Incidental Mutation 'IGL02097:Zfp334'
ID279608
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Zfp334
Ensembl Gene ENSMUSG00000017667
Gene Namezinc finger protein 334
SynonymsD2Ertd535e
Accession Numbers
Is this an essential gene? Non essential (E-score: 0.000) question?
Stock #IGL02097
Quality Score
Status
Chromosome2
Chromosomal Location165374264-165388259 bp(-) (GRCm38)
Type of Mutationnonsense
DNA Base Change (assembly) A to T at 165381723 bp
ZygosityHeterozygous
Amino Acid Change Tyrosine to Stop codon at position 133 (Y133*)
Ref Sequence ENSEMBL: ENSMUSP00000099373 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000103084]
Predicted Effect probably null
Transcript: ENSMUST00000103084
AA Change: Y133*
SMART Domains Protein: ENSMUSP00000099373
Gene: ENSMUSG00000017667
AA Change: Y133*

DomainStartEndE-ValueType
KRAB 8 68 5.91e-35 SMART
ZnF_C2H2 236 258 5.42e-2 SMART
ZnF_C2H2 264 286 1.2e-3 SMART
ZnF_C2H2 292 314 6.99e-5 SMART
ZnF_C2H2 320 342 1.22e-4 SMART
ZnF_C2H2 348 370 3.39e-3 SMART
ZnF_C2H2 376 398 7.15e-2 SMART
ZnF_C2H2 404 426 1.69e-3 SMART
ZnF_C2H2 432 454 1.92e-2 SMART
ZnF_C2H2 460 482 3.16e-3 SMART
ZnF_C2H2 543 565 1.82e-3 SMART
ZnF_C2H2 571 593 3.69e-4 SMART
ZnF_C2H2 599 621 1.58e-3 SMART
ZnF_C2H2 627 649 1.38e-3 SMART
ZnF_C2H2 655 677 3.89e-3 SMART
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the C2H2 zinc finger family. The encoded protein contains a Krueppel-associated box, fourteen C2H2 zinc finger domains, and four C2H2-type/integrase DNA-binding domains. Decreased expression of this gene may be a marker for rheumatoid arthritis. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Jul 2012]
Allele List at MGI
Other mutations in this stock
Total: 49 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abcg3 A T 5: 104,961,186 V415D possibly damaging Het
Adcy3 C T 12: 4,212,118 A1056V probably damaging Het
Adcy5 G A 16: 35,272,098 A610T probably damaging Het
Arhgap21 G A 2: 20,880,002 T788I probably benign Het
Asic1 T C 15: 99,694,686 probably benign Het
Cdhr4 T A 9: 107,993,000 M68K probably benign Het
Cdhr5 G T 7: 141,269,981 T637K probably damaging Het
Corin A T 5: 72,372,146 C289S probably damaging Het
Cpne4 T C 9: 104,686,502 V26A probably damaging Het
Csmd1 T C 8: 16,211,759 D908G probably null Het
Cyp2c29 A G 19: 39,307,620 D126G probably damaging Het
Ddx42 G A 11: 106,239,160 S426N probably benign Het
Dnah1 C T 14: 31,305,001 V689M possibly damaging Het
Dtwd1 A G 2: 126,164,795 T246A probably damaging Het
Fbn1 A T 2: 125,363,969 M1036K probably damaging Het
Fbxo10 T C 4: 45,048,527 N536S probably benign Het
Gnal G A 18: 67,217,208 probably benign Het
Gns A G 10: 121,390,693 T416A probably benign Het
Heatr5b G A 17: 78,817,514 T603I probably damaging Het
Hsp90b1 T A 10: 86,691,684 probably benign Het
Krt23 C T 11: 99,493,010 G19R probably benign Het
Lama2 C T 10: 27,138,960 R1584H probably benign Het
Lmbr1l C T 15: 98,917,891 V11M probably damaging Het
Man1a2 T C 3: 100,582,131 K511E possibly damaging Het
Mrgpra3 C A 7: 47,589,456 V241F possibly damaging Het
Myh3 A G 11: 67,082,924 D141G probably benign Het
Mylk2 G A 2: 152,915,136 C277Y probably damaging Het
Myo3b A T 2: 70,238,829 T471S probably damaging Het
Naip1 A G 13: 100,425,588 V1023A probably benign Het
Olfm5 T A 7: 104,154,231 T342S probably benign Het
Olfr1510 A G 14: 52,410,054 F273L probably benign Het
Olfr38 T A 6: 42,762,460 M136K probably damaging Het
Pglyrp4 T C 3: 90,735,603 F263L probably benign Het
Plekhh2 A T 17: 84,599,180 T1148S possibly damaging Het
Prrc2b T C 2: 32,191,501 probably benign Het
Rbm28 G T 6: 29,138,618 D398E possibly damaging Het
Rnf220 A G 4: 117,273,327 F234L probably benign Het
Sele T C 1: 164,053,093 S415P probably benign Het
Shpk T C 11: 73,203,995 L79P probably damaging Het
Slc35f4 C T 14: 49,306,246 A148T probably damaging Het
Slc6a20a G A 9: 123,660,619 P120S possibly damaging Het
Slc8a2 A G 7: 16,157,156 E701G possibly damaging Het
Slco1a1 T A 6: 141,940,039 I87F possibly damaging Het
Srebf1 T G 11: 60,202,824 D739A probably damaging Het
Thg1l A G 11: 45,950,228 Y175H probably benign Het
Traf3ip2 G A 10: 39,654,479 V540M probably damaging Het
Wdr48 A G 9: 119,924,263 D644G probably damaging Het
Zbtb1 A T 12: 76,386,597 K452N probably damaging Het
Zfhx2 C T 14: 55,062,894 G2467R probably damaging Het
Other mutations in Zfp334
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02185:Zfp334 APN 2 165386949 utr 5 prime probably benign
IGL02415:Zfp334 APN 2 165381851 missense possibly damaging 0.70
IGL02693:Zfp334 APN 2 165380513 missense possibly damaging 0.80
ANU23:Zfp334 UTSW 2 165381097 missense probably damaging 1.00
R0040:Zfp334 UTSW 2 165381572 missense probably benign 0.45
R1332:Zfp334 UTSW 2 165380856 missense probably damaging 1.00
R1579:Zfp334 UTSW 2 165381799 missense probably damaging 0.98
R2429:Zfp334 UTSW 2 165380512 missense probably damaging 1.00
R5556:Zfp334 UTSW 2 165380584 missense probably benign
R5579:Zfp334 UTSW 2 165380487 nonsense probably null
R6891:Zfp334 UTSW 2 165382724 missense probably benign
R6918:Zfp334 UTSW 2 165381879 missense possibly damaging 0.46
Posted On2015-04-16