Mutagenetix > Incidental Mutations

Incidental Mutation 'IGL02088:Mettl25'

279304

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Mettl25

Ensembl Gene

ENSMUSG00000036009

Gene Name

methyltransferase like 25

Synonyms

BC067068

Accession Numbers

Is this an essential gene?

Probably non essential (E-score: 0.102) question?

Stock #

IGL02088

Quality Score

Status

Chromosome

Chromosomal Location

105763189-105841380 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 105823250 bp

Zygosity

Heterozygous

Amino Acid Change

Phenylalanine to Leucine at position 391 (F391L)

Ref Sequence

ENSEMBL: ENSMUSP00000038665 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000046638] [ENSMUST00000176040] [ENSMUST00000176924]

Predicted Effect

probably damaging
Transcript: ENSMUST00000046638
AA Change: F391L

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000038665
Gene: ENSMUSG00000036009
AA Change: F391L

Domain	Start	End	E-Value	Type
Pfam:Methyltransf_32	149	413	1.9e-30	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000176040

Predicted Effect

probably benign
Transcript: ENSMUST00000176924

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 38 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Ackr4	T	C	9: 104,098,881	E289G	probably damaging	Het
Aldh1l1	A	T	6: 90,580,590		probably benign	Het
Ampd3	T	A	7: 110,793,686	D220E	probably benign	Het
Ank3	T	C	10: 69,999,373	V136A	probably damaging	Het
Atg14	T	C	14: 47,542,859	K486R	probably benign	Het
Axin1	A	G	17: 26,188,695	I637V	probably benign	Het
Axin2	T	A	11: 108,923,616	F110Y	probably damaging	Het
Cdh12	A	T	15: 21,480,339	K214*	probably null	Het
Cfap44	A	C	16: 44,451,628	E1248A	possibly damaging	Het
Cryba4	A	G	5: 112,251,009		probably benign	Het
Cyp2c68	A	G	19: 39,703,521		probably benign	Het
Dnah5	G	T	15: 28,459,118		probably null	Het
Dok3	A	T	13: 55,524,370	V165E	probably damaging	Het
Etl4	A	T	2: 20,806,548	R1147S	probably damaging	Het
Fam212a	A	G	9: 107,984,457	F220S	probably damaging	Het
Fbxl6	G	T	15: 76,535,906	C502*	probably null	Het
Gp2	A	T	7: 119,454,469	Y90N	probably damaging	Het
H1fnt	G	T	15: 98,257,178	T30K	probably damaging	Het
Itfg2	A	G	6: 128,411,606	V306A	probably benign	Het
Lrig2	T	C	3: 104,467,108	Y219C	probably damaging	Het
Mccc1	A	T	3: 35,974,202	I485N	probably damaging	Het
Muc19	C	T	15: 91,891,168		noncoding transcript	Het
Muc2	T	C	7: 141,751,504	C182R	probably damaging	Het
Nlrp4g	T	C	9: 124,350,453		noncoding transcript	Het
Nms	A	G	1: 38,939,277		probably benign	Het
Nr3c1	T	C	18: 39,424,391	N503S	probably damaging	Het
Olfr1495	T	C	19: 13,768,666	F108S	probably damaging	Het
Olfr186	A	G	16: 59,027,052	L285P	probably damaging	Het
Olfr828	C	T	9: 18,815,923	V124I	probably benign	Het
Pcdhb5	G	A	18: 37,321,959	S464N	probably benign	Het
Pcgf6	T	C	19: 47,050,804	T6A	unknown	Het
Rdx	A	G	9: 52,060,883		probably benign	Het
Shmt1	T	C	11: 60,789,653	T403A	probably damaging	Het
Slc35d1	A	G	4: 103,211,325	F148L	probably benign	Het
Tk1	A	G	11: 117,824,665		probably benign	Het
Tnks	T	A	8: 34,839,994	I1134F	possibly damaging	Het
Ttn	A	G	2: 76,726,691	V29990A	probably damaging	Het
Zcchc11	A	G	4: 108,512,218		probably benign	Het

Other mutations in Mettl25

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00310:Mettl25	APN	10	105826434	missense	probably benign
IGL00698:Mettl25	APN	10	105793340	missense	probably null	0.31
IGL00766:Mettl25	APN	10	105779582	splice site	probably benign
IGL01360:Mettl25	APN	10	105823197	missense	probably damaging	1.00
IGL01954:Mettl25	APN	10	105823207	missense	probably damaging	1.00
IGL02623:Mettl25	APN	10	105826324	missense	probably damaging	0.96
IGL03245:Mettl25	APN	10	105826497	missense	possibly damaging	0.86
IGL03134:Mettl25	UTSW	10	105826027	nonsense	probably null
R0238:Mettl25	UTSW	10	105826525	missense	probably damaging	1.00
R0238:Mettl25	UTSW	10	105826525	missense	probably damaging	1.00
R0239:Mettl25	UTSW	10	105826525	missense	probably damaging	1.00
R0239:Mettl25	UTSW	10	105826525	missense	probably damaging	1.00
R1297:Mettl25	UTSW	10	105823265	missense	probably benign	0.11
R1482:Mettl25	UTSW	10	105826590	missense	possibly damaging	0.61
R1526:Mettl25	UTSW	10	105832983	missense	possibly damaging	0.56
R1542:Mettl25	UTSW	10	105826120	missense	probably benign	0.04
R1589:Mettl25	UTSW	10	105779632	missense	probably damaging	1.00
R1901:Mettl25	UTSW	10	105826087	missense	probably damaging	0.96
R1902:Mettl25	UTSW	10	105826087	missense	probably damaging	0.96
R2016:Mettl25	UTSW	10	105797306	missense	probably benign	0.00
R2355:Mettl25	UTSW	10	105763455	missense	probably benign	0.00
R2920:Mettl25	UTSW	10	105765177	splice site	probably null
R3149:Mettl25	UTSW	10	105826353	missense	probably benign	0.00
R4547:Mettl25	UTSW	10	105826017	missense	probably damaging	1.00
R4646:Mettl25	UTSW	10	105826555	missense	probably damaging	1.00
R4652:Mettl25	UTSW	10	105779648	nonsense	probably null
R5020:Mettl25	UTSW	10	105826207	missense	possibly damaging	0.87
R5435:Mettl25	UTSW	10	105779586	critical splice donor site	probably null
R6947:Mettl25	UTSW	10	105826192	missense	probably benign	0.00
R7075:Mettl25	UTSW	10	105829924	missense	possibly damaging	0.68
R7729:Mettl25	UTSW	10	105766010	missense	probably benign	0.03
R8074:Mettl25	UTSW	10	105826080	missense	probably benign	0.02
R8108:Mettl25	UTSW	10	105823179	missense	possibly damaging	0.53
R8415:Mettl25	UTSW	10	105826141	missense	probably benign	0.05
RF009:Mettl25	UTSW	10	105833239	intron	probably benign
Z1176:Mettl25	UTSW	10	105826098	missense	possibly damaging	0.95

Posted On

2015-04-16