Mutagenetix > Incidental Mutations

Incidental Mutation 'IGL02088:Dok3'

279308

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Dok3

Ensembl Gene

ENSMUSG00000035711

Gene Name

docking protein 3

Synonyms

p62Dok-like protein

Accession Numbers

Is this an essential gene?

Probably non essential (E-score: 0.092) question?

Stock #

IGL02088

Quality Score

Status

Chromosome

Chromosomal Location

55523231-55529296 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

A to T at 55524370 bp

Zygosity

Heterozygous

Amino Acid Change

Valine to Glutamic Acid at position 165 (V165E)

Ref Sequence

ENSEMBL: ENSMUSP00000153308 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000047877] [ENSMUST00000223563]

Predicted Effect

probably damaging
Transcript: ENSMUST00000047877
AA Change: V165E

PolyPhen 2 Score 0.995 (Sensitivity: 0.68; Specificity: 0.97)

SMART Domains

Protein: ENSMUSP00000046695
Gene: ENSMUSG00000035711
AA Change: V165E

Domain	Start	End	E-Value	Type
PH	7	125	3.54e-5	SMART
IRS	157	256	1.61e-41	SMART
PTBI	158	256	2.59e-24	SMART
low complexity region	273	284	N/A	INTRINSIC
low complexity region	304	315	N/A	INTRINSIC
low complexity region	358	376	N/A	INTRINSIC
low complexity region	410	421	N/A	INTRINSIC

Predicted Effect

probably damaging
Transcript: ENSMUST00000223563
AA Change: V165E

PolyPhen 2 Score 0.995 (Sensitivity: 0.68; Specificity: 0.97)

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000223944

Coding Region Coverage

Validation Efficiency

MGI Phenotype

PHENOTYPE: Mice homozygous for a knock-out allele exhibit increased incidence of lung adenocarcinomas. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 38 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Ackr4	T	C	9: 104,098,881	E289G	probably damaging	Het
Aldh1l1	A	T	6: 90,580,590		probably benign	Het
Ampd3	T	A	7: 110,793,686	D220E	probably benign	Het
Ank3	T	C	10: 69,999,373	V136A	probably damaging	Het
Atg14	T	C	14: 47,542,859	K486R	probably benign	Het
Axin1	A	G	17: 26,188,695	I637V	probably benign	Het
Axin2	T	A	11: 108,923,616	F110Y	probably damaging	Het
Cdh12	A	T	15: 21,480,339	K214*	probably null	Het
Cfap44	A	C	16: 44,451,628	E1248A	possibly damaging	Het
Cryba4	A	G	5: 112,251,009		probably benign	Het
Cyp2c68	A	G	19: 39,703,521		probably benign	Het
Dnah5	G	T	15: 28,459,118		probably null	Het
Etl4	A	T	2: 20,806,548	R1147S	probably damaging	Het
Fam212a	A	G	9: 107,984,457	F220S	probably damaging	Het
Fbxl6	G	T	15: 76,535,906	C502*	probably null	Het
Gp2	A	T	7: 119,454,469	Y90N	probably damaging	Het
H1fnt	G	T	15: 98,257,178	T30K	probably damaging	Het
Itfg2	A	G	6: 128,411,606	V306A	probably benign	Het
Lrig2	T	C	3: 104,467,108	Y219C	probably damaging	Het
Mccc1	A	T	3: 35,974,202	I485N	probably damaging	Het
Mettl25	A	G	10: 105,823,250	F391L	probably damaging	Het
Muc19	C	T	15: 91,891,168		noncoding transcript	Het
Muc2	T	C	7: 141,751,504	C182R	probably damaging	Het
Nlrp4g	T	C	9: 124,350,453		noncoding transcript	Het
Nms	A	G	1: 38,939,277		probably benign	Het
Nr3c1	T	C	18: 39,424,391	N503S	probably damaging	Het
Olfr1495	T	C	19: 13,768,666	F108S	probably damaging	Het
Olfr186	A	G	16: 59,027,052	L285P	probably damaging	Het
Olfr828	C	T	9: 18,815,923	V124I	probably benign	Het
Pcdhb5	G	A	18: 37,321,959	S464N	probably benign	Het
Pcgf6	T	C	19: 47,050,804	T6A	unknown	Het
Rdx	A	G	9: 52,060,883		probably benign	Het
Shmt1	T	C	11: 60,789,653	T403A	probably damaging	Het
Slc35d1	A	G	4: 103,211,325	F148L	probably benign	Het
Tk1	A	G	11: 117,824,665		probably benign	Het
Tnks	T	A	8: 34,839,994	I1134F	possibly damaging	Het
Ttn	A	G	2: 76,726,691	V29990A	probably damaging	Het
Zcchc11	A	G	4: 108,512,218		probably benign	Het

Other mutations in Dok3

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01837:Dok3	APN	13	55523570	missense	probably damaging	1.00
IGL02218:Dok3	APN	13	55523786	missense	probably damaging	1.00
IGL02656:Dok3	APN	13	55528480	missense	probably damaging	0.97
IGL03410:Dok3	APN	13	55524231	nonsense	probably null
R0601:Dok3	UTSW	13	55524263	missense	probably benign	0.16
R1306:Dok3	UTSW	13	55527448	nonsense	probably null
R1749:Dok3	UTSW	13	55524355	frame shift	probably null
R3684:Dok3	UTSW	13	55524493	missense	probably damaging	1.00
R4863:Dok3	UTSW	13	55523457	missense	probably damaging	1.00
R6195:Dok3	UTSW	13	55523576	missense	probably benign	0.00
R7021:Dok3	UTSW	13	55524284	missense	probably benign	0.00
R7526:Dok3	UTSW	13	55527493	missense	probably benign	0.03
R8379:Dok3	UTSW	13	55524020	missense	probably benign

Posted On

2015-04-16