Incidental Mutation 'IGL01958:Gm10718'
ID 279241
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Gm10718
Ensembl Gene ENSMUSG00000095186
Gene Name predicted gene 10718
Synonyms
Accession Numbers
Essential gene? Possibly essential (E-score: 0.509) question?
Stock # IGL01958
Quality Score
Status
Chromosome 9
Chromosomal Location 3023547-3025218 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 3025118 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Tyrosine to Phenylalanine at position 194 (Y194F)
Ref Sequence ENSEMBL: ENSMUSP00000096645 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000075573] [ENSMUST00000099046] [ENSMUST00000099047] [ENSMUST00000099051] [ENSMUST00000177601] [ENSMUST00000177875] [ENSMUST00000179272] [ENSMUST00000179982]
AlphaFold D3Z1I7
Predicted Effect probably benign
Transcript: ENSMUST00000075573
SMART Domains Protein: ENSMUSP00000096644
Gene: ENSMUSG00000095891

DomainStartEndE-ValueType
internal_repeat_1 1 41 1.06e-10 PROSPERO
transmembrane domain 68 90 N/A INTRINSIC
internal_repeat_1 118 177 1.06e-10 PROSPERO
transmembrane domain 200 222 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000099046
AA Change: Y194F

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
SMART Domains Protein: ENSMUSP00000096645
Gene: ENSMUSG00000095186
AA Change: Y194F

DomainStartEndE-ValueType
internal_repeat_1 1 41 4.44e-7 PROSPERO
transmembrane domain 67 89 N/A INTRINSIC
internal_repeat_1 117 177 4.44e-7 PROSPERO
transmembrane domain 197 219 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000099047
SMART Domains Protein: ENSMUSP00000096646
Gene: ENSMUSG00000095547

DomainStartEndE-ValueType
internal_repeat_1 1 40 1.58e-10 PROSPERO
transmembrane domain 53 72 N/A INTRINSIC
transmembrane domain 77 99 N/A INTRINSIC
internal_repeat_1 117 176 1.58e-10 PROSPERO
transmembrane domain 199 221 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000099051
SMART Domains Protein: ENSMUSP00000096650
Gene: ENSMUSG00000095891

DomainStartEndE-ValueType
internal_repeat_1 2 38 6.22e-5 PROSPERO
transmembrane domain 58 80 N/A INTRINSIC
transmembrane domain 90 109 N/A INTRINSIC
internal_repeat_1 118 174 6.22e-5 PROSPERO
transmembrane domain 185 207 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000177601
SMART Domains Protein: ENSMUSP00000136755
Gene: ENSMUSG00000095891

DomainStartEndE-ValueType
internal_repeat_2 1 24 2.26e-6 PROSPERO
internal_repeat_1 2 37 2.26e-6 PROSPERO
internal_repeat_1 40 95 2.26e-6 PROSPERO
internal_repeat_2 118 142 2.26e-6 PROSPERO
low complexity region 147 159 N/A INTRINSIC
low complexity region 169 183 N/A INTRINSIC
transmembrane domain 186 208 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000177875
SMART Domains Protein: ENSMUSP00000137419
Gene: ENSMUSG00000095891

DomainStartEndE-ValueType
internal_repeat_1 1 49 1.49e-11 PROSPERO
transmembrane domain 68 90 N/A INTRINSIC
internal_repeat_1 118 186 1.49e-11 PROSPERO
transmembrane domain 197 219 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000179272
SMART Domains Protein: ENSMUSP00000136170
Gene: ENSMUSG00000095547

DomainStartEndE-ValueType
internal_repeat_1 1 49 2.1e-10 PROSPERO
transmembrane domain 74 96 N/A INTRINSIC
internal_repeat_1 118 186 2.1e-10 PROSPERO
transmembrane domain 198 217 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000179982
SMART Domains Protein: ENSMUSP00000136365
Gene: ENSMUSG00000095891

DomainStartEndE-ValueType
internal_repeat_1 1 35 7.76e-13 PROSPERO
transmembrane domain 67 89 N/A INTRINSIC
internal_repeat_1 117 152 7.76e-13 PROSPERO
low complexity region 157 169 N/A INTRINSIC
transmembrane domain 198 220 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000181572
Predicted Effect noncoding transcript
Transcript: ENSMUST00000181957
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 55 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4732465J04Rik T C 10: 95,629,659 (GRCm39) I29T probably damaging Het
Agps G A 2: 75,740,045 (GRCm39) probably null Het
Agxt2 A G 15: 10,393,794 (GRCm39) probably null Het
Ahnak T C 19: 8,992,273 (GRCm39) V4519A possibly damaging Het
Aktip T C 8: 91,852,853 (GRCm39) D159G probably damaging Het
Ankrd44 T C 1: 54,806,125 (GRCm39) I94V probably damaging Het
Asph T C 4: 9,474,904 (GRCm39) E674G possibly damaging Het
Atat1 T A 17: 36,219,735 (GRCm39) probably benign Het
Ccar1 G A 10: 62,626,714 (GRCm39) A20V possibly damaging Het
Cdc26 T C 4: 62,321,001 (GRCm39) D14G probably damaging Het
Cdh15 T C 8: 123,586,089 (GRCm39) F156S probably damaging Het
Dctn1 A G 6: 83,168,326 (GRCm39) T525A possibly damaging Het
Dnah8 T G 17: 31,074,869 (GRCm39) probably benign Het
Dnajc10 T A 2: 80,151,648 (GRCm39) probably benign Het
Dtl C A 1: 191,300,489 (GRCm39) W125L probably damaging Het
Fam3c G A 6: 22,318,954 (GRCm39) T149I probably damaging Het
Fgd6 A G 10: 93,974,170 (GRCm39) T1304A probably benign Het
Gm6578 A G 6: 12,099,766 (GRCm39) noncoding transcript Het
Gnai1 A G 5: 18,478,568 (GRCm39) F199S probably damaging Het
Grb7 T A 11: 98,345,480 (GRCm39) V480D probably damaging Het
Hdc A G 2: 126,436,452 (GRCm39) L473P possibly damaging Het
Hmcn1 T C 1: 150,479,622 (GRCm39) N4614S probably benign Het
Il20ra A G 10: 19,634,791 (GRCm39) D344G probably benign Het
Ints1 C T 5: 139,745,843 (GRCm39) R1342Q possibly damaging Het
Itga9 T A 9: 118,465,562 (GRCm39) probably benign Het
Kat14 T C 2: 144,236,285 (GRCm39) L339P probably damaging Het
Klhl22 A G 16: 17,594,326 (GRCm39) I152V probably benign Het
Krtap5-2 C A 7: 141,729,459 (GRCm39) G74* probably null Het
Lrrc59 C A 11: 94,529,354 (GRCm39) probably null Het
Map3k13 A G 16: 21,710,873 (GRCm39) Q52R probably benign Het
Mb21d2 A G 16: 28,646,495 (GRCm39) probably benign Het
Mphosph9 A T 5: 124,463,053 (GRCm39) probably benign Het
Myrf A G 19: 10,187,742 (GRCm39) probably benign Het
Nek11 T C 9: 105,177,502 (GRCm39) T250A probably benign Het
Nek5 A T 8: 22,586,842 (GRCm39) V323E probably benign Het
Nfasc A T 1: 132,536,176 (GRCm39) C586* probably null Het
Nup210l T A 3: 90,111,231 (GRCm39) L1711Q possibly damaging Het
Parp8 T G 13: 117,013,108 (GRCm39) K644Q probably benign Het
Pcnt G T 10: 76,269,513 (GRCm39) Q252K probably damaging Het
Pianp A G 6: 124,977,646 (GRCm39) T181A possibly damaging Het
Pkd1 T C 17: 24,799,298 (GRCm39) V2839A probably damaging Het
Poli C T 18: 70,659,657 (GRCm39) R58H possibly damaging Het
Ptk7 T C 17: 46,890,353 (GRCm39) D447G probably benign Het
Rapgef5 A G 12: 117,694,386 (GRCm39) I637V probably benign Het
Rasip1 A T 7: 45,286,188 (GRCm39) R804* probably null Het
Relt A G 7: 100,500,350 (GRCm39) V113A probably benign Het
Rnf215 G T 11: 4,090,317 (GRCm39) C345F probably damaging Het
Scart2 T C 7: 139,854,040 (GRCm39) C348R probably damaging Het
Scn2a A G 2: 65,532,173 (GRCm39) D595G probably damaging Het
Serpina3k G A 12: 104,307,316 (GRCm39) V183M probably damaging Het
Snapc4 T C 2: 26,256,452 (GRCm39) probably benign Het
Sparcl1 A T 5: 104,240,406 (GRCm39) D339E probably benign Het
Tg T C 15: 66,631,335 (GRCm39) F535L probably benign Het
Zbtb45 C A 7: 12,740,203 (GRCm39) A471S probably benign Het
Zfp106 T A 2: 120,365,288 (GRCm39) K373M probably benign Het
Other mutations in Gm10718
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01863:Gm10718 APN 9 3,025,118 (GRCm39) missense probably benign 0.00
IGL01865:Gm10718 APN 9 3,025,118 (GRCm39) missense probably benign 0.00
IGL01867:Gm10718 APN 9 3,025,118 (GRCm39) missense probably benign 0.00
IGL01868:Gm10718 APN 9 3,025,118 (GRCm39) missense probably benign 0.00
IGL01869:Gm10718 APN 9 3,025,118 (GRCm39) missense probably benign 0.00
IGL01870:Gm10718 APN 9 3,025,118 (GRCm39) missense probably benign 0.00
IGL01871:Gm10718 APN 9 3,025,118 (GRCm39) missense probably benign 0.00
IGL01874:Gm10718 APN 9 3,025,118 (GRCm39) missense probably benign 0.00
IGL01877:Gm10718 APN 9 3,025,118 (GRCm39) missense probably benign 0.00
IGL01878:Gm10718 APN 9 3,025,118 (GRCm39) missense probably benign 0.00
IGL01879:Gm10718 APN 9 3,025,118 (GRCm39) missense probably benign 0.00
IGL01880:Gm10718 APN 9 3,025,118 (GRCm39) missense probably benign 0.00
IGL01881:Gm10718 APN 9 3,025,118 (GRCm39) missense probably benign 0.00
IGL01883:Gm10718 APN 9 3,025,118 (GRCm39) missense probably benign 0.00
IGL01884:Gm10718 APN 9 3,025,118 (GRCm39) missense probably benign 0.00
IGL01885:Gm10718 APN 9 3,025,118 (GRCm39) missense probably benign 0.00
IGL01886:Gm10718 APN 9 3,025,118 (GRCm39) missense probably benign 0.00
IGL01887:Gm10718 APN 9 3,025,118 (GRCm39) missense probably benign 0.00
IGL01888:Gm10718 APN 9 3,025,118 (GRCm39) missense probably benign 0.00
IGL01890:Gm10718 APN 9 3,025,118 (GRCm39) missense probably benign 0.00
IGL01891:Gm10718 APN 9 3,025,118 (GRCm39) missense probably benign 0.00
IGL01894:Gm10718 APN 9 3,025,118 (GRCm39) missense probably benign 0.00
IGL01895:Gm10718 APN 9 3,025,118 (GRCm39) missense probably benign 0.00
IGL01896:Gm10718 APN 9 3,025,118 (GRCm39) missense probably benign 0.00
IGL01897:Gm10718 APN 9 3,025,118 (GRCm39) missense probably benign 0.00
IGL01898:Gm10718 APN 9 3,025,118 (GRCm39) missense probably benign 0.00
IGL01901:Gm10718 APN 9 3,025,118 (GRCm39) missense probably benign 0.00
IGL01903:Gm10718 APN 9 3,025,118 (GRCm39) missense probably benign 0.00
IGL01904:Gm10718 APN 9 3,025,118 (GRCm39) missense probably benign 0.00
IGL01905:Gm10718 APN 9 3,025,118 (GRCm39) missense probably benign 0.00
IGL01908:Gm10718 APN 9 3,025,118 (GRCm39) missense probably benign 0.00
IGL01909:Gm10718 APN 9 3,025,118 (GRCm39) missense probably benign 0.00
IGL01910:Gm10718 APN 9 3,025,118 (GRCm39) missense probably benign 0.00
IGL01912:Gm10718 APN 9 3,025,118 (GRCm39) missense probably benign 0.00
IGL01917:Gm10718 APN 9 3,025,118 (GRCm39) missense probably benign 0.00
IGL01918:Gm10718 APN 9 3,025,118 (GRCm39) missense probably benign 0.00
IGL01919:Gm10718 APN 9 3,025,118 (GRCm39) missense probably benign 0.00
IGL01920:Gm10718 APN 9 3,025,118 (GRCm39) missense probably benign 0.00
IGL01924:Gm10718 APN 9 3,025,118 (GRCm39) missense probably benign 0.00
IGL01925:Gm10718 APN 9 3,025,118 (GRCm39) missense probably benign 0.00
IGL01926:Gm10718 APN 9 3,025,118 (GRCm39) missense probably benign 0.00
IGL01928:Gm10718 APN 9 3,025,118 (GRCm39) missense probably benign 0.00
IGL01929:Gm10718 APN 9 3,025,118 (GRCm39) missense probably benign 0.00
IGL01932:Gm10718 APN 9 3,025,118 (GRCm39) missense probably benign 0.00
IGL01933:Gm10718 APN 9 3,025,118 (GRCm39) missense probably benign 0.00
IGL01934:Gm10718 APN 9 3,025,118 (GRCm39) missense probably benign 0.00
IGL01937:Gm10718 APN 9 3,025,118 (GRCm39) missense probably benign 0.00
IGL01938:Gm10718 APN 9 3,025,118 (GRCm39) missense probably benign 0.00
IGL01941:Gm10718 APN 9 3,025,118 (GRCm39) missense probably benign 0.00
IGL01944:Gm10718 APN 9 3,025,118 (GRCm39) missense probably benign 0.00
IGL01945:Gm10718 APN 9 3,025,118 (GRCm39) missense probably benign 0.00
IGL01946:Gm10718 APN 9 3,025,118 (GRCm39) missense probably benign 0.00
IGL01947:Gm10718 APN 9 3,025,118 (GRCm39) missense probably benign 0.00
IGL01949:Gm10718 APN 9 3,025,118 (GRCm39) missense probably benign 0.00
IGL01950:Gm10718 APN 9 3,025,118 (GRCm39) missense probably benign 0.00
IGL01951:Gm10718 APN 9 3,025,118 (GRCm39) missense probably benign 0.00
IGL01952:Gm10718 APN 9 3,025,118 (GRCm39) missense probably benign 0.00
IGL01953:Gm10718 APN 9 3,025,118 (GRCm39) missense probably benign 0.00
PIT4131001:Gm10718 UTSW 9 3,024,417 (GRCm39) missense probably benign 0.01
PIT4142001:Gm10718 UTSW 9 3,024,417 (GRCm39) missense probably benign 0.01
R4567:Gm10718 UTSW 9 3,023,716 (GRCm39) missense probably benign 0.01
R4850:Gm10718 UTSW 9 3,023,716 (GRCm39) missense probably benign 0.01
RF039:Gm10718 UTSW 9 3,024,385 (GRCm39) frame shift probably null
Posted On 2015-04-16