Incidental Mutation 'IGL02088:Olfr828'
ID279317
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Olfr828
Ensembl Gene ENSMUSG00000078116
Gene Nameolfactory receptor 828
SynonymsMOR149-1, GA_x6K02T2PVTD-12559294-12558356
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.140) question?
Stock #IGL02088
Quality Score
Status
Chromosome9
Chromosomal Location18814728-18819526 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) C to T at 18815923 bp
ZygosityHeterozygous
Amino Acid Change Valine to Isoleucine at position 124 (V124I)
Ref Sequence ENSEMBL: ENSMUSP00000148853 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000104914] [ENSMUST00000213018] [ENSMUST00000215380]
Predicted Effect probably benign
Transcript: ENSMUST00000104914
AA Change: V124I

PolyPhen 2 Score 0.030 (Sensitivity: 0.95; Specificity: 0.82)
SMART Domains Protein: ENSMUSP00000100514
Gene: ENSMUSG00000078116
AA Change: V124I

DomainStartEndE-ValueType
Pfam:7tm_4 31 310 1e-48 PFAM
Pfam:7TM_GPCR_Srsx 35 305 1.4e-5 PFAM
Pfam:7tm_1 41 290 2.1e-21 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000213018
AA Change: V124I
Predicted Effect probably benign
Transcript: ENSMUST00000215380
AA Change: V124I

PolyPhen 2 Score 0.030 (Sensitivity: 0.95; Specificity: 0.82)
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 38 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Ackr4 T C 9: 104,098,881 E289G probably damaging Het
Aldh1l1 A T 6: 90,580,590 probably benign Het
Ampd3 T A 7: 110,793,686 D220E probably benign Het
Ank3 T C 10: 69,999,373 V136A probably damaging Het
Atg14 T C 14: 47,542,859 K486R probably benign Het
Axin1 A G 17: 26,188,695 I637V probably benign Het
Axin2 T A 11: 108,923,616 F110Y probably damaging Het
Cdh12 A T 15: 21,480,339 K214* probably null Het
Cfap44 A C 16: 44,451,628 E1248A possibly damaging Het
Cryba4 A G 5: 112,251,009 probably benign Het
Cyp2c68 A G 19: 39,703,521 probably benign Het
Dnah5 G T 15: 28,459,118 probably null Het
Dok3 A T 13: 55,524,370 V165E probably damaging Het
Etl4 A T 2: 20,806,548 R1147S probably damaging Het
Fam212a A G 9: 107,984,457 F220S probably damaging Het
Fbxl6 G T 15: 76,535,906 C502* probably null Het
Gp2 A T 7: 119,454,469 Y90N probably damaging Het
H1fnt G T 15: 98,257,178 T30K probably damaging Het
Itfg2 A G 6: 128,411,606 V306A probably benign Het
Lrig2 T C 3: 104,467,108 Y219C probably damaging Het
Mccc1 A T 3: 35,974,202 I485N probably damaging Het
Mettl25 A G 10: 105,823,250 F391L probably damaging Het
Muc19 C T 15: 91,891,168 noncoding transcript Het
Muc2 T C 7: 141,751,504 C182R probably damaging Het
Nlrp4g T C 9: 124,350,453 noncoding transcript Het
Nms A G 1: 38,939,277 probably benign Het
Nr3c1 T C 18: 39,424,391 N503S probably damaging Het
Olfr1495 T C 19: 13,768,666 F108S probably damaging Het
Olfr186 A G 16: 59,027,052 L285P probably damaging Het
Pcdhb5 G A 18: 37,321,959 S464N probably benign Het
Pcgf6 T C 19: 47,050,804 T6A unknown Het
Rdx A G 9: 52,060,883 probably benign Het
Shmt1 T C 11: 60,789,653 T403A probably damaging Het
Slc35d1 A G 4: 103,211,325 F148L probably benign Het
Tk1 A G 11: 117,824,665 probably benign Het
Tnks T A 8: 34,839,994 I1134F possibly damaging Het
Ttn A G 2: 76,726,691 V29990A probably damaging Het
Zcchc11 A G 4: 108,512,218 probably benign Het
Other mutations in Olfr828
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02103:Olfr828 APN 9 18815709 missense probably damaging 1.00
IGL02792:Olfr828 APN 9 18815958 missense probably benign 0.00
IGL02964:Olfr828 APN 9 18815728 missense probably damaging 1.00
IGL03087:Olfr828 APN 9 18816084 missense probably damaging 1.00
IGL03105:Olfr828 APN 9 18815389 missense probably benign 0.03
R0330:Olfr828 UTSW 9 18815641 missense probably damaging 1.00
R0335:Olfr828 UTSW 9 18815994 missense probably damaging 1.00
R0862:Olfr828 UTSW 9 18815706 missense probably damaging 0.98
R1226:Olfr828 UTSW 9 18815970 missense probably benign 0.34
R2004:Olfr828 UTSW 9 18815505 missense probably benign 0.05
R2005:Olfr828 UTSW 9 18815505 missense probably benign 0.05
R2006:Olfr828 UTSW 9 18815505 missense probably benign 0.05
R2199:Olfr828 UTSW 9 18815923 missense probably damaging 0.97
R2230:Olfr828 UTSW 9 18815725 missense probably damaging 1.00
R2399:Olfr828 UTSW 9 18816027 missense probably benign 0.07
R5652:Olfr828 UTSW 9 18815626 missense probably damaging 1.00
R5738:Olfr828 UTSW 9 18815829 missense possibly damaging 0.81
R6416:Olfr828 UTSW 9 18815892 missense probably benign 0.21
R6813:Olfr828 UTSW 9 18815892 missense probably benign 0.21
R7092:Olfr828 UTSW 9 18816057 missense probably damaging 1.00
R7109:Olfr828 UTSW 9 18815608 missense probably benign 0.01
R7292:Olfr828 UTSW 9 18816190 missense probably damaging 1.00
R7429:Olfr828 UTSW 9 18815354 makesense probably null
R7430:Olfr828 UTSW 9 18815354 makesense probably null
R7490:Olfr828 UTSW 9 18815933 nonsense probably null
R7835:Olfr828 UTSW 9 18815809 missense probably benign 0.05
R8016:Olfr828 UTSW 9 18816292 start codon destroyed probably null 0.56
RF003:Olfr828 UTSW 9 18815482 missense probably benign 0.03
X0026:Olfr828 UTSW 9 18815763 missense possibly damaging 0.95
Z1176:Olfr828 UTSW 9 18815980 frame shift probably null
Z1177:Olfr828 UTSW 9 18816148 missense probably benign 0.09
Posted On2015-04-16