Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL00978:Vmn2r70'

27934

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Vmn2r70

Ensembl Gene

ENSMUSG00000090806

Gene Name

vomeronasal 2, receptor 70

Synonyms

EG620835

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.130) question?

Stock #

IGL00978

Quality Score

Status

Chromosome

Chromosomal Location

85207911-85218296 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to G at 85213007 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Methionine to Leucine at position 467 (M467L)

Ref Sequence

ENSEMBL: ENSMUSP00000129703 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000168230]

AlphaFold

K7N702

Predicted Effect

probably benign
Transcript: ENSMUST00000168230
AA Change: M467L

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)

SMART Domains

Protein: ENSMUSP00000129703
Gene: ENSMUSG00000090806
AA Change: M467L

Domain	Start	End	E-Value	Type
signal peptide	1	23	N/A	INTRINSIC
Pfam:ANF_receptor	77	468	2.5e-28	PFAM
Pfam:NCD3G	510	562	1.5e-19	PFAM
Pfam:7tm_3	592	830	1.2e-52	PFAM

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 35 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
0610009L18Rik	T	C	11: 120,241,773 (GRCm39)		probably benign	Het
Alpk2	A	T	18: 65,424,605 (GRCm39)		probably benign	Het
Angptl8	T	C	9: 21,748,349 (GRCm39)		probably benign	Het
AU040320	T	A	4: 126,722,632 (GRCm39)	D383E	probably benign	Het
Cep97	C	T	16: 55,745,323 (GRCm39)		probably benign	Het
Clcn4	A	T	7: 7,290,672 (GRCm39)	L649H	probably damaging	Het
Col5a2	T	C	1: 45,415,899 (GRCm39)	N1416S	probably benign	Het
Erbb2	C	T	11: 98,326,456 (GRCm39)	P1027S	probably damaging	Het
Eya1	A	G	1: 14,340,925 (GRCm39)		probably benign	Het
Gfm2	T	C	13: 97,299,485 (GRCm39)	I402T	probably benign	Het
Gmeb2	A	T	2: 180,900,836 (GRCm39)	V187E	probably benign	Het
Hectd1	T	C	12: 51,838,173 (GRCm39)	H662R	possibly damaging	Het
Ifne	T	C	4: 88,798,268 (GRCm39)	Q50R	probably benign	Het
Kidins220	A	G	12: 25,107,473 (GRCm39)	D1642G	probably damaging	Het
Klhl32	T	A	4: 24,682,245 (GRCm39)	D146V	probably damaging	Het
Krt36	T	C	11: 99,993,774 (GRCm39)	I355V	probably damaging	Het
Lrrcc1	T	A	3: 14,601,188 (GRCm39)	S73R	possibly damaging	Het
Ltbp3	A	T	19: 5,804,047 (GRCm39)	H853L	probably benign	Het
Map3k5	G	A	10: 20,017,313 (GRCm39)	R1369Q	probably damaging	Het
Mcm8	A	G	2: 132,663,326 (GRCm39)	N148S	probably benign	Het
Mylk3	A	T	8: 86,082,155 (GRCm39)	L211*	probably null	Het
Nras	T	C	3: 102,966,232 (GRCm39)		probably benign	Het
Or2n1c	A	T	17: 38,519,873 (GRCm39)	I246F	probably damaging	Het
Or52e18	A	T	7: 104,609,923 (GRCm39)	N5K	probably damaging	Het
Os9	A	T	10: 126,956,378 (GRCm39)	Y66N	probably damaging	Het
Pitpnm1	A	G	19: 4,151,228 (GRCm39)	D15G	possibly damaging	Het
Reg3a	A	T	6: 78,359,284 (GRCm39)	R95*	probably null	Het
Rnf17	C	T	14: 56,749,728 (GRCm39)	P1425S	probably damaging	Het
Smad2	T	C	18: 76,432,846 (GRCm39)		probably benign	Het
Ttll5	C	T	12: 85,980,256 (GRCm39)	Q76*	probably null	Het
Uri1	A	T	7: 37,696,156 (GRCm39)		probably benign	Het
Vmn2r102	G	T	17: 19,899,185 (GRCm39)		probably null	Het
Zfp318	T	A	17: 46,724,652 (GRCm39)	D2218E	possibly damaging	Het
Zfp692	T	C	11: 58,204,855 (GRCm39)	I405T	possibly damaging	Het
Zfp692	A	G	11: 58,200,824 (GRCm39)	H235R	possibly damaging	Het

Other mutations in Vmn2r70

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01140:Vmn2r70	APN	7	85,214,379 (GRCm39)	nonsense	probably null
IGL01287:Vmn2r70	APN	7	85,218,227 (GRCm39)	nonsense	probably null
IGL01581:Vmn2r70	APN	7	85,213,122 (GRCm39)	splice site	probably null
IGL01632:Vmn2r70	APN	7	85,215,280 (GRCm39)	missense	probably benign	0.00
IGL01725:Vmn2r70	APN	7	85,208,594 (GRCm39)	missense	probably damaging	1.00
IGL02244:Vmn2r70	APN	7	85,214,211 (GRCm39)	missense	probably benign
IGL02288:Vmn2r70	APN	7	85,214,342 (GRCm39)	missense	probably benign	0.31
IGL02313:Vmn2r70	APN	7	85,214,376 (GRCm39)	missense	probably damaging	0.99
IGL02591:Vmn2r70	APN	7	85,214,153 (GRCm39)	missense	probably damaging	0.96
IGL02725:Vmn2r70	APN	7	85,214,553 (GRCm39)	missense	possibly damaging	0.46
IGL02797:Vmn2r70	APN	7	85,208,295 (GRCm39)	missense	probably benign	0.00
R0045:Vmn2r70	UTSW	7	85,215,252 (GRCm39)	missense	probably damaging	1.00
R0729:Vmn2r70	UTSW	7	85,215,112 (GRCm39)	missense	probably benign	0.00
R0967:Vmn2r70	UTSW	7	85,208,827 (GRCm39)	missense	probably damaging	0.99
R1217:Vmn2r70	UTSW	7	85,208,269 (GRCm39)	missense	probably damaging	1.00
R1351:Vmn2r70	UTSW	7	85,214,262 (GRCm39)	missense	probably damaging	1.00
R1387:Vmn2r70	UTSW	7	85,207,969 (GRCm39)	missense	probably benign	0.12
R1483:Vmn2r70	UTSW	7	85,208,375 (GRCm39)	missense	probably benign	0.04
R1796:Vmn2r70	UTSW	7	85,213,011 (GRCm39)	nonsense	probably null
R1809:Vmn2r70	UTSW	7	85,215,130 (GRCm39)	missense	probably benign	0.23
R2154:Vmn2r70	UTSW	7	85,212,923 (GRCm39)	missense	possibly damaging	0.67
R2173:Vmn2r70	UTSW	7	85,214,290 (GRCm39)	missense	probably benign
R2334:Vmn2r70	UTSW	7	85,208,800 (GRCm39)	missense	probably benign	0.05
R2871:Vmn2r70	UTSW	7	85,208,227 (GRCm39)	missense	probably damaging	1.00
R2871:Vmn2r70	UTSW	7	85,208,227 (GRCm39)	missense	probably damaging	1.00
R3975:Vmn2r70	UTSW	7	85,208,540 (GRCm39)	missense	probably benign	0.00
R4525:Vmn2r70	UTSW	7	85,208,787 (GRCm39)	missense	probably damaging	1.00
R4527:Vmn2r70	UTSW	7	85,208,787 (GRCm39)	missense	probably damaging	1.00
R4535:Vmn2r70	UTSW	7	85,214,541 (GRCm39)	missense	probably damaging	1.00
R5181:Vmn2r70	UTSW	7	85,208,387 (GRCm39)	missense	probably damaging	0.99
R5600:Vmn2r70	UTSW	7	85,212,935 (GRCm39)	missense	probably benign	0.07
R5641:Vmn2r70	UTSW	7	85,208,572 (GRCm39)	missense	probably damaging	0.99
R5726:Vmn2r70	UTSW	7	85,208,315 (GRCm39)	missense	probably damaging	1.00
R5943:Vmn2r70	UTSW	7	85,215,199 (GRCm39)	missense	probably benign	0.09
R6166:Vmn2r70	UTSW	7	85,215,189 (GRCm39)	missense	probably benign	0.25
R6272:Vmn2r70	UTSW	7	85,208,194 (GRCm39)	missense	probably damaging	1.00
R6324:Vmn2r70	UTSW	7	85,208,087 (GRCm39)	missense	probably benign	0.01
R6429:Vmn2r70	UTSW	7	85,208,276 (GRCm39)	missense	probably damaging	1.00
R6449:Vmn2r70	UTSW	7	85,214,157 (GRCm39)	missense	probably damaging	1.00
R6512:Vmn2r70	UTSW	7	85,215,305 (GRCm39)	missense	probably benign
R7000:Vmn2r70	UTSW	7	85,208,819 (GRCm39)	missense	probably damaging	0.99
R7141:Vmn2r70	UTSW	7	85,208,044 (GRCm39)	missense	probably benign
R7153:Vmn2r70	UTSW	7	85,214,262 (GRCm39)	missense	probably damaging	1.00
R7424:Vmn2r70	UTSW	7	85,213,076 (GRCm39)	missense	probably damaging	1.00
R7565:Vmn2r70	UTSW	7	85,214,499 (GRCm39)	missense	probably benign	0.35
R7567:Vmn2r70	UTSW	7	85,214,243 (GRCm39)	missense	probably benign	0.41
R7593:Vmn2r70	UTSW	7	85,215,312 (GRCm39)	nonsense	probably null
R7660:Vmn2r70	UTSW	7	85,218,130 (GRCm39)	missense	probably damaging	0.99
R7806:Vmn2r70	UTSW	7	85,208,401 (GRCm39)	missense	probably benign
R7892:Vmn2r70	UTSW	7	85,208,588 (GRCm39)	missense	possibly damaging	0.58
R7965:Vmn2r70	UTSW	7	85,211,071 (GRCm39)	missense	probably damaging	0.96
R8052:Vmn2r70	UTSW	7	85,212,923 (GRCm39)	missense	probably benign
R8251:Vmn2r70	UTSW	7	85,215,186 (GRCm39)	nonsense	probably null
R8814:Vmn2r70	UTSW	7	85,215,169 (GRCm39)	missense	probably benign	0.00
R8934:Vmn2r70	UTSW	7	85,211,188 (GRCm39)	missense	possibly damaging	0.87
R9225:Vmn2r70	UTSW	7	85,208,242 (GRCm39)	missense	probably damaging	1.00
R9322:Vmn2r70	UTSW	7	85,208,498 (GRCm39)	missense	possibly damaging	0.92
R9430:Vmn2r70	UTSW	7	85,215,240 (GRCm39)	missense	probably benign	0.10
R9477:Vmn2r70	UTSW	7	85,218,244 (GRCm39)	missense	possibly damaging	0.50
Z1088:Vmn2r70	UTSW	7	85,213,968 (GRCm39)	missense	possibly damaging	0.53
Z1176:Vmn2r70	UTSW	7	85,218,253 (GRCm39)	missense	probably benign	0.00

Posted On

2013-04-17