Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02097:Zfp334'

279608

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Zfp334

Ensembl Gene

ENSMUSG00000017667

Gene Name

zinc finger protein 334

Synonyms

D2Ertd535e

Accession Numbers

Essential gene?

Non essential (E-score: 0.000) question?

Stock #

IGL02097

Quality Score

Status

Chromosome

Chromosomal Location

165216184-165230179 bp(-) (GRCm39)

Type of Mutation

nonsense

DNA Base Change (assembly)

A to T at 165223643 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Tyrosine to Stop codon at position 133 (Y133*)

Ref Sequence

ENSEMBL: ENSMUSP00000099373 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000103084]

AlphaFold

A2A4U6

Predicted Effect

probably null
Transcript: ENSMUST00000103084
AA Change: Y133*

SMART Domains

Protein: ENSMUSP00000099373
Gene: ENSMUSG00000017667
AA Change: Y133*

Domain	Start	End	E-Value	Type
KRAB	8	68	5.91e-35	SMART
ZnF_C2H2	236	258	5.42e-2	SMART
ZnF_C2H2	264	286	1.2e-3	SMART
ZnF_C2H2	292	314	6.99e-5	SMART
ZnF_C2H2	320	342	1.22e-4	SMART
ZnF_C2H2	348	370	3.39e-3	SMART
ZnF_C2H2	376	398	7.15e-2	SMART
ZnF_C2H2	404	426	1.69e-3	SMART
ZnF_C2H2	432	454	1.92e-2	SMART
ZnF_C2H2	460	482	3.16e-3	SMART
ZnF_C2H2	543	565	1.82e-3	SMART
ZnF_C2H2	571	593	3.69e-4	SMART
ZnF_C2H2	599	621	1.58e-3	SMART
ZnF_C2H2	627	649	1.38e-3	SMART
ZnF_C2H2	655	677	3.89e-3	SMART

Coding Region Coverage

Validation Efficiency

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the C2H2 zinc finger family. The encoded protein contains a Krueppel-associated box, fourteen C2H2 zinc finger domains, and four C2H2-type/integrase DNA-binding domains. Decreased expression of this gene may be a marker for rheumatoid arthritis. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Jul 2012]

Allele List at MGI

Other mutations in this stock

Total: 49 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Abcg3	A	T	5: 105,109,052 (GRCm39)	V415D	possibly damaging	Het
Adcy3	C	T	12: 4,262,118 (GRCm39)	A1056V	probably damaging	Het
Adcy5	G	A	16: 35,092,468 (GRCm39)	A610T	probably damaging	Het
Arhgap21	G	A	2: 20,884,813 (GRCm39)	T788I	probably benign	Het
Asic1	T	C	15: 99,592,567 (GRCm39)		probably benign	Het
Cdhr4	T	A	9: 107,870,199 (GRCm39)	M68K	probably benign	Het
Cdhr5	G	T	7: 140,849,894 (GRCm39)	T637K	probably damaging	Het
Corin	A	T	5: 72,529,489 (GRCm39)	C289S	probably damaging	Het
Cpne4	T	C	9: 104,563,701 (GRCm39)	V26A	probably damaging	Het
Csmd1	T	C	8: 16,261,773 (GRCm39)	D908G	probably null	Het
Cyp2c29	A	G	19: 39,296,064 (GRCm39)	D126G	probably damaging	Het
Ddx42	G	A	11: 106,129,986 (GRCm39)	S426N	probably benign	Het
Dnah1	C	T	14: 31,026,958 (GRCm39)	V689M	possibly damaging	Het
Dtwd1	A	G	2: 126,006,715 (GRCm39)	T246A	probably damaging	Het
Fbn1	A	T	2: 125,205,889 (GRCm39)	M1036K	probably damaging	Het
Fbxo10	T	C	4: 45,048,527 (GRCm39)	N536S	probably benign	Het
Gnal	G	A	18: 67,350,279 (GRCm39)		probably benign	Het
Gns	A	G	10: 121,226,598 (GRCm39)	T416A	probably benign	Het
Heatr5b	G	A	17: 79,124,943 (GRCm39)	T603I	probably damaging	Het
Hsp90b1	T	A	10: 86,527,548 (GRCm39)		probably benign	Het
Krt23	C	T	11: 99,383,836 (GRCm39)	G19R	probably benign	Het
Lama2	C	T	10: 27,014,956 (GRCm39)	R1584H	probably benign	Het
Lmbr1l	C	T	15: 98,815,772 (GRCm39)	V11M	probably damaging	Het
Man1a2	T	C	3: 100,489,447 (GRCm39)	K511E	possibly damaging	Het
Mrgpra3	C	A	7: 47,239,204 (GRCm39)	V241F	possibly damaging	Het
Myh3	A	G	11: 66,973,750 (GRCm39)	D141G	probably benign	Het
Mylk2	G	A	2: 152,757,056 (GRCm39)	C277Y	probably damaging	Het
Myo3b	A	T	2: 70,069,173 (GRCm39)	T471S	probably damaging	Het
Naip1	A	G	13: 100,562,096 (GRCm39)	V1023A	probably benign	Het
Olfm5	T	A	7: 103,803,438 (GRCm39)	T342S	probably benign	Het
Or10g1	A	G	14: 52,647,511 (GRCm39)	F273L	probably benign	Het
Or2f1b	T	A	6: 42,739,394 (GRCm39)	M136K	probably damaging	Het
Pglyrp4	T	C	3: 90,642,910 (GRCm39)	F263L	probably benign	Het
Plekhh2	A	T	17: 84,906,608 (GRCm39)	T1148S	possibly damaging	Het
Prrc2b	T	C	2: 32,081,513 (GRCm39)		probably benign	Het
Rbm28	G	T	6: 29,138,617 (GRCm39)	D398E	possibly damaging	Het
Rnf220	A	G	4: 117,130,524 (GRCm39)	F234L	probably benign	Het
Sele	T	C	1: 163,880,662 (GRCm39)	S415P	probably benign	Het
Shpk	T	C	11: 73,094,821 (GRCm39)	L79P	probably damaging	Het
Slc35f4	C	T	14: 49,543,703 (GRCm39)	A148T	probably damaging	Het
Slc6a20a	G	A	9: 123,489,684 (GRCm39)	P120S	possibly damaging	Het
Slc8a2	A	G	7: 15,891,081 (GRCm39)	E701G	possibly damaging	Het
Slco1a1	T	A	6: 141,885,765 (GRCm39)	I87F	possibly damaging	Het
Srebf1	T	G	11: 60,093,650 (GRCm39)	D739A	probably damaging	Het
Thg1l	A	G	11: 45,841,055 (GRCm39)	Y175H	probably benign	Het
Traf3ip2	G	A	10: 39,530,475 (GRCm39)	V540M	probably damaging	Het
Wdr48	A	G	9: 119,753,329 (GRCm39)	D644G	probably damaging	Het
Zbtb1	A	T	12: 76,433,371 (GRCm39)	K452N	probably damaging	Het
Zfhx2	C	T	14: 55,300,351 (GRCm39)	G2467R	probably damaging	Het

Other mutations in Zfp334

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL02185:Zfp334	APN	2	165,228,869 (GRCm39)	utr 5 prime	probably benign
IGL02415:Zfp334	APN	2	165,223,771 (GRCm39)	missense	possibly damaging	0.70
IGL02693:Zfp334	APN	2	165,222,433 (GRCm39)	missense	possibly damaging	0.80
ANU23:Zfp334	UTSW	2	165,223,017 (GRCm39)	missense	probably damaging	1.00
R0040:Zfp334	UTSW	2	165,223,492 (GRCm39)	missense	probably benign	0.45
R1332:Zfp334	UTSW	2	165,222,776 (GRCm39)	missense	probably damaging	1.00
R1579:Zfp334	UTSW	2	165,223,719 (GRCm39)	missense	probably damaging	0.98
R2429:Zfp334	UTSW	2	165,222,432 (GRCm39)	missense	probably damaging	1.00
R5556:Zfp334	UTSW	2	165,222,504 (GRCm39)	missense	probably benign
R5579:Zfp334	UTSW	2	165,222,407 (GRCm39)	nonsense	probably null
R6891:Zfp334	UTSW	2	165,224,644 (GRCm39)	missense	probably benign
R6918:Zfp334	UTSW	2	165,223,799 (GRCm39)	missense	possibly damaging	0.46
R8360:Zfp334	UTSW	2	165,225,278 (GRCm39)	missense	probably benign	0.00
R8998:Zfp334	UTSW	2	165,223,408 (GRCm39)	missense	possibly damaging	0.80
R9481:Zfp334	UTSW	2	165,222,271 (GRCm39)	missense	probably damaging	1.00

Posted On

2015-04-16