Incidental Mutation 'IGL01949:Gm21738'
ID279186
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Gm21738
Ensembl Gene ENSMUSG00000095280
Gene Namepredicted gene, 21738
Synonyms
Accession Numbers
Is this an essential gene? Probably essential (E-score: 0.845) question?
Stock #IGL01949
Quality Score
Status
Chromosome14
Chromosomal Location19415857-19418930 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) G to A at 19416979 bp
ZygosityHeterozygous
Amino Acid Change Serine to Leucine at position 144 (S144L)
Ref Sequence ENSEMBL: ENSMUSP00000137127 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000177817]
Predicted Effect probably benign
Transcript: ENSMUST00000177817
AA Change: S144L

PolyPhen 2 Score 0.011 (Sensitivity: 0.96; Specificity: 0.78)
SMART Domains Protein: ENSMUSP00000137127
Gene: ENSMUSG00000095280
AA Change: S144L

DomainStartEndE-ValueType
internal_repeat_1 1 19 1.11e-9 PROSPERO
transmembrane domain 20 42 N/A INTRINSIC
transmembrane domain 77 99 N/A INTRINSIC
internal_repeat_1 117 135 1.11e-9 PROSPERO
transmembrane domain 152 174 N/A INTRINSIC
low complexity region 179 195 N/A INTRINSIC
transmembrane domain 198 220 N/A INTRINSIC
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 31 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adamts20 C A 15: 94,326,106 R1247L probably benign Het
Atp2a3 T A 11: 72,981,897 M757K probably damaging Het
C130026I21Rik A G 1: 85,254,186 probably benign Het
D430042O09Rik G A 7: 125,761,842 W108* probably null Het
Dusp5 T C 19: 53,537,473 I182T probably damaging Het
Fuca1 T A 4: 135,923,109 probably benign Het
Gm10717 C T 9: 3,025,616 S67L probably benign Het
Gm10718 A T 9: 3,025,118 Y194F probably benign Het
Hap1 G T 11: 100,348,762 D610E probably damaging Het
Hoxa6 T A 6: 52,206,531 Y178F possibly damaging Het
Ighmbp2 A C 19: 3,265,538 D627E probably benign Het
Itgae T C 11: 73,118,184 I497T probably benign Het
Kbtbd3 A G 9: 4,331,066 D480G possibly damaging Het
Kmt2b A T 7: 30,577,161 probably null Het
Krt5 T A 15: 101,710,613 M278L probably benign Het
Krtap4-9 G A 11: 99,785,565 probably benign Het
Myl12a T C 17: 70,996,714 D56G probably benign Het
Olfr117 T C 17: 37,659,466 Y289C probably damaging Het
Pdgfra C A 5: 75,170,665 H310Q probably damaging Het
Pglyrp2 G T 17: 32,416,106 probably null Het
Polk C T 13: 96,483,538 S718N probably benign Het
Ppip5k1 T A 2: 121,337,860 H687L probably benign Het
Pram1 A T 17: 33,641,335 Q292L probably damaging Het
Prodh2 A G 7: 30,509,765 probably null Het
Rgs9 A T 11: 109,259,834 probably null Het
Stk-ps2 A G 1: 46,029,988 noncoding transcript Het
Svep1 C T 4: 58,176,006 G298R probably damaging Het
Troap T C 15: 99,081,221 S341P probably benign Het
Ugt3a2 T C 15: 9,335,729 F12S probably damaging Het
Vmn2r-ps159 C T 4: 156,338,254 noncoding transcript Het
Zfp236 G T 18: 82,624,396 T1123K probably damaging Het
Other mutations in Gm21738
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00990:Gm21738 APN 14 19418885 missense probably benign
IGL01010:Gm21738 APN 14 19417361 missense probably benign 0.03
IGL01018:Gm21738 APN 14 19418856 missense probably benign 0.39
IGL01865:Gm21738 APN 14 19416979 missense probably benign 0.01
IGL01869:Gm21738 APN 14 19416979 missense probably benign 0.01
IGL01873:Gm21738 APN 14 19416979 missense probably benign 0.01
IGL01877:Gm21738 APN 14 19416979 missense probably benign 0.01
IGL01878:Gm21738 APN 14 19416979 missense probably benign 0.01
IGL01879:Gm21738 APN 14 19416979 missense probably benign 0.01
IGL01880:Gm21738 APN 14 19416979 missense probably benign 0.01
IGL01882:Gm21738 APN 14 19416979 missense probably benign 0.01
IGL01883:Gm21738 APN 14 19416979 missense probably benign 0.01
IGL01884:Gm21738 APN 14 19416979 missense probably benign 0.01
IGL01885:Gm21738 APN 14 19416979 missense probably benign 0.01
IGL01886:Gm21738 APN 14 19416979 missense probably benign 0.01
IGL01888:Gm21738 APN 14 19416979 missense probably benign 0.01
IGL01891:Gm21738 APN 14 19416979 missense probably benign 0.01
IGL01892:Gm21738 APN 14 19416979 missense probably benign 0.01
IGL01893:Gm21738 APN 14 19416979 missense probably benign 0.01
IGL01894:Gm21738 APN 14 19416979 missense probably benign 0.01
IGL01895:Gm21738 APN 14 19416979 missense probably benign 0.01
IGL01896:Gm21738 APN 14 19416979 missense probably benign 0.01
IGL01898:Gm21738 APN 14 19416979 missense probably benign 0.01
IGL01899:Gm21738 APN 14 19416979 missense probably benign 0.01
IGL01900:Gm21738 APN 14 19416979 missense probably benign 0.01
IGL01901:Gm21738 APN 14 19416979 missense probably benign 0.01
IGL01902:Gm21738 APN 14 19416979 missense probably benign 0.01
IGL01903:Gm21738 APN 14 19416979 missense probably benign 0.01
IGL01904:Gm21738 APN 14 19416979 missense probably benign 0.01
IGL01905:Gm21738 APN 14 19416979 missense probably benign 0.01
IGL01906:Gm21738 APN 14 19416979 missense probably benign 0.01
IGL01908:Gm21738 APN 14 19416979 missense probably benign 0.01
IGL01909:Gm21738 APN 14 19416979 missense probably benign 0.01
IGL01910:Gm21738 APN 14 19416979 missense probably benign 0.01
IGL01911:Gm21738 APN 14 19416979 missense probably benign 0.01
IGL01912:Gm21738 APN 14 19416979 missense probably benign 0.01
IGL01913:Gm21738 APN 14 19416979 missense probably benign 0.01
IGL01914:Gm21738 APN 14 19416979 missense probably benign 0.01
IGL01915:Gm21738 APN 14 19416979 missense probably benign 0.01
IGL01916:Gm21738 APN 14 19416979 missense probably benign 0.01
IGL01917:Gm21738 APN 14 19416979 missense probably benign 0.01
IGL01918:Gm21738 APN 14 19416979 missense probably benign 0.01
IGL01919:Gm21738 APN 14 19416979 missense probably benign 0.01
IGL01922:Gm21738 APN 14 19416979 missense probably benign 0.01
IGL01923:Gm21738 APN 14 19416979 missense probably benign 0.01
IGL01924:Gm21738 APN 14 19416979 missense probably benign 0.01
IGL01925:Gm21738 APN 14 19416979 missense probably benign 0.01
IGL01926:Gm21738 APN 14 19416979 missense probably benign 0.01
IGL01932:Gm21738 APN 14 19416979 missense probably benign 0.01
IGL01940:Gm21738 APN 14 19416979 missense probably benign 0.01
PIT4131001:Gm21738 UTSW 14 19417330 missense probably benign 0.00
PIT4142001:Gm21738 UTSW 14 19417330 missense probably benign 0.00
R0831:Gm21738 UTSW 14 19415957 missense probably benign 0.01
R0831:Gm21738 UTSW 14 19415963 missense probably benign
R0976:Gm21738 UTSW 14 19415963 missense probably benign
R1029:Gm21738 UTSW 14 19415957 missense probably benign 0.01
R1146:Gm21738 UTSW 14 19415963 missense probably benign
R1231:Gm21738 UTSW 14 19415957 missense probably benign 0.01
R1231:Gm21738 UTSW 14 19415963 missense probably benign
R1402:Gm21738 UTSW 14 19415957 missense probably benign 0.01
R1402:Gm21738 UTSW 14 19415963 missense probably benign
R1638:Gm21738 UTSW 14 19418908 missense probably benign
R1874:Gm21738 UTSW 14 19418824 missense possibly damaging 0.64
R4392:Gm21738 UTSW 14 19417178 missense probably benign
R4393:Gm21738 UTSW 14 19417178 missense probably benign
R5049:Gm21738 UTSW 14 19415957 missense probably benign 0.01
R5257:Gm21738 UTSW 14 19415942 missense probably benign
R6756:Gm21738 UTSW 14 19418824 missense possibly damaging 0.64
R6915:Gm21738 UTSW 14 19415933 missense probably benign
V5622:Gm21738 UTSW 14 19417180 missense probably damaging 1.00
Posted On2015-04-16