Incidental Mutation 'IGL02089:Lypla2'
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ID279359
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Lypla2
Ensembl Gene ENSMUSG00000028670
Gene Namelysophospholipase 2
Synonymslysophospholipase II, LysoII
Accession Numbers
Is this an essential gene? Possibly non essential (E-score: 0.261) question?
Stock #IGL02089
Quality Score
Status
Chromosome4
Chromosomal Location135968224-135972626 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) C to T at 135969621 bp
ZygosityHeterozygous
Amino Acid Change Valine to Isoleucine at position 117 (V117I)
Ref Sequence ENSEMBL: ENSMUSP00000101478 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000067567] [ENSMUST00000102540] [ENSMUST00000102541] [ENSMUST00000105852] [ENSMUST00000143304] [ENSMUST00000149636]
Predicted Effect probably benign
Transcript: ENSMUST00000067567
AA Change: V117I

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
SMART Domains Protein: ENSMUSP00000064204
Gene: ENSMUSG00000028670
AA Change: V117I

DomainStartEndE-ValueType
Pfam:Abhydrolase_2 11 228 4.8e-89 PFAM
Pfam:Abhydrolase_5 26 211 2.6e-12 PFAM
Pfam:Abhydrolase_6 27 167 6.5e-13 PFAM
Pfam:Abhydrolase_3 80 170 3.1e-7 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000102540
SMART Domains Protein: ENSMUSP00000099599
Gene: ENSMUSG00000028671

DomainStartEndE-ValueType
Pfam:RmlD_sub_bind 1 194 1.9e-14 PFAM
Pfam:adh_short 2 142 4.4e-14 PFAM
Pfam:KR 3 146 3.6e-10 PFAM
Pfam:Polysacc_synt_2 4 193 8.8e-14 PFAM
Pfam:NAD_binding_10 4 213 1.1e-11 PFAM
Pfam:Epimerase 4 269 3.7e-55 PFAM
Pfam:3Beta_HSD 5 171 3.6e-18 PFAM
Pfam:NAD_binding_4 6 230 1.6e-11 PFAM
Pfam:Epimerase_Csub 282 343 3.1e-33 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000102541
SMART Domains Protein: ENSMUSP00000099600
Gene: ENSMUSG00000028671

DomainStartEndE-ValueType
Pfam:RmlD_sub_bind 1 184 3.5e-14 PFAM
Pfam:KR 3 144 9.5e-10 PFAM
Pfam:Polysacc_synt_2 4 193 7.6e-14 PFAM
Pfam:Epimerase 4 269 3.5e-54 PFAM
Pfam:3Beta_HSD 5 172 2e-18 PFAM
Pfam:GDP_Man_Dehyd 5 332 2.5e-60 PFAM
Pfam:NAD_binding_4 62 233 2.5e-7 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000105852
AA Change: V117I

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
SMART Domains Protein: ENSMUSP00000101478
Gene: ENSMUSG00000028670
AA Change: V117I

DomainStartEndE-ValueType
Pfam:Abhydrolase_2 11 228 2.3e-92 PFAM
Pfam:Abhydrolase_5 26 211 3.1e-12 PFAM
Pfam:Abhydrolase_6 27 225 1.2e-7 PFAM
Pfam:DLH 85 223 4.8e-8 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000128929
Predicted Effect probably benign
Transcript: ENSMUST00000143304
SMART Domains Protein: ENSMUSP00000119514
Gene: ENSMUSG00000028671

DomainStartEndE-ValueType
Pfam:Epimerase 4 55 1.2e-8 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000145350
Predicted Effect probably benign
Transcript: ENSMUST00000149636
SMART Domains Protein: ENSMUSP00000117923
Gene: ENSMUSG00000028671

DomainStartEndE-ValueType
Pfam:Epimerase 4 58 1.3e-8 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000150430
Predicted Effect noncoding transcript
Transcript: ENSMUST00000150978
Predicted Effect noncoding transcript
Transcript: ENSMUST00000153542
Predicted Effect noncoding transcript
Transcript: ENSMUST00000156948
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] Lysophospholipases are enzymes that act on biological membranes to regulate the multifunctional lysophospholipids. There are alternatively spliced transcript variants described for this gene but the full length nature is not known yet. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 52 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
9330160F10Rik C T 11: 69,060,187 silent Het
Adck1 G T 12: 88,446,710 V271F probably damaging Het
Aggf1 T C 13: 95,370,929 D116G probably benign Het
Anapc1 A T 2: 128,663,933 V661E probably damaging Het
Apoa5 T C 9: 46,269,139 probably null Het
Atp8a2 C T 14: 60,026,920 probably null Het
Bnipl A T 3: 95,250,266 probably benign Het
Cbs T G 17: 31,615,545 D490A probably benign Het
Chrdl1 G T X: 143,303,514 H199N possibly damaging Het
D3Ertd254e T C 3: 36,164,728 F300S possibly damaging Het
Dcaf1 C T 9: 106,863,111 T1232I probably benign Het
Ddx19b T C 8: 111,008,845 probably benign Het
Ephb4 A G 5: 137,370,762 K805E probably damaging Het
Ergic3 A G 2: 156,010,475 N135D probably benign Het
Fbxw18 C T 9: 109,701,322 V74I probably benign Het
Fmo4 G T 1: 162,799,080 T299N probably benign Het
Gmeb1 T C 4: 132,225,836 K540E probably damaging Het
H60c T A 10: 3,259,826 S154C possibly damaging Het
Herc1 T C 9: 66,480,869 L3812S probably damaging Het
Hipk3 T C 2: 104,431,379 D937G probably damaging Het
Ift122 A G 6: 115,925,437 D1079G probably benign Het
Il6st T C 13: 112,495,240 W438R probably benign Het
Mapk8ip1 T C 2: 92,385,875 Y516C probably damaging Het
Mmp24 G A 2: 155,812,293 G397D probably damaging Het
Muc4 G A 16: 32,751,313 S397N possibly damaging Het
Muc5b T G 7: 141,863,250 V3311G probably benign Het
Naca A G 10: 128,036,489 probably benign Het
Nrxn1 A G 17: 91,088,401 V109A probably benign Het
Nup210 T G 6: 91,076,698 D279A probably benign Het
Olfr1097 A G 2: 86,891,116 S20P possibly damaging Het
Olfr981 A T 9: 40,022,770 I126F probably damaging Het
Pappa T A 4: 65,156,124 V305E possibly damaging Het
Pcdh19 A T X: 133,588,496 M977K probably benign Het
Pdzph1 T A 17: 58,967,339 I837F possibly damaging Het
Phip A T 9: 82,871,319 L1791M probably damaging Het
Pkdrej C T 15: 85,816,288 V1816I possibly damaging Het
Ptprz1 G A 6: 23,033,448 V1063M probably damaging Het
Qprt A T 7: 127,108,356 M220K probably damaging Het
R3hcc1 T C 14: 69,700,026 K391E possibly damaging Het
Rbbp7 C A X: 162,771,056 P162Q probably benign Het
Rev3l A T 10: 39,825,099 N1864I probably damaging Het
Rims1 A G 1: 22,630,475 I84T possibly damaging Het
Rnase2b A T 14: 51,162,783 K107I probably benign Het
Sbf1 C A 15: 89,302,505 E864* probably null Het
Strip2 G A 6: 29,917,180 probably benign Het
Stx4a T C 7: 127,848,398 I238T probably damaging Het
Tbc1d2b C T 9: 90,222,359 V577I possibly damaging Het
Tex38 T C 4: 115,780,394 T71A possibly damaging Het
Usp38 T C 8: 80,985,714 E564G possibly damaging Het
Vmn2r72 A T 7: 85,738,166 V730E probably benign Het
Wwp2 T A 8: 107,554,057 L644Q probably damaging Het
Zpld1 A G 16: 55,251,611 I95T probably benign Het
Other mutations in Lypla2
AlleleSourceChrCoordTypePredicted EffectPPH Score
R1353:Lypla2 UTSW 4 135970467 missense probably null 0.15
R2171:Lypla2 UTSW 4 135970604 splice site probably null
R4177:Lypla2 UTSW 4 135969092 unclassified probably benign
R6692:Lypla2 UTSW 4 135970862 missense probably benign 0.00
R8074:Lypla2 UTSW 4 135969801 critical splice donor site unknown
X0024:Lypla2 UTSW 4 135969175 missense probably damaging 1.00
Posted On2015-04-16