Incidental Mutation 'IGL02089:Olfr981'
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ID279341
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Olfr981
Ensembl Gene ENSMUSG00000046678
Gene Nameolfactory receptor 981
SynonymsMOR223-8, GA_x6K02T2PVTD-33720892-33721824
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.207) question?
Stock #IGL02089
Quality Score
Status
Chromosome9
Chromosomal Location40021464-40030377 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) A to T at 40022770 bp
ZygosityHeterozygous
Amino Acid Change Isoleucine to Phenylalanine at position 126 (I126F)
Ref Sequence ENSEMBL: ENSMUSP00000149436 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000059859] [ENSMUST00000215956]
Predicted Effect probably damaging
Transcript: ENSMUST00000059859
AA Change: I126F

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000057952
Gene: ENSMUSG00000046678
AA Change: I126F

DomainStartEndE-ValueType
Pfam:7tm_4 31 304 1.4e-54 PFAM
Pfam:7tm_1 41 288 8.8e-21 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000215956
AA Change: I126F

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
Predicted Effect noncoding transcript
Transcript: ENSMUST00000219526
Predicted Effect noncoding transcript
Transcript: ENSMUST00000220338
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 52 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
9330160F10Rik C T 11: 69,060,187 silent Het
Adck1 G T 12: 88,446,710 V271F probably damaging Het
Aggf1 T C 13: 95,370,929 D116G probably benign Het
Anapc1 A T 2: 128,663,933 V661E probably damaging Het
Apoa5 T C 9: 46,269,139 probably null Het
Atp8a2 C T 14: 60,026,920 probably null Het
Bnipl A T 3: 95,250,266 probably benign Het
Cbs T G 17: 31,615,545 D490A probably benign Het
Chrdl1 G T X: 143,303,514 H199N possibly damaging Het
D3Ertd254e T C 3: 36,164,728 F300S possibly damaging Het
Dcaf1 C T 9: 106,863,111 T1232I probably benign Het
Ddx19b T C 8: 111,008,845 probably benign Het
Ephb4 A G 5: 137,370,762 K805E probably damaging Het
Ergic3 A G 2: 156,010,475 N135D probably benign Het
Fbxw18 C T 9: 109,701,322 V74I probably benign Het
Fmo4 G T 1: 162,799,080 T299N probably benign Het
Gmeb1 T C 4: 132,225,836 K540E probably damaging Het
H60c T A 10: 3,259,826 S154C possibly damaging Het
Herc1 T C 9: 66,480,869 L3812S probably damaging Het
Hipk3 T C 2: 104,431,379 D937G probably damaging Het
Ift122 A G 6: 115,925,437 D1079G probably benign Het
Il6st T C 13: 112,495,240 W438R probably benign Het
Lypla2 C T 4: 135,969,621 V117I probably benign Het
Mapk8ip1 T C 2: 92,385,875 Y516C probably damaging Het
Mmp24 G A 2: 155,812,293 G397D probably damaging Het
Muc4 G A 16: 32,751,313 S397N possibly damaging Het
Muc5b T G 7: 141,863,250 V3311G probably benign Het
Naca A G 10: 128,036,489 probably benign Het
Nrxn1 A G 17: 91,088,401 V109A probably benign Het
Nup210 T G 6: 91,076,698 D279A probably benign Het
Olfr1097 A G 2: 86,891,116 S20P possibly damaging Het
Pappa T A 4: 65,156,124 V305E possibly damaging Het
Pcdh19 A T X: 133,588,496 M977K probably benign Het
Pdzph1 T A 17: 58,967,339 I837F possibly damaging Het
Phip A T 9: 82,871,319 L1791M probably damaging Het
Pkdrej C T 15: 85,816,288 V1816I possibly damaging Het
Ptprz1 G A 6: 23,033,448 V1063M probably damaging Het
Qprt A T 7: 127,108,356 M220K probably damaging Het
R3hcc1 T C 14: 69,700,026 K391E possibly damaging Het
Rbbp7 C A X: 162,771,056 P162Q probably benign Het
Rev3l A T 10: 39,825,099 N1864I probably damaging Het
Rims1 A G 1: 22,630,475 I84T possibly damaging Het
Rnase2b A T 14: 51,162,783 K107I probably benign Het
Sbf1 C A 15: 89,302,505 E864* probably null Het
Strip2 G A 6: 29,917,180 probably benign Het
Stx4a T C 7: 127,848,398 I238T probably damaging Het
Tbc1d2b C T 9: 90,222,359 V577I possibly damaging Het
Tex38 T C 4: 115,780,394 T71A possibly damaging Het
Usp38 T C 8: 80,985,714 E564G possibly damaging Het
Vmn2r72 A T 7: 85,738,166 V730E probably benign Het
Wwp2 T A 8: 107,554,057 L644Q probably damaging Het
Zpld1 A G 16: 55,251,611 I95T probably benign Het
Other mutations in Olfr981
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01481:Olfr981 APN 9 40023278 missense possibly damaging 0.61
R0722:Olfr981 UTSW 9 40022999 missense probably damaging 1.00
R1117:Olfr981 UTSW 9 40022762 missense probably damaging 0.99
R1781:Olfr981 UTSW 9 40023245 missense probably damaging 1.00
R1874:Olfr981 UTSW 9 40022855 missense possibly damaging 0.86
R1893:Olfr981 UTSW 9 40022974 missense possibly damaging 0.64
R1942:Olfr981 UTSW 9 40022735 missense probably damaging 1.00
R1942:Olfr981 UTSW 9 40022752 missense probably damaging 1.00
R1999:Olfr981 UTSW 9 40022689 missense probably benign
R2000:Olfr981 UTSW 9 40022689 missense probably benign
R2173:Olfr981 UTSW 9 40023254 missense probably damaging 0.97
R2760:Olfr981 UTSW 9 40022396 start codon destroyed probably null 0.00
R4300:Olfr981 UTSW 9 40023139 missense probably benign 0.02
R4530:Olfr981 UTSW 9 40023293 missense probably benign
R4614:Olfr981 UTSW 9 40022959 missense probably damaging 1.00
R4661:Olfr981 UTSW 9 40022527 missense probably damaging 1.00
R4777:Olfr981 UTSW 9 40022698 missense possibly damaging 0.90
R5017:Olfr981 UTSW 9 40022376 start gained probably benign
R5065:Olfr981 UTSW 9 40023250 missense probably benign 0.44
R5467:Olfr981 UTSW 9 40022437 missense probably benign 0.00
R5668:Olfr981 UTSW 9 40022668 missense probably damaging 1.00
R5687:Olfr981 UTSW 9 40022435 missense probably damaging 1.00
R6432:Olfr981 UTSW 9 40022528 missense probably damaging 1.00
R6620:Olfr981 UTSW 9 40022929 missense probably damaging 1.00
R6992:Olfr981 UTSW 9 40022600 nonsense probably null
R7156:Olfr981 UTSW 9 40023230 missense probably benign 0.23
R7250:Olfr981 UTSW 9 40022754 nonsense probably null
R7273:Olfr981 UTSW 9 40022665 missense probably benign 0.04
R8006:Olfr981 UTSW 9 40022474 missense not run
Posted On2015-04-16