Incidental Mutation 'IGL02103:Or3a1'
ID 279816
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Or3a1
Ensembl Gene ENSMUSG00000063116
Gene Name olfactory receptor family 3 subfamily A member 1
Synonyms Olfr410, GA_x6K02T2P1NL-4467421-4466474, MOR255-5
Accession Numbers
Essential gene? Probably non essential (E-score: 0.114) question?
Stock # IGL02103
Quality Score
Status
Chromosome 11
Chromosomal Location 74225108-74226055 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 74225862 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Phenylalanine to Serine at position 65 (F65S)
Ref Sequence ENSEMBL: ENSMUSP00000150291 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000052254] [ENSMUST00000213831] [ENSMUST00000214490]
AlphaFold Q8VFX7
Predicted Effect probably damaging
Transcript: ENSMUST00000052254
AA Change: F65S

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000050456
Gene: ENSMUSG00000063116
AA Change: F65S

DomainStartEndE-ValueType
Pfam:7tm_4 34 311 5.4e-53 PFAM
Pfam:7TM_GPCR_Srsx 38 253 5e-6 PFAM
Pfam:7tm_1 44 293 7.7e-27 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000213831
AA Change: F65S

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
Predicted Effect probably damaging
Transcript: ENSMUST00000214490
AA Change: F65S

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 51 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abcd4 G A 12: 84,659,138 (GRCm39) T206M probably benign Het
Adcy3 T A 12: 4,184,390 (GRCm39) V22D possibly damaging Het
Alb G A 5: 90,611,990 (GRCm39) E140K probably benign Het
Aph1a G A 3: 95,803,125 (GRCm39) V193I probably damaging Het
Asb2 G A 12: 103,299,755 (GRCm39) R178* probably null Het
Celf3 A T 3: 94,394,108 (GRCm39) Q137L probably damaging Het
Cmya5 T C 13: 93,228,635 (GRCm39) D2151G probably benign Het
Cuedc1 T A 11: 88,079,625 (GRCm39) S353T probably damaging Het
Dlg5 A C 14: 24,194,414 (GRCm39) L1709R probably damaging Het
Dst T C 1: 34,229,199 (GRCm39) I1939T possibly damaging Het
Emx2 A T 19: 59,450,130 (GRCm39) N149I probably benign Het
Fancm A G 12: 65,142,558 (GRCm39) D472G probably benign Het
Fasn T C 11: 120,702,762 (GRCm39) Y1700C probably damaging Het
Fat2 T A 11: 55,180,122 (GRCm39) R1406S probably damaging Het
Fat4 C A 3: 38,943,348 (GRCm39) T747K probably damaging Het
Fer A G 17: 64,445,923 (GRCm39) M795V probably benign Het
Gm5916 A G 9: 36,039,970 (GRCm39) L6P probably damaging Het
Gpr139 A G 7: 118,744,355 (GRCm39) F77L possibly damaging Het
Kcnu1 T C 8: 26,395,976 (GRCm39) S654P possibly damaging Het
Kdm5c T A X: 151,031,762 (GRCm39) F408L probably damaging Het
Kel A G 6: 41,679,323 (GRCm39) S147P probably benign Het
Klra5 A T 6: 129,888,307 (GRCm39) probably null Het
Mastl A G 2: 23,030,010 (GRCm39) S239P probably benign Het
Med18 A T 4: 132,186,977 (GRCm39) V174D probably damaging Het
Mgat4a A T 1: 37,502,007 (GRCm39) M247K possibly damaging Het
Mx2 A C 16: 97,345,795 (GRCm39) D71A probably damaging Het
Nxt1 G T 2: 148,517,564 (GRCm39) E102* probably null Het
Or14j1 A G 17: 38,146,169 (GRCm39) Q93R possibly damaging Het
Or7g16 T C 9: 18,727,005 (GRCm39) N195S probably damaging Het
Pcdhb16 T A 18: 37,613,161 (GRCm39) V707E probably benign Het
Pdzrn4 T A 15: 92,667,768 (GRCm39) V640E probably damaging Het
Piwil4 T C 9: 14,637,282 (GRCm39) probably null Het
Pla2g4a A T 1: 149,776,950 (GRCm39) D55E probably damaging Het
Plekhg2 C A 7: 28,059,501 (GRCm39) R1276L probably damaging Het
Psd4 G A 2: 24,290,540 (GRCm39) W539* probably null Het
Rae1 G A 2: 172,845,306 (GRCm39) E33K probably damaging Het
Rbm12b1 T A 4: 12,145,563 (GRCm39) F512I probably damaging Het
Rfx6 A G 10: 51,602,952 (GRCm39) D823G possibly damaging Het
Samt3 A T X: 85,090,759 (GRCm39) Q217L probably damaging Het
Selenbp2 A G 3: 94,605,438 (GRCm39) N134S probably null Het
Selenoo T C 15: 88,984,173 (GRCm39) V663A probably damaging Het
Sp4 G T 12: 118,263,284 (GRCm39) T254N probably damaging Het
Spdya A G 17: 71,885,242 (GRCm39) K232R probably benign Het
Stom A T 2: 35,210,401 (GRCm39) V201E probably benign Het
Sycp3 A G 10: 88,302,334 (GRCm39) K108R possibly damaging Het
Usp2 A G 9: 44,000,425 (GRCm39) probably benign Het
Vmn1r226 T C 17: 20,907,926 (GRCm39) S53P probably damaging Het
Vmn2r14 C T 5: 109,372,349 (GRCm39) G47D probably damaging Het
Vwf T G 6: 125,623,318 (GRCm39) L1805W probably damaging Het
Washc3 A T 10: 88,037,687 (GRCm39) Q22L probably damaging Het
Wdr81 T A 11: 75,335,546 (GRCm39) D1761V probably damaging Het
Other mutations in Or3a1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02885:Or3a1 APN 11 74,225,519 (GRCm39) missense possibly damaging 0.95
R0363:Or3a1 UTSW 11 74,225,925 (GRCm39) missense probably damaging 1.00
R1033:Or3a1 UTSW 11 74,225,462 (GRCm39) missense possibly damaging 0.48
R1722:Or3a1 UTSW 11 74,225,271 (GRCm39) missense probably damaging 1.00
R1759:Or3a1 UTSW 11 74,225,808 (GRCm39) missense possibly damaging 0.49
R2007:Or3a1 UTSW 11 74,225,212 (GRCm39) missense possibly damaging 0.57
R2278:Or3a1 UTSW 11 74,225,991 (GRCm39) missense probably benign 0.00
R4756:Or3a1 UTSW 11 74,225,402 (GRCm39) missense probably benign
R5382:Or3a1 UTSW 11 74,225,806 (GRCm39) missense probably benign 0.00
R6026:Or3a1 UTSW 11 74,225,914 (GRCm39) missense probably damaging 0.99
R6048:Or3a1 UTSW 11 74,225,961 (GRCm39) missense probably benign 0.13
R8488:Or3a1 UTSW 11 74,225,932 (GRCm39) missense probably benign 0.01
R9134:Or3a1 UTSW 11 74,225,670 (GRCm39) missense probably damaging 1.00
R9368:Or3a1 UTSW 11 74,225,193 (GRCm39) missense probably damaging 1.00
X0067:Or3a1 UTSW 11 74,225,776 (GRCm39) missense probably benign 0.00
Z1088:Or3a1 UTSW 11 74,225,518 (GRCm39) missense probably damaging 1.00
Posted On 2015-04-16