Incidental Mutation 'IGL02000:Tmem25'
ID279268
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Tmem25
Ensembl Gene ENSMUSG00000002032
Gene Nametransmembrane protein 25
Synonyms0610039J01Rik
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.065) question?
Stock #IGL02000
Quality Score
Status
Chromosome9
Chromosomal Location44793769-44799307 bp(-) (GRCm38)
Type of Mutationnonsense
DNA Base Change (assembly) G to A at 44798271 bp
ZygosityHeterozygous
Amino Acid Change Arginine to Stop codon at position 78 (R78*)
Ref Sequence ENSEMBL: ENSMUSP00000149117 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000002099] [ENSMUST00000002100] [ENSMUST00000044694] [ENSMUST00000114705] [ENSMUST00000132020] [ENSMUST00000213203] [ENSMUST00000213363] [ENSMUST00000213972] [ENSMUST00000214431] [ENSMUST00000214833]
Predicted Effect probably benign
Transcript: ENSMUST00000002099
SMART Domains Protein: ENSMUSP00000002099
Gene: ENSMUSG00000002031

DomainStartEndE-ValueType
low complexity region 3 18 N/A INTRINSIC
low complexity region 29 52 N/A INTRINSIC
Pfam:IFT46_B_C 60 270 6.2e-106 PFAM
Predicted Effect probably null
Transcript: ENSMUST00000002100
AA Change: R78*
SMART Domains Protein: ENSMUSP00000002100
Gene: ENSMUSG00000002032
AA Change: R78*

DomainStartEndE-ValueType
low complexity region 5 23 N/A INTRINSIC
Pfam:C2-set_2 26 118 2.7e-14 PFAM
SCOP:d1ie5a_ 121 220 2e-6 SMART
transmembrane domain 238 260 N/A INTRINSIC
low complexity region 327 338 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000044694
SMART Domains Protein: ENSMUSP00000042183
Gene: ENSMUSG00000039438

DomainStartEndE-ValueType
low complexity region 22 39 N/A INTRINSIC
Pfam:TPR_11 46 112 2.1e-13 PFAM
Pfam:TPR_9 54 123 5.8e-7 PFAM
Pfam:TPR_1 82 113 2.3e-6 PFAM
Pfam:TPR_2 82 114 1.2e-5 PFAM
Predicted Effect probably null
Transcript: ENSMUST00000114705
AA Change: R78*
SMART Domains Protein: ENSMUSP00000110353
Gene: ENSMUSG00000002032
AA Change: R78*

DomainStartEndE-ValueType
low complexity region 5 23 N/A INTRINSIC
Pfam:C2-set_2 26 118 2.2e-15 PFAM
SCOP:d1ie5a_ 121 220 2e-6 SMART
transmembrane domain 238 260 N/A INTRINSIC
low complexity region 327 338 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000132020
Predicted Effect probably null
Transcript: ENSMUST00000213203
AA Change: R78*
Predicted Effect probably null
Transcript: ENSMUST00000213363
AA Change: R78*
Predicted Effect probably null
Transcript: ENSMUST00000213972
AA Change: R78*
Predicted Effect probably null
Transcript: ENSMUST00000214431
AA Change: R78*
Predicted Effect probably null
Transcript: ENSMUST00000214833
AA Change: R78*
Predicted Effect noncoding transcript
Transcript: ENSMUST00000214931
Predicted Effect noncoding transcript
Transcript: ENSMUST00000216449
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 42 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Arid5a T C 1: 36,319,497 F450S probably damaging Het
Astn1 C T 1: 158,674,614 R1133C probably damaging Het
Cd101 G A 3: 101,012,082 P568L probably benign Het
Cdkl4 T C 17: 80,543,763 E170G probably damaging Het
Chit1 A G 1: 134,146,675 E240G probably benign Het
Duox2 T C 2: 122,290,709 T741A probably benign Het
Eef2 T C 10: 81,180,011 V427A probably benign Het
Ewsr1 T C 11: 5,088,077 D105G probably damaging Het
Ftsj3 C T 11: 106,250,407 R629Q probably benign Het
Gm10406 C T 14: 7,009,867 G181E probably benign Het
Ilk A G 7: 105,741,169 H185R probably benign Het
Lamc1 A T 1: 153,240,433 C1001S probably damaging Het
Mcidas T C 13: 112,997,440 S153P probably benign Het
Mtcl1 T C 17: 66,354,190 E931G probably benign Het
Myo10 C T 15: 25,808,066 R1925C probably damaging Het
Notch3 A G 17: 32,122,742 V2012A probably damaging Het
Olfr809 C A 10: 129,776,069 H67N probably benign Het
Parp6 A G 9: 59,648,892 M542V probably benign Het
Rab27a G A 9: 73,084,972 G94D probably damaging Het
Ralgapb A G 2: 158,454,114 probably benign Het
Rassf4 T C 6: 116,645,972 E26G probably benign Het
Rnf166 C T 8: 122,467,222 D221N probably damaging Het
Rptn G T 3: 93,396,428 G356V probably benign Het
Rwdd2b T A 16: 87,436,940 probably benign Het
Scfd1 T A 12: 51,414,117 S337T probably benign Het
Sel1l3 T A 5: 53,145,493 D678V probably damaging Het
Sidt1 A T 16: 44,286,369 F233I probably damaging Het
Slc12a4 T C 8: 105,945,232 D917G probably damaging Het
Slc22a2 A T 17: 12,584,383 I35F possibly damaging Het
Smco1 A T 16: 32,273,933 T141S possibly damaging Het
Svs6 T C 2: 164,317,432 probably benign Het
Syne2 C T 12: 76,015,645 A4247V probably damaging Het
Tacc2 T A 7: 130,729,168 probably null Het
Tgm4 A T 9: 123,056,466 I358F probably damaging Het
Thnsl2 A G 6: 71,134,219 S222P probably damaging Het
Ube2l6 T C 2: 84,809,162 probably benign Het
Usp10 T A 8: 119,948,741 Y63N possibly damaging Het
Vit A G 17: 78,605,486 I283V possibly damaging Het
Vmn1r214 G A 13: 23,035,100 V255I possibly damaging Het
Xpo1 A G 11: 23,296,003 R1038G probably damaging Het
Ybx1 T A 4: 119,282,312 N50I probably damaging Het
Zhx1 T C 15: 58,054,287 K188E probably damaging Het
Other mutations in Tmem25
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00596:Tmem25 APN 9 44795519 unclassified probably benign
IGL01980:Tmem25 APN 9 44798271 nonsense probably null
IGL03407:Tmem25 APN 9 44796339 missense probably damaging 1.00
R0446:Tmem25 UTSW 9 44796581 missense probably damaging 1.00
R0690:Tmem25 UTSW 9 44795514 unclassified probably benign
R0960:Tmem25 UTSW 9 44795512 critical splice acceptor site probably null
R1204:Tmem25 UTSW 9 44795232 missense probably benign 0.17
R1899:Tmem25 UTSW 9 44798216 splice site probably null
R1927:Tmem25 UTSW 9 44796483 missense possibly damaging 0.77
R2088:Tmem25 UTSW 9 44796086 missense possibly damaging 0.94
R3027:Tmem25 UTSW 9 44798214 splice site probably null
R6854:Tmem25 UTSW 9 44796008 missense possibly damaging 0.46
R7305:Tmem25 UTSW 9 44795408 critical splice donor site probably null
R7655:Tmem25 UTSW 9 44798343 missense possibly damaging 0.82
R7656:Tmem25 UTSW 9 44798343 missense possibly damaging 0.82
R7951:Tmem25 UTSW 9 44795493 missense probably damaging 1.00
R7968:Tmem25 UTSW 9 44795686 missense probably benign 0.00
R8298:Tmem25 UTSW 9 44798819 start gained probably benign
Posted On2015-04-16