Incidental Mutation 'IGL02088:Mettl25'
ID279304
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Mettl25
Ensembl Gene ENSMUSG00000036009
Gene Namemethyltransferase like 25
SynonymsBC067068
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.102) question?
Stock #IGL02088
Quality Score
Status
Chromosome10
Chromosomal Location105763189-105841380 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) A to G at 105823250 bp
ZygosityHeterozygous
Amino Acid Change Phenylalanine to Leucine at position 391 (F391L)
Ref Sequence ENSEMBL: ENSMUSP00000038665 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000046638] [ENSMUST00000176040] [ENSMUST00000176924]
Predicted Effect probably damaging
Transcript: ENSMUST00000046638
AA Change: F391L

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000038665
Gene: ENSMUSG00000036009
AA Change: F391L

DomainStartEndE-ValueType
Pfam:Methyltransf_32 149 413 1.9e-30 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000176040
Predicted Effect probably benign
Transcript: ENSMUST00000176924
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 38 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Ackr4 T C 9: 104,098,881 E289G probably damaging Het
Aldh1l1 A T 6: 90,580,590 probably benign Het
Ampd3 T A 7: 110,793,686 D220E probably benign Het
Ank3 T C 10: 69,999,373 V136A probably damaging Het
Atg14 T C 14: 47,542,859 K486R probably benign Het
Axin1 A G 17: 26,188,695 I637V probably benign Het
Axin2 T A 11: 108,923,616 F110Y probably damaging Het
Cdh12 A T 15: 21,480,339 K214* probably null Het
Cfap44 A C 16: 44,451,628 E1248A possibly damaging Het
Cryba4 A G 5: 112,251,009 probably benign Het
Cyp2c68 A G 19: 39,703,521 probably benign Het
Dnah5 G T 15: 28,459,118 probably null Het
Dok3 A T 13: 55,524,370 V165E probably damaging Het
Etl4 A T 2: 20,806,548 R1147S probably damaging Het
Fam212a A G 9: 107,984,457 F220S probably damaging Het
Fbxl6 G T 15: 76,535,906 C502* probably null Het
Gp2 A T 7: 119,454,469 Y90N probably damaging Het
H1fnt G T 15: 98,257,178 T30K probably damaging Het
Itfg2 A G 6: 128,411,606 V306A probably benign Het
Lrig2 T C 3: 104,467,108 Y219C probably damaging Het
Mccc1 A T 3: 35,974,202 I485N probably damaging Het
Muc19 C T 15: 91,891,168 noncoding transcript Het
Muc2 T C 7: 141,751,504 C182R probably damaging Het
Nlrp4g T C 9: 124,350,453 noncoding transcript Het
Nms A G 1: 38,939,277 probably benign Het
Nr3c1 T C 18: 39,424,391 N503S probably damaging Het
Olfr1495 T C 19: 13,768,666 F108S probably damaging Het
Olfr186 A G 16: 59,027,052 L285P probably damaging Het
Olfr828 C T 9: 18,815,923 V124I probably benign Het
Pcdhb5 G A 18: 37,321,959 S464N probably benign Het
Pcgf6 T C 19: 47,050,804 T6A unknown Het
Rdx A G 9: 52,060,883 probably benign Het
Shmt1 T C 11: 60,789,653 T403A probably damaging Het
Slc35d1 A G 4: 103,211,325 F148L probably benign Het
Tk1 A G 11: 117,824,665 probably benign Het
Tnks T A 8: 34,839,994 I1134F possibly damaging Het
Ttn A G 2: 76,726,691 V29990A probably damaging Het
Zcchc11 A G 4: 108,512,218 probably benign Het
Other mutations in Mettl25
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00310:Mettl25 APN 10 105826434 missense probably benign
IGL00698:Mettl25 APN 10 105793340 missense probably null 0.31
IGL00766:Mettl25 APN 10 105779582 splice site probably benign
IGL01360:Mettl25 APN 10 105823197 missense probably damaging 1.00
IGL01954:Mettl25 APN 10 105823207 missense probably damaging 1.00
IGL02623:Mettl25 APN 10 105826324 missense probably damaging 0.96
IGL03245:Mettl25 APN 10 105826497 missense possibly damaging 0.86
IGL03134:Mettl25 UTSW 10 105826027 nonsense probably null
R0238:Mettl25 UTSW 10 105826525 missense probably damaging 1.00
R0238:Mettl25 UTSW 10 105826525 missense probably damaging 1.00
R0239:Mettl25 UTSW 10 105826525 missense probably damaging 1.00
R0239:Mettl25 UTSW 10 105826525 missense probably damaging 1.00
R1297:Mettl25 UTSW 10 105823265 missense probably benign 0.11
R1482:Mettl25 UTSW 10 105826590 missense possibly damaging 0.61
R1526:Mettl25 UTSW 10 105832983 missense possibly damaging 0.56
R1542:Mettl25 UTSW 10 105826120 missense probably benign 0.04
R1589:Mettl25 UTSW 10 105779632 missense probably damaging 1.00
R1901:Mettl25 UTSW 10 105826087 missense probably damaging 0.96
R1902:Mettl25 UTSW 10 105826087 missense probably damaging 0.96
R2016:Mettl25 UTSW 10 105797306 missense probably benign 0.00
R2355:Mettl25 UTSW 10 105763455 missense probably benign 0.00
R2920:Mettl25 UTSW 10 105765177 splice site probably null
R3149:Mettl25 UTSW 10 105826353 missense probably benign 0.00
R4547:Mettl25 UTSW 10 105826017 missense probably damaging 1.00
R4646:Mettl25 UTSW 10 105826555 missense probably damaging 1.00
R4652:Mettl25 UTSW 10 105779648 nonsense probably null
R5020:Mettl25 UTSW 10 105826207 missense possibly damaging 0.87
R5435:Mettl25 UTSW 10 105779586 critical splice donor site probably null
R6947:Mettl25 UTSW 10 105826192 missense probably benign 0.00
R7075:Mettl25 UTSW 10 105829924 missense possibly damaging 0.68
R7729:Mettl25 UTSW 10 105766010 missense probably benign 0.03
R8074:Mettl25 UTSW 10 105826080 missense probably benign 0.02
R8108:Mettl25 UTSW 10 105823179 missense possibly damaging 0.53
R8415:Mettl25 UTSW 10 105826141 missense probably benign 0.05
RF009:Mettl25 UTSW 10 105833239 intron probably benign
Z1176:Mettl25 UTSW 10 105826098 missense possibly damaging 0.95
Posted On2015-04-16