Incidental Mutation 'IGL02098:Olfr146'
ID 279666
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Olfr146
Ensembl Gene ENSMUSG00000058820
Gene Name olfactory receptor 146
Synonyms GA_x6K02T2PVTD-32715386-32714466, MOR171-10, M15
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.053) question?
Stock # IGL02098
Quality Score
Status
Chromosome 9
Chromosomal Location 39018073-39023377 bp(-) (GRCm38)
Type of Mutation missense
DNA Base Change (assembly) A to G at 39018891 bp (GRCm38)
Zygosity Heterozygous
Amino Acid Change Serine to Proline at position 217 (S217P)
Ref Sequence ENSEMBL: ENSMUSP00000149294 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000073671] [ENSMUST00000214369] [ENSMUST00000214410] [ENSMUST00000215383]
AlphaFold Q60884
Predicted Effect probably damaging
Transcript: ENSMUST00000073671
AA Change: S217P

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000073352
Gene: ENSMUSG00000058820
AA Change: S217P

DomainStartEndE-ValueType
Pfam:7tm_4 31 306 7.6e-54 PFAM
Pfam:7tm_1 41 290 8.1e-21 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000214369
Predicted Effect probably damaging
Transcript: ENSMUST00000214410
AA Change: S217P

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
Predicted Effect probably benign
Transcript: ENSMUST00000215383
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 32 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adam25 C T 8: 40,755,643 P649S probably benign Het
Ano3 T A 2: 110,666,441 R788* probably null Het
Ccdc18 A G 5: 108,202,111 E1043G probably damaging Het
Chd3 A T 11: 69,359,829 H691Q probably damaging Het
Cts7 G T 13: 61,356,529 F73L probably damaging Het
Cyp2c66 A G 19: 39,171,029 Y308C probably damaging Het
Eef1a2 G T 2: 181,152,789 P206T probably benign Het
Gcsh G T 8: 116,989,136 S69R probably damaging Het
Gm13023 T A 4: 143,793,678 probably null Het
Gm9989 T A 3: 81,922,221 noncoding transcript Het
Igkv6-25 C T 6: 70,215,735 T42I probably damaging Het
Iqca T C 1: 90,047,941 Y684C probably damaging Het
Kif6 G A 17: 49,870,894 G602D probably benign Het
Klb C A 5: 65,379,885 R853S probably benign Het
Mad1l1 A C 5: 140,310,589 probably benign Het
Magi1 T C 6: 93,678,787 N1077D probably damaging Het
Med12l T A 3: 59,275,855 S1858T possibly damaging Het
Ncapg2 A G 12: 116,444,332 E984G possibly damaging Het
Necab1 T A 4: 14,955,892 probably benign Het
Nexn G A 3: 152,243,903 R253* probably null Het
Npc1l1 A G 11: 6,214,581 L1156P probably damaging Het
Olfr1385 T A 11: 49,495,397 I288N probably damaging Het
Olfr1451 A G 19: 12,999,573 I196V probably benign Het
Olfr194 A T 16: 59,120,070 probably benign Het
Rassf7 T C 7: 141,218,290 S381P possibly damaging Het
Rdh7 G T 10: 127,884,738 T255K probably benign Het
Scn10a T A 9: 119,691,478 I119F possibly damaging Het
Slc15a3 T A 19: 10,848,678 F244L probably damaging Het
Syde1 T C 10: 78,589,371 S269G probably damaging Het
Teddm2 C T 1: 153,850,335 probably benign Het
Tenm3 T C 8: 48,276,576 D1465G possibly damaging Het
Zkscan2 A T 7: 123,499,841 S43T probably benign Het
Other mutations in Olfr146
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01533:Olfr146 APN 9 39018801 missense probably damaging 0.98
IGL01655:Olfr146 APN 9 39018918 missense probably benign 0.00
IGL01804:Olfr146 APN 9 39019401 missense probably benign 0.13
IGL02719:Olfr146 APN 9 39019016 missense probably benign 0.11
R0531:Olfr146 UTSW 9 39019176 missense probably damaging 0.97
R1270:Olfr146 UTSW 9 39019247 missense possibly damaging 0.90
R1511:Olfr146 UTSW 9 39019025 missense probably benign 0.03
R1590:Olfr146 UTSW 9 39018957 missense probably benign 0.09
R1649:Olfr146 UTSW 9 39019480 missense probably benign 0.03
R3419:Olfr146 UTSW 9 39019076 missense probably benign 0.03
R4669:Olfr146 UTSW 9 39019379 missense probably benign 0.10
R4788:Olfr146 UTSW 9 39018921 missense probably benign 0.07
R5184:Olfr146 UTSW 9 39018702 missense probably damaging 0.98
R5581:Olfr146 UTSW 9 39018702 missense probably damaging 0.98
R6032:Olfr146 UTSW 9 39018965 missense probably benign 0.00
R6032:Olfr146 UTSW 9 39018965 missense probably benign 0.00
R6319:Olfr146 UTSW 9 39019514 missense probably damaging 1.00
R6626:Olfr146 UTSW 9 39019106 missense possibly damaging 0.63
R6693:Olfr146 UTSW 9 39018801 missense probably damaging 0.98
R7165:Olfr146 UTSW 9 39023270 start gained probably benign
R7947:Olfr146 UTSW 9 39019451 missense probably damaging 0.99
R7957:Olfr146 UTSW 9 39019053 missense probably benign
R8052:Olfr146 UTSW 9 39019487 missense probably damaging 0.99
R8162:Olfr146 UTSW 9 39018953 missense probably benign 0.01
R9004:Olfr146 UTSW 9 39019284 missense probably benign 0.01
R9083:Olfr146 UTSW 9 39018720 missense probably damaging 1.00
R9584:Olfr146 UTSW 9 39019166 missense probably damaging 1.00
Z1088:Olfr146 UTSW 9 39018789 missense probably damaging 1.00
Z1191:Olfr146 UTSW 9 39018933 missense probably damaging 1.00
Posted On 2015-04-16