Incidental Mutation 'IGL02089:Zpld1'
ID279374
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Zpld1
Ensembl Gene ENSMUSG00000064310
Gene Namezona pellucida like domain containing 1
Synonyms
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.076) question?
Stock #IGL02089
Quality Score
Status
Chromosome16
Chromosomal Location55225175-55297986 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) A to G at 55251611 bp
ZygosityHeterozygous
Amino Acid Change Isoleucine to Threonine at position 95 (I95T)
Ref Sequence ENSEMBL: ENSMUSP00000119774 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000036412] [ENSMUST00000143914]
Predicted Effect probably benign
Transcript: ENSMUST00000036412
AA Change: I95T

PolyPhen 2 Score 0.003 (Sensitivity: 0.98; Specificity: 0.44)
SMART Domains Protein: ENSMUSP00000049012
Gene: ENSMUSG00000064310
AA Change: I95T

DomainStartEndE-ValueType
signal peptide 1 19 N/A INTRINSIC
ZP 43 316 2.24e-6 SMART
transmembrane domain 374 396 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000143914
AA Change: I95T

PolyPhen 2 Score 0.003 (Sensitivity: 0.98; Specificity: 0.44)
SMART Domains Protein: ENSMUSP00000119774
Gene: ENSMUSG00000064310
AA Change: I95T

DomainStartEndE-ValueType
signal peptide 1 19 N/A INTRINSIC
ZP 43 316 2.24e-6 SMART
transmembrane domain 374 396 N/A INTRINSIC
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 52 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
9330160F10Rik C T 11: 69,060,187 silent Het
Adck1 G T 12: 88,446,710 V271F probably damaging Het
Aggf1 T C 13: 95,370,929 D116G probably benign Het
Anapc1 A T 2: 128,663,933 V661E probably damaging Het
Apoa5 T C 9: 46,269,139 probably null Het
Atp8a2 C T 14: 60,026,920 probably null Het
Bnipl A T 3: 95,250,266 probably benign Het
Cbs T G 17: 31,615,545 D490A probably benign Het
Chrdl1 G T X: 143,303,514 H199N possibly damaging Het
D3Ertd254e T C 3: 36,164,728 F300S possibly damaging Het
Dcaf1 C T 9: 106,863,111 T1232I probably benign Het
Ddx19b T C 8: 111,008,845 probably benign Het
Ephb4 A G 5: 137,370,762 K805E probably damaging Het
Ergic3 A G 2: 156,010,475 N135D probably benign Het
Fbxw18 C T 9: 109,701,322 V74I probably benign Het
Fmo4 G T 1: 162,799,080 T299N probably benign Het
Gmeb1 T C 4: 132,225,836 K540E probably damaging Het
H60c T A 10: 3,259,826 S154C possibly damaging Het
Herc1 T C 9: 66,480,869 L3812S probably damaging Het
Hipk3 T C 2: 104,431,379 D937G probably damaging Het
Ift122 A G 6: 115,925,437 D1079G probably benign Het
Il6st T C 13: 112,495,240 W438R probably benign Het
Lypla2 C T 4: 135,969,621 V117I probably benign Het
Mapk8ip1 T C 2: 92,385,875 Y516C probably damaging Het
Mmp24 G A 2: 155,812,293 G397D probably damaging Het
Muc4 G A 16: 32,751,313 S397N possibly damaging Het
Muc5b T G 7: 141,863,250 V3311G probably benign Het
Naca A G 10: 128,036,489 probably benign Het
Nrxn1 A G 17: 91,088,401 V109A probably benign Het
Nup210 T G 6: 91,076,698 D279A probably benign Het
Olfr1097 A G 2: 86,891,116 S20P possibly damaging Het
Olfr981 A T 9: 40,022,770 I126F probably damaging Het
Pappa T A 4: 65,156,124 V305E possibly damaging Het
Pcdh19 A T X: 133,588,496 M977K probably benign Het
Pdzph1 T A 17: 58,967,339 I837F possibly damaging Het
Phip A T 9: 82,871,319 L1791M probably damaging Het
Pkdrej C T 15: 85,816,288 V1816I possibly damaging Het
Ptprz1 G A 6: 23,033,448 V1063M probably damaging Het
Qprt A T 7: 127,108,356 M220K probably damaging Het
R3hcc1 T C 14: 69,700,026 K391E possibly damaging Het
Rbbp7 C A X: 162,771,056 P162Q probably benign Het
Rev3l A T 10: 39,825,099 N1864I probably damaging Het
Rims1 A G 1: 22,630,475 I84T possibly damaging Het
Rnase2b A T 14: 51,162,783 K107I probably benign Het
Sbf1 C A 15: 89,302,505 E864* probably null Het
Strip2 G A 6: 29,917,180 probably benign Het
Stx4a T C 7: 127,848,398 I238T probably damaging Het
Tbc1d2b C T 9: 90,222,359 V577I possibly damaging Het
Tex38 T C 4: 115,780,394 T71A possibly damaging Het
Usp38 T C 8: 80,985,714 E564G possibly damaging Het
Vmn2r72 A T 7: 85,738,166 V730E probably benign Het
Wwp2 T A 8: 107,554,057 L644Q probably damaging Het
Other mutations in Zpld1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01360:Zpld1 APN 16 55226385 missense probably benign 0.10
IGL01380:Zpld1 APN 16 55251770 missense probably damaging 0.99
IGL03350:Zpld1 APN 16 55241329 splice site probably benign
whirl UTSW 16 55233630 missense probably damaging 1.00
R0324:Zpld1 UTSW 16 55251615 missense probably damaging 1.00
R1296:Zpld1 UTSW 16 55248334 missense probably damaging 0.99
R1500:Zpld1 UTSW 16 55233572 missense probably damaging 0.97
R3712:Zpld1 UTSW 16 55226436 nonsense probably null
R4096:Zpld1 UTSW 16 55233518 missense probably damaging 1.00
R4835:Zpld1 UTSW 16 55248255 missense probably damaging 0.99
R5153:Zpld1 UTSW 16 55246644 missense probably damaging 1.00
R5412:Zpld1 UTSW 16 55232283 missense possibly damaging 0.72
R5527:Zpld1 UTSW 16 55226362 missense probably benign 0.06
R5537:Zpld1 UTSW 16 55233640 missense possibly damaging 0.84
R6167:Zpld1 UTSW 16 55233599 missense probably damaging 1.00
R6178:Zpld1 UTSW 16 55233630 missense probably damaging 1.00
R6788:Zpld1 UTSW 16 55232240 missense possibly damaging 0.93
R6877:Zpld1 UTSW 16 55251671 missense probably damaging 0.99
R7165:Zpld1 UTSW 16 55232231 missense probably benign 0.03
R7382:Zpld1 UTSW 16 55246683 critical splice acceptor site probably null
R7423:Zpld1 UTSW 16 55233664 missense probably damaging 1.00
Posted On2015-04-16