Mutagenetix > Incidental Mutations

Incidental Mutation 'IGL02094:Tas2r109'

279543

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Tas2r109

Ensembl Gene

ENSMUSG00000062528

Gene Name

taste receptor, type 2, member 109

Synonyms

mt2r62, T2R09, Tas2r9, mGR09

Accession Numbers

Is this an essential gene?

Probably non essential (E-score: 0.049) question?

Stock #

IGL02094

Quality Score

Status

Chromosome

Chromosomal Location

132980015-132980965 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

T to A at 132980239 bp

Zygosity

Heterozygous

Amino Acid Change

Isoleucine to Phenylalanine at position 243 (I243F)

Ref Sequence

ENSEMBL: ENSMUSP00000069300 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000067539]

Predicted Effect

possibly damaging
Transcript: ENSMUST00000067539
AA Change: I243F

PolyPhen 2 Score 0.784 (Sensitivity: 0.85; Specificity: 0.93)

SMART Domains

Protein: ENSMUSP00000069300
Gene: ENSMUSG00000062528
AA Change: I243F

Domain	Start	End	E-Value	Type
Pfam:TAS2R	9	309	4.3e-81	PFAM

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 34 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Adam29	T	C	8: 55,871,445	N658S	possibly damaging	Het
Adcy10	T	C	1: 165,570,620	Y1429H	probably damaging	Het
Aebp1	G	A	11: 5,868,357	M98I	probably benign	Het
Arl3	T	C	19: 46,558,341	D15G	probably benign	Het
Casp2	T	A	6: 42,280,359	I414N	probably damaging	Het
Ceacam1	T	C	7: 25,474,543	D229G	probably damaging	Het
Cog7	G	T	7: 121,963,247	A234E	probably benign	Het
Csgalnact1	C	A	8: 68,401,492	G219V	probably damaging	Het
Cyp3a59	A	T	5: 146,104,821	T392S	probably benign	Het
Ebf2	G	A	14: 67,235,240	V36M	possibly damaging	Het
Fbxw15	A	C	9: 109,558,240	V229G	possibly damaging	Het
Got1l1	A	G	8: 27,199,845	V171A	probably benign	Het
Itgax	A	G	7: 128,131,473	Y121C	probably damaging	Het
Kcng4	C	A	8: 119,633,221	A139S	probably damaging	Het
Kcnj9	G	T	1: 172,325,708	T283K	probably damaging	Het
Mgl2	T	A	11: 70,137,097	I377K	possibly damaging	Het
Myo15	T	C	11: 60,510,647		probably benign	Het
Nod1	A	T	6: 54,939,390		probably null	Het
Nr1h5	A	T	3: 102,952,196	C182*	probably null	Het
Nup210l	G	T	3: 90,180,213		probably null	Het
Ptbp2	G	A	3: 119,752,940		probably benign	Het
Ptpn13	T	G	5: 103,594,617	F2401V	probably damaging	Het
Rbbp6	T	C	7: 122,997,262	S676P	probably damaging	Het
Recql4	T	A	15: 76,709,517	Q131L	probably benign	Het
Sbno2	G	A	10: 80,057,645	P1274L	probably benign	Het
Sec24c	T	C	14: 20,688,402	V341A	probably damaging	Het
Smc1b	A	T	15: 85,097,891		probably benign	Het
Sptbn1	T	C	11: 30,100,659	H2310R	probably benign	Het
Trpc1	A	C	9: 95,743,281	D97E	probably damaging	Het
Trpm2	G	A	10: 77,942,996	Q379*	probably null	Het
Ttn	A	G	2: 76,818,823		probably benign	Het
Vmn2r74	A	T	7: 85,961,461	F8I	probably benign	Het
Zfp36	C	T	7: 28,377,763	S240N	probably benign	Het
Zfp65	A	G	13: 67,708,185	I325T	possibly damaging	Het

Other mutations in Tas2r109

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00467:Tas2r109	APN	6	132980023	missense	probably benign	0.04
IGL01837:Tas2r109	APN	6	132980514	missense	probably benign	0.27
R0788:Tas2r109	UTSW	6	132980301	missense	probably benign	0.01
R0849:Tas2r109	UTSW	6	132980893	missense	probably benign	0.00
R1542:Tas2r109	UTSW	6	132980910	missense	possibly damaging	0.93
R1583:Tas2r109	UTSW	6	132980426	missense	probably benign	0.01
R2035:Tas2r109	UTSW	6	132980460	missense	probably benign
R3845:Tas2r109	UTSW	6	132980803	missense	probably damaging	0.99
R4060:Tas2r109	UTSW	6	132980185	missense	probably damaging	1.00
R4355:Tas2r109	UTSW	6	132980181	missense	probably benign
R5353:Tas2r109	UTSW	6	132980631	missense	possibly damaging	0.61
R5860:Tas2r109	UTSW	6	132980701	missense	probably benign	0.06
R6211:Tas2r109	UTSW	6	132980624	nonsense	probably null
R6378:Tas2r109	UTSW	6	132980881	missense	probably benign	0.00
R6861:Tas2r109	UTSW	6	132980085	missense	probably benign	0.43
R7319:Tas2r109	UTSW	6	132980700	missense	probably benign	0.33
R8553:Tas2r109	UTSW	6	132980208	missense	probably benign	0.33
Z1088:Tas2r109	UTSW	6	132980301	missense	probably benign	0.07

Posted On

2015-04-16