Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL00885:Snx25'

27970

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Snx25

Ensembl Gene

ENSMUSG00000038291

Gene Name

sorting nexin 25

Synonyms

LOC382008, SBBI31

Accession Numbers

Essential gene?

Essential (E-score: 1.000) question?

Stock #

IGL00885

Quality Score

Status

Chromosome

Chromosomal Location

46033261-46152159 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

G to A at 46038476 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Threonine to Methionine at position 859 (T859M)

Ref Sequence

ENSEMBL: ENSMUSP00000106007 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000041582] [ENSMUST00000110378] [ENSMUST00000170416]

AlphaFold

Q3ZT31

Predicted Effect

probably damaging
Transcript: ENSMUST00000041582
AA Change: T713M

PolyPhen 2 Score 0.998 (Sensitivity: 0.27; Specificity: 0.99)

SMART Domains

Protein: ENSMUSP00000035785
Gene: ENSMUSG00000038291
AA Change: T713M

Domain	Start	End	E-Value	Type
Pfam:PXA	1	163	9e-32	PFAM
RGS	287	401	6.62e-10	SMART
low complexity region	421	438	N/A	INTRINSIC
PX	512	624	1.38e-10	SMART
low complexity region	658	663	N/A	INTRINSIC
low complexity region	664	676	N/A	INTRINSIC
Pfam:Nexin_C	701	808	1.7e-35	PFAM
low complexity region	812	828	N/A	INTRINSIC

Predicted Effect

probably damaging
Transcript: ENSMUST00000110378
AA Change: T859M

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000106007
Gene: ENSMUSG00000038291
AA Change: T859M

Domain	Start	End	E-Value	Type
low complexity region	17	31	N/A	INTRINSIC
transmembrane domain	44	66	N/A	INTRINSIC
transmembrane domain	78	100	N/A	INTRINSIC
Pfam:PXA	145	306	8.7e-30	PFAM
RGS	433	547	6.62e-10	SMART
low complexity region	567	584	N/A	INTRINSIC
PX	658	770	1.38e-10	SMART
low complexity region	804	809	N/A	INTRINSIC
low complexity region	810	822	N/A	INTRINSIC
Pfam:Nexin_C	847	953	1e-28	PFAM
low complexity region	958	974	N/A	INTRINSIC

Predicted Effect

probably damaging
Transcript: ENSMUST00000170416
AA Change: T713M

PolyPhen 2 Score 0.998 (Sensitivity: 0.27; Specificity: 0.99)

SMART Domains

Protein: ENSMUSP00000127640
Gene: ENSMUSG00000038291
AA Change: T713M

Domain	Start	End	E-Value	Type
Pfam:PXA	1	163	9e-32	PFAM
RGS	287	401	6.62e-10	SMART
low complexity region	421	438	N/A	INTRINSIC
PX	512	624	1.38e-10	SMART
low complexity region	658	663	N/A	INTRINSIC
low complexity region	664	676	N/A	INTRINSIC
Pfam:Nexin_C	701	808	1.7e-35	PFAM
low complexity region	812	828	N/A	INTRINSIC

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000176410

Predicted Effect

probably benign
Transcript: ENSMUST00000177186

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 41 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Adgrf2	A	T	17: 42,714,315		probably benign	Het
Adora2a	T	G	10: 75,333,451	F250V	probably damaging	Het
Atp8b5	T	C	4: 43,355,567	S516P	probably damaging	Het
Btbd16	A	G	7: 130,788,822	I150V	probably damaging	Het
Capn13	A	T	17: 73,339,425	I331N	possibly damaging	Het
Capzb	A	G	4: 139,287,050	S233G	probably benign	Het
Clasp2	A	G	9: 113,911,416	R1171G	probably damaging	Het
Col16a1	T	G	4: 130,096,910	I1419S	probably damaging	Het
Coro7	T	A	16: 4,635,026	Y286F	probably benign	Het
Crygd	C	T	1: 65,062,091	R115Q	probably benign	Het
Cyp11b2	T	C	15: 74,853,515	T252A	probably benign	Het
Daam1	T	A	12: 71,944,091	C160S	unknown	Het
Ephx4	T	C	5: 107,406,125		probably benign	Het
Fbxo47	A	T	11: 97,878,120	D63E	probably benign	Het
Fgf3	A	T	7: 144,840,784		probably benign	Het
Fstl4	C	T	11: 53,148,982	T331I	possibly damaging	Het
Gm597	T	C	1: 28,776,845	E702G	unknown	Het
Gpr158	T	C	2: 21,649,021	F467S	probably damaging	Het
Igfbpl1	C	T	4: 45,826,478	V106I	probably damaging	Het
Ikzf2	T	C	1: 69,539,322	T271A	possibly damaging	Het
Kat14	T	A	2: 144,394,255	N302K	probably benign	Het
Kmt2c	G	T	5: 25,409,171	Q184K	possibly damaging	Het
Moxd2	A	G	6: 40,884,179		probably benign	Het
Nbeal2	C	A	9: 110,638,661	E479D	probably damaging	Het
Neo1	A	G	9: 58,888,463	L1231P	probably damaging	Het
Nfatc3	C	T	8: 106,099,177	P620L	probably damaging	Het
Nol9	T	C	4: 152,041,600	F253L	probably damaging	Het
Nutm2	T	A	13: 50,474,860	S653R	probably benign	Het
Olfr138	A	C	17: 38,274,899	I43L	probably benign	Het
Olfr1504	A	T	19: 13,888,168	M14K	probably benign	Het
Plcg1	A	G	2: 160,758,083	D921G	probably benign	Het
Plpp4	A	T	7: 129,321,533	I101F	probably damaging	Het
Psg17	A	T	7: 18,820,166	L53Q	probably damaging	Het
Ptpn4	A	T	1: 119,802,363	I20N	possibly damaging	Het
R3hdm1	A	T	1: 128,236,438	I1030L	probably damaging	Het
Rpl7	A	C	1: 16,102,583	S171A	possibly damaging	Het
Tmem94	A	G	11: 115,795,328	M990V	probably damaging	Het
Tnnt2	A	G	1: 135,846,764		probably benign	Het
Ttn	T	C	2: 76,709,685	H34319R	possibly damaging	Het
Vmn1r72	A	G	7: 11,670,497	V8A	probably benign	Het
Zbtb41	A	G	1: 139,430,324	T457A	probably benign	Het

Other mutations in Snx25

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01432:Snx25	APN	8	46105160	missense	probably damaging	0.96
IGL01600:Snx25	APN	8	46116310	missense	probably benign	0.00
IGL02150:Snx25	APN	8	46116281	missense	possibly damaging	0.89
IGL02386:Snx25	APN	8	46041349	missense	possibly damaging	0.93
IGL02691:Snx25	APN	8	46105265	missense	possibly damaging	0.88
IGL03338:Snx25	APN	8	46045210	missense	probably benign	0.04
IGL03377:Snx25	APN	8	46080301	unclassified	probably benign
duo	UTSW	8	46124082	start codon destroyed	probably null	0.88
R0047:Snx25	UTSW	8	46041365	missense	probably damaging	0.99
R0047:Snx25	UTSW	8	46041365	missense	probably damaging	0.99
R0048:Snx25	UTSW	8	46105109	splice site	probably benign
R0048:Snx25	UTSW	8	46105109	splice site	probably benign
R0056:Snx25	UTSW	8	46038513	missense	probably damaging	1.00
R0546:Snx25	UTSW	8	46103630	missense	probably benign	0.00
R0791:Snx25	UTSW	8	46124082	start codon destroyed	probably null	0.88
R1165:Snx25	UTSW	8	46035715	missense	probably damaging	0.99
R1255:Snx25	UTSW	8	46116238	missense	probably benign	0.13
R1262:Snx25	UTSW	8	46105291	missense	probably damaging	0.98
R1522:Snx25	UTSW	8	46124082	start codon destroyed	probably null	0.88
R1652:Snx25	UTSW	8	46049473	missense	probably damaging	0.99
R1710:Snx25	UTSW	8	46116207	missense	possibly damaging	0.69
R1829:Snx25	UTSW	8	46035632	missense	possibly damaging	0.82
R2090:Snx25	UTSW	8	46056113	missense	probably damaging	1.00
R2158:Snx25	UTSW	8	46041407	missense	probably damaging	1.00
R2906:Snx25	UTSW	8	46049523	splice site	probably null
R4244:Snx25	UTSW	8	46105254	missense	probably damaging	0.98
R4394:Snx25	UTSW	8	46035678	missense	probably damaging	1.00
R4465:Snx25	UTSW	8	46068229	missense	possibly damaging	0.78
R4586:Snx25	UTSW	8	46116437	intron	probably benign
R4663:Snx25	UTSW	8	46035579	missense	probably damaging	1.00
R4961:Snx25	UTSW	8	46068192	missense	probably damaging	0.99
R5104:Snx25	UTSW	8	46068166	makesense	probably null
R5634:Snx25	UTSW	8	46041391	missense	possibly damaging	0.94
R6128:Snx25	UTSW	8	46105203	missense	probably benign	0.01
R6344:Snx25	UTSW	8	46035638	nonsense	probably null
R6382:Snx25	UTSW	8	46055991	missense	probably benign
R6523:Snx25	UTSW	8	46055855	missense	probably damaging	0.96
R6798:Snx25	UTSW	8	46033773	missense	probably damaging	0.98
R7143:Snx25	UTSW	8	46035715	missense	possibly damaging	0.92
R7147:Snx25	UTSW	8	46105196	missense	probably damaging	0.98
R7519:Snx25	UTSW	8	46116272	missense	probably damaging	1.00
R7723:Snx25	UTSW	8	46038479	missense	probably damaging	1.00
R9084:Snx25	UTSW	8	46068166	makesense	probably null
R9519:Snx25	UTSW	8	46033746	missense	probably damaging	1.00
RF002:Snx25	UTSW	8	46116181	critical splice donor site	probably null

Posted On

2013-04-17