Mutagenetix > Incidental Mutations

Incidental Mutation 'IGL02102:Cdk14'

279790

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Cdk14

Ensembl Gene

ENSMUSG00000028926

Gene Name

cyclin-dependent kinase 14

Synonyms

Pftk1

Accession Numbers

Is this an essential gene?

Non essential (E-score: 0.000) question?

Stock #

IGL02102

Quality Score

Status

Chromosome

Chromosomal Location

4803391-5420312 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 5380083 bp

Zygosity

Heterozygous

Amino Acid Change

Lysine to Glutamic Acid at position 15 (K15E)

Ref Sequence

ENSEMBL: ENSMUSP00000030763 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000030763] [ENSMUST00000167567]

Predicted Effect

probably benign
Transcript: ENSMUST00000030763
AA Change: K15E

PolyPhen 2 Score 0.008 (Sensitivity: 0.96; Specificity: 0.76)

SMART Domains

Protein: ENSMUSP00000030763
Gene: ENSMUSG00000028926
AA Change: K15E

Domain	Start	End	E-Value	Type
low complexity region	119	127	N/A	INTRINSIC
S_TKc	135	419	3.63e-85	SMART

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000132390

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000134867

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000153331

Predicted Effect

probably benign
Transcript: ENSMUST00000167567

SMART Domains

Protein: ENSMUSP00000130895
Gene: ENSMUSG00000028926

Domain	Start	End	E-Value	Type
signal peptide	1	21	N/A	INTRINSIC
low complexity region	149	157	N/A	INTRINSIC

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000200637

Coding Region Coverage

Validation Efficiency

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] PFTK1 is a member of the CDC2 (MIM 116940)-related protein kinase family (Yang and Chen, 2001 [PubMed 11313143]).[supplied by OMIM, Mar 2008]

Allele List at MGI

Other mutations in this stock

Total: 45 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Adamts9	T	C	6: 92,777,439	T1338A	probably benign	Het
Adcy3	G	A	12: 4,134,699	C125Y	probably damaging	Het
Aoc1	A	T	6: 48,905,962	K257N	probably damaging	Het
Apob	T	C	12: 7,989,407	V497A	possibly damaging	Het
Atp8b5	T	A	4: 43,364,167	V684D	probably benign	Het
AW551984	A	G	9: 39,589,691	W763R	probably damaging	Het
Blm	G	A	7: 80,469,756	T1026M	probably damaging	Het
Cd160	A	G	3: 96,805,570	I126T	possibly damaging	Het
Cnot6l	T	C	5: 96,091,659	K261R	probably damaging	Het
Cyp3a13	T	G	5: 137,911,603	T153P	probably benign	Het
Ddx24	A	G	12: 103,408,484		probably benign	Het
Dido1	G	A	2: 180,662,247	T1288I	possibly damaging	Het
Dnajc13	A	G	9: 104,229,009	V322A	possibly damaging	Het
Dnajc25	T	A	4: 59,017,693	Y117*	probably null	Het
Dsg1a	A	G	18: 20,332,032	N427D	probably benign	Het
Gabrq	T	G	X: 72,827,545		probably null	Het
Glce	A	G	9: 62,070,601		probably benign	Het
Gm10477	T	C	X: 56,525,401	L45P	probably damaging	Het
Htt	T	A	5: 34,891,481		probably benign	Het
Ift140	A	G	17: 25,033,130	E317G	probably benign	Het
Jak1	A	G	4: 101,159,086	M827T	probably benign	Het
Kalrn	A	G	16: 34,220,222	V932A	probably damaging	Het
Mdm2	A	C	10: 117,692,717	S227R	possibly damaging	Het
Olfr1216	A	G	2: 89,013,126		probably benign	Het
Olfr153	T	C	2: 87,532,461	F143L	probably benign	Het
Olfr305	T	C	7: 86,363,866	Y157C	probably benign	Het
Olfr995	A	G	2: 85,438,267	V297A	probably damaging	Het
Olfr996	G	A	2: 85,579,673	V145I	probably damaging	Het
Pdilt	T	G	7: 119,486,950	E514A	probably benign	Het
Pepd	A	G	7: 34,945,603	D153G	probably damaging	Het
Ptgis	A	T	2: 167,225,447	V70E	probably damaging	Het
Rnf112	T	C	11: 61,452,015	K262E	probably benign	Het
Setd5	G	T	6: 113,150,985	G1300*	probably null	Het
Snx15	A	G	19: 6,122,074	L113P	possibly damaging	Het
Sptbn1	T	C	11: 30,137,427	D1004G	probably damaging	Het
Ston2	A	C	12: 91,639,724	*896G	probably null	Het
Suco	A	G	1: 161,827,705	S1073P	probably damaging	Het
Susd1	A	C	4: 59,369,636	D344E	possibly damaging	Het
Trnt1	G	T	6: 106,778,112		probably null	Het
Ttll12	A	G	15: 83,582,063	F399S	probably damaging	Het
Vmn1r124	C	T	7: 21,260,542	V26I	probably benign	Het
Vmn1r52	T	A	6: 90,179,207	N164K	possibly damaging	Het
Vmn1r56	A	T	7: 5,196,336	M94K	possibly damaging	Het
Vmn1r80	T	C	7: 12,193,691	F243L	probably damaging	Het
Zdhhc8	G	A	16: 18,225,199	S379F	possibly damaging	Het

Other mutations in Cdk14

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00678:Cdk14	APN	5	5249237	splice site	probably benign
IGL01376:Cdk14	APN	5	5010839	missense	probably damaging	1.00
IGL02179:Cdk14	APN	5	5103845	missense	probably damaging	1.00
IGL02423:Cdk14	APN	5	4888905	missense	probably benign	0.00
IGL03081:Cdk14	APN	5	4949527	splice site	probably benign
IGL02988:Cdk14	UTSW	5	5036484	missense	probably damaging	1.00
R0465:Cdk14	UTSW	5	5093019	missense	probably damaging	1.00
R0630:Cdk14	UTSW	5	5135422	splice site	probably benign
R1452:Cdk14	UTSW	5	4888927	missense	possibly damaging	0.85
R1601:Cdk14	UTSW	5	5135378	missense	probably damaging	1.00
R1629:Cdk14	UTSW	5	5103807	missense	probably benign	0.18
R1659:Cdk14	UTSW	5	4949571	missense	probably benign	0.08
R1809:Cdk14	UTSW	5	5010901	missense	probably damaging	0.98
R2013:Cdk14	UTSW	5	5093047	missense	probably damaging	1.00
R2015:Cdk14	UTSW	5	5380082	missense	probably benign
R2256:Cdk14	UTSW	5	4888924	missense	probably benign
R2257:Cdk14	UTSW	5	4888924	missense	probably benign
R2908:Cdk14	UTSW	5	5249051	missense	probably benign	0.33
R4324:Cdk14	UTSW	5	5036532	nonsense	probably null
R4432:Cdk14	UTSW	5	5036427	missense	probably damaging	1.00
R4907:Cdk14	UTSW	5	5249140	missense	probably damaging	0.96
R5426:Cdk14	UTSW	5	4888975	missense	possibly damaging	0.93
R5708:Cdk14	UTSW	5	5266036	intron	probably benign
R6006:Cdk14	UTSW	5	5249211	start codon destroyed	probably null	0.33
R6120:Cdk14	UTSW	5	4894029	missense	probably damaging	0.96
R7048:Cdk14	UTSW	5	5093005	missense	probably damaging	1.00
R7104:Cdk14	UTSW	5	5195325	missense	possibly damaging	0.92
R7712:Cdk14	UTSW	5	5380061	missense	possibly damaging	0.86
R8046:Cdk14	UTSW	5	5249159	missense	possibly damaging	0.86
R8121:Cdk14	UTSW	5	5227195	missense	possibly damaging	0.92
R8195:Cdk14	UTSW	5	5227159	splice site	probably null
R8279:Cdk14	UTSW	5	5266125	intron	probably benign
R8312:Cdk14	UTSW	5	4894141	missense	probably benign	0.03
R8543:Cdk14	UTSW	5	5380079	missense	probably benign	0.02
Z1176:Cdk14	UTSW	5	5135322	nonsense	probably null
Z1177:Cdk14	UTSW	5	4888894	missense	possibly damaging	0.92

Posted On

2015-04-16