Incidental Mutation 'IGL02094:Tas2r109'
ID279543
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Tas2r109
Ensembl Gene ENSMUSG00000062528
Gene Nametaste receptor, type 2, member 109
Synonymsmt2r62, T2R09, Tas2r9, mGR09
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.049) question?
Stock #IGL02094
Quality Score
Status
Chromosome6
Chromosomal Location132980015-132980965 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) T to A at 132980239 bp
ZygosityHeterozygous
Amino Acid Change Isoleucine to Phenylalanine at position 243 (I243F)
Ref Sequence ENSEMBL: ENSMUSP00000069300 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000067539]
Predicted Effect possibly damaging
Transcript: ENSMUST00000067539
AA Change: I243F

PolyPhen 2 Score 0.784 (Sensitivity: 0.85; Specificity: 0.93)
SMART Domains Protein: ENSMUSP00000069300
Gene: ENSMUSG00000062528
AA Change: I243F

DomainStartEndE-ValueType
Pfam:TAS2R 9 309 4.3e-81 PFAM
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 34 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adam29 T C 8: 55,871,445 N658S possibly damaging Het
Adcy10 T C 1: 165,570,620 Y1429H probably damaging Het
Aebp1 G A 11: 5,868,357 M98I probably benign Het
Arl3 T C 19: 46,558,341 D15G probably benign Het
Casp2 T A 6: 42,280,359 I414N probably damaging Het
Ceacam1 T C 7: 25,474,543 D229G probably damaging Het
Cog7 G T 7: 121,963,247 A234E probably benign Het
Csgalnact1 C A 8: 68,401,492 G219V probably damaging Het
Cyp3a59 A T 5: 146,104,821 T392S probably benign Het
Ebf2 G A 14: 67,235,240 V36M possibly damaging Het
Fbxw15 A C 9: 109,558,240 V229G possibly damaging Het
Got1l1 A G 8: 27,199,845 V171A probably benign Het
Itgax A G 7: 128,131,473 Y121C probably damaging Het
Kcng4 C A 8: 119,633,221 A139S probably damaging Het
Kcnj9 G T 1: 172,325,708 T283K probably damaging Het
Mgl2 T A 11: 70,137,097 I377K possibly damaging Het
Myo15 T C 11: 60,510,647 probably benign Het
Nod1 A T 6: 54,939,390 probably null Het
Nr1h5 A T 3: 102,952,196 C182* probably null Het
Nup210l G T 3: 90,180,213 probably null Het
Ptbp2 G A 3: 119,752,940 probably benign Het
Ptpn13 T G 5: 103,594,617 F2401V probably damaging Het
Rbbp6 T C 7: 122,997,262 S676P probably damaging Het
Recql4 T A 15: 76,709,517 Q131L probably benign Het
Sbno2 G A 10: 80,057,645 P1274L probably benign Het
Sec24c T C 14: 20,688,402 V341A probably damaging Het
Smc1b A T 15: 85,097,891 probably benign Het
Sptbn1 T C 11: 30,100,659 H2310R probably benign Het
Trpc1 A C 9: 95,743,281 D97E probably damaging Het
Trpm2 G A 10: 77,942,996 Q379* probably null Het
Ttn A G 2: 76,818,823 probably benign Het
Vmn2r74 A T 7: 85,961,461 F8I probably benign Het
Zfp36 C T 7: 28,377,763 S240N probably benign Het
Zfp65 A G 13: 67,708,185 I325T possibly damaging Het
Other mutations in Tas2r109
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00467:Tas2r109 APN 6 132980023 missense probably benign 0.04
IGL01837:Tas2r109 APN 6 132980514 missense probably benign 0.27
R0788:Tas2r109 UTSW 6 132980301 missense probably benign 0.01
R0849:Tas2r109 UTSW 6 132980893 missense probably benign 0.00
R1542:Tas2r109 UTSW 6 132980910 missense possibly damaging 0.93
R1583:Tas2r109 UTSW 6 132980426 missense probably benign 0.01
R2035:Tas2r109 UTSW 6 132980460 missense probably benign
R3845:Tas2r109 UTSW 6 132980803 missense probably damaging 0.99
R4060:Tas2r109 UTSW 6 132980185 missense probably damaging 1.00
R4355:Tas2r109 UTSW 6 132980181 missense probably benign
R5353:Tas2r109 UTSW 6 132980631 missense possibly damaging 0.61
R5860:Tas2r109 UTSW 6 132980701 missense probably benign 0.06
R6211:Tas2r109 UTSW 6 132980624 nonsense probably null
R6378:Tas2r109 UTSW 6 132980881 missense probably benign 0.00
R6861:Tas2r109 UTSW 6 132980085 missense probably benign 0.43
R7319:Tas2r109 UTSW 6 132980700 missense probably benign 0.33
R8553:Tas2r109 UTSW 6 132980208 missense probably benign 0.33
Z1088:Tas2r109 UTSW 6 132980301 missense probably benign 0.07
Posted On2015-04-16