Incidental Mutation 'IGL02088:Olfr186'
ID279310
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Olfr186
Ensembl Gene ENSMUSG00000047960
Gene Nameolfactory receptor 186
SynonymsGA_x54KRFPKG5P-55257214-55256285, MOR183-9
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.094) question?
Stock #IGL02088
Quality Score
Status
Chromosome16
Chromosomal Location59025797-59030291 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) A to G at 59027052 bp
ZygosityHeterozygous
Amino Acid Change Leucine to Proline at position 285 (L285P)
Ref Sequence ENSEMBL: ENSMUSP00000150366 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000062380] [ENSMUST00000206463] [ENSMUST00000216415]
Predicted Effect probably damaging
Transcript: ENSMUST00000062380
AA Change: L285P

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000056448
Gene: ENSMUSG00000047960
AA Change: L285P

DomainStartEndE-ValueType
Pfam:7tm_4 31 308 9.4e-49 PFAM
Pfam:7tm_1 41 290 7e-19 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000205894
Predicted Effect probably damaging
Transcript: ENSMUST00000206463
AA Change: L285P

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
Predicted Effect probably damaging
Transcript: ENSMUST00000216415
AA Change: L285P

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 38 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Ackr4 T C 9: 104,098,881 E289G probably damaging Het
Aldh1l1 A T 6: 90,580,590 probably benign Het
Ampd3 T A 7: 110,793,686 D220E probably benign Het
Ank3 T C 10: 69,999,373 V136A probably damaging Het
Atg14 T C 14: 47,542,859 K486R probably benign Het
Axin1 A G 17: 26,188,695 I637V probably benign Het
Axin2 T A 11: 108,923,616 F110Y probably damaging Het
Cdh12 A T 15: 21,480,339 K214* probably null Het
Cfap44 A C 16: 44,451,628 E1248A possibly damaging Het
Cryba4 A G 5: 112,251,009 probably benign Het
Cyp2c68 A G 19: 39,703,521 probably benign Het
Dnah5 G T 15: 28,459,118 probably null Het
Dok3 A T 13: 55,524,370 V165E probably damaging Het
Etl4 A T 2: 20,806,548 R1147S probably damaging Het
Fam212a A G 9: 107,984,457 F220S probably damaging Het
Fbxl6 G T 15: 76,535,906 C502* probably null Het
Gp2 A T 7: 119,454,469 Y90N probably damaging Het
H1fnt G T 15: 98,257,178 T30K probably damaging Het
Itfg2 A G 6: 128,411,606 V306A probably benign Het
Lrig2 T C 3: 104,467,108 Y219C probably damaging Het
Mccc1 A T 3: 35,974,202 I485N probably damaging Het
Mettl25 A G 10: 105,823,250 F391L probably damaging Het
Muc19 C T 15: 91,891,168 noncoding transcript Het
Muc2 T C 7: 141,751,504 C182R probably damaging Het
Nlrp4g T C 9: 124,350,453 noncoding transcript Het
Nms A G 1: 38,939,277 probably benign Het
Nr3c1 T C 18: 39,424,391 N503S probably damaging Het
Olfr1495 T C 19: 13,768,666 F108S probably damaging Het
Olfr828 C T 9: 18,815,923 V124I probably benign Het
Pcdhb5 G A 18: 37,321,959 S464N probably benign Het
Pcgf6 T C 19: 47,050,804 T6A unknown Het
Rdx A G 9: 52,060,883 probably benign Het
Shmt1 T C 11: 60,789,653 T403A probably damaging Het
Slc35d1 A G 4: 103,211,325 F148L probably benign Het
Tk1 A G 11: 117,824,665 probably benign Het
Tnks T A 8: 34,839,994 I1134F possibly damaging Het
Ttn A G 2: 76,726,691 V29990A probably damaging Het
Zcchc11 A G 4: 108,512,218 probably benign Het
Other mutations in Olfr186
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00951:Olfr186 APN 16 59027853 missense probably benign 0.00
IGL00969:Olfr186 APN 16 59027631 missense possibly damaging 0.48
IGL01102:Olfr186 APN 16 59027829 missense probably benign 0.03
IGL01348:Olfr186 APN 16 59027794 missense probably damaging 1.00
IGL01399:Olfr186 APN 16 59027266 missense probably benign 0.05
R0047:Olfr186 UTSW 16 59027224 missense probably benign 0.00
R0479:Olfr186 UTSW 16 59027128 missense possibly damaging 0.64
R0866:Olfr186 UTSW 16 59027428 missense probably benign
R0926:Olfr186 UTSW 16 59027688 missense possibly damaging 0.80
R1760:Olfr186 UTSW 16 59026987 missense probably benign 0.01
R1955:Olfr186 UTSW 16 59027411 missense probably damaging 0.99
R2085:Olfr186 UTSW 16 59027869 missense probably benign 0.02
R2118:Olfr186 UTSW 16 59027815 missense possibly damaging 0.78
R4156:Olfr186 UTSW 16 59027568 missense probably damaging 1.00
R4287:Olfr186 UTSW 16 59027613 missense probably benign 0.00
R4783:Olfr186 UTSW 16 59027897 missense probably benign
R4885:Olfr186 UTSW 16 59027155 missense probably damaging 1.00
R4947:Olfr186 UTSW 16 59027445 missense probably damaging 0.98
R4965:Olfr186 UTSW 16 59027333 missense probably damaging 1.00
R6314:Olfr186 UTSW 16 59027457 missense probably benign 0.18
R7624:Olfr186 UTSW 16 59027019 missense possibly damaging 0.80
R7683:Olfr186 UTSW 16 59027106 missense probably benign
R8197:Olfr186 UTSW 16 59027085 missense probably benign 0.03
Posted On2015-04-16