Incidental Mutation 'IGL02088:Dok3'
ID279308
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Dok3
Ensembl Gene ENSMUSG00000035711
Gene Namedocking protein 3
Synonymsp62Dok-like protein
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.092) question?
Stock #IGL02088
Quality Score
Status
Chromosome13
Chromosomal Location55523231-55529296 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) A to T at 55524370 bp
ZygosityHeterozygous
Amino Acid Change Valine to Glutamic Acid at position 165 (V165E)
Ref Sequence ENSEMBL: ENSMUSP00000153308 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000047877] [ENSMUST00000223563]
Predicted Effect probably damaging
Transcript: ENSMUST00000047877
AA Change: V165E

PolyPhen 2 Score 0.995 (Sensitivity: 0.68; Specificity: 0.97)
SMART Domains Protein: ENSMUSP00000046695
Gene: ENSMUSG00000035711
AA Change: V165E

DomainStartEndE-ValueType
PH 7 125 3.54e-5 SMART
IRS 157 256 1.61e-41 SMART
PTBI 158 256 2.59e-24 SMART
low complexity region 273 284 N/A INTRINSIC
low complexity region 304 315 N/A INTRINSIC
low complexity region 358 376 N/A INTRINSIC
low complexity region 410 421 N/A INTRINSIC
Predicted Effect probably damaging
Transcript: ENSMUST00000223563
AA Change: V165E

PolyPhen 2 Score 0.995 (Sensitivity: 0.68; Specificity: 0.97)
Predicted Effect noncoding transcript
Transcript: ENSMUST00000223944
Coding Region Coverage
Validation Efficiency
MGI Phenotype PHENOTYPE: Mice homozygous for a knock-out allele exhibit increased incidence of lung adenocarcinomas. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 38 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Ackr4 T C 9: 104,098,881 E289G probably damaging Het
Aldh1l1 A T 6: 90,580,590 probably benign Het
Ampd3 T A 7: 110,793,686 D220E probably benign Het
Ank3 T C 10: 69,999,373 V136A probably damaging Het
Atg14 T C 14: 47,542,859 K486R probably benign Het
Axin1 A G 17: 26,188,695 I637V probably benign Het
Axin2 T A 11: 108,923,616 F110Y probably damaging Het
Cdh12 A T 15: 21,480,339 K214* probably null Het
Cfap44 A C 16: 44,451,628 E1248A possibly damaging Het
Cryba4 A G 5: 112,251,009 probably benign Het
Cyp2c68 A G 19: 39,703,521 probably benign Het
Dnah5 G T 15: 28,459,118 probably null Het
Etl4 A T 2: 20,806,548 R1147S probably damaging Het
Fam212a A G 9: 107,984,457 F220S probably damaging Het
Fbxl6 G T 15: 76,535,906 C502* probably null Het
Gp2 A T 7: 119,454,469 Y90N probably damaging Het
H1fnt G T 15: 98,257,178 T30K probably damaging Het
Itfg2 A G 6: 128,411,606 V306A probably benign Het
Lrig2 T C 3: 104,467,108 Y219C probably damaging Het
Mccc1 A T 3: 35,974,202 I485N probably damaging Het
Mettl25 A G 10: 105,823,250 F391L probably damaging Het
Muc19 C T 15: 91,891,168 noncoding transcript Het
Muc2 T C 7: 141,751,504 C182R probably damaging Het
Nlrp4g T C 9: 124,350,453 noncoding transcript Het
Nms A G 1: 38,939,277 probably benign Het
Nr3c1 T C 18: 39,424,391 N503S probably damaging Het
Olfr1495 T C 19: 13,768,666 F108S probably damaging Het
Olfr186 A G 16: 59,027,052 L285P probably damaging Het
Olfr828 C T 9: 18,815,923 V124I probably benign Het
Pcdhb5 G A 18: 37,321,959 S464N probably benign Het
Pcgf6 T C 19: 47,050,804 T6A unknown Het
Rdx A G 9: 52,060,883 probably benign Het
Shmt1 T C 11: 60,789,653 T403A probably damaging Het
Slc35d1 A G 4: 103,211,325 F148L probably benign Het
Tk1 A G 11: 117,824,665 probably benign Het
Tnks T A 8: 34,839,994 I1134F possibly damaging Het
Ttn A G 2: 76,726,691 V29990A probably damaging Het
Zcchc11 A G 4: 108,512,218 probably benign Het
Other mutations in Dok3
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01837:Dok3 APN 13 55523570 missense probably damaging 1.00
IGL02218:Dok3 APN 13 55523786 missense probably damaging 1.00
IGL02656:Dok3 APN 13 55528480 missense probably damaging 0.97
IGL03410:Dok3 APN 13 55524231 nonsense probably null
R0601:Dok3 UTSW 13 55524263 missense probably benign 0.16
R1306:Dok3 UTSW 13 55527448 nonsense probably null
R1749:Dok3 UTSW 13 55524355 frame shift probably null
R3684:Dok3 UTSW 13 55524493 missense probably damaging 1.00
R4863:Dok3 UTSW 13 55523457 missense probably damaging 1.00
R6195:Dok3 UTSW 13 55523576 missense probably benign 0.00
R7021:Dok3 UTSW 13 55524284 missense probably benign 0.00
R7526:Dok3 UTSW 13 55527493 missense probably benign 0.03
R8379:Dok3 UTSW 13 55524020 missense probably benign
Posted On2015-04-16