSMUSG00000095891

DomainStartEndE-ValueType
internal_repeat_1 1 35 7.76e-13 PROSPERO
transmembrane domain 67 89 N/A INTRINSIC
internal_repeat_1 117 152 7.76e-13 PROSPERO
low complexity region 157 169 N/A INTRINSIC
transmembrane domain 198 220 N/A INTRINSIC
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 61 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1700017B05Rik C A 9: 57,164,650 (GRCm39) V575F possibly damaging Het
Abca2 T A 2: 25,334,123 (GRCm39) V1800E probably damaging Het
Acacb C T 5: 114,322,251 (GRCm39) probably benign Het
Adam34 C A 8: 44,104,569 (GRCm39) G359W probably damaging Het
Ankrd42 G A 7: 92,254,493 (GRCm39) T372I probably benign Het
Apc2 A G 10: 80,147,574 (GRCm39) D847G probably damaging Het
Arap3 T A 18: 38,111,506 (GRCm39) T1137S possibly damaging Het
Atp10b A C 11: 43,085,457 (GRCm39) T279P probably damaging Het
Bmp2 T A 2: 133,396,578 (GRCm39) M78K possibly damaging Het
Ccdc61 T G 7: 18,626,483 (GRCm39) M369L probably benign Het
Cep78 A T 19: 15,933,304 (GRCm39) I758N probably benign Het
Ces2a A G 8: 105,468,047 (GRCm39) *526W probably null Het
Cgnl1 C T 9: 71,552,765 (GRCm39) probably benign Het
Clec14a A G 12: 58,315,104 (GRCm39) Y173H probably damaging Het
Cntn4 G A 6: 106,671,345 (GRCm39) S976N probably damaging Het
Col6a4 G A 9: 105,937,313 (GRCm39) T1401I probably benign Het
D5Ertd579e T C 5: 36,773,100 (GRCm39) T432A probably benign Het
Dixdc1 G A 9: 50,614,558 (GRCm39) R163* probably null Het
Dmxl1 C A 18: 50,010,852 (GRCm39) T1003K probably benign Het
Dnah1 G A 14: 31,032,872 (GRCm39) R388W probably benign Het
Eci3 C T 13: 35,132,772 (GRCm39) A202T probably damaging Het
Egr2 T C 10: 67,376,024 (GRCm39) S220P probably damaging Het
Fntb C T 12: 76,966,880 (GRCm39) P405S probably benign Het
Gm26602 C A 10: 79,746,955 (GRCm39) R236L probably benign Het
Hao2 T C 3: 98,787,648 (GRCm39) probably benign Het
Irgm2 A T 11: 58,110,783 (GRCm39) N170I possibly damaging Het
Klhl20 G A 1: 160,934,357 (GRCm39) R221W probably damaging Het
Kmt2b A G 7: 30,268,939 (GRCm39) probably null Het
Lrrc46 C T 11: 96,926,354 (GRCm39) E181K probably benign Het
Lztr1 T A 16: 17,338,455 (GRCm39) V226E probably damaging Het
Myh9 G T 15: 77,665,418 (GRCm39) D684E probably benign Het
Myo7a T C 7: 97,732,349 (GRCm39) T713A probably damaging Het
Nrap G T 19: 56,377,250 (GRCm39) N62K probably damaging Het
Or51a10 T C 7: 103,699,021 (GRCm39) Y180C probably damaging Het
Or5an1 A T 19: 12,261,069 (GRCm39) Y219F probably damaging Het
Osbp2 T C 11: 3,662,016 (GRCm39) D708G probably damaging Het
Pcnx2 G A 8: 126,488,393 (GRCm39) P1717L probably damaging Het
Pex1 A G 5: 3,683,789 (GRCm39) D1095G probably damaging Het
Ptpn3 T C 4: 57,197,576 (GRCm39) H771R probably benign Het
R3hcc1l G A 19: 42,551,389 (GRCm39) A129T probably damaging Het
Rbm15 G A 3: 107,238,419 (GRCm39) R660W probably damaging Het
Recql C T 6: 142,310,364 (GRCm39) V489M probably benign Het
Sash1 A T 10: 8,626,897 (GRCm39) S162R probably damaging Het
Sec11a T C 7: 80,584,810 (GRCm39) I42M probably benign Het
Slc25a23 G A 17: 57,359,813 (GRCm39) Q61* probably null Het
Son A T 16: 91,454,903 (GRCm39) M1217L probably benign Het
Sp140l2 A G 1: 85,231,907 (GRCm39) probably benign Het
Srgap2 T C 1: 131,339,593 (GRCm39) N123S probably damaging Het
Ssh1 T C 5: 114,088,441 (GRCm39) probably benign Het
St13 T C 15: 81,273,899 (GRCm39) probably null Het
St3gal3 A T 4: 117,889,072 (GRCm39) D57E probably damaging Het
Stk4 C T 2: 163,940,505 (GRCm39) probably benign Het
Tln1 T A 4: 43,539,508 (GRCm39) T1605S probably benign Het
Tln1 T C 4: 43,555,894 (GRCm39) T107A possibly damaging Het
Tmem135 G T 7: 88,793,065 (GRCm39) probably benign Het
Tmtc3 A G 10: 100,283,467 (GRCm39) M696T probably benign Het
Trbv28 T A 6: 41,248,761 (GRCm39) L97Q probably damaging Het
Trpc4ap A T 2: 155,481,455 (GRCm39) F534I possibly damaging Het
Trpm8 T C 1: 88,254,127 (GRCm39) Y117H probably damaging Het
Zfp608 T C 18: 55,120,871 (GRCm39) T239A probably benign Het
Zmym5 T G 14: 57,041,617 (GRCm39) H162P probably damaging Het
Other mutations in Gm10718
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01863:Gm10718 APN 9 3,025,118 (GRCm39) missense probably benign 0.00
IGL01865:Gm10718 APN 9 3,025,118 (GRCm39) missense probably benign 0.00
IGL01867:Gm10718 APN 9 3,025,118 (GRCm39) missense probably benign 0.00
IGL01868:Gm10718 APN 9 3,025,118 (GRCm39) missense probably benign 0.00
IGL01869:Gm10718 APN 9 3,025,118 (GRCm39) missense probably benign 0.00
IGL01870:Gm10718 APN 9 3,025,118 (GRCm39) missense probably benign 0.00
IGL01871:Gm10718 APN 9 3,025,118 (GRCm39) missense probably benign 0.00
IGL01874:Gm10718 APN 9 3,025,118 (GRCm39) missense probably benign 0.00
IGL01877:Gm10718 APN 9 3,025,118 (GRCm39) missense probably benign 0.00
IGL01878:Gm10718 APN 9 3,025,118 (GRCm39) missense probably benign 0.00
IGL01879:Gm10718 APN 9 3,025,118 (GRCm39) missense probably benign 0.00
IGL01880:Gm10718 APN 9 3,025,118 (GRCm39) missense probably benign 0.00
IGL01881:Gm10718 APN 9 3,025,118 (GRCm39) missense probably benign 0.00
IGL01883:Gm10718 APN 9 3,025,118 (GRCm39) missense probably benign 0.00
IGL01884:Gm10718 APN 9 3,025,118 (GRCm39) missense probably benign 0.00
IGL01885:Gm10718 APN 9 3,025,118 (GRCm39) missense probably benign 0.00
IGL01886:Gm10718 APN 9 3,025,118 (GRCm39) missense probably benign 0.00
IGL01887:Gm10718 APN 9 3,025,118 (GRCm39) missense probably benign 0.00
IGL01888:Gm10718 APN 9 3,025,118 (GRCm39) missense probably benign 0.00
IGL01890:Gm10718 APN 9 3,025,118 (GRCm39) missense probably benign 0.00
IGL01891:Gm10718 APN 9 3,025,118 (GRCm39) missense probably benign 0.00
IGL01894:Gm10718 APN 9 3,025,118 (GRCm39) missense probably benign 0.00
IGL01895:Gm10718 APN 9 3,025,118 (GRCm39) missense probably benign 0.00
IGL01896:Gm10718 APN 9 3,025,118 (GRCm39) missense probably benign 0.00
IGL01897:Gm10718 APN 9 3,025,118 (GRCm39) missense probably benign 0.00
IGL01898:Gm10718 APN 9 3,025,118 (GRCm39) missense probably benign 0.00
IGL01901:Gm10718 APN 9 3,025,118 (GRCm39) missense probably benign 0.00
IGL01903:Gm10718 APN 9 3,025,118 (GRCm39) missense probably benign 0.00
IGL01904:Gm10718 APN 9 3,025,118 (GRCm39) missense probably benign 0.00
IGL01905:Gm10718 APN 9 3,025,118 (GRCm39) missense probably benign 0.00
IGL01908:Gm10718 APN 9 3,025,118 (GRCm39) missense probably benign 0.00
IGL01909:Gm10718 APN 9 3,025,118 (GRCm39) missense probably benign 0.00
IGL01910:Gm10718 APN 9 3,025,118 (GRCm39) missense probably benign 0.00
IGL01912:Gm10718 APN 9 3,025,118 (GRCm39) missense probably benign 0.00
IGL01917:Gm10718 APN 9 3,025,118 (GRCm39) missense probably benign 0.00
IGL01918:Gm10718 APN 9 3,025,118 (GRCm39) missense probably benign 0.00
IGL01919:Gm10718 APN 9 3,025,118 (GRCm39) missense probably benign 0.00
IGL01920:Gm10718 APN 9 3,025,118 (GRCm39) missense probably benign 0.00
IGL01924:Gm10718 APN 9 3,025,118 (GRCm39) missense probably benign 0.00
IGL01925:Gm10718 APN 9 3,025,118 (GRCm39) missense probably benign 0.00
IGL01926:Gm10718 APN 9 3,025,118 (GRCm39) missense probably benign 0.00
IGL01928:Gm10718 APN 9 3,025,118 (GRCm39) missense probably benign 0.00
IGL01929:Gm10718 APN 9 3,025,118 (GRCm39) missense probably benign 0.00
IGL01932:Gm10718 APN 9 3,025,118 (GRCm39) missense probably benign 0.00
IGL01934:Gm10718 APN 9 3,025,118 (GRCm39) missense probably benign 0.00
IGL01937:Gm10718 APN 9 3,025,118 (GRCm39) missense probably benign 0.00
IGL01938:Gm10718 APN 9 3,025,118 (GRCm39) missense probably benign 0.00
IGL01941:Gm10718 APN 9 3,025,118 (GRCm39) missense probably benign 0.00
IGL01944:Gm10718 APN 9 3,025,118 (GRCm39) missense probably benign 0.00
IGL01945:Gm10718 APN 9 3,025,118 (GRCm39) missense probably benign 0.00
IGL01946:Gm10718 APN 9 3,025,118 (GRCm39) missense probably benign 0.00
IGL01947:Gm10718 APN 9 3,025,118 (GRCm39) missense probably benign 0.00
IGL01949:Gm10718 APN 9 3,025,118 (GRCm39) missense probably benign 0.00
IGL01950:Gm10718 APN 9 3,025,118 (GRCm39) missense probably benign 0.00
IGL01951:Gm10718 APN 9 3,025,118 (GRCm39) missense probably benign 0.00
IGL01952:Gm10718 APN 9 3,025,118 (GRCm39) missense probably benign 0.00
IGL01953:Gm10718 APN 9 3,025,118 (GRCm39) missense probably benign 0.00
IGL01958:Gm10718 APN 9 3,025,118 (GRCm39) missense probably benign 0.00
PIT4131001:Gm10718 UTSW 9 3,024,417 (GRCm39) missense probably benign 0.01
PIT4142001:Gm10718 UTSW 9 3,024,417 (GRCm39) missense probably benign 0.01
R4567:Gm10718 UTSW 9 3,023,716 (GRCm39) missense probably benign 0.01
R4850:Gm10718 UTSW 9 3,023,716 (GRCm39) missense probably benign 0.01
RF039:Gm10718 UTSW 9 3,024,385 (GRCm39) frame shift probably null
Posted On 2015-04-16