Incidental Mutation 'IGL02097:Gnal'
ID 279652
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Gnal
Ensembl Gene ENSMUSG00000024524
Gene Name guanine nucleotide binding protein, alpha stimulating, olfactory type
Synonyms 2610011C15Rik, G alpha 10, Galphaolf, 9630020G10Rik, Gna10, Golf
Accession Numbers
Essential gene? Probably essential (E-score: 0.757) question?
Stock # IGL02097
Quality Score
Chromosome 18
Chromosomal Location 67221369-67359863 bp(+) (GRCm39)
Type of Mutation splice site
DNA Base Change (assembly) G to A at 67350279 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000075908 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000025402] [ENSMUST00000076605]
AlphaFold Q8CGK7
Predicted Effect probably benign
Transcript: ENSMUST00000025402
SMART Domains Protein: ENSMUSP00000025402
Gene: ENSMUSG00000024524

low complexity region 32 46 N/A INTRINSIC
G_alpha 89 447 1.18e-172 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000076605
SMART Domains Protein: ENSMUSP00000075908
Gene: ENSMUSG00000024524

G_alpha 22 380 5.02e-176 SMART
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a stimulatory G protein alpha subunit which mediates odorant signaling in the olfactory epithelium. This protein couples dopamine type 1 receptors and adenosine A2A receptors and is widely expressed in the central nervous system. Mutations in this gene have been associated with dystonia 25 and this gene is located in a susceptibility region for bipolar disorder and schizophrenia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2013]
PHENOTYPE: Homozygous for a targeted mutation fail to feed, and ~75% die within 2 days after birth. Rare survivors reach sexual maturity and mate but are hyperactive and anosmic, exhibitng severely reduced odor-evoked electrophysical responses and significantly perturbed maternal behaviors. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 49 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abcg3 A T 5: 105,109,052 (GRCm39) V415D possibly damaging Het
Adcy3 C T 12: 4,262,118 (GRCm39) A1056V probably damaging Het
Adcy5 G A 16: 35,092,468 (GRCm39) A610T probably damaging Het
Arhgap21 G A 2: 20,884,813 (GRCm39) T788I probably benign Het
Asic1 T C 15: 99,592,567 (GRCm39) probably benign Het
Cdhr4 T A 9: 107,870,199 (GRCm39) M68K probably benign Het
Cdhr5 G T 7: 140,849,894 (GRCm39) T637K probably damaging Het
Corin A T 5: 72,529,489 (GRCm39) C289S probably damaging Het
Cpne4 T C 9: 104,563,701 (GRCm39) V26A probably damaging Het
Csmd1 T C 8: 16,261,773 (GRCm39) D908G probably null Het
Cyp2c29 A G 19: 39,296,064 (GRCm39) D126G probably damaging Het
Ddx42 G A 11: 106,129,986 (GRCm39) S426N probably benign Het
Dnah1 C T 14: 31,026,958 (GRCm39) V689M possibly damaging Het
Dtwd1 A G 2: 126,006,715 (GRCm39) T246A probably damaging Het
Fbn1 A T 2: 125,205,889 (GRCm39) M1036K probably damaging Het
Fbxo10 T C 4: 45,048,527 (GRCm39) N536S probably benign Het
Gns A G 10: 121,226,598 (GRCm39) T416A probably benign Het
Heatr5b G A 17: 79,124,943 (GRCm39) T603I probably damaging Het
Hsp90b1 T A 10: 86,527,548 (GRCm39) probably benign Het
Krt23 C T 11: 99,383,836 (GRCm39) G19R probably benign Het
Lama2 C T 10: 27,014,956 (GRCm39) R1584H probably benign Het
Lmbr1l C T 15: 98,815,772 (GRCm39) V11M probably damaging Het
Man1a2 T C 3: 100,489,447 (GRCm39) K511E possibly damaging Het
Mrgpra3 C A 7: 47,239,204 (GRCm39) V241F possibly damaging Het
Myh3 A G 11: 66,973,750 (GRCm39) D141G probably benign Het
Mylk2 G A 2: 152,757,056 (GRCm39) C277Y probably damaging Het
Myo3b A T 2: 70,069,173 (GRCm39) T471S probably damaging Het
Naip1 A G 13: 100,562,096 (GRCm39) V1023A probably benign Het
Olfm5 T A 7: 103,803,438 (GRCm39) T342S probably benign Het
Or10g1 A G 14: 52,647,511 (GRCm39) F273L probably benign Het
Or2f1b T A 6: 42,739,394 (GRCm39) M136K probably damaging Het
Pglyrp4 T C 3: 90,642,910 (GRCm39) F263L probably benign Het
Plekhh2 A T 17: 84,906,608 (GRCm39) T1148S possibly damaging Het
Prrc2b T C 2: 32,081,513 (GRCm39) probably benign Het
Rbm28 G T 6: 29,138,617 (GRCm39) D398E possibly damaging Het
Rnf220 A G 4: 117,130,524 (GRCm39) F234L probably benign Het
Sele T C 1: 163,880,662 (GRCm39) S415P probably benign Het
Shpk T C 11: 73,094,821 (GRCm39) L79P probably damaging Het
Slc35f4 C T 14: 49,543,703 (GRCm39) A148T probably damaging Het
Slc6a20a G A 9: 123,489,684 (GRCm39) P120S possibly damaging Het
Slc8a2 A G 7: 15,891,081 (GRCm39) E701G possibly damaging Het
Slco1a1 T A 6: 141,885,765 (GRCm39) I87F possibly damaging Het
Srebf1 T G 11: 60,093,650 (GRCm39) D739A probably damaging Het
Thg1l A G 11: 45,841,055 (GRCm39) Y175H probably benign Het
Traf3ip2 G A 10: 39,530,475 (GRCm39) V540M probably damaging Het
Wdr48 A G 9: 119,753,329 (GRCm39) D644G probably damaging Het
Zbtb1 A T 12: 76,433,371 (GRCm39) K452N probably damaging Het
Zfhx2 C T 14: 55,300,351 (GRCm39) G2467R probably damaging Het
Zfp334 A T 2: 165,223,643 (GRCm39) Y133* probably null Het
Other mutations in Gnal
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00790:Gnal APN 18 67,267,360 (GRCm39) splice site probably null
IGL01290:Gnal APN 18 67,344,169 (GRCm39) missense probably damaging 1.00
IGL02519:Gnal APN 18 67,221,836 (GRCm39) missense unknown
IGL02691:Gnal APN 18 67,355,746 (GRCm39) missense probably damaging 1.00
R0455:Gnal UTSW 18 67,268,720 (GRCm39) splice site probably benign
R0506:Gnal UTSW 18 67,221,744 (GRCm39) missense unknown
R2107:Gnal UTSW 18 67,346,649 (GRCm39) missense probably damaging 1.00
R3937:Gnal UTSW 18 67,268,441 (GRCm39) splice site probably null
R4246:Gnal UTSW 18 67,221,654 (GRCm39) missense unknown
R4247:Gnal UTSW 18 67,221,654 (GRCm39) missense unknown
R4299:Gnal UTSW 18 67,221,654 (GRCm39) missense unknown
R4343:Gnal UTSW 18 67,268,659 (GRCm39) missense probably benign 0.29
R5309:Gnal UTSW 18 67,346,178 (GRCm39) missense possibly damaging 0.49
R5579:Gnal UTSW 18 67,221,842 (GRCm39) missense unknown
R5939:Gnal UTSW 18 67,324,456 (GRCm39) missense probably damaging 0.98
R6277:Gnal UTSW 18 67,346,143 (GRCm39) missense probably damaging 1.00
R7031:Gnal UTSW 18 67,355,659 (GRCm39) missense probably damaging 0.99
R7142:Gnal UTSW 18 67,351,599 (GRCm39) missense probably damaging 1.00
R7343:Gnal UTSW 18 67,268,596 (GRCm39) missense probably benign 0.03
R7366:Gnal UTSW 18 67,344,142 (GRCm39) missense possibly damaging 0.58
R7806:Gnal UTSW 18 67,346,145 (GRCm39) missense probably damaging 1.00
R8269:Gnal UTSW 18 67,268,693 (GRCm39) missense possibly damaging 0.87
R8504:Gnal UTSW 18 67,350,255 (GRCm39) nonsense probably null
R9005:Gnal UTSW 18 67,221,830 (GRCm39) nonsense probably null
R9369:Gnal UTSW 18 67,324,439 (GRCm39) critical splice acceptor site probably null
Z1088:Gnal UTSW 18 67,324,474 (GRCm39) missense probably damaging 1.00
Posted On 2015-04-16