Incidental Mutation 'IGL02000:Tmem25'
| ID |
279268 |
| Institutional Source |
Australian Phenomics Network
(link to record)
|
| Gene Symbol |
Tmem25
|
| Ensembl Gene |
ENSMUSG00000002032 |
| Gene Name |
transmembrane protein 25 |
| Synonyms |
0610039J01Rik |
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.061)
|
| Stock # |
IGL02000
|
| Quality Score |
|
|
Status
|
|
| Chromosome |
9 |
| Chromosomal Location |
44705066-44710604 bp(-) (GRCm39) |
| Type of Mutation |
nonsense |
| DNA Base Change (assembly) |
G to A
at 44709568 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Arginine to Stop codon
at position 78
(R78*)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000149117
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000002099]
[ENSMUST00000002100]
[ENSMUST00000044694]
[ENSMUST00000114705]
[ENSMUST00000132020]
[ENSMUST00000213203]
[ENSMUST00000213363]
[ENSMUST00000213972]
[ENSMUST00000214431]
[ENSMUST00000214833]
|
| AlphaFold |
Q9DCF1 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000002099
|
| SMART Domains |
Protein: ENSMUSP00000002099
Gene: ENSMUSG00000002031
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
3 |
18 |
N/A |
INTRINSIC |
|
low complexity region
|
29 |
52 |
N/A |
INTRINSIC |
|
Pfam:IFT46_B_C
|
60 |
270 |
6.2e-106 |
PFAM |
|
| Predicted Effect |
probably null
Transcript: ENSMUST00000002100
AA Change: R78*
|
| SMART Domains |
Protein: ENSMUSP00000002100
Gene: ENSMUSG00000002032
AA Change: R78*
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
5 |
23 |
N/A |
INTRINSIC |
|
Pfam:C2-set_2
|
26 |
118 |
2.7e-14 |
PFAM |
|
SCOP:d1ie5a_
|
121 |
220 |
2e-6 |
SMART |
|
transmembrane domain
|
238 |
260 |
N/A |
INTRINSIC |
|
low complexity region
|
327 |
338 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000044694
|
| SMART Domains |
Protein: ENSMUSP00000042183
Gene: ENSMUSG00000039438
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
22 |
39 |
N/A |
INTRINSIC |
|
Pfam:TPR_11
|
46 |
112 |
2.1e-13 |
PFAM |
|
Pfam:TPR_9
|
54 |
123 |
5.8e-7 |
PFAM |
|
Pfam:TPR_1
|
82 |
113 |
2.3e-6 |
PFAM |
|
Pfam:TPR_2
|
82 |
114 |
1.2e-5 |
PFAM |
|
| Predicted Effect |
probably null
Transcript: ENSMUST00000114705
AA Change: R78*
|
| SMART Domains |
Protein: ENSMUSP00000110353
Gene: ENSMUSG00000002032
AA Change: R78*
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
5 |
23 |
N/A |
INTRINSIC |
|
Pfam:C2-set_2
|
26 |
118 |
2.2e-15 |
PFAM |
|
SCOP:d1ie5a_
|
121 |
220 |
2e-6 |
SMART |
|
transmembrane domain
|
238 |
260 |
N/A |
INTRINSIC |
|
low complexity region
|
327 |
338 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000132020
|
| Predicted Effect |
probably null
Transcript: ENSMUST00000213203
AA Change: R78*
|
| Predicted Effect |
probably null
Transcript: ENSMUST00000213363
AA Change: R78*
|
| Predicted Effect |
probably null
Transcript: ENSMUST00000213972
AA Change: R78*
|
| Predicted Effect |
probably null
Transcript: ENSMUST00000214431
AA Change: R78*
|
| Predicted Effect |
probably null
Transcript: ENSMUST00000214833
AA Change: R78*
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000214931
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000216449
|
| Coding Region Coverage |
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 42 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Arid5a |
T |
C |
1: 36,358,578 (GRCm39) |
F450S |
probably damaging |
Het |
| Astn1 |
C |
T |
1: 158,502,184 (GRCm39) |
R1133C |
probably damaging |
Het |
| Cd101 |
G |
A |
3: 100,919,398 (GRCm39) |
P568L |
probably benign |
Het |
| Cdkl4 |
T |
C |
17: 80,851,192 (GRCm39) |
E170G |
probably damaging |
Het |
| Chit1 |
A |
G |
1: 134,074,413 (GRCm39) |
E240G |
probably benign |
Het |
| Duox2 |
T |
C |
2: 122,121,190 (GRCm39) |
T741A |
probably benign |
Het |
| Eef2 |
T |
C |
10: 81,015,845 (GRCm39) |
V427A |
probably benign |
Het |
| Ewsr1 |
T |
C |
11: 5,038,077 (GRCm39) |
D105G |
probably damaging |
Het |
| Ftsj3 |
C |
T |
11: 106,141,233 (GRCm39) |
R629Q |
probably benign |
Het |
| Gm10406 |
C |
T |
14: 18,341,703 (GRCm39) |
G181E |
probably benign |
Het |
| Ilk |
A |
G |
7: 105,390,376 (GRCm39) |
H185R |
probably benign |
Het |
| Lamc1 |
A |
T |
1: 153,116,179 (GRCm39) |
C1001S |
probably damaging |
Het |
| Mcidas |
T |
C |
13: 113,133,974 (GRCm39) |
S153P |
probably benign |
Het |
| Mtcl1 |
T |
C |
17: 66,661,185 (GRCm39) |
E931G |
probably benign |
Het |
| Myo10 |
C |
T |
15: 25,808,152 (GRCm39) |
R1925C |
probably damaging |
Het |
| Notch3 |
A |
G |
17: 32,341,716 (GRCm39) |
V2012A |
probably damaging |
Het |
| Or6c76 |
C |
A |
10: 129,611,938 (GRCm39) |
H67N |
probably benign |
Het |
| Parp6 |
A |
G |
9: 59,556,175 (GRCm39) |
M542V |
probably benign |
Het |
| Rab27a |
G |
A |
9: 72,992,254 (GRCm39) |
G94D |
probably damaging |
Het |
| Ralgapb |
A |
G |
2: 158,296,034 (GRCm39) |
|
probably benign |
Het |
| Rassf4 |
T |
C |
6: 116,622,933 (GRCm39) |
E26G |
probably benign |
Het |
| Rnf166 |
C |
T |
8: 123,193,961 (GRCm39) |
D221N |
probably damaging |
Het |
| Rptn |
G |
T |
3: 93,303,735 (GRCm39) |
G356V |
probably benign |
Het |
| Rwdd2b |
T |
A |
16: 87,233,828 (GRCm39) |
|
probably benign |
Het |
| Scfd1 |
T |
A |
12: 51,460,900 (GRCm39) |
S337T |
probably benign |
Het |
| Sel1l3 |
T |
A |
5: 53,302,835 (GRCm39) |
D678V |
probably damaging |
Het |
| Sidt1 |
A |
T |
16: 44,106,732 (GRCm39) |
F233I |
probably damaging |
Het |
| Slc12a4 |
T |
C |
8: 106,671,864 (GRCm39) |
D917G |
probably damaging |
Het |
| Slc22a2 |
A |
T |
17: 12,803,270 (GRCm39) |
I35F |
possibly damaging |
Het |
| Smco1 |
A |
T |
16: 32,092,751 (GRCm39) |
T141S |
possibly damaging |
Het |
| Svs6 |
T |
C |
2: 164,159,352 (GRCm39) |
|
probably benign |
Het |
| Syne2 |
C |
T |
12: 76,062,419 (GRCm39) |
A4247V |
probably damaging |
Het |
| Tacc2 |
T |
A |
7: 130,330,898 (GRCm39) |
|
probably null |
Het |
| Tgm4 |
A |
T |
9: 122,885,531 (GRCm39) |
I358F |
probably damaging |
Het |
| Thnsl2 |
A |
G |
6: 71,111,203 (GRCm39) |
S222P |
probably damaging |
Het |
| Ube2l6 |
T |
C |
2: 84,639,506 (GRCm39) |
|
probably benign |
Het |
| Usp10 |
T |
A |
8: 120,675,480 (GRCm39) |
Y63N |
possibly damaging |
Het |
| Vit |
A |
G |
17: 78,912,915 (GRCm39) |
I283V |
possibly damaging |
Het |
| Vmn1r214 |
G |
A |
13: 23,219,270 (GRCm39) |
V255I |
possibly damaging |
Het |
| Xpo1 |
A |
G |
11: 23,246,003 (GRCm39) |
R1038G |
probably damaging |
Het |
| Ybx1 |
T |
A |
4: 119,139,509 (GRCm39) |
N50I |
probably damaging |
Het |
| Zhx1 |
T |
C |
15: 57,917,683 (GRCm39) |
K188E |
probably damaging |
Het |
|
| Other mutations in Tmem25 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00596:Tmem25
|
APN |
9 |
44,706,816 (GRCm39) |
unclassified |
probably benign |
|
|
IGL01980:Tmem25
|
APN |
9 |
44,709,568 (GRCm39) |
nonsense |
probably null |
|
|
IGL03407:Tmem25
|
APN |
9 |
44,707,636 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0446:Tmem25
|
UTSW |
9 |
44,707,878 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0690:Tmem25
|
UTSW |
9 |
44,706,811 (GRCm39) |
unclassified |
probably benign |
|
|
R0960:Tmem25
|
UTSW |
9 |
44,706,809 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
R1204:Tmem25
|
UTSW |
9 |
44,706,529 (GRCm39) |
missense |
probably benign |
0.17 |
|
R1899:Tmem25
|
UTSW |
9 |
44,709,513 (GRCm39) |
splice site |
probably null |
|
|
R1927:Tmem25
|
UTSW |
9 |
44,707,780 (GRCm39) |
missense |
possibly damaging |
0.77 |
|
R2088:Tmem25
|
UTSW |
9 |
44,707,383 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R3027:Tmem25
|
UTSW |
9 |
44,709,511 (GRCm39) |
splice site |
probably null |
|
|
R6854:Tmem25
|
UTSW |
9 |
44,707,305 (GRCm39) |
missense |
possibly damaging |
0.46 |
|
R7305:Tmem25
|
UTSW |
9 |
44,706,705 (GRCm39) |
critical splice donor site |
probably null |
|
|
R7655:Tmem25
|
UTSW |
9 |
44,709,640 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
R7656:Tmem25
|
UTSW |
9 |
44,709,640 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
R7951:Tmem25
|
UTSW |
9 |
44,706,790 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7968:Tmem25
|
UTSW |
9 |
44,706,983 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8298:Tmem25
|
UTSW |
9 |
44,710,116 (GRCm39) |
start gained |
probably benign |
|
|
R9177:Tmem25
|
UTSW |
9 |
44,709,529 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R9207:Tmem25
|
UTSW |
9 |
44,710,476 (GRCm39) |
critical splice donor site |
probably null |
|
|
R9274:Tmem25
|
UTSW |
9 |
44,706,336 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9291:Tmem25
|
UTSW |
9 |
44,706,799 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R9645:Tmem25
|
UTSW |
9 |
44,706,515 (GRCm39) |
missense |
|
|
|
| Posted On |
2015-04-16 |
Incidental Mutation