Mutagenetix > Incidental Mutations

Incidental Mutation 'IGL00978:Vmn2r70'

27934

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Vmn2r70

Ensembl Gene

ENSMUSG00000090806

Gene Name

vomeronasal 2, receptor 70

Synonyms

EG620835

Accession Numbers

Is this an essential gene?

Probably non essential (E-score: 0.152) question?

Stock #

IGL00978

Quality Score

Status

Chromosome

Chromosomal Location

85558703-85569088 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

T to G at 85563799 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Methionine to Leucine at position 467 (M467L)

Ref Sequence

ENSEMBL: ENSMUSP00000129703 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000168230]

AlphaFold

K7N702

Predicted Effect

probably benign
Transcript: ENSMUST00000168230
AA Change: M467L

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)

SMART Domains

Protein: ENSMUSP00000129703
Gene: ENSMUSG00000090806
AA Change: M467L

Domain	Start	End	E-Value	Type
signal peptide	1	23	N/A	INTRINSIC
Pfam:ANF_receptor	77	468	2.5e-28	PFAM
Pfam:NCD3G	510	562	1.5e-19	PFAM
Pfam:7tm_3	592	830	1.2e-52	PFAM

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 35 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
0610009L18Rik	T	C	11: 120,350,947		probably benign	Het
Alpk2	A	T	18: 65,291,534		probably benign	Het
Angptl8	T	C	9: 21,837,053		probably benign	Het
AU040320	T	A	4: 126,828,839	D383E	probably benign	Het
Cep97	C	T	16: 55,924,960		probably benign	Het
Clcn4	A	T	7: 7,287,673	L649H	probably damaging	Het
Col5a2	T	C	1: 45,376,739	N1416S	probably benign	Het
Erbb2	C	T	11: 98,435,630	P1027S	probably damaging	Het
Eya1	A	G	1: 14,270,701		probably benign	Het
Gfm2	T	C	13: 97,162,977	I402T	probably benign	Het
Gmeb2	A	T	2: 181,259,043	V187E	probably benign	Het
Hectd1	T	C	12: 51,791,390	H662R	possibly damaging	Het
Ifne	T	C	4: 88,880,031	Q50R	probably benign	Het
Kidins220	A	G	12: 25,057,474	D1642G	probably damaging	Het
Klhl32	T	A	4: 24,682,245	D146V	probably damaging	Het
Krt36	T	C	11: 100,102,948	I355V	probably damaging	Het
Lrrcc1	T	A	3: 14,536,128	S73R	possibly damaging	Het
Ltbp3	A	T	19: 5,754,019	H853L	probably benign	Het
Map3k5	G	A	10: 20,141,567	R1369Q	probably damaging	Het
Mcm8	A	G	2: 132,821,406	N148S	probably benign	Het
Mylk3	A	T	8: 85,355,526	L211*	probably null	Het
Nras	T	C	3: 103,058,916		probably benign	Het
Olfr135	A	T	17: 38,208,982	I246F	probably damaging	Het
Olfr670	A	T	7: 104,960,716	N5K	probably damaging	Het
Os9	A	T	10: 127,120,509	Y66N	probably damaging	Het
Pitpnm1	A	G	19: 4,101,228	D15G	possibly damaging	Het
Reg3a	A	T	6: 78,382,301	R95*	probably null	Het
Rnf17	C	T	14: 56,512,271	P1425S	probably damaging	Het
Smad2	T	C	18: 76,299,775		probably benign	Het
Ttll5	C	T	12: 85,933,482	Q76*	probably null	Het
Uri1	A	T	7: 37,996,731		probably benign	Het
Vmn2r102	G	T	17: 19,678,923		probably null	Het
Zfp318	T	A	17: 46,413,726	D2218E	possibly damaging	Het
Zfp692	T	C	11: 58,314,029	I405T	possibly damaging	Het
Zfp692	A	G	11: 58,309,998	H235R	possibly damaging	Het

Other mutations in Vmn2r70

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01140:Vmn2r70	APN	7	85565171	nonsense	probably null
IGL01287:Vmn2r70	APN	7	85569019	nonsense	probably null
IGL01581:Vmn2r70	APN	7	85563914	splice site	probably null
IGL01632:Vmn2r70	APN	7	85566072	missense	probably benign	0.00
IGL01725:Vmn2r70	APN	7	85559386	missense	probably damaging	1.00
IGL02244:Vmn2r70	APN	7	85565003	missense	probably benign
IGL02288:Vmn2r70	APN	7	85565134	missense	probably benign	0.31
IGL02313:Vmn2r70	APN	7	85565168	missense	probably damaging	0.99
IGL02591:Vmn2r70	APN	7	85564945	missense	probably damaging	0.96
IGL02725:Vmn2r70	APN	7	85565345	missense	possibly damaging	0.46
IGL02797:Vmn2r70	APN	7	85559087	missense	probably benign	0.00
R0045:Vmn2r70	UTSW	7	85566044	missense	probably damaging	1.00
R0729:Vmn2r70	UTSW	7	85565904	missense	probably benign	0.00
R0967:Vmn2r70	UTSW	7	85559619	missense	probably damaging	0.99
R1217:Vmn2r70	UTSW	7	85559061	missense	probably damaging	1.00
R1351:Vmn2r70	UTSW	7	85565054	missense	probably damaging	1.00
R1387:Vmn2r70	UTSW	7	85558761	missense	probably benign	0.12
R1483:Vmn2r70	UTSW	7	85559167	missense	probably benign	0.04
R1796:Vmn2r70	UTSW	7	85563803	nonsense	probably null
R1809:Vmn2r70	UTSW	7	85565922	missense	probably benign	0.23
R2154:Vmn2r70	UTSW	7	85563715	missense	possibly damaging	0.67
R2173:Vmn2r70	UTSW	7	85565082	missense	probably benign
R2334:Vmn2r70	UTSW	7	85559592	missense	probably benign	0.05
R2871:Vmn2r70	UTSW	7	85559019	missense	probably damaging	1.00
R2871:Vmn2r70	UTSW	7	85559019	missense	probably damaging	1.00
R3975:Vmn2r70	UTSW	7	85559332	missense	probably benign	0.00
R4525:Vmn2r70	UTSW	7	85559579	missense	probably damaging	1.00
R4527:Vmn2r70	UTSW	7	85559579	missense	probably damaging	1.00
R4535:Vmn2r70	UTSW	7	85565333	missense	probably damaging	1.00
R5181:Vmn2r70	UTSW	7	85559179	missense	probably damaging	0.99
R5600:Vmn2r70	UTSW	7	85563727	missense	probably benign	0.07
R5641:Vmn2r70	UTSW	7	85559364	missense	probably damaging	0.99
R5726:Vmn2r70	UTSW	7	85559107	missense	probably damaging	1.00
R5943:Vmn2r70	UTSW	7	85565991	missense	probably benign	0.09
R6166:Vmn2r70	UTSW	7	85565981	missense	probably benign	0.25
R6272:Vmn2r70	UTSW	7	85558986	missense	probably damaging	1.00
R6324:Vmn2r70	UTSW	7	85558879	missense	probably benign	0.01
R6429:Vmn2r70	UTSW	7	85559068	missense	probably damaging	1.00
R6449:Vmn2r70	UTSW	7	85564949	missense	probably damaging	1.00
R6512:Vmn2r70	UTSW	7	85566097	missense	probably benign
R7000:Vmn2r70	UTSW	7	85559611	missense	probably damaging	0.99
R7141:Vmn2r70	UTSW	7	85558836	missense	probably benign
R7153:Vmn2r70	UTSW	7	85565054	missense	probably damaging	1.00
R7424:Vmn2r70	UTSW	7	85563868	missense	probably damaging	1.00
R7565:Vmn2r70	UTSW	7	85565291	missense	probably benign	0.35
R7567:Vmn2r70	UTSW	7	85565035	missense	probably benign	0.41
R7593:Vmn2r70	UTSW	7	85566104	nonsense	probably null
R7660:Vmn2r70	UTSW	7	85568922	missense	probably damaging	0.99
R7806:Vmn2r70	UTSW	7	85559193	missense	probably benign
R7892:Vmn2r70	UTSW	7	85559380	missense	possibly damaging	0.58
R7965:Vmn2r70	UTSW	7	85561863	missense	probably damaging	0.96
R8052:Vmn2r70	UTSW	7	85563715	missense	probably benign
R8251:Vmn2r70	UTSW	7	85565978	nonsense	probably null
R8814:Vmn2r70	UTSW	7	85565961	missense	probably benign	0.00
R8934:Vmn2r70	UTSW	7	85561980	missense	possibly damaging	0.87
R9225:Vmn2r70	UTSW	7	85559034	missense	probably damaging	1.00
R9322:Vmn2r70	UTSW	7	85559290	missense	possibly damaging	0.92
R9430:Vmn2r70	UTSW	7	85566032	missense	probably benign	0.10
R9477:Vmn2r70	UTSW	7	85569036	missense	possibly damaging	0.50
Z1088:Vmn2r70	UTSW	7	85564760	missense	possibly damaging	0.53
Z1176:Vmn2r70	UTSW	7	85569045	missense	probably benign	0.00

Posted On

2013-04-17