Incidental Mutation 'IGL01980:Tmem25'
ID279261
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Tmem25
Ensembl Gene ENSMUSG00000002032
Gene Nametransmembrane protein 25
Synonyms0610039J01Rik
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.064) question?
Stock #IGL01980
Quality Score
Status
Chromosome9
Chromosomal Location44793769-44799307 bp(-) (GRCm38)
Type of Mutationnonsense
DNA Base Change (assembly) G to A at 44798271 bp
ZygosityHeterozygous
Amino Acid Change Arginine to Stop codon at position 78 (R78*)
Ref Sequence ENSEMBL: ENSMUSP00000149117 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000002099] [ENSMUST00000002100] [ENSMUST00000044694] [ENSMUST00000114705] [ENSMUST00000132020] [ENSMUST00000213203] [ENSMUST00000213363] [ENSMUST00000213972] [ENSMUST00000214431] [ENSMUST00000214833]
Predicted Effect probably benign
Transcript: ENSMUST00000002099
SMART Domains Protein: ENSMUSP00000002099
Gene: ENSMUSG00000002031

DomainStartEndE-ValueType
low complexity region 3 18 N/A INTRINSIC
low complexity region 29 52 N/A INTRINSIC
Pfam:IFT46_B_C 60 270 6.2e-106 PFAM
Predicted Effect probably null
Transcript: ENSMUST00000002100
AA Change: R78*
SMART Domains Protein: ENSMUSP00000002100
Gene: ENSMUSG00000002032
AA Change: R78*

DomainStartEndE-ValueType
low complexity region 5 23 N/A INTRINSIC
Pfam:C2-set_2 26 118 2.7e-14 PFAM
SCOP:d1ie5a_ 121 220 2e-6 SMART
transmembrane domain 238 260 N/A INTRINSIC
low complexity region 327 338 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000044694
SMART Domains Protein: ENSMUSP00000042183
Gene: ENSMUSG00000039438

DomainStartEndE-ValueType
low complexity region 22 39 N/A INTRINSIC
Pfam:TPR_11 46 112 2.1e-13 PFAM
Pfam:TPR_9 54 123 5.8e-7 PFAM
Pfam:TPR_1 82 113 2.3e-6 PFAM
Pfam:TPR_2 82 114 1.2e-5 PFAM
Predicted Effect probably null
Transcript: ENSMUST00000114705
AA Change: R78*
SMART Domains Protein: ENSMUSP00000110353
Gene: ENSMUSG00000002032
AA Change: R78*

DomainStartEndE-ValueType
low complexity region 5 23 N/A INTRINSIC
Pfam:C2-set_2 26 118 2.2e-15 PFAM
SCOP:d1ie5a_ 121 220 2e-6 SMART
transmembrane domain 238 260 N/A INTRINSIC
low complexity region 327 338 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000132020
Predicted Effect probably null
Transcript: ENSMUST00000213203
AA Change: R78*
Predicted Effect probably null
Transcript: ENSMUST00000213363
AA Change: R78*
Predicted Effect probably null
Transcript: ENSMUST00000213972
AA Change: R78*
Predicted Effect probably null
Transcript: ENSMUST00000214431
AA Change: R78*
Predicted Effect probably null
Transcript: ENSMUST00000214833
AA Change: R78*
Predicted Effect noncoding transcript
Transcript: ENSMUST00000214931
Predicted Effect noncoding transcript
Transcript: ENSMUST00000216449
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 38 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Ankrd60 C T 2: 173,571,203 C164Y probably benign Het
Atp13a2 C T 4: 141,006,152 A979V probably benign Het
Col5a2 C T 1: 45,382,233 probably benign Het
Col6a6 T C 9: 105,780,985 N676S probably damaging Het
Cpa1 T C 6: 30,641,582 F192L possibly damaging Het
Entpd6 T A 2: 150,762,366 probably null Het
Fam185a A G 5: 21,459,173 K302E probably damaging Het
Il12rb2 T C 6: 67,360,535 K121E probably benign Het
Impg2 G A 16: 56,221,527 C178Y probably damaging Het
Kdm3b G T 18: 34,834,236 C1698F probably damaging Het
Llgl2 A G 11: 115,850,025 D451G probably damaging Het
Mgat4b T A 11: 50,230,713 L52Q probably damaging Het
Mmp9 C A 2: 164,950,916 S363R probably benign Het
Mtfmt A G 9: 65,437,074 Y94C probably benign Het
Myo7b G A 18: 31,961,900 L1881F possibly damaging Het
Olfr642 A T 7: 104,050,093 M87K probably benign Het
Olfr782 G T 10: 129,351,517 probably benign Het
Pex5 T C 6: 124,398,380 N524S probably damaging Het
Plppr1 A T 4: 49,319,992 Y206F possibly damaging Het
Polr3e A G 7: 120,940,296 probably benign Het
Rhbdd1 A G 1: 82,340,834 probably benign Het
Rims4 A T 2: 163,865,782 probably benign Het
Smarcal1 A T 1: 72,616,520 K653* probably null Het
Stt3b C T 9: 115,276,699 probably null Het
Syt8 C A 7: 142,440,140 L343M probably damaging Het
Tbc1d23 G A 16: 57,189,252 probably benign Het
Tfec T C 6: 16,845,466 I65V probably damaging Het
Tmem236 A T 2: 14,218,905 Q168H probably benign Het
Tnip2 A G 5: 34,496,868 V288A probably benign Het
Ttc1 G A 11: 43,730,464 probably benign Het
Tubb4b-ps1 A C 5: 7,179,843 probably benign Het
Tut1 T C 19: 8,954,000 C21R probably damaging Het
Ubr4 C A 4: 139,429,602 Q2313K probably damaging Het
Unc5b T C 10: 60,780,187 E119G probably damaging Het
Vmn1r23 T A 6: 57,926,490 Q101L probably damaging Het
Vmn2r77 A G 7: 86,801,470 D188G probably benign Het
Vmn2r79 A G 7: 87,037,082 E557G possibly damaging Het
Zfp738 A G 13: 67,669,977 F632L possibly damaging Het
Other mutations in Tmem25
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00596:Tmem25 APN 9 44795519 unclassified probably benign
IGL02000:Tmem25 APN 9 44798271 nonsense probably null
IGL03407:Tmem25 APN 9 44796339 missense probably damaging 1.00
R0446:Tmem25 UTSW 9 44796581 missense probably damaging 1.00
R0690:Tmem25 UTSW 9 44795514 unclassified probably benign
R0960:Tmem25 UTSW 9 44795512 critical splice acceptor site probably null
R1204:Tmem25 UTSW 9 44795232 missense probably benign 0.17
R1899:Tmem25 UTSW 9 44798216 splice site probably null
R1927:Tmem25 UTSW 9 44796483 missense possibly damaging 0.77
R2088:Tmem25 UTSW 9 44796086 missense possibly damaging 0.94
R3027:Tmem25 UTSW 9 44798214 splice site probably null
R6854:Tmem25 UTSW 9 44796008 missense possibly damaging 0.46
R7305:Tmem25 UTSW 9 44795408 critical splice donor site probably null
R7655:Tmem25 UTSW 9 44798343 missense possibly damaging 0.82
R7656:Tmem25 UTSW 9 44798343 missense possibly damaging 0.82
R7951:Tmem25 UTSW 9 44795493 missense probably damaging 1.00
R7968:Tmem25 UTSW 9 44795686 missense probably benign 0.00
R8298:Tmem25 UTSW 9 44798819 start gained probably benign
Posted On2015-04-16