Incidental Mutation 'IGL02095:Olfr1424'
ID279579
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Olfr1424
Ensembl Gene ENSMUSG00000067528
Gene Nameolfactory receptor 1424
SynonymsGA_x6K02T2RE5P-2418550-2417609, MOR239-2
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.074) question?
Stock #IGL02095
Quality Score
Status
Chromosome19
Chromosomal Location12058624-12062682 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) C to A at 12059549 bp
ZygosityHeterozygous
Amino Acid Change Valine to Phenylalanine at position 68 (V68F)
Ref Sequence ENSEMBL: ENSMUSP00000146552 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000087830] [ENSMUST00000207681]
Predicted Effect probably benign
Transcript: ENSMUST00000087830
AA Change: V68F

PolyPhen 2 Score 0.002 (Sensitivity: 0.99; Specificity: 0.30)
SMART Domains Protein: ENSMUSP00000085132
Gene: ENSMUSG00000067528
AA Change: V68F

DomainStartEndE-ValueType
Pfam:7tm_4 31 304 2.4e-47 PFAM
Pfam:7tm_1 41 306 2.8e-21 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000207681
AA Change: V68F

PolyPhen 2 Score 0.002 (Sensitivity: 0.99; Specificity: 0.30)
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 48 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
3425401B19Rik T A 14: 32,661,626 Q794L probably benign Het
Acrbp C A 6: 125,053,956 Y313* probably null Het
Adam9 A G 8: 24,996,729 S178P probably benign Het
Adgrv1 T C 13: 81,579,790 I244V possibly damaging Het
Atad5 A G 11: 80,094,707 S207G probably benign Het
Atp10a A G 7: 58,807,393 D880G probably damaging Het
Cadps2 A G 6: 23,427,310 I573T probably benign Het
Camsap3 A G 8: 3,603,845 D494G probably damaging Het
Cbfa2t3 T C 8: 122,633,493 E438G probably damaging Het
Cisd2 T C 3: 135,411,219 D37G possibly damaging Het
Cndp2 T C 18: 84,681,032 E36G possibly damaging Het
Ddx54 G A 5: 120,623,791 G544D possibly damaging Het
Dok2 G T 14: 70,777,861 G343W possibly damaging Het
Dscaml1 A G 9: 45,447,703 N87D probably damaging Het
Ehf T C 2: 103,266,991 Y237C probably damaging Het
Exoc3 T C 13: 74,180,536 T569A probably damaging Het
Fam151a T C 4: 106,747,875 V478A probably damaging Het
Fam227b T A 2: 126,101,004 H291L probably damaging Het
Fmn2 A G 1: 174,502,601 T186A unknown Het
Ggnbp2 T C 11: 84,833,128 Y660C probably damaging Het
Ggt5 G A 10: 75,608,803 M318I probably benign Het
Gprc5d A G 6: 135,116,177 I244T probably damaging Het
Gucy2e A G 11: 69,232,787 S429P possibly damaging Het
Igf2r T C 17: 12,702,005 D1341G probably damaging Het
Kcnq4 T C 4: 120,700,027 probably benign Het
Krt40 T C 11: 99,541,671 D173G probably damaging Het
Lrrc27 C T 7: 139,230,253 T380I probably benign Het
Lrrc4c A G 2: 97,629,404 N125S probably benign Het
Mtor C T 4: 148,544,541 R2217C probably damaging Het
Nfrkb C T 9: 31,411,231 R866W probably damaging Het
Olfr982 T A 9: 40,074,671 Y125* probably null Het
P2ry6 T A 7: 100,938,864 D96V probably damaging Het
Pcdh18 A T 3: 49,756,156 S237T probably benign Het
Pck2 G A 14: 55,542,510 R72Q probably benign Het
Pik3c2a C T 7: 116,346,188 R1461Q probably damaging Het
Polr3a A G 14: 24,454,610 V1130A possibly damaging Het
Ppm1d T A 11: 85,327,006 D198E probably benign Het
Rasa1 T A 13: 85,216,155 E1022D probably benign Het
Rbm25 T C 12: 83,671,974 Y507H probably damaging Het
Rbm26 A T 14: 105,144,260 I488K probably damaging Het
Ryr2 T A 13: 11,759,759 E1170D probably damaging Het
Sdk2 T G 11: 113,834,830 T1198P probably damaging Het
Sema3g C T 14: 31,227,824 T654I probably benign Het
Spag9 A T 11: 94,108,582 H1108L probably damaging Het
Tcrg-C2 T A 13: 19,307,410 probably benign Het
Ubap2 T C 4: 41,229,709 N142S probably benign Het
Usp33 T C 3: 152,381,794 F699L possibly damaging Het
Ythdc2 A G 18: 44,873,140 probably benign Het
Other mutations in Olfr1424
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02045:Olfr1424 APN 19 12058889 missense possibly damaging 0.96
IGL02743:Olfr1424 APN 19 12059447 missense probably damaging 1.00
IGL02745:Olfr1424 APN 19 12059201 missense probably benign 0.05
R0834:Olfr1424 UTSW 19 12059615 missense probably benign 0.00
R1474:Olfr1424 UTSW 19 12059480 missense probably benign 0.30
R5590:Olfr1424 UTSW 19 12059278 missense probably benign 0.01
R6386:Olfr1424 UTSW 19 12059556 missense probably damaging 0.98
R6864:Olfr1424 UTSW 19 12059413 missense probably damaging 1.00
R8207:Olfr1424 UTSW 19 12058858 missense possibly damaging 0.94
R8213:Olfr1424 UTSW 19 12059092 missense probably benign 0.32
Z1088:Olfr1424 UTSW 19 12059129 missense probably benign 0.03
Posted On2015-04-16