Incidental Mutation 'IGL02097:Mrgpra3'
ID 279610
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Mrgpra3
Ensembl Gene ENSMUSG00000078698
Gene Name MAS-related GPR, member A3
Synonyms G protein-coupled receptor, MrgA3
Accession Numbers
Essential gene? Probably non essential (E-score: 0.048) question?
Stock # IGL02097
Quality Score
Status
Chromosome 7
Chromosomal Location 47238698-47251120 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) C to A at 47239204 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Valine to Phenylalanine at position 241 (V241F)
Ref Sequence ENSEMBL: ENSMUSP00000135437 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000176369]
AlphaFold no structure available at present
Predicted Effect possibly damaging
Transcript: ENSMUST00000176369
AA Change: V241F

PolyPhen 2 Score 0.940 (Sensitivity: 0.80; Specificity: 0.94)
SMART Domains Protein: ENSMUSP00000135437
Gene: ENSMUSG00000078698
AA Change: V241F

DomainStartEndE-ValueType
low complexity region 14 31 N/A INTRINSIC
Pfam:7TM_GPCR_Srx 48 234 6.3e-7 PFAM
Pfam:7tm_1 57 286 2.7e-9 PFAM
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 49 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abcg3 A T 5: 105,109,052 (GRCm39) V415D possibly damaging Het
Adcy3 C T 12: 4,262,118 (GRCm39) A1056V probably damaging Het
Adcy5 G A 16: 35,092,468 (GRCm39) A610T probably damaging Het
Arhgap21 G A 2: 20,884,813 (GRCm39) T788I probably benign Het
Asic1 T C 15: 99,592,567 (GRCm39) probably benign Het
Cdhr4 T A 9: 107,870,199 (GRCm39) M68K probably benign Het
Cdhr5 G T 7: 140,849,894 (GRCm39) T637K probably damaging Het
Corin A T 5: 72,529,489 (GRCm39) C289S probably damaging Het
Cpne4 T C 9: 104,563,701 (GRCm39) V26A probably damaging Het
Csmd1 T C 8: 16,261,773 (GRCm39) D908G probably null Het
Cyp2c29 A G 19: 39,296,064 (GRCm39) D126G probably damaging Het
Ddx42 G A 11: 106,129,986 (GRCm39) S426N probably benign Het
Dnah1 C T 14: 31,026,958 (GRCm39) V689M possibly damaging Het
Dtwd1 A G 2: 126,006,715 (GRCm39) T246A probably damaging Het
Fbn1 A T 2: 125,205,889 (GRCm39) M1036K probably damaging Het
Fbxo10 T C 4: 45,048,527 (GRCm39) N536S probably benign Het
Gnal G A 18: 67,350,279 (GRCm39) probably benign Het
Gns A G 10: 121,226,598 (GRCm39) T416A probably benign Het
Heatr5b G A 17: 79,124,943 (GRCm39) T603I probably damaging Het
Hsp90b1 T A 10: 86,527,548 (GRCm39) probably benign Het
Krt23 C T 11: 99,383,836 (GRCm39) G19R probably benign Het
Lama2 C T 10: 27,014,956 (GRCm39) R1584H probably benign Het
Lmbr1l C T 15: 98,815,772 (GRCm39) V11M probably damaging Het
Man1a2 T C 3: 100,489,447 (GRCm39) K511E possibly damaging Het
Myh3 A G 11: 66,973,750 (GRCm39) D141G probably benign Het
Mylk2 G A 2: 152,757,056 (GRCm39) C277Y probably damaging Het
Myo3b A T 2: 70,069,173 (GRCm39) T471S probably damaging Het
Naip1 A G 13: 100,562,096 (GRCm39) V1023A probably benign Het
Olfm5 T A 7: 103,803,438 (GRCm39) T342S probably benign Het
Or10g1 A G 14: 52,647,511 (GRCm39) F273L probably benign Het
Or2f1b T A 6: 42,739,394 (GRCm39) M136K probably damaging Het
Pglyrp4 T C 3: 90,642,910 (GRCm39) F263L probably benign Het
Plekhh2 A T 17: 84,906,608 (GRCm39) T1148S possibly damaging Het
Prrc2b T C 2: 32,081,513 (GRCm39) probably benign Het
Rbm28 G T 6: 29,138,617 (GRCm39) D398E possibly damaging Het
Rnf220 A G 4: 117,130,524 (GRCm39) F234L probably benign Het
Sele T C 1: 163,880,662 (GRCm39) S415P probably benign Het
Shpk T C 11: 73,094,821 (GRCm39) L79P probably damaging Het
Slc35f4 C T 14: 49,543,703 (GRCm39) A148T probably damaging Het
Slc6a20a G A 9: 123,489,684 (GRCm39) P120S possibly damaging Het
Slc8a2 A G 7: 15,891,081 (GRCm39) E701G possibly damaging Het
Slco1a1 T A 6: 141,885,765 (GRCm39) I87F possibly damaging Het
Srebf1 T G 11: 60,093,650 (GRCm39) D739A probably damaging Het
Thg1l A G 11: 45,841,055 (GRCm39) Y175H probably benign Het
Traf3ip2 G A 10: 39,530,475 (GRCm39) V540M probably damaging Het
Wdr48 A G 9: 119,753,329 (GRCm39) D644G probably damaging Het
Zbtb1 A T 12: 76,433,371 (GRCm39) K452N probably damaging Het
Zfhx2 C T 14: 55,300,351 (GRCm39) G2467R probably damaging Het
Zfp334 A T 2: 165,223,643 (GRCm39) Y133* probably null Het
Other mutations in Mrgpra3
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00162:Mrgpra3 APN 7 47,239,267 (GRCm39) missense probably benign 0.00
IGL02101:Mrgpra3 APN 7 47,239,300 (GRCm39) missense probably damaging 0.99
IGL03071:Mrgpra3 APN 7 47,238,929 (GRCm39) utr 3 prime probably benign
PIT4445001:Mrgpra3 UTSW 7 47,239,908 (GRCm39) missense possibly damaging 0.88
R0828:Mrgpra3 UTSW 7 47,239,884 (GRCm39) missense probably benign 0.12
R1118:Mrgpra3 UTSW 7 47,239,039 (GRCm39) missense possibly damaging 0.83
R1835:Mrgpra3 UTSW 7 47,239,694 (GRCm39) nonsense probably null
R2258:Mrgpra3 UTSW 7 47,239,842 (GRCm39) missense probably benign 0.35
R2393:Mrgpra3 UTSW 7 47,239,365 (GRCm39) missense possibly damaging 0.92
R3437:Mrgpra3 UTSW 7 47,239,314 (GRCm39) missense probably damaging 1.00
R3973:Mrgpra3 UTSW 7 47,239,414 (GRCm39) missense probably benign 0.22
R4273:Mrgpra3 UTSW 7 47,239,180 (GRCm39) missense probably benign 0.01
R4495:Mrgpra3 UTSW 7 47,239,813 (GRCm39) missense probably benign 0.00
R4768:Mrgpra3 UTSW 7 47,239,476 (GRCm39) missense possibly damaging 0.94
R4822:Mrgpra3 UTSW 7 47,239,716 (GRCm39) missense possibly damaging 0.69
R4967:Mrgpra3 UTSW 7 47,239,267 (GRCm39) missense probably benign 0.33
R5207:Mrgpra3 UTSW 7 47,239,909 (GRCm39) missense probably benign 0.06
R5569:Mrgpra3 UTSW 7 47,239,759 (GRCm39) missense probably benign 0.00
R5763:Mrgpra3 UTSW 7 47,239,355 (GRCm39) nonsense probably null
R6102:Mrgpra3 UTSW 7 47,239,897 (GRCm39) missense possibly damaging 0.92
R6612:Mrgpra3 UTSW 7 47,239,783 (GRCm39) missense probably benign 0.00
R6718:Mrgpra3 UTSW 7 47,239,444 (GRCm39) missense probably benign 0.25
R6859:Mrgpra3 UTSW 7 47,239,781 (GRCm39) missense probably benign 0.04
R7029:Mrgpra3 UTSW 7 47,239,290 (GRCm39) missense probably benign 0.00
R7034:Mrgpra3 UTSW 7 47,239,838 (GRCm39) missense possibly damaging 0.49
R7036:Mrgpra3 UTSW 7 47,239,838 (GRCm39) missense possibly damaging 0.49
R7097:Mrgpra3 UTSW 7 47,239,389 (GRCm39) missense probably benign
R7475:Mrgpra3 UTSW 7 47,239,695 (GRCm39) missense probably damaging 1.00
R8289:Mrgpra3 UTSW 7 47,239,468 (GRCm39) missense possibly damaging 0.76
R8315:Mrgpra3 UTSW 7 47,251,051 (GRCm39) start codon destroyed probably null 0.93
R9500:Mrgpra3 UTSW 7 47,239,400 (GRCm39) nonsense probably null
Z1177:Mrgpra3 UTSW 7 47,251,049 (GRCm39) nonsense probably null
Posted On 2015-04-16