Incidental Mutation 'IGL02095:Rbm25'
ID 279561
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Rbm25
Ensembl Gene ENSMUSG00000010608
Gene Name RNA binding motif protein 25
Synonyms 2610015J01Rik, A130095G20Rik, 2600011C06Rik
Accession Numbers
Essential gene? Essential (E-score: 1.000) question?
Stock # IGL02095
Quality Score
Status
Chromosome 12
Chromosomal Location 83678990-83729901 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 83718748 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Tyrosine to Histidine at position 507 (Y507H)
Ref Sequence ENSEMBL: ENSMUSP00000048470 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000048155] [ENSMUST00000181983] [ENSMUST00000182450]
AlphaFold B2RY56
Predicted Effect probably damaging
Transcript: ENSMUST00000048155
AA Change: Y507H

PolyPhen 2 Score 0.996 (Sensitivity: 0.55; Specificity: 0.98)
SMART Domains Protein: ENSMUSP00000048470
Gene: ENSMUSG00000010608
AA Change: Y507H

DomainStartEndE-ValueType
low complexity region 10 44 N/A INTRINSIC
RRM 88 160 2.52e-11 SMART
low complexity region 234 241 N/A INTRINSIC
coiled coil region 270 351 N/A INTRINSIC
coiled coil region 382 549 N/A INTRINSIC
low complexity region 556 606 N/A INTRINSIC
low complexity region 616 625 N/A INTRINSIC
PWI 758 831 2.79e-38 SMART
Predicted Effect unknown
Transcript: ENSMUST00000181983
AA Change: Y507H
SMART Domains Protein: ENSMUSP00000138572
Gene: ENSMUSG00000010608
AA Change: Y507H

DomainStartEndE-ValueType
low complexity region 10 44 N/A INTRINSIC
RRM 88 160 2.52e-11 SMART
internal_repeat_1 187 203 3e-5 PROSPERO
low complexity region 234 241 N/A INTRINSIC
internal_repeat_1 258 274 3e-5 PROSPERO
coiled coil region 382 549 N/A INTRINSIC
low complexity region 556 571 N/A INTRINSIC
low complexity region 575 584 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000182255
Predicted Effect probably benign
Transcript: ENSMUST00000182450
SMART Domains Protein: ENSMUSP00000138416
Gene: ENSMUSG00000010608

DomainStartEndE-ValueType
low complexity region 10 44 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000182840
Predicted Effect noncoding transcript
Transcript: ENSMUST00000183181
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 48 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
3425401B19Rik T A 14: 32,383,583 (GRCm39) Q794L probably benign Het
Acrbp C A 6: 125,030,919 (GRCm39) Y313* probably null Het
Adam9 A G 8: 25,486,745 (GRCm39) S178P probably benign Het
Adgrv1 T C 13: 81,727,909 (GRCm39) I244V possibly damaging Het
Atad5 A G 11: 79,985,533 (GRCm39) S207G probably benign Het
Atp10a A G 7: 58,457,141 (GRCm39) D880G probably damaging Het
Cadps2 A G 6: 23,427,309 (GRCm39) I573T probably benign Het
Camsap3 A G 8: 3,653,845 (GRCm39) D494G probably damaging Het
Cbfa2t3 T C 8: 123,360,232 (GRCm39) E438G probably damaging Het
Cisd2 T C 3: 135,116,980 (GRCm39) D37G possibly damaging Het
Cndp2 T C 18: 84,699,157 (GRCm39) E36G possibly damaging Het
Ddx54 G A 5: 120,761,856 (GRCm39) G544D possibly damaging Het
Dok2 G T 14: 71,015,301 (GRCm39) G343W possibly damaging Het
Dscaml1 A G 9: 45,359,001 (GRCm39) N87D probably damaging Het
Ehf T C 2: 103,097,336 (GRCm39) Y237C probably damaging Het
Exoc3 T C 13: 74,328,655 (GRCm39) T569A probably damaging Het
Fam151a T C 4: 106,605,072 (GRCm39) V478A probably damaging Het
Fam227b T A 2: 125,942,924 (GRCm39) H291L probably damaging Het
Fmn2 A G 1: 174,330,167 (GRCm39) T186A unknown Het
Ggnbp2 T C 11: 84,723,954 (GRCm39) Y660C probably damaging Het
Ggt5 G A 10: 75,444,637 (GRCm39) M318I probably benign Het
Gprc5d A G 6: 135,093,175 (GRCm39) I244T probably damaging Het
Gucy2e A G 11: 69,123,613 (GRCm39) S429P possibly damaging Het
Igf2r T C 17: 12,920,892 (GRCm39) D1341G probably damaging Het
Kcnq4 T C 4: 120,557,224 (GRCm39) probably benign Het
Krt40 T C 11: 99,432,497 (GRCm39) D173G probably damaging Het
Lrrc27 C T 7: 138,810,169 (GRCm39) T380I probably benign Het
Lrrc4c A G 2: 97,459,749 (GRCm39) N125S probably benign Het
Mtor C T 4: 148,628,998 (GRCm39) R2217C probably damaging Het
Nfrkb C T 9: 31,322,527 (GRCm39) R866W probably damaging Het
Or10s1 T A 9: 39,985,967 (GRCm39) Y125* probably null Het
Or4d10b C A 19: 12,036,913 (GRCm39) V68F probably benign Het
P2ry6 T A 7: 100,588,071 (GRCm39) D96V probably damaging Het
Pcdh18 A T 3: 49,710,605 (GRCm39) S237T probably benign Het
Pck2 G A 14: 55,779,967 (GRCm39) R72Q probably benign Het
Pik3c2a C T 7: 115,945,423 (GRCm39) R1461Q probably damaging Het
Polr3a A G 14: 24,504,678 (GRCm39) V1130A possibly damaging Het
Ppm1d T A 11: 85,217,832 (GRCm39) D198E probably benign Het
Rasa1 T A 13: 85,364,274 (GRCm39) E1022D probably benign Het
Rbm26 A T 14: 105,381,696 (GRCm39) I488K probably damaging Het
Ryr2 T A 13: 11,774,645 (GRCm39) E1170D probably damaging Het
Sdk2 T G 11: 113,725,656 (GRCm39) T1198P probably damaging Het
Sema3g C T 14: 30,949,781 (GRCm39) T654I probably benign Het
Spag9 A T 11: 93,999,408 (GRCm39) H1108L probably damaging Het
Trgc2 T A 13: 19,491,580 (GRCm39) probably benign Het
Ubap2 T C 4: 41,229,709 (GRCm39) N142S probably benign Het
Usp33 T C 3: 152,087,431 (GRCm39) F699L possibly damaging Het
Ythdc2 A G 18: 45,006,207 (GRCm39) probably benign Het
Other mutations in Rbm25
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01614:Rbm25 APN 12 83,706,341 (GRCm39) missense probably damaging 1.00
IGL02227:Rbm25 APN 12 83,719,527 (GRCm39) missense probably damaging 1.00
IGL02454:Rbm25 APN 12 83,707,096 (GRCm39) missense probably benign 0.02
IGL02704:Rbm25 APN 12 83,689,500 (GRCm39) missense probably damaging 1.00
IGL02726:Rbm25 APN 12 83,719,626 (GRCm39) missense probably damaging 1.00
IGL03384:Rbm25 APN 12 83,706,297 (GRCm39) missense probably benign 0.28
Complexities UTSW 12 83,724,630 (GRCm39) missense probably damaging 1.00
R0380:Rbm25 UTSW 12 83,707,130 (GRCm39) missense probably benign 0.02
R0829:Rbm25 UTSW 12 83,707,150 (GRCm39) splice site probably benign
R1330:Rbm25 UTSW 12 83,724,666 (GRCm39) missense probably damaging 1.00
R1346:Rbm25 UTSW 12 83,691,167 (GRCm39) splice site probably benign
R1518:Rbm25 UTSW 12 83,715,219 (GRCm39) missense possibly damaging 0.91
R1566:Rbm25 UTSW 12 83,721,828 (GRCm39) missense probably damaging 0.98
R1660:Rbm25 UTSW 12 83,714,924 (GRCm39) unclassified probably benign
R1809:Rbm25 UTSW 12 83,719,501 (GRCm39) splice site probably benign
R2213:Rbm25 UTSW 12 83,722,856 (GRCm39) missense probably benign 0.00
R2336:Rbm25 UTSW 12 83,698,192 (GRCm39) missense probably damaging 1.00
R2943:Rbm25 UTSW 12 83,707,415 (GRCm39) missense probably damaging 1.00
R3971:Rbm25 UTSW 12 83,721,982 (GRCm39) missense probably benign 0.03
R4349:Rbm25 UTSW 12 83,721,947 (GRCm39) missense probably damaging 0.99
R4740:Rbm25 UTSW 12 83,691,181 (GRCm39) missense possibly damaging 0.61
R4987:Rbm25 UTSW 12 83,724,630 (GRCm39) missense probably damaging 1.00
R5205:Rbm25 UTSW 12 83,719,643 (GRCm39) missense probably benign 0.03
R5579:Rbm25 UTSW 12 83,715,281 (GRCm39) missense probably benign 0.41
R5603:Rbm25 UTSW 12 83,710,990 (GRCm39) nonsense probably null
R5909:Rbm25 UTSW 12 83,728,362 (GRCm39) missense probably damaging 0.97
R5930:Rbm25 UTSW 12 83,724,640 (GRCm39) missense possibly damaging 0.46
R5982:Rbm25 UTSW 12 83,718,725 (GRCm39) missense probably damaging 0.99
R6233:Rbm25 UTSW 12 83,706,200 (GRCm39) missense probably benign 0.24
R6275:Rbm25 UTSW 12 83,691,206 (GRCm39) missense probably damaging 0.98
R6282:Rbm25 UTSW 12 83,722,863 (GRCm39) missense probably damaging 0.98
R7156:Rbm25 UTSW 12 83,710,965 (GRCm39) missense unknown
R7188:Rbm25 UTSW 12 83,710,772 (GRCm39) missense unknown
R7217:Rbm25 UTSW 12 83,710,991 (GRCm39) missense unknown
R7403:Rbm25 UTSW 12 83,722,908 (GRCm39) missense probably damaging 1.00
R7508:Rbm25 UTSW 12 83,719,651 (GRCm39) missense probably damaging 0.99
R7703:Rbm25 UTSW 12 83,721,864 (GRCm39) missense possibly damaging 0.69
R8004:Rbm25 UTSW 12 83,721,166 (GRCm39) missense possibly damaging 0.61
R8154:Rbm25 UTSW 12 83,691,205 (GRCm39) missense unknown
R8444:Rbm25 UTSW 12 83,711,025 (GRCm39) missense unknown
Z1176:Rbm25 UTSW 12 83,719,658 (GRCm39) missense possibly damaging 0.92
Posted On 2015-04-16