Incidental Mutation 'IGL00566:Clec4g'
ID27968
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Clec4g
Ensembl Gene ENSMUSG00000074491
Gene NameC-type lectin domain family 4, member g
Synonyms4930572L20Rik
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.050) question?
Stock #IGL00566
Quality Score
Status
Chromosome8
Chromosomal Location3707064-3720651 bp(-) (GRCm38)
Type of Mutationintron
DNA Base Change (assembly) T to C at 3716410 bp
ZygosityHeterozygous
Amino Acid Change
Gene Model predicted gene model for transcript(s): [ENSMUST00000058040] [ENSMUST00000062037]
Predicted Effect probably benign
Transcript: ENSMUST00000058040
Predicted Effect probably benign
Transcript: ENSMUST00000062037
SMART Domains Protein: ENSMUSP00000059574
Gene: ENSMUSG00000074491

DomainStartEndE-ValueType
transmembrane domain 31 53 N/A INTRINSIC
coiled coil region 98 153 N/A INTRINSIC
CLECT 165 288 8.85e-35 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000159612
Predicted Effect noncoding transcript
Transcript: ENSMUST00000160490
Predicted Effect probably benign
Transcript: ENSMUST00000160527
SMART Domains Protein: ENSMUSP00000124493
Gene: ENSMUSG00000074491

DomainStartEndE-ValueType
CLECT 2 97 7.75e-8 SMART
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a glycan-binding receptor and member of the C-type lectin family which plays a role in the T-cell immune response. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]
PHENOTYPE: Mice homozygous for a knock-out allele exhibit increased intrahepatic T cell immunity, enhanced immune-mediated liver injury during Con A-induced experimental acute hepatitis, and accelerated CTL-dependent adenovirus clearance. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 20 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
2610021A01Rik A G 7: 41,625,391 T173A possibly damaging Het
Acaa2 G A 18: 74,793,378 G135E probably damaging Het
Actr2 C A 11: 20,072,487 R328L possibly damaging Het
Adam1b T C 5: 121,500,993 D663G probably damaging Het
Adcy10 A T 1: 165,551,914 E915V probably benign Het
Antxr2 G A 5: 97,886,607 probably benign Het
Ckap5 T A 2: 91,568,627 probably benign Het
Cramp1l A G 17: 24,983,951 V368A probably benign Het
Diaph3 C T 14: 87,002,871 R248K probably benign Het
Fut10 T C 8: 31,235,684 Y156H probably damaging Het
Ice2 T C 9: 69,416,113 V630A probably benign Het
Ints13 A T 6: 146,565,676 V179D probably damaging Het
Kcnj2 A C 11: 111,071,827 E15A probably damaging Het
Kif1bp G T 10: 62,559,339 S508* probably null Het
Lpcat2b T A 5: 107,433,804 L333Q probably damaging Het
Lrguk A C 6: 34,056,174 L258F probably damaging Het
M6pr A T 6: 122,313,378 K100M probably damaging Het
Nop14 T C 5: 34,641,313 probably benign Het
Pcdh20 A G 14: 88,467,881 V661A possibly damaging Het
Vcan A T 13: 89,688,979 H2815Q probably benign Het
Other mutations in Clec4g
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01090:Clec4g APN 8 3719482 missense probably damaging 1.00
IGL01331:Clec4g APN 8 3717190 splice site probably benign
IGL01593:Clec4g APN 8 3719474 critical splice donor site probably null
IGL02942:Clec4g APN 8 3718356 missense probably damaging 0.96
IGL03176:Clec4g APN 8 3718441 missense possibly damaging 0.90
R0071:Clec4g UTSW 8 3717489 start gained probably benign
R0379:Clec4g UTSW 8 3718440 missense probably benign 0.00
R4571:Clec4g UTSW 8 3718766 critical splice donor site probably null
R4854:Clec4g UTSW 8 3716534 missense probably damaging 1.00
R4856:Clec4g UTSW 8 3716419 intron probably benign
R4886:Clec4g UTSW 8 3716419 intron probably benign
R5370:Clec4g UTSW 8 3718344 missense probably benign 0.13
R5390:Clec4g UTSW 8 3718441 missense probably benign 0.02
R6522:Clec4g UTSW 8 3718803 missense probably benign 0.11
R6737:Clec4g UTSW 8 3707716 utr 3 prime probably benign
R7097:Clec4g UTSW 8 3719518 missense possibly damaging 0.58
R7834:Clec4g UTSW 8 3716500 missense probably damaging 1.00
R7917:Clec4g UTSW 8 3716500 missense probably damaging 1.00
Z1088:Clec4g UTSW 8 3707796 utr 3 prime probably benign
Z1088:Clec4g UTSW 8 3716548 missense probably damaging 1.00
Posted On2013-04-17