Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02097:Olfm5'

279621

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Olfm5

Ensembl Gene

ENSMUSG00000044265

Gene Name

olfactomedin 5

Synonyms

E030002O03Rik

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.069) question?

Stock #

IGL02097

Quality Score

Status

Chromosome

Chromosomal Location

103802220-103814023 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to A at 103803438 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Threonine to Serine at position 342 (T342S)

Ref Sequence

ENSEMBL: ENSMUSP00000052174 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000051137] [ENSMUST00000059121] [ENSMUST00000154555]

AlphaFold

Q8BU90

Predicted Effect

probably benign
Transcript: ENSMUST00000051137
AA Change: T342S

PolyPhen 2 Score 0.200 (Sensitivity: 0.92; Specificity: 0.88)

SMART Domains

Protein: ENSMUSP00000052174
Gene: ENSMUSG00000044265
AA Change: T342S

Domain	Start	End	E-Value	Type
signal peptide	1	20	N/A	INTRINSIC
coiled coil region	47	85	N/A	INTRINSIC
coiled coil region	157	198	N/A	INTRINSIC
OLF	211	468	3.13e-70	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000059121

SMART Domains

Protein: ENSMUSP00000056365
Gene: ENSMUSG00000051437

Domain	Start	End	E-Value	Type
UBQ	31	101	5.13e-16	SMART
Blast:STI1	199	237	8e-11	BLAST
low complexity region	339	350	N/A	INTRINSIC
low complexity region	402	419	N/A	INTRINSIC
PDB:2DNA\|A	561	610	3e-26	PDB
Blast:UBA	568	604	1e-10	BLAST

Predicted Effect

probably benign
Transcript: ENSMUST00000154555
AA Change: T267S

PolyPhen 2 Score 0.143 (Sensitivity: 0.92; Specificity: 0.86)

SMART Domains

Protein: ENSMUSP00000117893
Gene: ENSMUSG00000044265
AA Change: T267S

Domain	Start	End	E-Value	Type
signal peptide	1	20	N/A	INTRINSIC
coiled coil region	47	123	N/A	INTRINSIC
OLF	136	304	3.65e-10	SMART

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 49 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Abcg3	A	T	5: 105,109,052 (GRCm39)	V415D	possibly damaging	Het
Adcy3	C	T	12: 4,262,118 (GRCm39)	A1056V	probably damaging	Het
Adcy5	G	A	16: 35,092,468 (GRCm39)	A610T	probably damaging	Het
Arhgap21	G	A	2: 20,884,813 (GRCm39)	T788I	probably benign	Het
Asic1	T	C	15: 99,592,567 (GRCm39)		probably benign	Het
Cdhr4	T	A	9: 107,870,199 (GRCm39)	M68K	probably benign	Het
Cdhr5	G	T	7: 140,849,894 (GRCm39)	T637K	probably damaging	Het
Corin	A	T	5: 72,529,489 (GRCm39)	C289S	probably damaging	Het
Cpne4	T	C	9: 104,563,701 (GRCm39)	V26A	probably damaging	Het
Csmd1	T	C	8: 16,261,773 (GRCm39)	D908G	probably null	Het
Cyp2c29	A	G	19: 39,296,064 (GRCm39)	D126G	probably damaging	Het
Ddx42	G	A	11: 106,129,986 (GRCm39)	S426N	probably benign	Het
Dnah1	C	T	14: 31,026,958 (GRCm39)	V689M	possibly damaging	Het
Dtwd1	A	G	2: 126,006,715 (GRCm39)	T246A	probably damaging	Het
Fbn1	A	T	2: 125,205,889 (GRCm39)	M1036K	probably damaging	Het
Fbxo10	T	C	4: 45,048,527 (GRCm39)	N536S	probably benign	Het
Gnal	G	A	18: 67,350,279 (GRCm39)		probably benign	Het
Gns	A	G	10: 121,226,598 (GRCm39)	T416A	probably benign	Het
Heatr5b	G	A	17: 79,124,943 (GRCm39)	T603I	probably damaging	Het
Hsp90b1	T	A	10: 86,527,548 (GRCm39)		probably benign	Het
Krt23	C	T	11: 99,383,836 (GRCm39)	G19R	probably benign	Het
Lama2	C	T	10: 27,014,956 (GRCm39)	R1584H	probably benign	Het
Lmbr1l	C	T	15: 98,815,772 (GRCm39)	V11M	probably damaging	Het
Man1a2	T	C	3: 100,489,447 (GRCm39)	K511E	possibly damaging	Het
Mrgpra3	C	A	7: 47,239,204 (GRCm39)	V241F	possibly damaging	Het
Myh3	A	G	11: 66,973,750 (GRCm39)	D141G	probably benign	Het
Mylk2	G	A	2: 152,757,056 (GRCm39)	C277Y	probably damaging	Het
Myo3b	A	T	2: 70,069,173 (GRCm39)	T471S	probably damaging	Het
Naip1	A	G	13: 100,562,096 (GRCm39)	V1023A	probably benign	Het
Or10g1	A	G	14: 52,647,511 (GRCm39)	F273L	probably benign	Het
Or2f1b	T	A	6: 42,739,394 (GRCm39)	M136K	probably damaging	Het
Pglyrp4	T	C	3: 90,642,910 (GRCm39)	F263L	probably benign	Het
Plekhh2	A	T	17: 84,906,608 (GRCm39)	T1148S	possibly damaging	Het
Prrc2b	T	C	2: 32,081,513 (GRCm39)		probably benign	Het
Rbm28	G	T	6: 29,138,617 (GRCm39)	D398E	possibly damaging	Het
Rnf220	A	G	4: 117,130,524 (GRCm39)	F234L	probably benign	Het
Sele	T	C	1: 163,880,662 (GRCm39)	S415P	probably benign	Het
Shpk	T	C	11: 73,094,821 (GRCm39)	L79P	probably damaging	Het
Slc35f4	C	T	14: 49,543,703 (GRCm39)	A148T	probably damaging	Het
Slc6a20a	G	A	9: 123,489,684 (GRCm39)	P120S	possibly damaging	Het
Slc8a2	A	G	7: 15,891,081 (GRCm39)	E701G	possibly damaging	Het
Slco1a1	T	A	6: 141,885,765 (GRCm39)	I87F	possibly damaging	Het
Srebf1	T	G	11: 60,093,650 (GRCm39)	D739A	probably damaging	Het
Thg1l	A	G	11: 45,841,055 (GRCm39)	Y175H	probably benign	Het
Traf3ip2	G	A	10: 39,530,475 (GRCm39)	V540M	probably damaging	Het
Wdr48	A	G	9: 119,753,329 (GRCm39)	D644G	probably damaging	Het
Zbtb1	A	T	12: 76,433,371 (GRCm39)	K452N	probably damaging	Het
Zfhx2	C	T	14: 55,300,351 (GRCm39)	G2467R	probably damaging	Het
Zfp334	A	T	2: 165,223,643 (GRCm39)	Y133*	probably null	Het

Other mutations in Olfm5

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01843:Olfm5	APN	7	103,809,951 (GRCm39)	missense	possibly damaging	0.77
IGL02322:Olfm5	APN	7	103,803,608 (GRCm39)	missense	probably damaging	1.00
IGL02324:Olfm5	APN	7	103,803,302 (GRCm39)	splice site	probably null
IGL02702:Olfm5	APN	7	103,803,564 (GRCm39)	missense	probably damaging	1.00
R0128:Olfm5	UTSW	7	103,810,133 (GRCm39)	missense	probably benign
R0400:Olfm5	UTSW	7	103,803,386 (GRCm39)	missense	probably damaging	1.00
R0600:Olfm5	UTSW	7	103,803,076 (GRCm39)	nonsense	probably null
R0610:Olfm5	UTSW	7	103,803,652 (GRCm39)	nonsense	probably null
R0699:Olfm5	UTSW	7	103,803,326 (GRCm39)	missense	probably damaging	1.00
R1960:Olfm5	UTSW	7	103,809,619 (GRCm39)	missense	possibly damaging	0.85
R1978:Olfm5	UTSW	7	103,813,948 (GRCm39)	missense	unknown
R2391:Olfm5	UTSW	7	103,810,041 (GRCm39)	missense	probably benign	0.00
R3774:Olfm5	UTSW	7	103,811,056 (GRCm39)	missense	possibly damaging	0.67
R4632:Olfm5	UTSW	7	103,810,100 (GRCm39)	missense	probably benign	0.00
R4770:Olfm5	UTSW	7	103,809,685 (GRCm39)	missense	probably benign	0.04
R4838:Olfm5	UTSW	7	103,803,572 (GRCm39)	missense	probably damaging	1.00
R5274:Olfm5	UTSW	7	103,809,190 (GRCm39)	missense	probably damaging	1.00
R5455:Olfm5	UTSW	7	103,803,669 (GRCm39)	missense	probably damaging	0.99
R5930:Olfm5	UTSW	7	103,803,362 (GRCm39)	missense	probably damaging	1.00
R6416:Olfm5	UTSW	7	103,803,260 (GRCm39)	missense	probably damaging	1.00
R7126:Olfm5	UTSW	7	103,809,187 (GRCm39)	missense	probably damaging	1.00
R7535:Olfm5	UTSW	7	103,803,444 (GRCm39)	missense	possibly damaging	0.92
R7682:Olfm5	UTSW	7	103,810,979 (GRCm39)	missense	probably null	0.49
R7835:Olfm5	UTSW	7	103,803,652 (GRCm39)	nonsense	probably null
R8308:Olfm5	UTSW	7	103,803,606 (GRCm39)	missense	probably damaging	1.00
R8531:Olfm5	UTSW	7	103,803,029 (GRCm39)	missense	probably benign	0.00
R9035:Olfm5	UTSW	7	103,803,099 (GRCm39)	missense	probably damaging	1.00
R9072:Olfm5	UTSW	7	103,802,984 (GRCm39)	missense	probably benign
R9185:Olfm5	UTSW	7	103,810,095 (GRCm39)	nonsense	probably null
X0011:Olfm5	UTSW	7	103,803,153 (GRCm39)	missense	possibly damaging	0.91
Z1088:Olfm5	UTSW	7	103,803,357 (GRCm39)	missense	probably damaging	1.00

Posted On

2015-04-16