Incidental Mutation 'IGL02103:Mx2'
ID 279858
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Mx2
Ensembl Gene ENSMUSG00000023341
Gene Name MX dynamin-like GTPase 2
Synonyms Mx-2
Accession Numbers
Essential gene? Probably non essential (E-score: 0.178) question?
Stock # IGL02103
Quality Score
Status
Chromosome 16
Chromosomal Location 97337281-97362101 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to C at 97345795 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Aspartic acid to Alanine at position 71 (D71A)
Ref Sequence ENSEMBL: ENSMUSP00000141038 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000024112] [ENSMUST00000188251] [ENSMUST00000190447]
AlphaFold Q9WVP9
Predicted Effect probably damaging
Transcript: ENSMUST00000024112
AA Change: D71A

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000024112
Gene: ENSMUSG00000023341
AA Change: D71A

DomainStartEndE-ValueType
DYNc 39 282 2.71e-135 SMART
Blast:DYNc 426 539 4e-17 BLAST
GED 562 653 9.88e-30 SMART
Predicted Effect probably damaging
Transcript: ENSMUST00000188251
AA Change: D71A

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000141038
Gene: ENSMUSG00000023341
AA Change: D71A

DomainStartEndE-ValueType
DYNc 39 282 1.3e-137 SMART
low complexity region 592 603 N/A INTRINSIC
low complexity region 619 637 N/A INTRINSIC
Predicted Effect possibly damaging
Transcript: ENSMUST00000190447
AA Change: D71A

PolyPhen 2 Score 0.457 (Sensitivity: 0.89; Specificity: 0.90)
SMART Domains Protein: ENSMUSP00000140229
Gene: ENSMUSG00000023341
AA Change: D71A

DomainStartEndE-ValueType
DYNc 39 282 1.3e-137 SMART
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 51 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abcd4 G A 12: 84,659,138 (GRCm39) T206M probably benign Het
Adcy3 T A 12: 4,184,390 (GRCm39) V22D possibly damaging Het
Alb G A 5: 90,611,990 (GRCm39) E140K probably benign Het
Aph1a G A 3: 95,803,125 (GRCm39) V193I probably damaging Het
Asb2 G A 12: 103,299,755 (GRCm39) R178* probably null Het
Celf3 A T 3: 94,394,108 (GRCm39) Q137L probably damaging Het
Cmya5 T C 13: 93,228,635 (GRCm39) D2151G probably benign Het
Cuedc1 T A 11: 88,079,625 (GRCm39) S353T probably damaging Het
Dlg5 A C 14: 24,194,414 (GRCm39) L1709R probably damaging Het
Dst T C 1: 34,229,199 (GRCm39) I1939T possibly damaging Het
Emx2 A T 19: 59,450,130 (GRCm39) N149I probably benign Het
Fancm A G 12: 65,142,558 (GRCm39) D472G probably benign Het
Fasn T C 11: 120,702,762 (GRCm39) Y1700C probably damaging Het
Fat2 T A 11: 55,180,122 (GRCm39) R1406S probably damaging Het
Fat4 C A 3: 38,943,348 (GRCm39) T747K probably damaging Het
Fer A G 17: 64,445,923 (GRCm39) M795V probably benign Het
Gm5916 A G 9: 36,039,970 (GRCm39) L6P probably damaging Het
Gpr139 A G 7: 118,744,355 (GRCm39) F77L possibly damaging Het
Kcnu1 T C 8: 26,395,976 (GRCm39) S654P possibly damaging Het
Kdm5c T A X: 151,031,762 (GRCm39) F408L probably damaging Het
Kel A G 6: 41,679,323 (GRCm39) S147P probably benign Het
Klra5 A T 6: 129,888,307 (GRCm39) probably null Het
Mastl A G 2: 23,030,010 (GRCm39) S239P probably benign Het
Med18 A T 4: 132,186,977 (GRCm39) V174D probably damaging Het
Mgat4a A T 1: 37,502,007 (GRCm39) M247K possibly damaging Het
Nxt1 G T 2: 148,517,564 (GRCm39) E102* probably null Het
Or14j1 A G 17: 38,146,169 (GRCm39) Q93R possibly damaging Het
Or3a1 A G 11: 74,225,862 (GRCm39) F65S probably damaging Het
Or7g16 T C 9: 18,727,005 (GRCm39) N195S probably damaging Het
Pcdhb16 T A 18: 37,613,161 (GRCm39) V707E probably benign Het
Pdzrn4 T A 15: 92,667,768 (GRCm39) V640E probably damaging Het
Piwil4 T C 9: 14,637,282 (GRCm39) probably null Het
Pla2g4a A T 1: 149,776,950 (GRCm39) D55E probably damaging Het
Plekhg2 C A 7: 28,059,501 (GRCm39) R1276L probably damaging Het
Psd4 G A 2: 24,290,540 (GRCm39) W539* probably null Het
Rae1 G A 2: 172,845,306 (GRCm39) E33K probably damaging Het
Rbm12b1 T A 4: 12,145,563 (GRCm39) F512I probably damaging Het
Rfx6 A G 10: 51,602,952 (GRCm39) D823G possibly damaging Het
Samt3 A T X: 85,090,759 (GRCm39) Q217L probably damaging Het
Selenbp2 A G 3: 94,605,438 (GRCm39) N134S probably null Het
Selenoo T C 15: 88,984,173 (GRCm39) V663A probably damaging Het
Sp4 G T 12: 118,263,284 (GRCm39) T254N probably damaging Het
Spdya A G 17: 71,885,242 (GRCm39) K232R probably benign Het
Stom A T 2: 35,210,401 (GRCm39) V201E probably benign Het
Sycp3 A G 10: 88,302,334 (GRCm39) K108R possibly damaging Het
Usp2 A G 9: 44,000,425 (GRCm39) probably benign Het
Vmn1r226 T C 17: 20,907,926 (GRCm39) S53P probably damaging Het
Vmn2r14 C T 5: 109,372,349 (GRCm39) G47D probably damaging Het
Vwf T G 6: 125,623,318 (GRCm39) L1805W probably damaging Het
Washc3 A T 10: 88,037,687 (GRCm39) Q22L probably damaging Het
Wdr81 T A 11: 75,335,546 (GRCm39) D1761V probably damaging Het
Other mutations in Mx2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00421:Mx2 APN 16 97,345,678 (GRCm39) missense probably damaging 0.99
IGL01111:Mx2 APN 16 97,359,919 (GRCm39) missense probably benign
IGL02678:Mx2 APN 16 97,357,320 (GRCm39) critical splice donor site probably null
IGL03166:Mx2 APN 16 97,347,990 (GRCm39) missense probably damaging 1.00
IGL03323:Mx2 APN 16 97,347,575 (GRCm39) missense probably damaging 0.99
R0254:Mx2 UTSW 16 97,357,295 (GRCm39) missense probably benign
R0699:Mx2 UTSW 16 97,345,753 (GRCm39) missense probably damaging 1.00
R1180:Mx2 UTSW 16 97,357,209 (GRCm39) missense probably damaging 1.00
R1702:Mx2 UTSW 16 97,359,883 (GRCm39) missense probably benign
R1762:Mx2 UTSW 16 97,339,903 (GRCm39) missense probably benign 0.09
R1922:Mx2 UTSW 16 97,361,551 (GRCm39) missense probably benign 0.05
R2049:Mx2 UTSW 16 97,339,903 (GRCm39) missense probably benign 0.09
R2141:Mx2 UTSW 16 97,339,903 (GRCm39) missense probably benign 0.09
R2142:Mx2 UTSW 16 97,339,903 (GRCm39) missense probably benign 0.09
R3010:Mx2 UTSW 16 97,347,999 (GRCm39) missense possibly damaging 0.85
R4079:Mx2 UTSW 16 97,357,236 (GRCm39) missense probably damaging 0.98
R4553:Mx2 UTSW 16 97,353,205 (GRCm39) missense possibly damaging 0.52
R4594:Mx2 UTSW 16 97,348,632 (GRCm39) nonsense probably null
R5211:Mx2 UTSW 16 97,348,633 (GRCm39) missense probably damaging 1.00
R5785:Mx2 UTSW 16 97,339,904 (GRCm39) missense possibly damaging 0.90
R6091:Mx2 UTSW 16 97,347,635 (GRCm39) missense probably damaging 1.00
R7250:Mx2 UTSW 16 97,348,664 (GRCm39) missense probably damaging 0.99
R7485:Mx2 UTSW 16 97,346,918 (GRCm39) missense probably benign 0.11
R7793:Mx2 UTSW 16 97,348,083 (GRCm39) missense probably damaging 1.00
R7816:Mx2 UTSW 16 97,346,812 (GRCm39) missense probably damaging 1.00
Posted On 2015-04-16