Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02101:Dpp10'

279755

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Dpp10

Ensembl Gene

ENSMUSG00000036815

Gene Name

dipeptidylpeptidase 10

Synonyms

6430601K09Rik, DPRP3

Accession Numbers

Essential gene?

Non essential (E-score: 0.000) question?

Stock #

IGL02101

Quality Score

Status

Chromosome

Chromosomal Location

123259871-124773774 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 123339555 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Tyrosine to Cysteine at position 324 (Y324C)

Ref Sequence

ENSEMBL: ENSMUSP00000108225 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000112603] [ENSMUST00000112606]

AlphaFold

no structure available at present

Predicted Effect

probably damaging
Transcript: ENSMUST00000112603
AA Change: Y313C

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000108222
Gene: ENSMUSG00000036815
AA Change: Y313C

Domain	Start	End	E-Value	Type
low complexity region	10	25	N/A	INTRINSIC
Pfam:DPPIV_N	83	450	4.9e-118	PFAM
Pfam:Peptidase_S9	530	734	6.4e-47	PFAM
Pfam:DLH	556	711	1.4e-6	PFAM

Predicted Effect

probably damaging
Transcript: ENSMUST00000112606
AA Change: Y324C

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000108225
Gene: ENSMUSG00000036815
AA Change: Y324C

Domain	Start	End	E-Value	Type
transmembrane domain	38	60	N/A	INTRINSIC
low complexity region	64	79	N/A	INTRINSIC
Pfam:DPPIV_N	137	504	4.4e-115	PFAM
Pfam:Peptidase_S9	584	788	8.6e-48	PFAM
Pfam:DLH	604	774	1.1e-7	PFAM

Coding Region Coverage

Validation Efficiency

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a single-pass type II membrane protein that is a member of the S9B family in clan SC of the serine proteases. This protein has no detectable protease activity, most likely due to the absence of the conserved serine residue normally present in the catalytic domain of serine proteases. However, it does bind specific voltage-gated potassium channels and alters their expression and biophysical properties. Mutations in this gene have been associated with asthma. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]

Allele List at MGI

Other mutations in this stock

Total: 27 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Cd163	T	A	6: 124,284,246 (GRCm39)	C139*	probably null	Het
Ces2g	A	G	8: 105,691,769 (GRCm39)		probably null	Het
Ckap5	T	C	2: 91,402,885 (GRCm39)		probably benign	Het
Cmtm7	T	C	9: 114,592,336 (GRCm39)	H87R	probably damaging	Het
Dennd3	A	G	15: 73,399,794 (GRCm39)	D220G	possibly damaging	Het
Dsc3	C	T	18: 20,134,963 (GRCm39)	R7Q	probably benign	Het
Ezh1	T	C	11: 101,086,392 (GRCm39)	K598E	possibly damaging	Het
Ighv7-3	A	G	12: 114,117,045 (GRCm39)	L39P	probably damaging	Het
Il1rap	T	A	16: 26,442,932 (GRCm39)	S9R	possibly damaging	Het
Mrgpra3	A	G	7: 47,239,300 (GRCm39)	C209R	probably damaging	Het
Oc90	G	T	15: 65,769,638 (GRCm39)	P73Q	probably damaging	Het
Or2m12	T	C	16: 19,105,363 (GRCm39)	I43M	probably benign	Het
Or3a1b	G	A	11: 74,012,571 (GRCm39)	W152*	probably null	Het
Pccb	A	G	9: 100,869,894 (GRCm39)	F346L	possibly damaging	Het
Pdxdc1	A	G	16: 13,687,720 (GRCm39)	I225T	probably damaging	Het
Pold3	A	T	7: 99,749,703 (GRCm39)	M154K	probably damaging	Het
Polr1a	T	G	6: 71,927,786 (GRCm39)	C846G	probably benign	Het
Ppip5k1	C	A	2: 121,162,089 (GRCm39)	R978L	possibly damaging	Het
Ptpn4	A	G	1: 119,615,408 (GRCm39)	V582A	probably damaging	Het
Sez6l	G	T	5: 112,620,612 (GRCm39)	Q323K	probably damaging	Het
Slc27a5	A	T	7: 12,727,270 (GRCm39)	I384N	possibly damaging	Het
Slc39a10	G	A	1: 46,857,288 (GRCm39)	A696V	probably damaging	Het
Slc7a2	T	C	8: 41,355,631 (GRCm39)	F227L	probably benign	Het
Smad4	C	A	18: 73,791,723 (GRCm39)	A273S	probably benign	Het
Spata17	T	C	1: 186,849,657 (GRCm39)	I84V	probably benign	Het
Sphkap	T	C	1: 83,268,708 (GRCm39)	T95A	probably damaging	Het
Tie1	T	C	4: 118,329,995 (GRCm39)	D1076G	probably benign	Het

Other mutations in Dpp10

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01592:Dpp10	APN	1	123,262,099 (GRCm39)	missense	probably damaging	1.00
IGL01618:Dpp10	APN	1	123,295,596 (GRCm39)	missense	probably benign
IGL02284:Dpp10	APN	1	123,973,103 (GRCm39)	splice site	probably benign
IGL02324:Dpp10	APN	1	123,295,531 (GRCm39)	missense	probably benign	0.02
IGL02391:Dpp10	APN	1	123,578,087 (GRCm39)	missense	probably damaging	0.98
IGL02458:Dpp10	APN	1	123,269,418 (GRCm39)	missense	probably benign	0.01
IGL02469:Dpp10	APN	1	123,339,532 (GRCm39)	missense	probably benign	0.01
IGL02501:Dpp10	APN	1	123,613,999 (GRCm39)	missense	possibly damaging	0.93
IGL02522:Dpp10	APN	1	123,351,381 (GRCm39)	missense	probably benign	0.24
IGL02672:Dpp10	APN	1	123,304,376 (GRCm39)	missense	probably benign	0.45
IGL03034:Dpp10	APN	1	123,269,348 (GRCm39)	missense	probably damaging	1.00
PIT1430001:Dpp10	UTSW	1	123,268,911 (GRCm39)	splice site	probably benign
R0104:Dpp10	UTSW	1	123,295,572 (GRCm39)	missense	probably benign	0.00
R0114:Dpp10	UTSW	1	123,413,821 (GRCm39)	missense	probably benign	0.07
R0242:Dpp10	UTSW	1	123,326,275 (GRCm39)	missense	possibly damaging	0.56
R0242:Dpp10	UTSW	1	123,326,275 (GRCm39)	missense	possibly damaging	0.56
R0682:Dpp10	UTSW	1	123,832,852 (GRCm39)	missense	probably damaging	0.98
R0815:Dpp10	UTSW	1	123,360,658 (GRCm39)	critical splice donor site	probably null
R1549:Dpp10	UTSW	1	123,269,109 (GRCm39)	critical splice acceptor site	probably null
R1742:Dpp10	UTSW	1	123,372,935 (GRCm39)	missense	probably damaging	1.00
R1859:Dpp10	UTSW	1	123,281,333 (GRCm39)	missense	possibly damaging	0.47
R1991:Dpp10	UTSW	1	123,832,833 (GRCm39)	missense	probably null	1.00
R1992:Dpp10	UTSW	1	123,832,833 (GRCm39)	missense	probably null	1.00
R2079:Dpp10	UTSW	1	123,360,721 (GRCm39)	missense	probably damaging	1.00
R2882:Dpp10	UTSW	1	123,372,932 (GRCm39)	missense	probably damaging	1.00
R2974:Dpp10	UTSW	1	123,339,434 (GRCm39)	splice site	probably benign
R3827:Dpp10	UTSW	1	123,339,519 (GRCm39)	missense	possibly damaging	0.56
R3852:Dpp10	UTSW	1	123,413,653 (GRCm39)	nonsense	probably null
R3876:Dpp10	UTSW	1	123,281,216 (GRCm39)	missense	probably damaging	0.98
R3899:Dpp10	UTSW	1	123,281,286 (GRCm39)	missense	probably damaging	1.00
R4735:Dpp10	UTSW	1	123,326,356 (GRCm39)	missense	probably benign	0.15
R4922:Dpp10	UTSW	1	123,305,882 (GRCm39)	missense	probably benign	0.44
R5457:Dpp10	UTSW	1	123,339,539 (GRCm39)	missense	possibly damaging	0.51
R5599:Dpp10	UTSW	1	123,832,803 (GRCm39)	missense	probably damaging	0.99
R5913:Dpp10	UTSW	1	123,312,018 (GRCm39)	missense	probably damaging	1.00
R5979:Dpp10	UTSW	1	123,312,012 (GRCm39)	critical splice donor site	probably null
R6378:Dpp10	UTSW	1	123,339,468 (GRCm39)	missense	probably damaging	1.00
R6429:Dpp10	UTSW	1	123,295,330 (GRCm39)	missense	possibly damaging	0.72
R6505:Dpp10	UTSW	1	123,264,580 (GRCm39)	missense	probably damaging	0.99
R6776:Dpp10	UTSW	1	123,295,385 (GRCm39)	nonsense	probably null
R6894:Dpp10	UTSW	1	123,264,593 (GRCm39)	missense	probably damaging	1.00
R6951:Dpp10	UTSW	1	123,269,379 (GRCm39)	missense	possibly damaging	0.93
R7182:Dpp10	UTSW	1	123,268,880 (GRCm39)	missense	probably benign	0.15
R7246:Dpp10	UTSW	1	123,262,106 (GRCm39)	missense	probably damaging	1.00
R7297:Dpp10	UTSW	1	123,281,157 (GRCm39)	nonsense	probably null
R7375:Dpp10	UTSW	1	123,295,524 (GRCm39)	missense	probably benign
R7387:Dpp10	UTSW	1	123,268,869 (GRCm39)	missense	probably benign	0.01
R7661:Dpp10	UTSW	1	123,312,681 (GRCm39)	missense	probably damaging	1.00
R8065:Dpp10	UTSW	1	123,280,389 (GRCm39)	missense	probably benign
R8067:Dpp10	UTSW	1	123,280,389 (GRCm39)	missense	probably benign
R8260:Dpp10	UTSW	1	123,614,024 (GRCm39)	missense	probably benign
R8324:Dpp10	UTSW	1	123,781,901 (GRCm39)	missense	probably benign	0.02
R8373:Dpp10	UTSW	1	123,781,958 (GRCm39)	missense	possibly damaging	0.94
R8434:Dpp10	UTSW	1	123,360,739 (GRCm39)	missense	probably damaging	1.00
R9068:Dpp10	UTSW	1	123,360,667 (GRCm39)	missense	probably damaging	1.00
R9104:Dpp10	UTSW	1	123,339,484 (GRCm39)	missense	probably damaging	1.00
R9477:Dpp10	UTSW	1	123,304,370 (GRCm39)	missense	possibly damaging	0.46
R9492:Dpp10	UTSW	1	123,281,159 (GRCm39)	missense	probably damaging	1.00
R9524:Dpp10	UTSW	1	123,264,611 (GRCm39)	missense	probably damaging	1.00
R9576:Dpp10	UTSW	1	123,269,409 (GRCm39)	missense	probably damaging	1.00
R9631:Dpp10	UTSW	1	123,269,432 (GRCm39)	missense	probably damaging	1.00
R9736:Dpp10	UTSW	1	123,262,088 (GRCm39)	missense	possibly damaging	0.64
X0019:Dpp10	UTSW	1	123,326,314 (GRCm39)	missense	possibly damaging	0.88
X0020:Dpp10	UTSW	1	123,326,311 (GRCm39)	missense	probably benign	0.36
X0021:Dpp10	UTSW	1	123,360,721 (GRCm39)	missense	probably damaging	1.00
X0024:Dpp10	UTSW	1	123,312,015 (GRCm39)	missense	probably damaging	1.00
Z1176:Dpp10	UTSW	1	123,281,169 (GRCm39)	nonsense	probably null

Posted On

2015-04-16